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Evidence That The Inner Nuclear Membrane Is A Functional Β1-Adrenergic Receptor Signaling Platform In Astrocytes, Kelsey Benton Apr 2023

Evidence That The Inner Nuclear Membrane Is A Functional Β1-Adrenergic Receptor Signaling Platform In Astrocytes, Kelsey Benton

Dissertations (1934 -)

The noradrenergic system exerts powerful modulatory influences over fundamental brain processes including attention, arousal, learning, and memory by activating adrenergic receptors on neuronal and glial cells. In addition to triggering rapid, transient changes in cellular physiology that drive short-term behavioral actions, these G-protein-coupled receptors also initiate delayed, long-lasting changes in cellular function by regulating gene expression. For example, in astrocytes, norepinephrine-induced activation of β-adrenergic receptors (β-ARs) rapidly induces glucose mobilization from glycogen stores, while simultaneously initiating delayed changes in the expression of glycogen storage genes. Regulation of gene expression requires adrenergic receptor-initiated intracellular signals to reach the nuclear compartment. To …

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Altered Motivation & Dopamine Subcircuit Plasticity Unique To Sex During Protracted Opioid Withdrawal, Devan Marc Gomez Apr 2023

Altered Motivation & Dopamine Subcircuit Plasticity Unique To Sex During Protracted Opioid Withdrawal, Devan Marc Gomez

Dissertations (1934 -)

Opioid use disorder (OUD) is associated with enduring psychological withdrawal symptoms believed to contribute to drug abuse. Amongst these are shifts in motivational states, wherein pursuit of drug consumption exceeds that of non-drug rewards, reinforcing escalated opioid use and relapse vulnerability. A critical regulator of behavioral reinforcement, the mesoaccumbal dopamine system is thought to be both necessary and sufficient for opioid motivation. However, previous research into its involvement in opioid withdrawal has been limited to acute rather than protracted timepoints, global neuroadaptations rather than those in subcircuits, and overwhelmingly focused on males over females. Using a rodent model of self-administration …

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Generalized Joint Hypermobility And Lower Extremity Musculoskeletal Biomechanics In Female Athletes, Christopher F. Geiser Apr 2023

Generalized Joint Hypermobility And Lower Extremity Musculoskeletal Biomechanics In Female Athletes, Christopher F. Geiser

Dissertations (1934 -)

Generalized Joint Hypermobility (GJH), in lay terms being “double-jointed”, affects 5 to 43 percent of the general population. In severe forms, GJH impacts systems across the body, with cardiovascular, ocular, and musculoskeletal effects that can be quite debilitating. Most of the literature examining GJH is in this severely impacted group of people. However less severe forms of GJH are present in the athlete population in the same proportions, and athletes with GJH are more likely to be injured while participating in activities. They also experience greater time-loss injuries while participating in athletic activities. The movement biomechanics of those with severe …

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Computationally Efficient Analysis And Optimization Of Induction Motors, Hossein Nejadi Koti Apr 2023

Computationally Efficient Analysis And Optimization Of Induction Motors, Hossein Nejadi Koti

Dissertations (1934 -)

The goal of this dissertation is to establish computationally efficient large-scale design optimization procedures for induction motors that are not only computationally efficient, but also do not sacrifice the accuracy of the results. To achieve this goal, the topic of the lengthy numerical transient response of Time-Stepping Finite Element Analysis (TS-FEA) of induction motors was investigated. This is because this lengthy transient affects the computational efficiency aspect of the optimization process. The effect of different parameters on the numerical transient response phenomenon were studied, and two different techniques for mitigation of this numerical transient were evaluated. The superior one amongst …

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Gothic Transformations And Remediations In Cheap Nineteenth-Century Fiction, Wendy Fall Apr 2023

Gothic Transformations And Remediations In Cheap Nineteenth-Century Fiction, Wendy Fall

Dissertations (1934 -)

My project considers the transformation of gothic characters as they move among different types of publications in the nineteenth century. As they meander from triple-decker novels to chapbooks, to theatrical scripts, to periodicals, and to penny serials, gothic stories and portrayals of people in them are altered by the length and technological capability of each form. They also mutate to reflect the tastes and ideologies of their changing audiences, and to hybridize genres under the popular influence of realism toward the mid-century. The mainstays of the gothic mode remain stable; these publications adhere to ambiguous or pluralistic ideologies, are obsessed …

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Those Who Came Before: Learning From Native American College Alumni About Walking The Path Of Persistence, Jacqueline Schram Apr 2023

Those Who Came Before: Learning From Native American College Alumni About Walking The Path Of Persistence, Jacqueline Schram

Dissertations (1934 -)

The very low college success rate of American Indians and Alaska Natives has inspired a scholarly literature that seeks to explain this outcome and, more recently, to account for why some Native students persist in college. Few studies, however, look at Native students who actually have graduated from college, and these rarely reflect Native voices or examine the life histories of Indigenous students. To achieve a broader understanding of successful educational trajectories, this qualitative exploration moves beyond the category of students currently attending college and examines the lives of five Indigenous Marquette University alumni. Employing an archival oral history method …

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Exploring New Techniques For Precision Deuteration Of Alkenes And Alkynes, Zoua Pa Vang Apr 2023

Exploring New Techniques For Precision Deuteration Of Alkenes And Alkynes, Zoua Pa Vang

Dissertations (1934 -)

Deuterium labeled compounds are often utilized in chemical research as internal standards in mass spectrometry, to study reaction mechanisms and in the pharmaceutical industry to slow the rate of metabolism. With the increase interest for deuterium labeled molecules, there is a renewed interest in selective methods for the installation of deuterium atoms into small organic molecules. However, current methods to incorporate deuterium atoms into organic molecules can lead to isotopic mixtures such as isotopologues and isotopomers. These isotopic species are indistinguishable due to their similar physical properties, leading to inseparable products by common purification techniques. Furthermore, common spectroscopic techniques to …

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Person And Society: The Trinitarian Anthropology Of Henri De Lubac, Sara Hulse Apr 2023

Person And Society: The Trinitarian Anthropology Of Henri De Lubac, Sara Hulse

Dissertations (1934 -)

This dissertation argues that the Trinity is central to the theological anthropology of Henri de Lubac. Although the Trinitarian dimension of his thought receives scant attention in secondary scholarship, de Lubac insists on the centrality of the Trinity to anthropology from his first public lecture through his final, post-conciliar works. This dissertation further illustrates how de Lubac’s Trinitarian anthropology shapes his anthropological works, concluding that he deserves to be counted among the Trinitarian thinkers of the twentieth century. To make this argument, Chapter One defines Trinitarian anthropology as the application of the Trinitarian mystery to the human person, and sketches …

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Milton’S Learning: Complementarity And Difference In Paradise Lost, Peter Spaulding Apr 2023

Milton’S Learning: Complementarity And Difference In Paradise Lost, Peter Spaulding

Dissertations (1934 -)

When we consider, in the vein of Golda Werman’s Milton and Midrash, the idea of Milton’s Paradise Lost as self-consciously responding to the Bible, the question of why he makes the changes and additions that he does comes to the fore. This dissertation explores the middle books of Paradise Lost as Milton’s midrashic interventions that, among other things, emphasize the presence of education in the Garden. These scenes shed some light on Milton’s own views of education. Specifically, these interventions show a theory of education that conceives of difference as non-combative, a distinctly non-Hobbesian view of difference. Using Aristotle’s four …

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The Categories Argument For The Real Distinction Between Being And Essence: Avicenna, Aquinas, And Their Greek Sources, Nathaniel Taylor Apr 2023

The Categories Argument For The Real Distinction Between Being And Essence: Avicenna, Aquinas, And Their Greek Sources, Nathaniel Taylor

Dissertations (1934 -)

There is a distinctively Avicennian way of understanding the categories to be found in the works of Thomas Aquinas that vindicates Aquinas’s early argument for the distinction between being and essence. Two of the most important and influential Aquinas scholars in the twentieth century recognized the roots of this Avicennian way in Aquinas, but neither Etienne Gilson and Cornelio Fabro made good on their insights. In this dissertation, I trace this Avicennian way through its sources in the Greek commentators and demonstrate how it provides the necessary insight into the structure and nature of the categories that render Aquinas’s Genus …

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Evaluating The Impact Of Land Use Changes, Drivers Of Tmdl Development, And Green Infrastructure On Stream Impairments, Charitha Jayasri Gunawardana Apr 2023

Evaluating The Impact Of Land Use Changes, Drivers Of Tmdl Development, And Green Infrastructure On Stream Impairments, Charitha Jayasri Gunawardana

Dissertations (1934 -)

Despite the water quality improvements and regulatory advancements over the last 50 years since the enactment of the Clean Water Act, water bodies within the United States are still impaired for a broad range of contaminants from non-point source pollution. Improving watershed management approaches to meet this challenge will require a greater understanding of (1) how changes within a watershed, such as changing land use, impact stream water quality, (2) what influence socioeconomic, spatial and political factors may have on the progress towards meeting water quality goals, such as those set within Total Maximum Daily Loads (TMDLs), and (3) how …

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Downstream Task Self-Supervised Learning For Object Recognition And Tracking, Abubakar Siddique Apr 2023

Downstream Task Self-Supervised Learning For Object Recognition And Tracking, Abubakar Siddique

Dissertations (1934 -)

This dissertation addresses three limitations of deep learning methods in image and video understanding-based machine vision applications. Firstly, although deep convolutional neural networks (CNNs) are efficient for image recognition applications such as object detection and segmentation, they perform poorly under perspective distortions. In real-world applications, the camera perspective is a common problem that we can address by annotating large amounts of data, thus limiting the applicability of the deep learning models. Secondly, the typical approach for single-camera tracking problems is to use separate motion and appearance models, which are expensive in terms of computations and training data requirements. Finally, conventional …

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“The Development Of The Conceptive Plot Through Early 19th-Century English Novels”, Jannea R. Thomason Apr 2023

“The Development Of The Conceptive Plot Through Early 19th-Century English Novels”, Jannea R. Thomason

Dissertations (1934 -)

My dissertation, “The Development of the Conceptive Plot through Early 19th Century English Novels,” reads these novels through the history of midwifery and reproduction to show how authors developed a coherent set of narrative features to challenge ideas about women’s agency in reproduction. Building on recent explorations of the maternal and feminist aspects of the novels, I further nuance the representations of women and reproduction in the novels. Nineteenth-century authors explored reproductive rhetoric, law, and medical practices, and their explorations appear as what I call “the conceptive plot”: a set of narrative features illustrating how different systems strip women of …

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Trauma Exposure And Resident Assistants: A Study Of Meaning Making, Sarah Ann Olejniczak Apr 2023

Trauma Exposure And Resident Assistants: A Study Of Meaning Making, Sarah Ann Olejniczak

Dissertations (1934 -)

Resident assistants are at the front line of crisis management within college campus residence halls. As such, it is imperative that student affairs professionals consider the specific needs of this paraprofessional group and build networks to guide these student leaders through the traumatic occurrences to which they respond through their roles. This dissertation studies the impact of resident assistants' exposure to traumatic occurrences and the meaning making that happens following these experiences, in an effort to expand a knowledge base that will support future student development practices. This dissertation employs a phenomenological approach to qualitatively understand the impact of trauma …

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Probabilistic Model Development And Risk Management Strategies For Pipelines With Anomalies, Kiswendsida Jules Kere Apr 2023

Probabilistic Model Development And Risk Management Strategies For Pipelines With Anomalies, Kiswendsida Jules Kere

Dissertations (1934 -)

Metal pipelines are exposed to many threats such as corrosion and cracking during their service life, which can weaken pipeline integrity and cause leaks or ruptures, leading to significant safety, economic and environmental consequences. For corrosion, many models have been developed to predict failure pressure of pipeline with an isolated defect, and only a few models consider interacting defects. On the other hand, the existing models for predicting failure pressure of pipeline with crack defects are very limited. Several model performance evaluations have shown that most of the existing models for either corrosion or cracking-like defects are conservative since they …

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Design And Advanced Model Predictive Control Of Wide Bandgap Based Power Converters, Waqar Ahmed Khan Apr 2023

Design And Advanced Model Predictive Control Of Wide Bandgap Based Power Converters, Waqar Ahmed Khan

Dissertations (1934 -)

The field of power electronics (PE) is experiencing a revolution by harnessing the superior technical characteristics of wide-band gap (WBG) materials, namely Silicone Carbide (SiC) and Gallium Nitride (GaN). Semiconductor devices devised using WBG materials enable high temperature operation at reduced footprint, offer higher blocking voltages, and operate at much higher switching frequencies compared to conventional Silicon (Si) based counterpart. These characteristics are highly desirable as they allow converter designs for challenging applications such as more-electric-aircraft (MEA), electric vehicle (EV) power train, and the like. This dissertation presents designs of a WBG based power converters for a 1 MW, 1 …

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A Package Of Smartphone And Sensor-Based Objective Measurement Tools For Physical And Social Exertional Activities For Patients With Illness-Limiting Capacities, Arafat Mahmood Apr 2023

A Package Of Smartphone And Sensor-Based Objective Measurement Tools For Physical And Social Exertional Activities For Patients With Illness-Limiting Capacities, Arafat Mahmood

Dissertations (1934 -)

Patients with several incompletely diagnosed and understood chronic diseases suffer from symptoms that limit their functional capacity. In particular, patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and long covid syndromes have variable fatigue, malaise, poor and unrefreshing sleep, and delayed post-exertional exacerbations of these symptoms. There are no specific tests for these patients to diagnose their diseases properly. These patients must be aware of their daily activities and energy expenditure. Even a little physical effort or socially extroverted behavior can make them tired and incapable of continuing their daily routine. A comprehensive summary of the measured activities at any particular …

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Describing Parents' Beliefs About The Causes Of Mental Health Problems In Youth: Implications For Service Utilization, Madeline Buchanan Apr 2023

Describing Parents' Beliefs About The Causes Of Mental Health Problems In Youth: Implications For Service Utilization, Madeline Buchanan

Dissertations (1934 -)

Parents have an important role in accessing mental health services for youth. Understanding what factors might enhance or impede this process is critical to engaging more children and adolescents in treatment. Evidence suggests parents’ beliefs about the causes of youth mental health problems likely influence mental health service utilization, though existing research is limited. The current study examined parents’ causal beliefs about youth mental health problems and their impact on factors related to help-seeking and service utilization. A diverse group of parents (N = 417; 36.9% non-Hispanic White; 33.3% Black/African American; 29.7% Hispanic/Latino) completed a series of questionnaires via an …

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The Alliance Apart: Anticommunism And The Anglo-American Relationship, 1948-1954, Edward Longe Apr 2023

The Alliance Apart: Anticommunism And The Anglo-American Relationship, 1948-1954, Edward Longe

Dissertations (1934 -)

The dominant political dynamic in the United States during the late 1940s and early 1950s was a paranoid focus on anticommunism and the perceived threat posed by the Soviet Union, a nation many believed was seeking global domination. As a result of these fears, dissenters were cast as disloyal, federal employees lost their jobs, the press was muzzled, the entertainment industry was purged, labor movements faced increased scrutiny, and others, like Julius and Ethel Rosenberg, paid the ultimate price. While historians have focused considerable attention on the domestic impact of these anxieties, few have explored the diplomatic ramifications of the …

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Targeted Mapping Of Oryza Sativa Chilling Tolerance Candidate Genes Using Multiple Stress-Relevant Quantitative Traits, Naoki Simon Shimoyama Apr 2023

Targeted Mapping Of Oryza Sativa Chilling Tolerance Candidate Genes Using Multiple Stress-Relevant Quantitative Traits, Naoki Simon Shimoyama

Dissertations (1934 -)

Developing chilling tolerant accessions of domesticated Asian rice is a potential source of significant crop improvement to address the needs of a growing global population. The uniquely chilling sensitive nature of the tropically originating Oryza sativa make it the most important staple crop that could gain the maximum benefit from improved tolerance to low temperature stress. However, mechanisms underlying this complex trait are not fully understood. Oryza sativa has two major varietal groups with different levels of chilling tolerance, JAPONICA and INDICA, providing an ideal tool to investigate mechanistic differences in the chilling stress tolerance responses within this important crop …

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Neuronal Glutamate Transporters Modulate Reward-Based Behaviors In Mice, Corey Nilon Apr 2023

Neuronal Glutamate Transporters Modulate Reward-Based Behaviors In Mice, Corey Nilon

Biological Sciences

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by uncontrollable, intrusive thoughts (obsessions), restlessness, and repetitive behaviors (compulsions). One of the genes associated with OCD encodes the neuronal glutamate transporter EAAC1. EAAC1 is expressed in the striatum, the main input nucleus of the basal ganglia, implicated with reward, which shows patterns of hyperactivity in patients with OCD. What remains unknown is how EAAC1 contributes to the different behavioral abnormalities of OCD. To address this question, we performed a set of behavioral tests in EAAC1-/- mice. Specifically, we asked how the execution of repetitive reward-based behaviors changed in these mice. Our …

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A Review Of The Forensic Applications For The Analysis Of Biological Fluids Using Fluorescence Spectroscopy, Raghavi Patel Apr 2023

A Review Of The Forensic Applications For The Analysis Of Biological Fluids Using Fluorescence Spectroscopy, Raghavi Patel

Biological Sciences

The use of science to compile information to assist in solving crimes is known as forensic science. Numerous bodily fluids, such as blood, semen, saliva, and vaginal fluid, are frequently discovered at crime scenes. This makes it crucial for forensic scientists to use analytical methods to examine these fluids to learn more about the crime, including the offender, victim, time since deposition, and other details. Although there are many techniques, the focus of this paper is fluorescence spectroscopy. Fluorescence spectroscopy is a rapid, inexpensive, and non-destructive technique used for forensic examination (Weber & Lednev, 2022). Fluorescence spectroscopy can be used …

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Translanguaging Or Code-Switching?: A Case Study Of Multilingual Activities In College-Level Mandarin And Japanese Classrooms, Huayu Liu , '23 Apr 2023

Translanguaging Or Code-Switching?: A Case Study Of Multilingual Activities In College-Level Mandarin And Japanese Classrooms, Huayu Liu , '23

Senior Theses, Projects, and Awards

Classroom translanguaging has recently gained popularity in ESL and foreign language classrooms, where students come from diverse linguistic backgrounds. In a nutshell, translanguaging researchers highlight an individual’s linguistic repertoire, which goes beyond the boundaries of named languages and focuses on all language elements that an individual knows. As a pedagogy, translanguaging advocates linguistic equity because it encourages students to access their linguistic repertoire, which is not limited to the target language in the classroom. Yet, the viability of this approach in the classroom is unclear, and its distinction from code-switching can also be ambiguous. Therefore, this thesis studies this issue …

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Social And Linguistic Marginalization, And The Question Of ‘Standard’: An Analysis And Translation Of Giulio Cesare Cortese’S La Vaiasseide, Lina R. Marsella , '23 Apr 2023

Social And Linguistic Marginalization, And The Question Of ‘Standard’: An Analysis And Translation Of Giulio Cesare Cortese’S La Vaiasseide, Lina R. Marsella , '23

Senior Theses, Projects, and Awards

No abstract provided.

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At The Foothills Of The Highest Hill In The Swamp: A Policy Brief For East Little York, Major Eason , '23 Apr 2023

At The Foothills Of The Highest Hill In The Swamp: A Policy Brief For East Little York, Major Eason , '23

Senior Theses, Projects, and Awards

No abstract provided.

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Navigating Creative Careers On Social Media: Self-Employment And Neoliberalism, Katherine Carlson , '23 Apr 2023

Navigating Creative Careers On Social Media: Self-Employment And Neoliberalism, Katherine Carlson , '23

Senior Theses, Projects, and Awards

This thesis describes and analyzes the working conditions of illustrators who work on social media platforms such as YouTube, Instagram, and Patreon. Ultimately, it argues that the perceived perks of self-employment that artists publicly discuss on social media are paradoxical because they are limited by the social media platforms on which the artists post. Additionally, the cons of self-employment artists experience, such as burnout, are systemic issues, even though they are framed as personal problems on social media. The various solutions that artists used throughout the course of this project to combat these issues are individual, rather than collective. Finally, …

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“I Don’T Want To Produce Academic Results”: Mapping The Daily And Costly Persistence Of First-Generation And Low-Income College Students Of Color, Aleina Dume , '23 Apr 2023

“I Don’T Want To Produce Academic Results”: Mapping The Daily And Costly Persistence Of First-Generation And Low-Income College Students Of Color, Aleina Dume , '23

Senior Theses, Projects, and Awards

No abstract provided.

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Quaker Interpretation: The Role Of Communication And Identity In The Production Of Quaker Values, Katalina I. Kastrong , '23 Apr 2023

Quaker Interpretation: The Role Of Communication And Identity In The Production Of Quaker Values, Katalina I. Kastrong , '23

Senior Theses, Projects, and Awards

In this thesis, I examine the shift in Quaker language use over time, focusing on the formation of group identity, the accessibility of Quaker language, and legacy and silence in a history of racial discrimination. These aspects of Quaker practice are crucial in addressing concerns about inclusivity and justice work, providing the potential for greater metalinguistic intentionality. My research analyzes language's role in shaping such attitudes, beliefs, and action. I examine seventeenth century Quakers’ use of Quaker Plain Speech (QPS), observing that the progression towards modern Quaker language is uneven among these three areas of focus. I claim that these …

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¿Gays, Maricas O Algo Más? La Más Draga’S Queer Performance Of Mexicanidad At The Intersection Of Art, Nationalism, And Popular Entertainment, José E. Valdivia Heredia , '23 Apr 2023

¿Gays, Maricas O Algo Más? La Más Draga’S Queer Performance Of Mexicanidad At The Intersection Of Art, Nationalism, And Popular Entertainment, José E. Valdivia Heredia , '23

Senior Theses, Projects, and Awards

No abstract provided.

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Crna Decision-Making Within The Anesthesia Care Team, Cindi L. Dabney Apr 2023

Crna Decision-Making Within The Anesthesia Care Team, Cindi L. Dabney

Theses and Dissertations (ETD)

This research focused on Certified Registered Nurse Anesthesiologists’ (CRNAs’) perspectives on the value placed on their decision-making skills within the Anesthesia Care Team (ACT). The emphasis of the study was to examine CRNA’s perspectives on the strengths, challenges, conflict resolutions, and any other information they were willing to divulge when working with physician anesthesiologists in the ACT model. An electronic survey questionnaire was sent to practicing CRNAs, primarily in the southeast region of the United States, with 171 informants completing the questionnaire. Data analysis included demographic information of the convenience sample that included age, gender, initial educational preparation as a …

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