Digital Commons Network^™

Jemc '05 Named 2023 Guggenheim Fellow, Mj Soria

News and Events (Discontinued Series)

No abstract provided.

Combined Inhibition Of Bcl-2 And Mcl-1 Overcomes Bax Deficiency-Mediated Resistance Of Tp53-Mutant Acute Myeloid Leukemia To Individual Bh3 Mimetics, Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Kornblau, Muharrem Muftuoglu, Michael Andreeff

Faculty, Staff and Student Publications

TP53-mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and reverse phase protein array datasets revealed significantly lower BAX RNA and protein levels in TP53-mutant compared to TP53-wild-type (WT) AML, a finding confirmed in isogenic CRISPR-generated TP53-knockout and -mutant AML. The response to either BCL-2 (venetoclax) or MCL-1 (AMG176) inhibition was BAX-dependent and much reduced in TP53-mutant compared to TP53-WT cells, while the combination of two BH3 mimetics effectively activated BAX, circumventing survival mechanisms in cells treated with either BH3 mimetic, and synergistically induced …

The Colours Of Rethoryk: The Medieval World’S Influence On Red And White Color Symbolism In Geoffrey Chaucer’S The Canterbury Tales, Frederick W. Smallshaw

Undergraduate Theses and Capstone Projects

Chaucer’s use of visual imagery and symbolism in The Canterbury Tales. From a literary approach, scholars point to Chaucer’s diverse and extensive descriptions of visuals in poetry as a primary rhetorical avenue, where he applies commentary to instances where a physical image (known in this case as a symbol) is most appropriate to elicit a desired emotion or convey a certain idea concerning moralit

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Iliad, The Odyssey, And All Of Greek Mythology In 99 Minutes Or Less! (2023) | Program, Jacksonville State University

Department of Theatre & Film Performance Archive

Performed: 14 April 2023; "The Iliad, The Odyssey, and All of Greek Mythology in 99 Minutes or Less!" entails all of Greek Mythology on stage. The director was Addie Zaner, stage manager was Laurellei Veasey, assistant stage manager was El Hataway, dramaturg was Leah Bussey, assistant dramaturg was Murchison Murray, scenic designer was Erin Rose Pempel, props designer was Nikki Walker, lighting designer was Carley Carey, costume designer was Jess Collier, puppet designer was Elizabeth Freeman, and sound designer was Grayson Singleton. This item is contained within the Theatre & Film Production Archive.

The Iliad, The Odyssey, And All Of Greek Mythology In 99 Minutes Or Less! (2023) | Poster, Jacksonville State University

Department of Theatre & Film Performance Archive

Performed: 14 April 2023; "The Iliad, The Odyssey, and All of Greek Mythology in 99 Minutes or Less!" entails all of Greek Mythology on stage. The director was Addie Zaner, stage manager was Laurellei Veasey, assistant stage manager was El Hataway, dramaturg was Leah Bussey, assistant dramaturg was Murchison Murray, scenic designer was Erin Rose Pempel, props designer was Nikki Walker, lighting designer was Carley Carey, costume designer was Jess Collier, puppet designer was Elizabeth Freeman, and sound designer was Grayson Singleton. This item is contained within the Theatre & Film Production Archive.

Genomic Analyses Of Hair From Ludwig Van Beethoven, Tristan James Alexander Begg, Axel Schmidt, Arthur Kocher, Maarten H.D. Larmuseau, Göran Runfeldt, Paul Andrew Maier, John D. Wilson, Rodrigo Barquera, Carlo Maj, András Szolek, Michael Sager, Stephen Clayton, Alexander Peltzer, Ruoyun Hui, Julia Ronge, Ella Reiter, Cäcilia Freund, William Rhea Meredith, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Ludwig van Beethoven (1770–1827) remains among the most influential and popular classical music composers. Health problems significantly impacted his career as a composer and pianist, including progressive hearing loss, recurring gastrointestinal complaints, and liver disease. In 1802, Beethoven requested that following his death, his disease be described and made public. Medical biographers have since proposed numerous hypotheses, including many substantially heritable conditions. Here we attempt a genomic analysis of Beethoven in order to elucidate potential underlying genetic and infectious causes of his illnesses. We incorporated improvements in ancient DNA methods into existing protocols for ancient hair samples, enabling the sequencing …

Understanding China's Cryptocurrency Stance: Analysis Of The Recent Developments And Future Prospects, Zhengchun Wan

Cardozo International & Comparative Law Review (CICLR) Blog

In September 2021, the People’s Bank of China (PBOC), China’s central bank, in conjunction with nine other state bodies, including the police and the supreme court, issued a statement regarding the country’s stance on cryptocurrency businesses. There, regulators have explicitly stated that all cryptocurrency trading, exchanges, and investments—both crypto-to-crypto and crypto-to-fiat—are prohibited, whether they are carried out through domestic or international platforms. Despite China’s official strong hostilities toward cryptocurrencies, some believe the policy might change soon.

This post was originally published on the Cardozo International & Comparative Law Review on April 24, 2023. The original post can be accessed via …

Multi-Specific Calibration Of The B Isotope Proxy In Calcareous Red Algae For Ph Reconstruction, Giulia Piazza, Eduardo Paredes, Valentina Alice Bracchi, Leopoldo David Pena, Jason Hall-Spencer, Chiara Ferrara, Isabel Cacho, Daniela Basso

School of Biological and Marine Sciences

Calcareous red algae have calcified cell walls constituted by high-Mg calcite or aragonite (Morse et al., 2006). They are considered suitable paleoclimate archives due to their worldwide distribution and their longevity through indeterminate growth (Kamenos et al., 2008). Boron isotopes (δ11B) measured in their calcified thallus are considered a pH proxy (Hemming and Hanson, 1992). In seawater, boron occurs as boric acid and borate ion. Both species are enriched in 11B as pH increases, with boric acid characterized by an enrichment factor of 27‰ compared to borate. The boron isotope proxy theory states that borate is exclusively incorporated in the …

Biophysical Flocculation Reduces Variability Of Cohesive Sediment Settling Velocity, L Ye, Ja Penaloza-Giraldo, Aj Manning, J Holyoke, T-J Hsu

School of Biological and Marine Sciences

Biophysical cohesion, introduced predominantly by Extracellular Polymeric Substances (EPS) during mineral flocculation in subaqueous environments, plays important role in morphodynamics, biogeochemical cycles and ecosystem processes. However, the mechanism of how EPS functioning with cohesive particles and affects settling behaviors remain poorly understood. We measure initial flocculation rate, floc size and settling velocity of mineral and artificial EPS (Xanthan gum) mixtures. Combining results from these and previous studies demonstrate coherent intensification of EPS-related flocculation compare with those of pure mineral and oil-mineral mixtures. Importantly, the presence of EPS fundamentally changes floc structure and reduces variability of settling velocity. Measured data shows …

Nyls Moot Court Team Celebrates Impressive Performance At Competition, Moot Court Association

NYLS Community News

No abstract provided.

The Power Of Praise, Joseph Khabbaz

The Main Thing Devotional

I will sing to the LORD as long as I live; I will sing praise to my God while I have my being. (Psalm 104:33)

You can experience great strength through song.

Inquiry As Practice: The Pathway To Redesigning An Educational Leadership Doctoral Research Seminar Series, Steve Tolman, Daniel W. Calhoun, Juliann S. Mcbrayer, Nikheal Patel, Elise J. Cain

Leadership, Technology & Human Development: Faculty Publications

As faculty of an educational leadership doctoral program (EdD) aligned with the Carnegie Project on the Education Doctorate (CPED) principles, we acknowledge the importance of inquiry to develop scholarly practitioners. Applying the tenet of Inquiry as Practice, our EdD faculty critically examined the doctoral curriculum to explore ways to effectively prepare our doctoral students to learn and apply research methodology meaningfully. This essay details how the review of our research curriculum led to a pedagogical and curriculum redesign of our research seminar series. This revised research seminar series culminates in a course offered every fall/spring semester in the final two …

Start-Ups Vs Google: Action Can Be Taken Only As Per Law: Rahul Singh, Rahul Singh

Popular Media

The Alliance of Digital India Foundation (ADIF) filed a plea against Google’s user choice billing system (UCB) in the Delhi High Court. The court asked the Competition Commission of India to look into ADIF’s complaint by April 26—the day the new billing system was to go into effect. In this podcast episode, Associate Professor Rahul Singh helps listeners understand the dynamics between start-ups and Google. He also talks about the possibility of tech giants like Google being monitored.

Why The Elevation Of Disabled Advocate Moxa Kiran Thakker Is Important, Sanjay Jain, Rahul Bajaj

Popular Media

Appointments such as that of disabled advocate Moxa Kiran Thakker as a judge in the Gujarat High Court repudiate the theory that persons with disability are not competent enough to discharge responsibilities.

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

Celebrate University Awards of Excellence and Years of Service Recognition on Friday

USG required cybersecurity training due by Friday

12th Annual Georgia Legal Food Frenzy is underway

GS Behavioral Assessment Team (BAT) is available to identify resources and appropriate interventions

Help University Communications and Marketing highlight graduating students

Today begins Georgia Southern’s first Faculty & Staff Wellness Week

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

• National Youth Advocacy and Resilience Conference Serves 1,300 Professionals

• Students tackle nonfiction literacy with hands-on activities

• COE Supports Special Olympics

Discriminating Wirelesshart Communication Devices Using Sub-Nyquist Stimulated Responses, Jeffrey D. Long, Michael A. Temple, Christopher M. Rondeau

Faculty Publications

Reliable detection of counterfeit electronic, electrical, and electromechanical devices within critical information and communications technology systems ensures that operational integrity and resiliency are maintained. Counterfeit detection extends the device’s service life that spans manufacture and pre-installation to removal and disposition activity. This is addressed here using Distinct Native Attribute (DNA) fingerprinting while considering the effects of sub-Nyquist sampling on DNA-based discrimination. The sub-Nyquist sampled signals were obtained using factor-of-205 decimation on Nyquist-compliant WirelessHART response signals. The DNA is extracted from actively stimulated responses of eight commercial WirelessHART adapters and metrics introduced to characterize classifier performance. Adverse effects of sub-Nyquist decimation …

University Philharmonic Orchestra & University Band

Bailey School of Music Concert Programs

Nancy Conley, conductor

Brandon Meeks, conductor

Quantifying Phenotypic Variation Among The Head Photophores And Nasal Rosettes Of The Myctophid Species, Diaphus Dumerilii In Relation To Body Size, Ryan E. Byrne

All HCAS Student Capstones, Theses, and Dissertations

The myctophid genus Diaphus is known for having highly developed head photophores and nasal rosettes. The head photophores of Diaphus are typically enlarged and vary between species and possibly sexes. Diaphus dumerilii is also a macrosmatic species with large olfactory organs. The aim of this study is to quantify the variances in location, size, and shape of the head photophores and nasal rosettes between selected individuals from Diaphus dumerilii to understand how these variances relate to morphometric measurements such as body length, inferred maturity and nasal rosette size and shape. Diaphus possess many highly conserved traits that are useful for …

Effects Of Cyanobacteria Harmful Algal Blooms On The Microbial Community Within Lake Okeechobee, Fl, Usa, Paisley S. Samuel

All HCAS Student Capstones, Theses, and Dissertations

The Lake Okeechobee (Lake O) watershed is a Floridian freshwater ecosystem that has been affected by the increased frequency and intensity of harmful cyanobacterial bloom (cyanoHAB) events occurring over recent decades. Lake O has several ecological and economic purposes such as providing habitats for various organisms and providing drinking water to urban communities surrounding the lake. Toxic cyanoHAB events are posing a threat to the ecosystem and economy of the lake due to the degradation of water quality. This study investigates how the microbial community structure within Lake O is affected by annual cyanobacterial harmful algal blooms over several years …

Recital: Double Reed, April 24, 2023, Illinois State University School Of Music

School of Music Programs

Kemp Recital Hall
April 24, 2022
Monday Evening
7:30 p.m.

A Predictive Study Of Self-Regulated Learning In Teacher Candidates And Praxis Examination Achievement, Ayanna Danielle Perkins

Electronic Theses and Dissertations Archive

Nationally, teacher candidates struggle to pass the Praxis examination, which they need to be licensed. Little research has been done to examine the characteristics and learning strategies of teacher candidates who pass and who do not pass the Praxis examination. Studies have shown benefits in the use of self-regulation and achievement in courses and on other examinations. Zimmerman’s (1989) self-regulated learning theory describes how teacher candidates engage in self-directed planning, learning, and reflecting to achieve a goal. The purpose of this dissertation is to describe the purpose, method, design, and analysis of a predictive study to determine whether self-regulation, as …

Work-Life Balance And The Perceived Value Of Rewards When Faculty Consider Promotions In Administration, Judi Waldrip

Electronic Theses and Dissertations Archive

The purpose of this study was to examine the relationship between work-life balance and faculty perceptions of promotions in academia using Vroom’s (1964) Expectancy Theory of Motivation as the theoretical framework. The study was conducted at two universities in the Southeast, and all faculty were invited to participate in an online survey. Multiple regression analysis was used to test three hypotheses relating to expectancy, instrumentality, and valence. These three factors were used for the dependent variables. The same independent variables were used for each regression model, and they included age, gender, tenure status, marital status, children under the age of …

Performance Of 3d Printed Columns Using Self-Sensing Cementitious Composites, Cynthia D. Atkinson, Farhad Aslani

Research outputs 2022 to 2026

Self-sensing cementitious composites can be used as an economical method of structural health monitoring. This is achieved by using the piezoresistivity effect to assist in the detection of defects and enabling repairs to be conducted early which can therefore avoid structural failures. This study uses an established self-sensing cementitious composite mix to 3D print column to examine its structural performance and sensing capabilities in components of large-scale concrete structures. An extrusion-based 3D printer was used to print hollow square column segments. These segments were then joined and filled with steel rebar reinforcement and cast concrete. Another column was created using …

Transannular Functionalization Of Multiple C(Sp3)-H Bonds Of Tropane Via An Alkene-Bridged Palladium(I) Dimer, Ellen Y. Aguilera, En Chih Liu, Scott M. Thullen, Melanie S. Sanford

Chemistry Faculty Research & Creative Works

This Communication describes the Pd-catalyzed C(sp³)-H functionalization of a tropane derivative to generate products with functionalization at two (β/γ) or three (β/γ/β) different sites on the alicyclic amine core. These reactions proceed via an initial dehydrogenation to generate an alkene product that can react further to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer affords β/γ/β-functionalized allylic arylation and allylic acetoxylation products.

45 Senolytic Therapy Transiently Reduces Inflammatory Markers In Primary Blood Mononuclear Cells Of Individuals With Early Alzheimer’S Disease: Exploring The Conserved Transcriptional Response To Adversity As A Biomarker For Disease State, Valentina R. Garbarino, Peng Xu, Bin Zhang, Mitzi M. Gonzales, Miranda E. Orr

School of Medicine Publications

OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC) of chronically stress caregivers, is present in individuals with early Alzheimer’s disease. Chronic stress is a risk factor for Alzheimer’s, and may be an untapped biomarker for disease risk and pathology.

METHODS/STUDY POPULATION: To collect preliminary data on the Conserved Transcriptional Response to Adversity profile in individuals with Alzheimer’s disease, we were able to utilize primary blood mononuclear cell samples from a small open label pilot study called Senolytic Therapy to Modulate the Progression of Alzheimer’s Disease, designed to clear stressed senescent …

101 Quincy Llc V. Wilkinson

All Decisions

No abstract provided.

Emile V. Augustine

All Decisions

Handwritten Opinion.

A Unified Two Independent Stress Variable Approach To Moisture-Change-Induced Unsaturated Soil Volume Change, Sandra Houston, Xiong Zhang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

In 1968, Matyas and Radhakrishna introduced the concept of the state surface, demonstrating that unsaturated soil volume change is dependent on two independent stress state variables, net total stress and suction. For decades the basic theory of unsaturated soils has been known, and a holistic view of the elastoplastic response of unsaturated soils, based on a modified state surface approach (MSSA), makes it clear that a method accounting for independent roles of net total stress and suction is required to quantify volume change of unsaturated soils. Still, reliance on pre-unsaturated-soil-mechanics-era methods persists, particularly within the geotechnical practice community. Unsaturated soil …