Digital Commons Network^™

Variability And Magnitude Of Brain Glutamate Levels In Schizophrenia: A Meta And Mega-Analysis., Kate Merritt, Robert A Mccutcheon, André Aleman, Sarah Ashley, Katherine Beck, Wolfgang Block, Oswald J N Bloemen, Faith Borgan, Christiana Boules, Juan R Bustillo, Aristides A Capizzano, Jennifer M Coughlin, Anthony David, Camilo De La Fuente-Sandoval, Arsime Demjaha, Kara Dempster, Kim Q Do, Fei Du, Peter Falkai, Beata Galińska-Skok, Jürgen Gallinat, Charles Gasparovic, Cedric E Ginestet, Naoki Goto, Ariel Graff-Guerrero, Beng-Choon Ho, Oliver Howes, Sameer Jauhar, Peter Jeon, Tadafumi Kato, Charles A Kaufmann, Lawrence S Kegeles, Matcheri S Keshavan, Sang-Young Kim, Bridget King, Hiroshi Kunugi, J Lauriello, Pablo León-Ortiz, Edith Liemburg, Meghan E Mcilwain, Gemma Modinos, Elias Mouchlianitis, Jun Nakamura, Igor Nenadic, Dost Öngür, Miho Ota, Lena Palaniyappan, Christos Pantelis, Tulsi Patel, Eric Plitman, Sotirios Posporelis, Scot E Purdon, Jürgen R Reichenbach, Perry F Renshaw, Francisco Reyes-Madrigal, Bruce R Russell, Akira Sawa, Martin Schaefer, Dikoma C Shungu, Stefan Smesny, Jeffrey A Stanley, James Stone, Agata Szulc, Reggie Taylor, Katharine N Thakkar, Jean Theberge, Philip G Tibbo, Thérèse Van Amelsvoort, Jerzy Walecki, Peter C Williamson, Stephen J Wood, Lijing Xin, Hidenori Yamasue, Philip Mcguire, Alice Egerton

Department of Medicine Publications

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophrenia than the general population. We conducted meta-analyses to assess (1) variability of glutamate measures in patients relative to controls (log coefficient of variation ratio: CVR); (2) standardised mean differences (SMD) using Hedges g; (3) modal distribution of individual-level glutamate data (Hartigan's unimodality dip test). MEDLINE and EMBASE databases were searched from inception to September 2022 for proton magnetic resonance spectroscopy (1H-MRS) studies reporting glutamate, glutamine or Glx in schizophrenia. 123 studies reporting on …

Sound, Senses, Semantics: A Music And Movement Curriculum For Children With Asd In A Therapeutic Nursery School Setting, Nathan J. P. Saignes

Graduate Student Independent Studies

This Integrative Master’s Project (IMP) uses a literature review of strength-based, child-centric, and behavioral to devise a 12-unit music and movement curriculum for a therapeutic nursery school setting, with children diagnosed with ASD or emotional regulation disabilities. Within those specifics, this curriculum also aims to center children’s culture and lived experience, with the goals of anti-bias education and the developmental-interaction approach in mind.

Examining Ndufab1 Expression In Head And Neck Squamous Cell Carcinoma, Addison Stevens

Poster Presentations

Honors research poster.

Introduction: Head and neck squamous cell carcinoma (HNSCC) is approximately 4% of all cancers and 2% of all cancer associated mortality in the United States. In 2023, there will be an estimated 67,000 new cases of HNSCC, along with 15,400 deaths, in the United States. HNSCC locations include the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx. Major risk factors for HNSCC include tobacco use, alcohol use, and human papilloma virus (HPV). Epidermal growth factor receptor (EGFR) is currently the only approved molecular targeted therapy for HNSCC. Therefore, new therapeutics and biomarkers for HNSCC are warranted. Mitochondria are …

Comparator Groups In Icu-Based Studies Of Physical Rehabilitation: A Scoping Review Of 125 Studies, Heather K O'Grady, Julie C Reid, Christopher Farley, Quincy E B Hanna, Janelle Unger, David J Zorko, Jackie Bosch, Lyn S Turkstra, Michelle E Kho

Physical Therapy Publications

OBJECTIVES: To characterize comparator groups (CGs) in ICU-based studies of physical rehabilitation (PR), including the type, content, and reporting.

DATA SOURCES: We followed a five-stage scoping review methodology, searching five databases from inception to June 30, 2022. Study selection and data extraction were completed independently, in duplicate.

STUDY SELECTION: We screened studies by title and abstract, then full-text. We included prospective studies with greater than or equal to two arms enrolling mechanically ventilated adults (≥ 18 yr), with any planned PR intervention initiated in the ICU.

DATA EXTRACTION: We conducted a quantitative content analysis of authors' description of CG type …

Perspectives Of A Day Gone Bad, Mike Shields

The Prairie Light Review

No abstract provided.

The Shadow Letters, Sarah Kueking

The Prairie Light Review

No abstract provided.

Editorial Team

The Prairie Light Review

No abstract provided.

Withering Away, Mary Paulius

The Prairie Light Review

No abstract provided.

Faceless, Adam Sana

The Prairie Light Review

No abstract provided.

Summer Dream, Alexa Solonenko

The Prairie Light Review

No abstract provided.

Empty The Water, Khadijah Rashid

The Prairie Light Review

No abstract provided.

The First Surs World Congress Of Robotic Surgery At Mount Sinai Hospital In New York City: A Tribute To The Past And The Future Of Robotic Urologic Surgery, Raghav Gupta, Deepak Chopra, Ashok K. Hemal, Siddhartha Mukherjee, Craig G. Rogers, Chandru P. Sundaram, Ashutosh K. Tewari

Urology Articles

No abstract provided.

The Role Of Near-Façade Flow In Wind-Dominant Single-Sided Natural Ventilation For An Isolated Three-Storey Building: An Les Study, Nima Najafi Ziarani, Malcolm J. Cook, Farnood Freidooni, Paul D. O'Sullivan

Publications

Wind-driven single-sided ventilation is present in many existing buildings globally, and its performance can be unreliable and challenging to improve. To address these performance challenges, a better understanding of the interconnected relationship between the external and internal flows is required. Therefore, a detailed assessment of this type of natural ventilation is vital. A detailed CFD analysis of wind-dominant single-sided natural ventilation is presented by adopting the Large Eddy Simulation method, validated using previous wind tunnel studies. An isolated cube, representing a three-storey building, was used to investigate four case studies with different opening positions on the building façade. The …

Using Transformative Leadership To Understand White Male Community College Presidents And Their Efforts To Improve Outcomes For All Students, Ruthanne Keenan Orihuela

Dissertations

This critical constructivist study was grounded in the belief that there is an urgent need to address attainment gaps between White students and students of color at community colleges, that equity-minded leadership is needed to address these gaps, and that the call for transformative leadership must be answered not solely by leaders with minoritized identities alone but also by leaders with privileged social identities who comprise the majority of community college presidents. The intent of this study was to examine the ways in which White male community college presidents come to understand their privilege and navigate their roles as leaders …

Technology Integration In School-Based Physical Activity, Taemin Ha

Dissertations

The purpose of this study was to understand the current practice of technology use for physical activity promotion in K-12 schools in the United States by conducting two studies. Using a quantitative research design, study one aimed to identify the current practice of technology use in school-based physical activity promotion. Study two investigated what attributes contribute to the use of technology in schools for physical activity facilitation and promotion. A sequential explanatory mixed-methods study design was used for study two, and Rogers’ (2003) diffusion of innovations theory served this study as a theoretical framework. A total of 367 registered Active …

The Intersection Of Queer And Atheist Identities: A Critical Inquiry, Jennifer Geiman

Dissertations

The purposes of this study were to explore the lived experiences of queer atheists, to examine how they were impacted by various oppressive systems, and how to assess their needs might be better met by counseling psychologists and other mental health clinicians. The two research questions of focus were: Q1 What are the lived experiences of individuals who hold intersecting queer and atheist identities? Q2 How might individuals who hold intersecting queer and atheist identities be better served by counseling psychologists? While extant literature on the experiences of queer people and how to support them clinically has grown in the …

A Double-Edged Sword: Lived Experiences Of Hispanic/ Latino Nursing Students Who Speak English As An Additional Language, Esmeralda Araceli Clark

Dissertations

As the population of the United States continues to become more diverse, the nursing profession is working toward diversifying its nursing workforce. Diversification of the nursing profession is linked to improved patient outcomes and culturally competent care. The experiences of minority nursing students with English as an additional language (EAL) have been studied including some interventional studies. Still, there is a gap in exploring the experiences of Hispanic/Latino nursing students with EAL. The literature described EAL as the most significant risk factor for non-acceptance into a Bachelor of Science in Nursing program for any group of otherwise qualified applicants. Since …

Fragment Based Drug Development Based On 6,7-Dimethoxyquinazoline As A Core Scaffold, Cody M. Orahoske

ETD Archive

The work entitled “Fragment Based Drug Design based on 6,7- Dimethoxyquinazoline core structure” presents a unique approach to drug discovery, specifically focusing on the pharmacophore 6,7-dimethoxyquinazoline. This study explores the structural diversity of 6,7-Dimethoxyquinazoline derivatives to identify other pharmacologically relevant targets, with evidence indicating that this core structure possesses intrinsic properties that make it suitable as a base structure of small molecule drugs. Furthermore, this pharmacophore has been observed in various approved therapeutics or drug candidates under investigation, highlighting its importance in drug discovery. My research showcases of 6,7-dimethoxyquinazoline core structure been derivatized to generate an anti-trypanosomiasis drug candidates and …

Compounding And Melt Blending/Extrusion Of Polyether Ether Ketone (Peek) And Amorphous Magnesium Phosphate (Amp) For Fused Deposition Modelling (Fdm) Based 3d Printing, Vijay Kumar Bokam

ETD Archive

Polyether ether ketone (PEEK) is a high-performance polymer material for developing implants for orthopedic, spinal, cranial, maxillofacial, and dentistry applications. However, the major limitation of PEEK implants is their bio-inertness, i.e., their incapability to integrate with tissues. Therefore, prior efforts have always focused on developing Hydroxyapatite (HA) coatings on PEEK or PEEK-HA composites or sulfonation of PEEK surface or plasma treatment. As opposed, in this study, we engineered a highly novel bio-ceramic known as amorphous magnesium phosphate (AMP), which surpasses the bioactivity and biodegradation kinetics of HA. In this study, we employed High energy planetary ball milling, a mechanical alloying …

Evaporation And Condensation From Epiphytes During Saturated Conditions In A Maritime Live-Oak Forest (Georgia, Usa)., Akosh Raffai

ETD Archive

Most of the rain that falls over land, falls over forests, which cover approximately one-third of global land surface. Significant immediate and wide-ranging impacts are exerted on hydrological, ecological, and societal systems due to canopyrainfall interactions, altering rainwater supply to the surface. All storm-related hydrological processes are impacted by the relative rates that canopy surfaces retain, evaporate, and redistribute rain. Many forest canopies host a community of plants called epiphytes that are generally capable of storing and evaporating substantial water. Epiphytes are comparatively under-researched regarding their role in rainfall partitioning compared to bark and leaves. Skidaway Island in Savannah, Georgia, …

Narratives. Anthropocentrism, And The Fall Of Man In Matt Bell's Appleseed, Jessica L. Tresko

ETD Archive

Both literary and scientific texts often demonstrate the powerful role that stories serve in helping to shape humanity’s beliefs and behaviors. In his climate fiction novel Appleseed (2021), Matt Bell deploys the polyphonic method to follow three main character storylines. This technique provides the opportunity for heteroglossic dialogue, and Bell also utilizes metaponsdialogue to ensure the reader is invested and understands his/her complicity and function in the climate emergency, which leads to a reflection on personal responsibility and culpability. Theories from Mikhail Bakhtin’s essay “Discourse in the Novel” from his collection called The Dialogic Imagination support the examination of multi-perspective …

Before And After The World Turned Virtual: Examining Intimate Partner Violence And Problematic Alcohol Use Before Versus During The Covid-19 Pandemic In A Couple's Based Sample, Ishita Munshi

ETD Archive

About 1 in 4 women and 1 in 10 men report experiencing intimate partner violence (IPV) in their lifetime. For several decades, problematic alcohol use is a consistent predictor of IPV perpetration. However, as the COVID-19 pandemic transformed the romantic lives of people, it is crucial to investigate how it may have altered the prevalence of IPV perpetration and the link between IPV perpetration and problematic alcohol use. Among a sample of dating young adult couples, this study compared the IPV prevalence pre-COVID-19 pandemic (Wave 1) to during COVID-19 conditions (Wave 2). Furthermore, the study examined if problematic alcohol use …

Autonomous Raman Hyperspectral Imaging And Analysis; Advances Towards Mapping Crystalline Character In Biologically Important Polymers, Sadeq H. Alkhalifa

ETD Archive

Poly-l-lactic acid has been of a great interest to the medical profession in recent years because of its biodegradability and biocompatibility. The biodegradation rate can be controlled by its crystallinity content. One method to modify its crystallinity content is by cold drawing. Raman spectroscopy is utilized to distinguish between the different crystalline content on the sample. However, a chemical imaging method is needed to characterize the polymer on the macro level. Chemical imaging using Raman spectroscopy is an important method of characterization that is non-invasive and non-destructive. The emphasis of my research has been to develop a method to characterize …

The Relationship Between Perception Of Barriers And Life Satisfaction As Mediated By Coping Efficacy, Lela L. Pickett

ETD Archive

This study examined the relationship between life satisfaction and perception of educational and career-related barriers. Perceived barriers threaten career development and can subsequently enhance negative appraisals of personal worth and ability. Coping efficacy, an individual's belief or confidence in their ability to manage and overcome challenging or stressful situations, was evaluated as a mediator of this relationship among a sample of 208 undergraduate college students.

The findings of this study suggest a significant negative relationship between the perception of barriers and life satisfaction, which indicates that individuals with higher levels of perceived barriers endorsed lower life satisfaction and vice versa. …

Designing The American Dreamscape: Suburbs Of Worship And The American Dream, Rebecca Virgl

Masters in Architecture Program: Theses

This thesis explores suburbia as the physical manifestation of the American Dream as a pseudo-religious system. This religious system and contemporary suburban ideology are explained and disseminated through a historical review and analysis of suburban media. Pop culture serves as a signpost that directs public opinion and cultural value; much of media today wrestles with the ideas of the American Dream, fore fronting these cultural values in our collective identity. Once the baseline of socio-economic religious ideology has been established in the American Dream, the extremes of these beliefs were explored in three suburban environments: home, labor, and retail. Each …

Nevaeh Braucks Honors Portfolio, Nevaeh Braucks

Honors Capstone Portfolios

Nevaeh Braucks' honors portfolio captured in May 2023.

The Weaponization Of Attorney’S Fees In An Age Of Constitutional Warfare, Rebecca Aviel, Wiley Kersh

Sturm College of Law: Faculty Scholarship

If you want to win battles in the culture war, you enact legislation that regulates firearms, prohibits abortions, restricts discussion of critical race theory, or advances whatever other substantive policy preferences represent a victory for your side. But to win the war decisively with an incapacitating strike, you make it as difficult as possible for your adversaries to challenge those laws in court. Clever deployment of justiciability doctrines will help to insulate constitutionally questionable laws from judicial review, but some of the challenges you have sought to evade will manage to squeak through.

To fully disarm your opponents in an …

In-Service Education And The Provision Of Educational Materials To Improve Awareness Of Chronic Wasting Disease Management Efforts In Arkansas, Mary Claire Stewart

Animal Science Undergraduate Honors Theses

Chronic Wasting Disease (CWD) is a disease caused by an accumulation of misfolded prions throughout the nervous system. This disease affects animals within the Cervidae Family, which includes deer, elk, moose, and caribou. This disease is fatal and physical symptoms often do not materialize until the animal is near death. CWD has become an increasing issue in Arkansas since an elk (Cervus canadensis) in Newton County tested positive for CWD in 2016. Since then, the Arkansas Game and Fish Commission (AGFC) has worked with the University of Arkansas Division of Agriculture (UADA) and others to develop management strategies to slow …

Peaks Island Star : May 2023, Vol. 43, Issue 5, Service Agencies Of The Island

Peaks Island Star, 2023

The Peaks Island Star is the newsletter of the island's service agencies and other community news.

Relationship Between Consumer Confidence Index And Leading Sectors In Turkey, Erhan Aslanoğlu, Yasin Enes Aksu, Jonberk Okan

Topics in Middle Eastern and North African Economies

As a leading indicator, the ability to measure the predictive power of consumer surveys are very important for economic policy makers, especially to capture a forward-looking perspective on consumer trends. Trends in leading sectors such as real estate, automobile and consumer electronics are expected to signal direction of consumption demand in an economy. Within this framework, whether the consumer confidence signals the trends in leading sectors or the trend in leading sectors effect the consumer sentiment are vital questions to detect the dynamics of domestic demand. Macroeconomic cycles like high and volatile inflationary environments might create counter effect to determine …