Digital Commons Network^™

Review Of Imagined Audiences: How Journalists Perceive And Pursue The Public, Patrick R. Johnson

College of Communication Faculty Research and Publications

No abstract provided.

An Antibody-Drug Conjugate Targeting Gpr56 Demonstrates Efficacy In Preclinical Models Of Colorectal Cancer, Joan Jacob, Liezl E Francisco, Treena Chatterjee, Zhengdong Liang, Shraddha Subramanian, Qingyun J Liu, Julie H Rowe, Kendra S Carmon

Faculty, Staff and Student Publications

BACKGROUND: Long-term prognosis remains poor for colorectal cancer (CRC) patients with advanced disease due to treatment resistance. The identification of novel targets is essential for the development of new therapeutic approaches. GPR56, an adhesion GPCR, is highly expressed in CRC tumours and correlates with poor survival. Here, we describe the generation and preclinical evaluation of a novel ADC consisting of an anti-GPR56 antibody (10C7) conjugated with the DNA-damaging payload duocarmycin.

METHODS: RNA-seq dataset analysis was performed to determine GPR56 expression in CRC subtypes. The specificity of binding, epitope mapping, and internalisation of 10C7 was examined. 10C7 was conjugated to payload …

Peristomal Irritant Contact Dermatitis Treated With Dupilumab, Emma Villamaria, Chelsea Steele, Megan Rogge

Faculty, Staff and Student Publications

No abstract provided.

Unicentric Castleman Disease In The Temporal Region Of A Pediatric Patient, Jeffrey Dickman, Samantha Haraszti, Karen Warschaw, Weimin Hu

GME Publications

No abstract provided.

A Semiotic Analysis Of Two Linear A Inscribed Ladles, Leah Rosen

Honors Projects

On the peak sanctuary Agio Georgios on the island of Kythera, and at the archaeological site of Troullos on Crete, two Linear A (LA) inscribed ladles have been found. They are unique in that they are the only inscribed Minoan ladles found to date. Because inscription is not a common feature of Minoan ladles, the purpose of these two inscriptions is of particular interest. However, Linear A, the writing system of the Minoans, remains undeciphered and is unlikely to be translated for the foreseeable future. In the meantime, other approaches to studying Linear A inscriptions can still provide insight into …

Duloxetine For Postoperative Pain Control Following Knee Or Hip Replacement: A Systematic Review And Meta-Analysis, Ian A. Jones, Arad Talehakimi, Linda S. Murphy, Jennifer C. Wang, Amit S. Piple, Alexander B. Christ, Nathanael D. Heckmann

Student Publications

Background: Duloxetine is a Food and Drug Administration-approved selective norepinephrine reuptake inhibitor for treating depression, anxiety, fibromyalgia, and neuropathic and chronic musculoskeletal pain. This meta-analysis aims to evaluate the efficacy of duloxetine in reducing pain and postoperative opioid use following lower extremity total joint arthroplasty.

Methods: A literature search was performed, identifying randomized controlled trials investigating duloxetine for pain management after total hip and total knee arthroplasty. Data from the visual analog scale (VAS) for pain during movement and at rest were extracted for postoperative days (PODs) 1, 3, 7, and 14, as well as postoperative week 6 and postoperative …

Inclusive Pedagogy Through Digital Scholarship: A Case Study, Rebecca Fitzsimmons, Anne Shelley

Faculty and Staff Publications – Milner Library

After a coordinated effort in 2019 to determine faculty activities and needs related to digital humanities, our library began offering outreach and support to faculty using digital humanities in research and teaching. In summer 2020, after two librarians facilitated a faculty development workshop on using digital humanities tools in the classroom, an instructor in educational leadership invited the librarians to help her incorporate multimodal publishing, data visualization, and mapping methods into one of her fall 2020 courses related to community building in K-12 education. The tools incorporated into the course allowed a range of collaborative possibilities between students, creating new …

Sharksrx Newsletter Spring 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

State: The Magazine Of Illinois State University, Spring 2023, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

Vibration Control Of A Two-Story Base-Isolated Building Using A New Tuned Mass Multi-Sliding Friction Damper, Mohsen Amjadian, Syed Muhammad Bilal Haider

Civil Engineering Faculty Publications

This paper studies the use of a new Tuned Mass Multi-Sliding Friction Damper (TMMSFD) to increase the damping capacity of seismic isolators installed on a two-story base-isolated building to limit their lateral deformations. The proposed TMMSFD consists of a set of several masses that are laterally attached to the superstructure floor through linear springs. These masses are placed on top of each other one by one and are allowed to slide with respect to each other during the earthquake. The bottom mass that carries the weight of upper masses is in contact with the superstructure floor. The damping of system …

Therapeutic Implications Of Uvb Irradiation In Cancer By Enhancing Anti-Tumor Immunity, Bilal B. Hafeez, Ed W. Alvarado, Dae Joon Kim

School of Medicine Publications

UVB irradiation is well known for its impact in the development of skin cancer. However, low UVB irradiation plays protective role against various human diseases including cancer through its effect on tumor suppression. This article summarizes the key findings of the paper by Park et al., which describes a novel molecular mechanism of moderate UVB irradiation in suppressing the growth of melanoma and colorectal cancer. Key observations in this paper are that moderate UVB irradiation can enhance tumor immunity by 1) increased infiltration of CD4+ and CD8+ T cells, 2) increased infiltration of CD103+ conventional type 1 dendritic cells (cDC1), …

Feasibility Analysis Of A Wave Powered Autonomous Underwater Vehicle, Yingchen Yang, Erick Martinez

Mechanical Engineering Faculty Publications

An autonomous underwater vehicle (AUV) powered by renewable energy would enable it to extend endurance and forward presence with no logistics tail for fuel. A wave powered concept AUV is proposed and analyzed for this purpose. The AUV is in a torpedo shape and employs a fully hull-encapsulated mass-spring-damper system as its power take-off (PTO) unit. While in the recharging mode, the AUV surfaces and converts wave energy for electricity. Considering the AUV of a common size, our analysis indicates that resonance of the AUV and/or its PTO, to be excited by ocean waves, becomes impossible in typical ocean conditions. …

Role Of T Cells In Cancer Immunotherapy: Opportunities And Challenges, Hossain Ahmed, Aar Rafi Mahmud, Mohd. Faijanur - Rob – Siddiquee, Asif Shahriar, Partha Biswas, Md. Ebrahim Khalil Shimul, Shahlaa Zernaz Ahmed, Tanzila Ismail Ema, Nova Rahman, Md. Arif Khan

School of Medicine Publications

Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types, yet clinical responses differ among patients and cancers. Recently, there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor responses. Antigen-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune system. The molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy, including checkpoint blockade, adoptive and chimeric antigen receptor (CAR) T cell therapy, and cancer …

Ramanujan–Sato Series For 1/Π, Timothy Huber, Daniel Schultz, Dongxi Ye

School of Mathematical & Statistical Sciences Faculty Publications

We compute Ramanujan–Sato series systematically in terms of Thompson series and their modular equations. A complete list of rational and quadratic series corresponding to singular values of the parameters is derived.

P-Adic Cellular Neural Networks: Applications To Image Processing, B. A. Zambrano-Luna, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

The p-adic cellular neural networks (CNNs) are mathematical generalizations of the neural networks introduced by Chua and Yang in the 80s. In this work we present two new types of -adic CNNs that can perform computations with real data, and whose dynamics can be understood almost completely. The first type of networks are edge detectors for grayscale images. The stationary states of these networks are organized hierarchically in a lattice structure. The dynamics of any of these networks consists of transitions toward some minimal state in the lattice. The second type is a new class of reaction–diffusion networks. We investigate …

A Short Solution Of The Kissing Number Problem In Dimension Three, Alexey Glazyrin

School of Mathematical & Statistical Sciences Faculty Publications

We give a short solution of the kissing number problem in dimension three.

Diurnal Variability Of Cortisol In The Pennsylvania Adult Smoking Study: Exploration Of Association With Nicotine Intake, Michael Machiorlatti, Nicole Krebs, Dongxiao Sun, Joshua E. Muscat

School of Medicine Publications

Cortisol in saliva, urine and plasma follows a diurnal rhythm typically characterized as a morning peak and a decline throughout the waking day. While often measured under controlled conditions, inter-individual differences in cortisol diurnal rhythms in free living populations are not well characterized. Cortisol levels may vary substantially between individuals and the level of variation may differ depending on the time of day. Further, associations with individual characteristics such as nicotine dependence on cortisol rhythms have not been adequately determined. We developed a Liquid Chromatography-Tandem Mass Spectrometry method to measure cortisol in saliva of 180 smokers from the Pennsylvania Adult …

Evaluating Species-Specific Replenishment Solution Effects On Plant Growth And Root Zone Nutrients With Hydroponic Arugula (Eruca Sativa L.) And Basil (Ocimum Basilicum L.), Lauren L. Houston, Ryan W. Dickson, Matthew B. Bertucci, Trenton L. Roberts

Horticulture Faculty Publications and Presentations

Managing nutrients in recirculating solutions can be challenging in hydroponic production, and poor management practices can rapidly result in root zone nutrient imbalances in reduced yield. Using mass balance principles to formulate hydroponic replenishment solutions is a proposed strategy to reduce nutrient imbalances and the need to periodically replace the hydroponic solution. Objectives were to (1) formulate species-specific nutrient replenishment solutions for arugula (Eruca sativa L.) and basil (Ocimum basilicum L.) using mass balance principles and (2) evaluate the effects of using these replenishment solutions on plant growth and root zone nutrients over time. In the first experiment, …

Bronchiolitis: Hypertonic Saline, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Ranunculus Cut Flower Production In Utah, Shannon Rauter, Melanie Stock

All Current Publications

Ranunculus (Ranunculus asiaticus) is grown as a cool-season annual for cut flower production in Utah. Tuberous roots can be planted as early as November in a high tunnel for blooms beginning in April. For field production, plant in November with insulation or as early as possible in spring for blooms beginning in May. Flower production ceases when temperatures reach approximately 80°F, usually by early July in northern Utah. In North Logan, UT, high tunnels produced an average of 3 to 7 marketable stems per plant, compared to 1 to 2 stems per plant in the field. Profit potential …

Anemone Cut Flower Production In Utah, Shannon Rauter, Melanie Stock

All Current Publications

Anemone (Anemone coronaria) is grown as a cool-season annual for cut flower production in Utah. Tubers can be planted as early as November in a high tunnel for blooms beginning in March. For field production, plant in fall with insulation or as early as possible in spring (i.e., the soil is workable, approximately early March) for blooms beginning in May. Flower production ceases when temperatures reach approximately 80°F, usually by early July in northern Utah. In North Logan, UT, high tunnels produced an average of 2 to 7 marketable stems per plant, compared to 1 to 4 stems …

Polycyclic Aromatic Hydrocarbon (Pah) Contamination In Urban Soils: Testing And Management, Melissa Chilinski, Paul Grossl, Melanie Stock

All Current Publications

Polycyclic aromatic hydrocarbons (PAHs) are a large class of chemicals and common environmental pollutants. Understanding which PAHs and soil test levels may impact human health is an important aspect of gardening and micro-farming, particularly in urban environments that are at increased risk of soil contamination. Land use histories, such as sites associated with vehicle and industrial emissions, burning, and dumping, can elevate concentrations of PAHs in soils. This fact sheet provides instructions on assessing your site for PAHs that may present health risks to humans, testing the soil, and first steps for interpretation and management.

Impact Of Covid-19 On Mental Health In Bhutan: A Way Forward For Action, T Tsheten, D Chateau, N Dorji, Hp Pokhrel, Et Al

Peninsula Medical School

The coronavirus disease 2019 (COVID-19) pandemic continues to impact mental health and wellbeing globally. There is a lack of scientific documentation highlighting the mental health impact of COVID-19 in Bhutan. We present the mental health burdens and control measures taken, and suggest ways to further strengthen mental health services in Bhutan. During the pandemic, a rise in depression and anxiety had been reported in Bhutan. Depression rose from an average prevalence of 9 per 10,000 between 2011 and 2019 to 16 per 10,000 in 2020 and 32 per 10,000 in 2021. Similarly, anxiety rose from an average prevalence of 18 …

The United States After The Third Religious Disestablishment: A Case Study Of The Adf’S Strategies In Prolonging Culture Wars, Rachel Williams

Honors Projects

In the early ‘90s, several conservative Christian legal organizations (CCLOs) sprung up in the United States in response to pluralism. These CCLOs sought to match the strategies and power of long-standing liberal public interest groups, like the American Civil Liberties Union (ACLU). Much literature has been produced on the activities of CCLOs, but few have considered the CCLOs’ lasting impact on the nation. Using Willamette University College of Law Professor Steven K. Green's framework of religious disestablishments across U.S. history, this paper proposes that the country has entered a prolonged period of moral reestablishment partly thanks to CCLOs. With a …

Policy Type And Presidential Messaging As Factors Of Legislative Productivity, Madison Garofalo

Honors Projects

This paper attempts to settle scholarly debates around significant legislation’s passage rates within the context of presidential mentions and influence amongst legislation. The first section of this paper will lay out significant literature surrounding topics such as: quantifying congressional-presidential relations, scholarly investigations centered around divided and unified government, works concerning institutional effects on legislative productivity, as well as investigations into legislative success by policy type. Secondly, the paper will discuss the methodological processes and standards used to determine if presidential mentioning is influential on legislative success. The next section will identify key findings to determine if the hypotheses of the …

Motives For Independence: The Case Of Spain’S Catalonia, Emma Stroh

Honors Projects

After decades of struggling for autonomy, Catalonia, Spain has initiated a renewed independence movement. This paper seeks to answer the question: what economic motives are driving the possibility of Catalan secession from Spain, and how have these motives affected Catalonia’s economy and ways of life? I will focus on the politically and economically significant timeline of 2008-2019, analyzing indicators of economic health such as Gross Domestic Product, Foreign Direct Investment Rates, Unemployment, and the actions of Ibex-35 Businesses within Catalonia. Further, I will use public opinion polls on independence and national identity to gauge support for independence within the region, …

Large Eddy Simulation For Empirical Modeling Of The Wake Of Three Urban Air Mobility Vehicles, Denis-Gabriel Caprace, Andrew Ning

Faculty Publications

Recent advances in urban air mobility have driven the development of many new VTOL concepts. These vehicles often feature original designs departing from the conventional helicopter configuration. Due to their novelty, the characteristics of the super-vortices forming in the wake of such aircraft are unknown. However, these vortices may endanger any other vehicle evolving in their close proximity, owing to potentially large induced velocities. Therefore, improved knowledge about the wakes of VTOL vehicles is needed to guarantee safe urban air mobility operations. In this work, we study the wake of three VTOL aircraft in cruise by means of large eddy …

Eli And Susannah Wiggill: South African Saints, Jay H. Buckley, Joshua Rust

Faculty Publications

Eli Wiggill’s story of migration from Gloucester, England, to South Africa and then to Salt Lake City, Utah Territory, epitomizes an inspiring and informative example of the gathering of the Saints to Zion in the mid-nineteenth century. Eli and his wife, Susannah Bentley Wiggill, joined The Church of Jesus Christ of Latter-day Saints in South Africa while Eli served as a Methodist missionary. Both became stalwart members following their conversion. Eli and Susannah Wiggill’s faithful dedication affected the lives of hundreds of South African Saints. This essay adds to scholarship about Eli and Susannah Wiggill’s immigration from England to South …

Acting In Good Faith, Tanya Dean

Articles

No abstract provided.

Exploring Incidence And Risk Factors For Persistent Postoperative Opioid Use In Adult Surgical Patients: A Systematic Review Protocol, Harry Griffiths, Bridie Kent, Daniel Martin

School of Nursing and Midwifery

Objective: The objective of this review is to determine the incidence of persistent postsurgical use of opioids in adult patients and the associated risk factors. Introduction: Surgery has been identified as an independent risk factor for unwarranted chronic opioid use, contributing to opioid-related harm in the community. Persistent opioid use after surgery is associated with morbidity and mortality from opioid-related adverse events, indicating a significant yet mitigable public health concern. There is substantial variation in the reported incidence and risk factors for postoperative opioid use, which require evaluation for future evidence-based risk-reduction strategies. Inclusion criteria: This review will include studies …