Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 562351 - 562380 of 5167810

Full-Text Articles in Entire DC Network

Management Plan For The Western Painted Turtle At The Sandy River Delta In Troutdale, Oregon, Emma Scott Apr 2023

Management Plan For The Western Painted Turtle At The Sandy River Delta In Troutdale, Oregon, Emma Scott

Environmental Science and Management Professional Master's Project Reports

This management plan has been prepared for the Lower Columbia Estuary Partnership and is intended to provide guidance for the improvement and protection of western painted turtle (Chrysemys picta bellii) habitat at the Sandy River Delta in Troutdale, Oregon. The Sandy River Delta is a 1500-acre natural area situated where the Columbia and Sandy Rivers meet. Its dynamic floodplain habitat supports a diverse assemblage of species, including the western painted turtle, an Oregon Conservation Strategy Species. A small, unknown number of western painted turtles utilize the wetland habitats of the Sandy River Delta, and the frequency in observations …


Homelessness, Water Access, And Environmental Justice In An Urban Environment, Alicia Gamble Apr 2023

Homelessness, Water Access, And Environmental Justice In An Urban Environment, Alicia Gamble

Environmental Science and Management Professional Master's Project Reports

Only in recent years has houselessness been viewed as an environmental justice issue, and little is understood about the environmental injustices of water insecurity among unhoused individuals, especially during the COVID-19 pandemic. In order to understand the environmental injustices (i.e., distributive, procedural, and recognition) of the water insecurity process using the cause-response-effect theoretical model, unhoused participants living near services were interviewed in Portland, Oregon about their lived experiences gaining access to water, the barriers they encounter when trying to access water, and the impacts that result from these barriers. Results revealed that COVID-19 was a barrier to water access and …


An Examination Of The Current Knowledge Of Contaminants In Mangroves: Hawaii And Globally, Geoffrey Szafranski Apr 2023

An Examination Of The Current Knowledge Of Contaminants In Mangroves: Hawaii And Globally, Geoffrey Szafranski

Environmental Science and Management Professional Master's Project Reports

The geographic range of mangrove forests is shifting quickly as they expand poleward in response to climate change while simultaneously being removed from their native extent to clear space for anthropogenic land-uses. Mangrove forests are also known to be sinks for anthropogenic contamination. Yet contamination research is under-researched in mangrove ecosystems, specifically the environmental fate, effect on biodiversity, and risk to human populations from contamination in the context of these changing conditions requires further research. The goal of this thesis is to address this data gap through analysis of contamination in the literature and through an investigational survey of mangrove …


Exploring The Lexical Profile Of Advanced L2 Writers: Longitudinal Data From The Russian Overseas Flagship Program, William J. Comer Apr 2023

Exploring The Lexical Profile Of Advanced L2 Writers: Longitudinal Data From The Russian Overseas Flagship Program, William J. Comer

World Languages and Literatures Faculty Publications and Presentations

This study explores the lexical profile of essays written by 48 advanced learners of second language (L2) Russian who participated in the Russian Overseas Flagship, an intensive year-long study abroad program, designed to help students reach Interagency Language Roundtable (ILR) Level 3 proficiency in all skills. Using the lexical frequency profile (LFP) and P–Lex as measures of vocabulary sophistication, the study found that over the 9 months of the program, students significantly increased their usage of words from the lowest frequency bands. This adds to the findings of Hacking and Tschirner (2017) that knowledge of lexical items at the 3,000–5,000 …


Trust Model System For The Energy Grid Of Things Network Communications, Narmada Sonali Fernando, Zhongkai Zheng, John M. Acken, Robert B. Bass Apr 2023

Trust Model System For The Energy Grid Of Things Network Communications, Narmada Sonali Fernando, Zhongkai Zheng, John M. Acken, Robert B. Bass

Electrical and Computer Engineering Faculty Publications and Presentations

Network communication is crucial in the Energy Grid of Things (EGoT). Without a network connection, the energy grid becomes just a power grid where the energy resources are available to the customer uni-directionally. A mechanism to analyze and optimize the energy usage of the grid can only happen through a medium, a communications network, that enables information exchange between the grid participants and the service provider. Security implementers of EGoT network communication take extraordinary measures to ensure the safety of the energy grid, a critical infrastructure, as well as the safety and privacy of the grid participants. With the dynamic …


Association Of Clinical Outcomes And Connectivity In Awake Versus Asleep Deep Brain Stimulation For Parkinson Disease, Ron Gadot, Nora Vanegas Arroyave, Huy Dang, Adrish Anand, Ricardo A Najera, Lisa Yutong Taneff, Steven Bellows, Arjun Tarakad, Joseph Jankovic, Andreas Horn, Ben Shofty, Ashwin Viswanathan, Sameer A Sheth Apr 2023

Association Of Clinical Outcomes And Connectivity In Awake Versus Asleep Deep Brain Stimulation For Parkinson Disease, Ron Gadot, Nora Vanegas Arroyave, Huy Dang, Adrish Anand, Ricardo A Najera, Lisa Yutong Taneff, Steven Bellows, Arjun Tarakad, Joseph Jankovic, Andreas Horn, Ben Shofty, Ashwin Viswanathan, Sameer A Sheth

Faculty, Staff and Students Publications

OBJECTIVE: Deep brain stimulation (DBS) for Parkinson disease (PD) is traditionally performed with awake intraoperative testing and/or microelectrode recording. Recently, however, the procedure has been increasingly performed under general anesthesia with image-based verification. The authors sought to compare structural and functional networks engaged by awake and asleep PD-DBS of the subthalamic nucleus (STN) and correlate them with clinical outcomes.

METHODS: Levodopa equivalent daily dose (LEDD), pre- and postoperative motor scores on the Movement Disorders Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III), and total electrical energy delivered (TEED) at 6 months were retroactively assessed in patients with PD who …


Paving The Road For Chimeric Antigen Receptor T Cells: American Society For Transplantation And Cellular Therapy 80/20 Task Force Consensus On Challenges And Solutions To Improving Efficiency Of Clinical Center Certification And Maintenance Of Operations For Commercially Approved Immune Effector Cell Therapies, Sarah Nikiforow, Matthew J Frigault, Noelle V Frey, Rebecca A Gardner, Krishna V Komanduri, Miguel-Angel Perales, Partow Kebriaei, Phyllis Irene Warkentin, Marcelo Pasquini, Joy Lynn Aho, Bruce L Levine, Helen E Heslop, Tracey L Hlucky, Karen Habucky, Mecide Gharibo, Madan Jagasia, Frederick L Locke Apr 2023

Paving The Road For Chimeric Antigen Receptor T Cells: American Society For Transplantation And Cellular Therapy 80/20 Task Force Consensus On Challenges And Solutions To Improving Efficiency Of Clinical Center Certification And Maintenance Of Operations For Commercially Approved Immune Effector Cell Therapies, Sarah Nikiforow, Matthew J Frigault, Noelle V Frey, Rebecca A Gardner, Krishna V Komanduri, Miguel-Angel Perales, Partow Kebriaei, Phyllis Irene Warkentin, Marcelo Pasquini, Joy Lynn Aho, Bruce L Levine, Helen E Heslop, Tracey L Hlucky, Karen Habucky, Mecide Gharibo, Madan Jagasia, Frederick L Locke

Faculty, Staff and Students Publications

As the number and type of regulatory authority-approved cellular therapies grow, clinical treatment centers face a heavy burden of duplicative documentation around initial qualification, ongoing auditing, and reporting, with overlapping requirements from each manufacturer to ensure safe use of their specific product, which in the United States are stipulated under individual Food and Drug Administration (FDA) Biologic License Applications. The American Society for Transplantation and Cellular Therapy (ASTCT) convened the 80/20 Task Force to consider challenges and potential solutions to these issues. The Task Force proposed that 80% of manufacturers' requirements for onboarding and ongoing operations of commercially available products …


Coevolutionary Signals In Metabotropic Glutamate Receptors Capture Residue Contacts And Long-Range Functional Interactions, Eunna Huh, Melina A Agosto, Theodore G Wensel, Olivier Lichtarge Apr 2023

Coevolutionary Signals In Metabotropic Glutamate Receptors Capture Residue Contacts And Long-Range Functional Interactions, Eunna Huh, Melina A Agosto, Theodore G Wensel, Olivier Lichtarge

Faculty, Staff and Students Publications

Upon ligand binding to a G protein-coupled receptor, extracellular signals are transmitted into a cell through sets of residue interactions that translate ligand binding into structural rearrangements. These interactions needed for functions impose evolutionary constraints so that, on occasion, mutations in one position may be compensated by other mutations at functionally coupled positions. To quantify the impact of amino acid substitutions in the context of major evolutionary divergence in the G protein-coupled receptor subfamily of metabotropic glutamate receptors (mGluRs), we combined two phylogenetic-based algorithms, Evolutionary Trace and covariation Evolutionary Trace, to infer potential structure-function couplings and roles in mGluRs. We …


Association Of Coronary Artery Calcium Density And Volume With Predicted Atherosclerotic Cardiovascular Disease Risk And Cardiometabolic Risk Factors In South Asians: The Mediators Of Atherosclerosis In South Asians Living In America (Masala) Study, Mahmoud Al Rifai, Alka M Kanaya, Namratha R Kandula, Jaideep Patel, Mouaz H Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H Criqui, Salim S Virani Apr 2023

Association Of Coronary Artery Calcium Density And Volume With Predicted Atherosclerotic Cardiovascular Disease Risk And Cardiometabolic Risk Factors In South Asians: The Mediators Of Atherosclerosis In South Asians Living In America (Masala) Study, Mahmoud Al Rifai, Alka M Kanaya, Namratha R Kandula, Jaideep Patel, Mouaz H Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H Criqui, Salim S Virani

Faculty, Staff and Students Publications

Background:

Individuals of South Asians (SA) ancestry are predisposed to higher risk of atherosclerotic cardiovascular disease (ASCVD). Coronary artery calcium (CAC) volume and density can identify coronary plaque characteristics unique to SA that may provide important prognostic information to identify high risk individuals beyond traditional CAC scores.

Methods:

We used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA). CAC density and volume were calculated according to established protocols. ASCVD risk was estimated using the pooled cohort equations (PCE). Multivariable-adjusted linear regression models were used to study the association between the PCE and advanced CAC measures, …


Lobar Pneumonia Presenting As Fever, Headaches, And A Negative Chest Radiograph, David R Rendon, Jason Shiau, Stephanie V Sherman Apr 2023

Lobar Pneumonia Presenting As Fever, Headaches, And A Negative Chest Radiograph, David R Rendon, Jason Shiau, Stephanie V Sherman

Faculty, Staff and Students Publications

No abstract provided.


Colonization Of Patients Hospitalized At Orthopedic Department Of Tertiary Hospital In Uganda With Extended-Spectrum Beta-Lactamase-Producing Enterobacterales, Jules Bizimana, Jerome Ndayisenga, Henry Kajumbura, Phillip Mulepo, Najjuka Florence Christine Apr 2023

Colonization Of Patients Hospitalized At Orthopedic Department Of Tertiary Hospital In Uganda With Extended-Spectrum Beta-Lactamase-Producing Enterobacterales, Jules Bizimana, Jerome Ndayisenga, Henry Kajumbura, Phillip Mulepo, Najjuka Florence Christine

Faculty, Staff and Students Publications

BACKGROUND: Beta-lactamase production remains the most contributing factor to beta-lactam resistance. Extended-Spectrum Beta-Lactamase-Producing Enterobacterales (ESBL-PE) are associated with risk factors both in hospital and community settings.

OBJECTIVES: To assess the incidence and risk factors for intestinal carriage of ESBL-PE among patients admitted to orthopedic ward of Mulago National Referral Hospital, and to analyze the acquisition of ESBL-PE during hospital stay and associated factors.

METHODS: We screened 172 patients aged 18 years old and above who got admitted to the orthopedic ward of Mulago National Referral Hospital between May to July 2017. Stool samples or rectal swabs were collected at admission, …


Editorial, Janet Brennan Croft Apr 2023

Editorial, Janet Brennan Croft

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.


Terry Pratchett’S Witches Novels And The Consensus Fantasy Universe: A Feminist Perspective, Clair J. Hutchings-Budd Ms Apr 2023

Terry Pratchett’S Witches Novels And The Consensus Fantasy Universe: A Feminist Perspective, Clair J. Hutchings-Budd Ms

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Abstract

Between 1987 and 2015, Terry Pratchett published eleven novels and one short story within his Discworld universe that came to be known as his “Witches” sub-series. In these texts he engaged with the narrative imperatives, preoccupations, and tropes which together make up the consensus fantasy universe, and those deeper mythologies and legendarium with which the author necessarily has an intertextual relationship. This paper focuses upon one aspect of that consensus universe, which is the difference between male and female magical practitioners—witches and wizards—in the fantasy canon, and how Pratchett sought to challenge and subvert the stereotypes of the genre …


Blood On The Snow, Soot On The Carpet: Belief As Pedagogy In Terry Pratchett’S Hogfather, Michael A. Moir Jr. Apr 2023

Blood On The Snow, Soot On The Carpet: Belief As Pedagogy In Terry Pratchett’S Hogfather, Michael A. Moir Jr.

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

In Terry Pratchett’s Discworld novels, children largely refuse to conform to the ideas that adults form about them as a class. While the adults of the Discworld seem to regard childhood as a time of innocence and wonder, the children who inhabit Pratchett’s universe show themselves to be violent, cynical, manipulative, and naturally skeptical of any phenomena which they cannot directly sense. As such, when the beloved seasonal figure of the Hogfather, a former Winter Solstice deity transformed over time into a gift-giving fat man with a taste for sherry and pork-pies, is assaulted by entities who want to make …


Mythopoesis In Tennyson's Idylls Of The King, Rebecca A. Umland Apr 2023

Mythopoesis In Tennyson's Idylls Of The King, Rebecca A. Umland

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This essay examines mythopoesis in Tennyson’s Idylls of the King. This epic Arthurian poem includes features of the futuristic and fantasy genres and confounds linear time. The poet creates an imaginary geography—one steeped in history and myth—for the arrival and departure of his remarkable hero, Arthur. Moreover, through the mythopoesis of his epic poem, Tennyson’s King is more than human, differing in both degree and kind from his knights. The bookend poems that open and close the combined Idylls represent two of Tennyson’s boldest departures from the received legend that emerged out of the Middle Ages.


The Dragon And The Railway Station, Verlyn Flieger Apr 2023

The Dragon And The Railway Station, Verlyn Flieger

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

The curious substitution of Bletchley Station for Paddington Station between two versions of “On Fairy-stories” may have a simple origin in Tolkien’s interest in code-breaking, but on investigation (as with most things Tolkien-related) goes deeper.


Delving Too Greedily: Analyzing Prejudice Against Tolkien's Dwarves As Historical Bias, Mitchell T. Dennis, Kenton Sena Apr 2023

Delving Too Greedily: Analyzing Prejudice Against Tolkien's Dwarves As Historical Bias, Mitchell T. Dennis, Kenton Sena

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Tolkien's writings are imbued with the perspectives of their narrators and within them, the narrators' biases. This is most evident in the bias against the dwarves, particularly in the third age. Dismissing testimonials from neutral sources and dwarves alike, scholars have continuously inaccurately treated the anti-dwarf bias as a criticism of the Dwarves’ relationship with nature. The criticisms levelled by scholars have led to the dwarves being dismissed as particularly environmentally destructive, a direct contradiction to how the dwarves interact with natural spaces and how they construct their own. Consequently, a more nuanced reading of the dwarves lends itself to …


Thinking Queerly: Medievalism, Wizardry, And Neurodiversity In Young Adult Texts By Jes Battis, Marisa Mills Apr 2023

Thinking Queerly: Medievalism, Wizardry, And Neurodiversity In Young Adult Texts By Jes Battis, Marisa Mills

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This is my review of Jes Battis's book Thinking Queerly: Medievalism, Wizardry, and Neurodiversity in Young Adult Texts. Battis’s book reads beautifully and easily, even if you are not well-versed in disability studies or queer theory, and I imagine that even a reader who is not especially knowledgeable about either medievalisms or YA literature could also follow along well. This book is written in an uncommonly accessible, even conversational style, that is utterly enthralling, and yet Battis’s work still shows impressive scholarly rigor and scope. If I were to describe the book in a single sentence, it would be this …


George Macdonald In The Age Of Miracles: Incarnation, Doubt, And Reenchantment By Timothy Larsen, James Hamby Apr 2023

George Macdonald In The Age Of Miracles: Incarnation, Doubt, And Reenchantment By Timothy Larsen, James Hamby

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.


Harry Potter And The Other; Race, Justice And Difference In The Wizarding World, Edited By Sarah Park Dahlen And Ebony Elizabeth Thomas, And Open At The Close: Literary Essays On Harry Potter, Edited By Cecelia Koncharr Farr, Joseph R. Young Apr 2023

Harry Potter And The Other; Race, Justice And Difference In The Wizarding World, Edited By Sarah Park Dahlen And Ebony Elizabeth Thomas, And Open At The Close: Literary Essays On Harry Potter, Edited By Cecelia Koncharr Farr, Joseph R. Young

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This is a review of the book Harry Potter and the Other; Race, Justice and Difference in the Wizarding World edited by Sarah Park Dahlen and Ebony Elizabeth Thomas.


The Map Of Wilderland: Ecocritical Reflections On Tolkien’S Myth Of Wilderness By Amber Lehning, Maria K. Alberto Apr 2023

The Map Of Wilderland: Ecocritical Reflections On Tolkien’S Myth Of Wilderness By Amber Lehning, Maria K. Alberto

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.


Superman In Myth And Folklore By Daniel Peretti, And The Mythology Of The Superhero By Andrew R. Bahlmann, David L. Emerson Apr 2023

Superman In Myth And Folklore By Daniel Peretti, And The Mythology Of The Superhero By Andrew R. Bahlmann, David L. Emerson

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Reviews of Superman in Myth and Folklore and The Mythology of the Superhero


Fairy Tales, Myth, And Psychoanalytic Theory: Feminism And Retelling The Tale By Veronica L. Schanoes, John Rosegrant Apr 2023

Fairy Tales, Myth, And Psychoanalytic Theory: Feminism And Retelling The Tale By Veronica L. Schanoes, John Rosegrant

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

NA


The Gallant Edith Bratt: J.R.R. Tolkien’S Inspiration By Nancy Bunting And Seamus Hamill-Keays, María Fernández Portaencasa Apr 2023

The Gallant Edith Bratt: J.R.R. Tolkien’S Inspiration By Nancy Bunting And Seamus Hamill-Keays, María Fernández Portaencasa

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.


Ithell Colquhuon Taro As Colour Tarot Deck And Book By Ithell Colquhoun, Emily E. Auger Apr 2023

Ithell Colquhuon Taro As Colour Tarot Deck And Book By Ithell Colquhoun, Emily E. Auger

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

A brief note regarding Fulgur's release of Ithell Colquhoun's "Taro" deck (2022) with links to a full-length review of it and to other reviews of related publications about Colquhoun and Leonora Carrington's work with Tarot.


Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation In Preterm Pigs, Line I Christiansen, Bo Holmqvist, Xiaoyu Pan, Kristine Holgersen, Sandy E H Lindholm, Nicole L Henriksen, Douglas G Burrin, David Ley, Thomas Thymann, Per Torp Sangild, Stanislava Pankratova Apr 2023

Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation In Preterm Pigs, Line I Christiansen, Bo Holmqvist, Xiaoyu Pan, Kristine Holgersen, Sandy E H Lindholm, Nicole L Henriksen, Douglas G Burrin, David Ley, Thomas Thymann, Per Torp Sangild, Stanislava Pankratova

Faculty, Staff and Students Publications

Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is associated with postnatal growth restriction and poor neurologic outcomes. It remains unknown whether supplemental IGF-1 may stimulate neurodevelopment in preterm neonates. Using cesarean-delivered preterm pigs as a model of preterm infants, we investigated the effects of supplemental IGF-1 on motor function and on regional and cellular brain development. Pigs were treated with 2.25 mg/kg/d recombinant human IGF-1/IGF binding protein-3 complex from birth until day 5 or 9 before the collection of brain samples for quantitative immunohistochemistry (IHC), RNA sequencing, and quantitative PCR analyses. Brain protein synthesis was …


Cigarette Smoke Condensate Induces Centrosome Clustering In Normal Lung Epithelial Cells, Jose Thaiparambil, Chandra S Amara, Subrata Sen, Nagireddy Putluri, Randa El-Zein Apr 2023

Cigarette Smoke Condensate Induces Centrosome Clustering In Normal Lung Epithelial Cells, Jose Thaiparambil, Chandra S Amara, Subrata Sen, Nagireddy Putluri, Randa El-Zein

Faculty, Staff and Students Publications

BACKGROUND: Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division. Inhibiting centrosome clustering, therefore, holds therapeutic promise to promote cancer cell-specific cell death.

METHODS: We used confocal microscopy, real-time PCR, siRNA knockdown, and western blot to analyze centrosome clustering and declustering using normal lung bronchial epithelial and nonsmall-cell lung cancer (NSCLC) cell lines. Also, we used Ingenuity Pathway Analysis software to identify novel pathways associated with centrosome clustering.

RESULTS: In this study, we found that exposure to cigarette smoke condensate induces centrosome amplification and clustering in …


Machine Learning And Health Care: Potential Benefits And Issues, J Graham Atkinson, Elizabeth G Atkinson Apr 2023

Machine Learning And Health Care: Potential Benefits And Issues, J Graham Atkinson, Elizabeth G Atkinson

Faculty, Staff and Students Publications

We discuss the potential for machine learning (ML) and artificial intelligence (AI) to improve health care, while detailing caveats and important considerations to ensure unbiased and equitable implementation. If disparities exist in the data used to train ML algorithms, they must be recognized and accounted for, so they do not bias performance accuracy or are not interpreted by the algorithm as simply a lack of need. We pay particular attention to an area in which bias in data composition is particularly striking, that is in large-scale genetics databases, as people of European descent are vastly overrepresented in the existing resources.


Telemental Health In Emergency Care Settings: A Qualitative Analysis Of Considerations For Sustainability And Spread, Mckenzie K Roddy, Patricia Chen, Alvin D Jeffery, Jeydith Gutierrez, Melissa Rubenstein, Corey Campbell, Eric Blake, Michael J Ward Apr 2023

Telemental Health In Emergency Care Settings: A Qualitative Analysis Of Considerations For Sustainability And Spread, Mckenzie K Roddy, Patricia Chen, Alvin D Jeffery, Jeydith Gutierrez, Melissa Rubenstein, Corey Campbell, Eric Blake, Michael J Ward

Faculty, Staff and Students Publications

Objectives: Following rapid uptake of telehealth during the COVID-19 pandemic, we examined barriers and facilitators for sustainability and spread of telemental health video (TMH-V) as policies regarding precautions from the pandemic waned.

Methods: We conducted a qualitative study using semistructured interviews and observations guided by RE-AIM. We asked four groups, local clinicians, facility leadership, Veterans, and external partners, about barriers and facilitators impacting patient willingness to engage in TMH-V (reach), quality of care (effectiveness), barriers and facilitators impacting provider uptake (adoption), possible adaptations to TMH-V (implementation), and possibilities for long-term use of TMH-V (maintenance). Interviews were recorded, transcribed, and analyzed …


Familial Hypercholesterolemia In The Electronic Medical Records And Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, And Outcomes After Return Of Results, Ozan Dikilitas, Alborz Sherafati, Seyedmohammad Saadatagah, Benjamin A Satterfield, David C Kochan, Katherine C Anderson, Wendy K Chung, Scott J Hebbring, Zachary M Salvati, Richard R Sharp, Amy C Sturm, Richard A Gibbs, Robb Rowley, Eric Venner, Jodell E Linder, Laney K Jones, Emma F Perez, Josh F Peterson, Gail P Jarvik, Heidi L Rehm, Hana Zouk, Dan M Roden, Marc S Williams, Teri A Manolio, Iftikhar J Kullo Apr 2023

Familial Hypercholesterolemia In The Electronic Medical Records And Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, And Outcomes After Return Of Results, Ozan Dikilitas, Alborz Sherafati, Seyedmohammad Saadatagah, Benjamin A Satterfield, David C Kochan, Katherine C Anderson, Wendy K Chung, Scott J Hebbring, Zachary M Salvati, Richard R Sharp, Amy C Sturm, Richard A Gibbs, Robb Rowley, Eric Venner, Jodell E Linder, Laney K Jones, Emma F Perez, Josh F Peterson, Gail P Jarvik, Heidi L Rehm, Hana Zouk, Dan M Roden, Marc S Williams, Teri A Manolio, Iftikhar J Kullo

Faculty, Staff and Students Publications

BACKGROUND: The implications of secondary findings detected in large-scale sequencing projects remain uncertain. We assessed prevalence and penetrance of pathogenic familial hypercholesterolemia (FH) variants, their association with coronary heart disease (CHD), and 1-year outcomes following return of results in phase III of the electronic medical records and genomics network.

METHODS: Adult participants (n=18 544) at 7 sites were enrolled in a prospective cohort study to assess the clinical impact of returning results from targeted sequencing of 68 actionable genes, including

RESULTS: The prevalence of FH-associated pathogenic variants was 1 in 188 (69 of 13,019 unselected participants). Penetrance was 87.5%. The …