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Recreational Fishing Participation In Utah: Comparing Active And Non-Active Angler Constraint Perceptions With The Use Of License Purchase Data, Will Rempel May 2023

Recreational Fishing Participation In Utah: Comparing Active And Non-Active Angler Constraint Perceptions With The Use Of License Purchase Data, Will Rempel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As a leisure activity, recreational fishing provides numerous social, physical, and psychological benefits to its participants. It can also provide socioeconomic opportunities to specific communities, and as an outdoor activity can create support for natural fisheries resources and public lands. License and equipment taxes are also important funding mechanisms for state wildlife managers. Though fishing participation as a percentage of the population has overall decreased in the last century, there is a recent increase in fishing participation. However, participation dynamics result in a shifting cycle of entries, departures, and re-entries to the sport. In an effort to maintain participation and …


Generative Neural Network Approach To Designing And Optimizing Dynamic Inductive Power Transfer Systems, Andrew Pond Curtis May 2023

Generative Neural Network Approach To Designing And Optimizing Dynamic Inductive Power Transfer Systems, Andrew Pond Curtis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Electric vehicles (EVs) offer many improvements over traditional combustion engines including increasing efficiency, while decreasing cost of operation and emissions. There is a need for the development of cheap and efficient charging systems for the future success of EVs. Most EVs currently utilize static plug-in charging systems. An alternative charging method of significant interest is dynamic inductive power transfer systems (DIPT). These systems utilize two coils, one placed in the vehicle and one in the roadway to wirelessly charge the vehicle as it passes over. This method removes the current limitations on EVs where they must stop and statically charge …


Using Genome Analysis Methods To Screen Lactococcus Starter Cultures For Bitter‐Related Genes And Establish A Differentiation Method Using Qpcr For Lactococcus Lactis And Lactococcus Cremoris Species In Cheddar Cheese, Brantzen R. Wood May 2023

Using Genome Analysis Methods To Screen Lactococcus Starter Cultures For Bitter‐Related Genes And Establish A Differentiation Method Using Qpcr For Lactococcus Lactis And Lactococcus Cremoris Species In Cheddar Cheese, Brantzen R. Wood

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Consumers of Cheddar cheese expect consistent flavor and texture in the cheese they eat. Cheese flavor and texture is highly influenced by the bacteria cheese makers add during cheese production. These bacteria are generally responsible for the flavors and textures consumers associate with Cheddar cheese and are referred to as starters.

Sometimes during cheese manufacture off-flavors and textures can arise that make the cheese unappealing to eat. One such flavor that is off putting is bitterness. The bitter taste in cheese arises while the cheese is aging and is largely due to the same flavor producing starters added to the …


Differing Mastery Criteria Effects On Maintenance Of 1-Step Instruction Following In Children With Disabilities, Kyle Wagner May 2023

Differing Mastery Criteria Effects On Maintenance Of 1-Step Instruction Following In Children With Disabilities, Kyle Wagner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The majority of Early Intervention clinics throughout the United States are currently using a practice that is not considered evidence based. When teaching skills to children with developmental disabilities, clinicians assign an accuracy standard for those skills. The most common accuracy standard, called a “mastery criterion,” is 80% across three teaching sessions. There is little to no evidence to support using this specific mastery criterion. The purpose of this study was to add more research regarding this topic, and how it affects how the skills taught maintain over time when teaching has ceased for a specific skill. Two children were …


Young Children's Nutrition, Growth, And Cognitive Development In The Ecuadorian Amazon, Kristin N. Murphy May 2023

Young Children's Nutrition, Growth, And Cognitive Development In The Ecuadorian Amazon, Kristin N. Murphy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The first few years of life are viewed as a critical period for development. Children who do not grow and develop well in these early years can experience life-long negative implications. Many children under the age of five in Ecuador suffer from high rates of malnutrition, stunting (low height-for-age), and delayed cognitive development. This dissertation aims to better understand why children from Ecuador, specifically from the Amazon region, are experiencing such high rates of delayed development. Fifty children and their mothers living in the Amazon region of Ecuador participated in this research study.

First, interviews were conducted by an Ecuadorian …


Use Of Protective Lactic Acid Bacteria Adjunct Cultures To Decrease The Incidence Of Gas Defects In Cheddar Cheese, Rhees T. Crompton May 2023

Use Of Protective Lactic Acid Bacteria Adjunct Cultures To Decrease The Incidence Of Gas Defects In Cheddar Cheese, Rhees T. Crompton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Gas production in cheese making is becoming increasingly prevalent in the dairy industry. This gas is produced by microbes that are naturally found in the cheese, and when they metabolize sugar or other sources of energy, they can produce gas. This gas causes slits and cracks in the cheese, which causes the cheese to be worth less and causes issues during slicing and shredding. There are many microbes that cause unwanted gas in cheese, this research focuses on four know gas producers and five other protective microbes that use the same energy sources or have the ability to inhibit the …


The Influence Of Surface Roughness Frequency On Rotating Sphere Aerodynamics, Jack C. Elliott May 2023

The Influence Of Surface Roughness Frequency On Rotating Sphere Aerodynamics, Jack C. Elliott

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Solving the problems of increasing highway fuel efficiency, throwing a better curve ball, and preventing an aircraft from stalling all have a common thread: controlling flow separation. Defined by the fast moving flow around an object detaching from the object, flow separation has implications for a broad number of engineering fields. Research regarding flow separation control has led to the understanding that the easiest method for delaying flow separation for a given shape is to vary how turbulent the flow around the object is. Varying this turbulence around an object may be achieved through various methods including changing the …


Reimagining Culture With Youth: Relationship And Representation In Culturally Centered Learning Environments, Lili Yan May 2023

Reimagining Culture With Youth: Relationship And Representation In Culturally Centered Learning Environments, Lili Yan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation intends to develop an understanding of how culturally centered learning environments impact youth’s relationship with culture. Working alongside a multicultural team of researchers, educators, and designers who came together with a shared goal of designing curricular activities to engage sixth graders with culture, I followed 12 sixth graders for a school year to understand their development of relationships with culture. I (re)conceptualize the holistic process of learning and engagement with culture as Ti-Wu and propose a cultural learning model that helps us understand how youth develop multiple relationships with culture. I further share how multimedia technology mediates youth’s …


Producing Analytical Models Of The Sport Spacecraft For Science Data Processing, Jason L. Powell May 2023

Producing Analytical Models Of The Sport Spacecraft For Science Data Processing, Jason L. Powell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Scintillation Prediction Observation Research Task (SPORT) is a joint United States of America and Brazil 6U CubeSat mission. The SPORT mission is to understand how the Earth’s ionosphere evolves during day and night transitions. Space Weather Probes, a suite of instruments developed by Utah State University, monitors the ionosphere by observing currents and voltages around the SPORT spacecraft body. This thesis presents the data collected by Space Weather Probes and how it is used to measure the ionosphere. Modeling techniques are also presented to demonstrate how the Space Weather Probes instrument is expected to respond to the ionosphere.


The Critical Role Of Mentorship In Academic Career Development: A Commentary On Proposed Initiatives By The International Society For Bipolar Disorders Early Mid-Career Committee, Parnian Shobeiri, Khader M Hasan May 2023

The Critical Role Of Mentorship In Academic Career Development: A Commentary On Proposed Initiatives By The International Society For Bipolar Disorders Early Mid-Career Committee, Parnian Shobeiri, Khader M Hasan

Faculty, Staff and Student Publications

The Papez circuit, first proposed by James Papez in 1937, is a circuit believed to control memory and emotions, composed of the cingulate cortex, entorhinal cortex, parahippocampal gyrus, hippocampus, hypothalamus, and thalamus. Pursuant to James Papez, Paul Yakovlev and Paul MacLean incorporated the prefrontal/orbitofrontal cortex, septum, amygdalae, and anterior temporal lobes into the limbic system. Over the past few years, diffusion-weighted tractography techniques revealed additional limbic fiber connectivity, which incorporates multiple circuits to the already known complex limbic network. In the current review, we aimed to comprehensively summarize the anatomy of the limbic system and elaborate on the anatomical connectivity …


Pandemic Rendering The Transgender People More Vulnerable, As If It Was Not Already Enough: A Qualitative Exploration From Odisha, India, Prachi Parimita Rout, Ajitesh Mathur, Pranaya Kumar Swain May 2023

Pandemic Rendering The Transgender People More Vulnerable, As If It Was Not Already Enough: A Qualitative Exploration From Odisha, India, Prachi Parimita Rout, Ajitesh Mathur, Pranaya Kumar Swain

The Qualitative Report

The COVID-19 pandemic impacted people's livelihoods worldwide to an unprecedented magnitude, the most affected being the socially and economically disadvantaged and marginalized communities, including the transgender people that constitute one of the most vulnerable sections that are often subjected to discriminated in various sectors such as education, health, housing, and livelihood opportunities. The present study attempts to offer insights into the impact of the pandemic on the livelihood of transgender people in India, given that the pandemic adversely affected their primary sources of livelihood, such as begging, sex-work, singing, and dancing, due mainly to the restrictive measures: lockdown, shutdown, social/physical …


Tpsol Teachers' Beliefs About Providing Corrective Feedback On Learners' Writing Performance: A Transcendental Phenomenology, Hussein Meihami May 2023

Tpsol Teachers' Beliefs About Providing Corrective Feedback On Learners' Writing Performance: A Transcendental Phenomenology, Hussein Meihami

The Qualitative Report

The purpose of this study was to investigate Teaching Persian to Speakers of Other Languages (TPSOL) teachers' beliefs about providing corrective feedback (CF) on TPSOL students' writing. To that end, the transcendental phenomenological design was used in which the experiences and practices of six TPSOL teachers (four male and two female teachers) were examined to obtain TPSOL teachers' beliefs about providing CF on students' writing. A series of phenomenological interviews were conducted with TPSOL teachers. Moreover, students' writing samples corrected by TPSOL teachers were collected and analyzed. Finally, the data were analyzed and synthesized using Giorgi's (2009) five steps framework. …


Qualitative Research With Former International Students: Reflections On Conceptualization, Planning And Relational Engagement, Jon Woodend, Nancy Arthur May 2023

Qualitative Research With Former International Students: Reflections On Conceptualization, Planning And Relational Engagement, Jon Woodend, Nancy Arthur

The Qualitative Report

The number of international students seeking a foreign education, particularly in Westernized countries, has grown dramatically over the past decade, and is predicted to continue to increase, despite a period of disruption due to COVID-19. Given this growth, there is a significant body of research on key insights into the initial transition experiences, both academic and personal, of international students to the host country, with a developing body of research exploring their post-study transition. Understanding these post-study transitions is important in creating policy and services that appropriately support international students. Due to the diverse and sometimes complex post-study pathways of …


Scan2drawing: Use Of Deep Learning For As-Built Model Landscape Architecture, Sisi Han, Yuhan Jiang, Yilei Huang, Mingzhu Wang, Yong Bai, Andrea Spool-White May 2023

Scan2drawing: Use Of Deep Learning For As-Built Model Landscape Architecture, Sisi Han, Yuhan Jiang, Yilei Huang, Mingzhu Wang, Yong Bai, Andrea Spool-White

Biomedical Engineering Faculty Research and Publications

This paper presents an innovative and fully automatic solution of generating as-built computer-aided design (CAD) drawings for landscape architecture (LA) with three dimensional (3D) reality data scanned via drone, camera, and LiDAR. To start with the full pipeline, 2D feature images of ortho-image and elevation-map are converted from the reality data. A deep learning-based light convolutional encoder–decoder was developed, and compared with U-Net (a binary segmentation model), for image pixelwise segmentation to realize automatic site surface classification, object detection, and ground control point identification. Then, the proposed elevation clustering and segmentation algorithms can automatically extract contours for each instance from …


Bioenergetics And Neuroimaging Research: A Neuropathophysiological Linkage In The Setting Of Cocaine Use Amongst Persons With Hiv, Cory J. White, Karl Goodkin May 2023

Bioenergetics And Neuroimaging Research: A Neuropathophysiological Linkage In The Setting Of Cocaine Use Amongst Persons With Hiv, Cory J. White, Karl Goodkin

School of Medicine Publications

Despite innovations in antiretroviral therapy (ART) that have transformed HIV infection from an acute illness with high mortality risk into a chronic, largely manageable disease, the viral reservoir that persists in brain continues to pose a risk for neurocognitive impairment and other deleterious clinical outcomes. ART regimens can inhibit viral integration and suppress replication to nondetectable levels in plasma and cerebrospinal fluid (CSF) but do not eliminate viral reservoirs, including that in brain [1]. Moreover, HIV transcripts within CSF cells have been associated with brain injury despite suppressive ART [2]. Comorbid HIV and cocaine use exacerbates brain atrophy …


Determining Habitat Preferences Of Dasypus Novemcinctus And Assessing Prevalence Of Hansen's Disease In Tennessee With Assistance From Community Science Data, Carissa Turner May 2023

Determining Habitat Preferences Of Dasypus Novemcinctus And Assessing Prevalence Of Hansen's Disease In Tennessee With Assistance From Community Science Data, Carissa Turner

Masters Theses and Doctoral Dissertations

The nine-banded armadillo (Dasypus novemcinctus L.) is currently considered an invasive species in parts of its range in the United States. As it continues to expand its range, more states may begin to consider armadillos an invasive or nuisance species and will need to make management decisions regarding this species as (1) a pest for landowners or land managers, (2) a possible threat to other species of conservation concern, and (3) a vector for Hansen’s disease (leprosy). Although research funds are scarce for a species that is currently not seen as a threat or an endangered animal, there are ways …


Transfer Pathways In Higher Education: Exploring Differences Between Pathway And Nonpathway Student Success After University Transfer In One State System, Eva W. Lewis May 2023

Transfer Pathways In Higher Education: Exploring Differences Between Pathway And Nonpathway Student Success After University Transfer In One State System, Eva W. Lewis

Masters Theses and Doctoral Dissertations

Years of research in higher education have focused on innovations in curricula and student support services aimed toward improving student retention and success. Despite this, increases in student enrollment and degree completions have not increased. In 2009, the federal American Graduation Initiative began with the goal to achieve 10 million more U.S. citizens with postsecondary credentials by 2020. The state of Tennessee enacted the 2010 Complete College Tennessee Act, resulting in new statewide strategies to achieve goals for credential attainment. One strategy was the guided pathway approach, intended to increase associate and baccalaureate degree completions and reduce the number of …


Advancing Iot Security Through Blockchain-Based Decentralized Platform And Ai-Powered Digital Forensics, Ruipeng Zhang May 2023

Advancing Iot Security Through Blockchain-Based Decentralized Platform And Ai-Powered Digital Forensics, Ruipeng Zhang

Masters Theses and Doctoral Dissertations

The proliferation of Internet of Things (IoT) devices, from smartphones, smart thermostats to smart home security systems, is revolutionizing our society and daily lives. However, it also has posed significant challenges to IoT security and forensics. To tackle those challenges, innovative solutions are designed to enhancing IoT security and accelerating investigation of cybersecurity incidents by leveraging recent technological advancements in Blockchain and Artificial Intelligence (AI). First, an IoT service platform, called DISP, is proposed to improve the security and interoperability of IoT systems. DISP utilizes the consortium blockchain technology to transform centralized, insecure IoT communications into decentralized, secure, and traceable …


The Perception Of Hybrid Nutrition Education Among Limited Income Families In Tennessee, Rita Jackson May 2023

The Perception Of Hybrid Nutrition Education Among Limited Income Families In Tennessee, Rita Jackson

Masters Theses and Doctoral Dissertations

The issue of obesity continues to be a concern in the US. Throughout the years, research has shown that adopting healthier eating habits and increasing physical activity can help people lead healthier lives. Families of low socioeconomic status suffer disproportionately from poor health. Nutrition education programs have been successful in supporting program participant’s efforts towards health; however, recruiting and retaining program participation has been challenging. Completing a series of face-to-face classes has been difficult for this population due to various barriers they face. Providing distance-based opportunities, such as hybrid nutrition education programs, could assist in overcoming some of these barriers. …


The Role Of The Tennessee 4-H Specialist As Perceived By 4-H Agents, Justin Crowe May 2023

The Role Of The Tennessee 4-H Specialist As Perceived By 4-H Agents, Justin Crowe

Masters Theses and Doctoral Dissertations

The primary purpose of this study was to examine the perception of 4-H agents in terms of the role of the state level Extension 4-H specialist. The population included 225 county level 4-H agents employed by either University of Tennessee or Tennessee State University Extension. Data analyses for this study included an examination of demographic factors and 13 questions related to perception (quantitative) as well as three open ended questions (qualitative). Five research questions were examined to determine the perceived role of the 4-H specialists from the perspective of the current 4-H agents and identify what differences exist between role …


Bronze Monuments: The Terror Of Death And Its Role In The Great Gatsby, Samuel Talley May 2023

Bronze Monuments: The Terror Of Death And Its Role In The Great Gatsby, Samuel Talley

Masters Theses and Doctoral Dissertations

This thesis is about the way humans cope with death through the lens of F. Scott Fitzgerald’s The Great Gatsby in the wake of war. The thesis contains three chapters all of which work in succession to build a picture of various characters’ death denial. Chapter 2 considers how Nick’s narrative is an attempt to deny death through the ritual of mourning. Chapter 3 analyzes wealth in the novel and its role in striving for immortality. Gatsby transcends the limits of an ordinary life with his interest in opulence, while Nick’s wealth provides a level of privilege that allows for …


A Recipe For Balance Or Conflict: Factors Related To Work-Nonwork Dynamics Among Chefs, Sophia Vlass May 2023

A Recipe For Balance Or Conflict: Factors Related To Work-Nonwork Dynamics Among Chefs, Sophia Vlass

Masters Theses and Doctoral Dissertations

The availability of quality information is critical to making informed career decisions. Presently, there is a void of information regarding the level of job demands that impact work-nonwork balance and conflict in various occupations. This study examined the relationship between work-nonwork conflict (WNC) and work-nonwork balance (WNB) and various occupational factors and personal factors among chefs and head cooks and found that occupational demands generally had stronger relationships to outcomes of WNC and WNB than personal factors. The findings outlined from this research suggest that occupational demand information, as it relates to work-nonwork dynamics, is largely generalizable to most individuals …


The Portrayal Of Dissent And The Anglican Church In Victorian Literature, Hannah L. Badger May 2023

The Portrayal Of Dissent And The Anglican Church In Victorian Literature, Hannah L. Badger

Masters Theses and Doctoral Dissertations

The reduction of the power of the Church of England during the Victorian era was inevitably reflected in the work of Charles Dickens, Elizabeth Gaskell, and Charlotte Brontë. In this paper, I will examine one novel from each writer to explore how each responded to the decline of the Church of England and the growth of other denominations. This thesis project rests on the idea that Gaskell presents religious dissent in a sympathetic light and Dickens and Brontë respond to this topic with trepidation. Although the Victorian era brought a new religious standard, Dickens’s and Brontë’s fear of Gaskell’s dissent …


Three-Stage Assessment As Reverse Innovation In Interprofessional Student Clinical Rotations, Michael Toppe, Lushiku Nkombua May 2023

Three-Stage Assessment As Reverse Innovation In Interprofessional Student Clinical Rotations, Michael Toppe, Lushiku Nkombua

Physician Assistant Studies Faculty Research and Publications

Social determinants of health are increasingly recognized as important factors in individual and public health outcomes and are therefore of interest to both health care systems and medical schools. However, teaching holistic assessment strategies during clinical education remains a challenge. This article reports on the experiences of American physician assistant students who completed an elective clinical rotation in South Africa. In particular, the students’ training and practice with 3-stage assessment is highlighted as an example of a reverse innovation practice that could be incorporated in interprofessional health care education models in the United States.


Personal Protective Equipment Usage And Injury Type, Nathan Giannini May 2023

Personal Protective Equipment Usage And Injury Type, Nathan Giannini

Construction Management

Workers in the construction industry have many injuries both minor and life-altering. The industry suffers from injuries of all kinds such as falls, electrocution, and being struck by flying objects. To protect against this, workers wear certain types of personal protective equipment (PPE) on construction sites as a last line of defense. The equipment available such as hard hats, safety glasses, gloves, respirators, and hearing protection either protects against acute injuries (those that occur instantly) or chronic injuries (those that occur over time). This study investigates whether the type of injury that PPE protects against, acute or chronic, affects the …


Examining The Effectiveness Of The Mandatory Training On Relationship Violence Administered By California Polytechnic State University, San Luis Obispo, Sophia Mcdevitt May 2023

Examining The Effectiveness Of The Mandatory Training On Relationship Violence Administered By California Polytechnic State University, San Luis Obispo, Sophia Mcdevitt

Journalism

This project intends to examine the effectiveness of California Polytechnic State University’s (“Cal Poly’s”) current student requirements on the subject of intimate partner violence. The existing mandatory training is meant to inform students on the prevalence of intimate partner violence and advise them on prevention and intervention techniques. The research in this project explores a broad contextualization of intimate partner violence from a social and historical perspective, which intends to explore the possibility that students may be more likely to internalize the significance of the information if such context was included in the training model. The research also presents information …


Harnessing Technology And Innovation To Address Emerging Issues: Covid-19 Opportunities And Challenges, Mercy Igoki, Jackson Langat May 2023

Harnessing Technology And Innovation To Address Emerging Issues: Covid-19 Opportunities And Challenges, Mercy Igoki, Jackson Langat

Institute for Educational Development, East Africa

This study explores the opportunities and challenges presented through harnessing technology and innovation to address COVID-19 as an emerging issue in higher education institutions in Kenya. COVID-19 pandemic has presented unprecedented challenges to higher education institutions in sub-Saharan Africa, specifically in Kenya. The pandemic forced institutions to migrate to online learning, impacting the quality of education, enrollment rates, and mental health challenges students face. The study used a mixed-methods approach, incorporating secondary sources of information and primary data from experts such as Ministry of Education officials, university management, students' counsellors, and teaching staff from Kenyan universities. It focused on teaching …


Association Of Sex With Neurobehavioral Markers Of Executive Function In 2-Year-Olds At High And Low Likelihood Of Autism, Tanya St John, Natasha Marrus, Kelly N Botteron, Et Al. May 2023

Association Of Sex With Neurobehavioral Markers Of Executive Function In 2-Year-Olds At High And Low Likelihood Of Autism, Tanya St John, Natasha Marrus, Kelly N Botteron, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Children with autism and their siblings exhibit executive function (EF) deficits early in development, but associations between EF and biological sex or early brain alterations in this population are largely unexplored.

OBJECTIVE: To investigate the interaction of sex, autism likelihood group, and structural magnetic resonance imaging alterations on EF in 2-year-old children at high familial likelihood (HL) and low familial likelihood (LL) of autism, based on having an older sibling with autism or no family history of autism in first-degree relatives.

DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study assessed 165 toddlers at HL (n = 110) and LL …


Expanded Directly Binds Conserved Regions Of Fat To Restrain Growth Via The Hippo Pathway, Alexander D Fulford, Leonie Enderle, Jannette Rusch, Didier Hodzic, Maxine V Holder, Alex Earl, Robin Hyunseo Oh, Nicolas Tapon, Helen Mcneill May 2023

Expanded Directly Binds Conserved Regions Of Fat To Restrain Growth Via The Hippo Pathway, Alexander D Fulford, Leonie Enderle, Jannette Rusch, Didier Hodzic, Maxine V Holder, Alex Earl, Robin Hyunseo Oh, Nicolas Tapon, Helen Mcneill

2020-Current year OA Pubs

The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein Expanded is a key signaling hub that promotes activation of the Hippo pathway, thereby inhibiting the transcriptional co-activator Yorkie. Previous work identified the polarity determinant Crumbs as a primary regulator of Expanded. Here, we show that the giant cadherin Fat also regulates Expanded directly and independently of Crumbs. We show that direct binding between Expanded and a highly conserved region of the Fat cytoplasmic domain recruits Expanded to the apicolateral junctional zone and stabilizes Expanded. In vivo deletion of Expanded binding regions in Fat causes …


Influence Of Genomic Landscape On Cancer Immunotherapy For Newly Diagnosed Ovarian Cancer: Biomarker Analyses From The Imagyn050 Randomized Clinical Trial, Charles N Landen, Premal H Thaker, Et Al. May 2023

Influence Of Genomic Landscape On Cancer Immunotherapy For Newly Diagnosed Ovarian Cancer: Biomarker Analyses From The Imagyn050 Randomized Clinical Trial, Charles N Landen, Premal H Thaker, Et Al.

2020-Current year OA Pubs

PURPOSE: To explore whether patients with BRCA1/2-mutated or homologous recombination deficient (HRD) ovarian cancers benefitted from atezolizumab in the phase III IMagyn050 (NCT03038100) trial.

PATIENTS AND METHODS: Patients with newly diagnosed ovarian cancer were randomized to either atezolizumab or placebo with standard chemotherapy and bevacizumab. Programmed death-ligand 1 (PD-L1) status of tumor-infiltrating immune cells (IC) was determined centrally (VENTANA SP142 assay). Genomic alterations, including deleterious BRCA1/2 alterations, genomic loss of heterozygosity (gLOH), tumor mutation burden (TMB), and microsatellite instability (MSI), were evaluated using the FoundationOne assay. HRD was defined as gLOH ≥ 16%, regardless of BRCA1/2 mutation status. Potential associations …