Digital Commons Network^™

Why The Elevation Of Disabled Advocate Moxa Kiran Thakker Is Important, Sanjay Jain, Rahul Bajaj

Popular Media

Appointments such as that of disabled advocate Moxa Kiran Thakker as a judge in the Gujarat High Court repudiate the theory that persons with disability are not competent enough to discharge responsibilities.

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

Celebrate University Awards of Excellence and Years of Service Recognition on Friday

USG required cybersecurity training due by Friday

12th Annual Georgia Legal Food Frenzy is underway

GS Behavioral Assessment Team (BAT) is available to identify resources and appropriate interventions

Help University Communications and Marketing highlight graduating students

Today begins Georgia Southern’s first Faculty & Staff Wellness Week

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

• National Youth Advocacy and Resilience Conference Serves 1,300 Professionals

• Students tackle nonfiction literacy with hands-on activities

• COE Supports Special Olympics

Glutathione-Responsive Tannic Acid-Assisted Fret Nanomedicine For Cancer Therapy, Partha Laskar, Anupam Dhasmana, Sudhir Kotnala, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

In cancer combination therapy, a multimodal delivery vector is used to improve the bioavailability of multiple anti-cancer hydrophobic drugs. Further, targeted delivery of therapeutics along with simultaneous monitoring of the drug release at the tumor site without normal organ toxicity is an emerging and effective strategy for cancer treatment. However, the lack of a smart nano-delivery system limits the application of this therapeutic strategy. To overcome this issue, a PEGylated dual drug, conjugated amphiphilic polymer (CPT-S-S-PEG-CUR), has been successfully synthesized by conjugating two hydrophobic fluorescent anti-cancer drugs, curcumin (CUR) and camptothecin (CPT), through an ester and a redox-sensitive disulfide (-S-S-) …

An Epimetabolomics Approach To Understanding Alzheimer's Disease, Stewart F. Graham

Conference Presentation Abstracts

No abstract provided.

When It Clicks, Mitch Goldstein

Theses

“When It Clicks” examines my relationship to the chaos, discomfort, and anxiety of traveling through life, and the moments of calm, understanding, and clarity that intersect and juxtapose with my journey — those moments when things seem to click together and allow me to see a path through the complexities and ambiguity of life.

Serologic Responses To Covid-19 Vaccination In Children With History Of Multisystem Inflammatory Syndrome (Mis-C), Maria A Perez, Carol M Kao, David A Hunstad, Et Al.

2020-Current year OA Pubs

Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. We found that SARS-CoV-2 variant cross-reactive IgG antibodies variably waned following acute MIS-C, but were significantly boosted with vaccination and maintained for up to 3 months. We then compared post-vaccination binding, pseudovirus neutralizing, and functional antibody-dependent cell-mediated cytotoxicity (ADCC) titers to the reference strain (Wuhan-hu-1) and Omicron variant (B.1.1.529) among previously healthy children (n = 16) …

Direct Selection Of Dna-Encoded Libraries For Biased Agonists Of Gpcrs On Live Cells, Bo Cai, Amal El Daibani, Yuntian Bai, Tao Che, Casey J Krusemark

2020-Current year OA Pubs

G protein-coupled receptors (GPCRs) are the largest superfamily of human membrane target proteins for approved drugs. GPCR ligands can have a complex array of pharmacological activities. Among these activities, biased agonists have potential to serve as both chemical probes to understand specific aspects of receptor signaling and therapeutic leads with more specific, desired activity. Challenges exist, however, in the development of new biased activators due, in part, to the low throughput of traditional screening approaches. DNA-encoded chemical libraries (DELs) dramatically improve the throughput of drug discovery by allowing a collective selection, rather than discrete screening, of large compound libraries. The …

Performance Of 3d Printed Columns Using Self-Sensing Cementitious Composites, Cynthia D. Atkinson, Farhad Aslani

Research outputs 2022 to 2026

Self-sensing cementitious composites can be used as an economical method of structural health monitoring. This is achieved by using the piezoresistivity effect to assist in the detection of defects and enabling repairs to be conducted early which can therefore avoid structural failures. This study uses an established self-sensing cementitious composite mix to 3D print column to examine its structural performance and sensing capabilities in components of large-scale concrete structures. An extrusion-based 3D printer was used to print hollow square column segments. These segments were then joined and filled with steel rebar reinforcement and cast concrete. Another column was created using …

Draft Final 2023 Residential Metals Abatement Program (Rmap) Walkerville Park (Walkerville Drive And Ryan Road) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

45 Senolytic Therapy Transiently Reduces Inflammatory Markers In Primary Blood Mononuclear Cells Of Individuals With Early Alzheimer’S Disease: Exploring The Conserved Transcriptional Response To Adversity As A Biomarker For Disease State, Valentina R. Garbarino, Peng Xu, Bin Zhang, Mitzi M. Gonzales, Miranda E. Orr

School of Medicine Publications

OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC) of chronically stress caregivers, is present in individuals with early Alzheimer’s disease. Chronic stress is a risk factor for Alzheimer’s, and may be an untapped biomarker for disease risk and pathology.

METHODS/STUDY POPULATION: To collect preliminary data on the Conserved Transcriptional Response to Adversity profile in individuals with Alzheimer’s disease, we were able to utilize primary blood mononuclear cell samples from a small open label pilot study called Senolytic Therapy to Modulate the Progression of Alzheimer’s Disease, designed to clear stressed senescent …

Microfluidic Device Facilitates In Vitro Modeling Of Human Neonatal Necrotizing Enterocolitis-On-A-Chip, Wyatt E. Lanik, Cliff J. Luke, Lila S. Nolan, Qingqing Gong, Lauren C. Frazer, Jamie M. Rimer, Sarah E. Gale, Raymond Luc, Shay S. Bidani, Carrie A. Sibbald, Angela N. Lewis, Belgacem Mihi, Pranjal Agrawal, Martin Goree, Marlie Maestas, Elise Hu, David F. Peters, Misty Good

2020-Current year OA Pubs

Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut barrier disruption. We describe an in vitro model of the human neonatal small intestinal epithelium (Neonatal-Intestine-on-a-Chip) that mimics key features of intestinal physiology. This model utilizes intestinal enteroids grown from surgically harvested intestinal tissue from premature infants and cocultured with human intestinal microvascular endothelial cells within a microfluidic device. We used our Neonatal-Intestine-on-a-Chip to recapitulate NEC pathophysiology by adding infant-derived microbiota. This model, named NEC-on-a-Chip, simulates the predominant features of …

Modifiable Risk Factors In Women At High Risk Of Breast Cancer: A Systematic Review, Sarah Y Cohen, Carolyn R Stoll, Akila Anandarajah, Michelle Doering, Graham A Colditz

2020-Current year OA Pubs

BACKGROUND: Modifiable risk factors (alcohol, smoking, obesity, hormone use, and physical activity) affect a woman's breast cancer (BC) risk. Whether these factors affect BC risk in women with inherited risk (family history, BRCA1/2 mutations, or familial cancer syndrome) remains unclear.

METHODS: This review included studies on modifiable risk factors for BC in women with inherited risk. Pre-determined eligibility criteria were used and relevant data were extracted.

RESULTS: The literature search resulted in 93 eligible studies. For women with family history, most studies indicated that modifiable risk factors had no association with BC and some indicated decreased (physical activity) or increased …

101 Quincy Llc V. Wilkinson

All Decisions

No abstract provided.

Emile V. Augustine

All Decisions

Handwritten Opinion.

Altmetrics Study On Research Outputs In Fields Of Social Sciences In Top Iranian Universities, Amir Ghasemian, Amir Reza Asnafi, Amin Erfanmanesh

Library Philosophy and Practice (e-journal)

Purpose: The purpose of the present work was Altmetrics study of research outputs in the field of social and behavioral sciences in major Iranian universities during 2010-2020.

Methodology: The research outputs of the thematic domains of social and behavior of sciences major Iranian universities indexed in the Scopus database were reviewed. This applied research was conducted with a Altmetrics approach. Scopus and Altmetrics Explorer databases were used to collect data. Data analysis was performed using descriptive and inferential statistical tests in Excel software.

Findings: Current study revealed Shahid Beheshti, Tehran, Tarbiat Modares, Tabriz, and Shiraz universities, in the field of …

Attitude Formation, Use Of Library Resources, And Perceived Academic Performance Of Students In Private Universities In Ibadan, Olumuyiwa Folajimi Akindehin Mr

Library Philosophy and Practice (e-journal)

ABSTRACT

The research delved into the attitude of postgraduate students when it comes to research and studying and the use of library resources. The study reveals that some postgraduate students are cumbered with many thoughts and think of the best way to ensure they balance their academic needs and family needs. The researcher talked about time management at some point to encourage postgraduate students to schedule their time appropriately to maximize research and family time. The researcher made some conclusions and recommendations at the end of the research.

Library As A Promoter Of Reading Habits Among Students In Nigeria, John Gibson Ogonu Dr, Comfort N. Owate Dr

Library Philosophy and Practice (e-journal)

The focus of this paper is to examine the roles of library in promoting Reading Habits among students. The paper saw the library as a social service oriented institution aimed at encouraging students to cultivate reading habits. It looked at library as learning environments that provide space, access to resources, activities and services to encourage and support students, teachers, and community learning. The paper also explained the concept of reading and that reading provides the information needed to expand our understanding of thing. The paper defined reading habits as a passion and zeal for reading and outlined its importance to …

A Small Secreted Protein Nicol Regulates Lumicrine-Mediated Sperm Maturation And Male Fertility, Daiji Kiyozumi, Kentaro Shimada, Michael Chalick, Chihiro Emori, Mayo Kodani, Seiya Oura, Taichi Noda, Tsutomu Endo, Martin M Matzuk, Daniel H Wreschner, Masahito Ikawa

Faculty, Staff and Students Publications

The mammalian spermatozoa produced in the testis require functional maturation in the epididymis for their full competence. Epididymal sperm maturation is regulated by lumicrine signalling pathways in which testis-derived secreted signals relocate to the epididymis lumen and promote functional differentiation. However, the detailed mechanisms of lumicrine regulation are unclear. Herein, we demonstrate that a small secreted protein, NELL2-interacting cofactor for lumicrine signalling (NICOL), plays a crucial role in lumicrine signalling in mice. NICOL is expressed in male reproductive organs, including the testis, and forms a complex with the testis-secreted protein NELL2, which is transported transluminally from the testis to the …

A Predictive Study Of Self-Regulated Learning In Teacher Candidates And Praxis Examination Achievement, Ayanna Danielle Perkins

Electronic Theses and Dissertations Archive

Nationally, teacher candidates struggle to pass the Praxis examination, which they need to be licensed. Little research has been done to examine the characteristics and learning strategies of teacher candidates who pass and who do not pass the Praxis examination. Studies have shown benefits in the use of self-regulation and achievement in courses and on other examinations. Zimmerman’s (1989) self-regulated learning theory describes how teacher candidates engage in self-directed planning, learning, and reflecting to achieve a goal. The purpose of this dissertation is to describe the purpose, method, design, and analysis of a predictive study to determine whether self-regulation, as …

Work-Life Balance And The Perceived Value Of Rewards When Faculty Consider Promotions In Administration, Judi Waldrip

Electronic Theses and Dissertations Archive

The purpose of this study was to examine the relationship between work-life balance and faculty perceptions of promotions in academia using Vroom’s (1964) Expectancy Theory of Motivation as the theoretical framework. The study was conducted at two universities in the Southeast, and all faculty were invited to participate in an online survey. Multiple regression analysis was used to test three hypotheses relating to expectancy, instrumentality, and valence. These three factors were used for the dependent variables. The same independent variables were used for each regression model, and they included age, gender, tenure status, marital status, children under the age of …

Controller-Driven Event-Based Network Heat Map Visualisation, Praveen Kumar, Navdeep Sood

Defensive Publications Series

Network controllers have available to them all manner of data from the different network elements and the various network links. Techniques are presented herein that leverage that data to support a new heat map concept. The presented techniques begin with the generation of node-level heat maps and services-level heat maps. Those artifacts may be employed to study the impact of a given failure on the nodes and the services that are present in a network. The presented techniques also support the development of a network-level heat map from those artifacts. The model that is supported by the presented techniques is …

Brief Report: Out Of Sight Out Of Mind - Preventable Childhood Kidney Disease In The Far North, Johanna Neville, Allison Hempenstall, Caroline Taunton, Valmay Fisher, Malcolm Mcdonald

Journal of the Australian Indigenous HealthInfoNet

APSGN is an immune-mediated kidney disease that occurs after a Streptococcus pyogenes skin or throat infection in children and contributes to chronic kidney disease later in life. It is a disease of poverty and regrettably common in Aboriginal and Torres Strait Islander children. There have been seven documented APSGN outbreaks across Far North Queensland in the last nine years. Despite this disease being notifiable in both Western Australia and the Northern Territory, Queensland is yet to acknowledge the importance of early notification in the management of APSGN. Notification-driven publication of APSGN incidence should help raise its profile and stimulate better …

Exploring The Experiences Of The Consent Process For Aboriginal And Torres Strait Islander People Having Cardiac Surgery And Participating In Medical Research: A Study Protocol, Julieann Coombes, Keziah Bennett-Brook, Kate Hunter, Tamara Mackean, Edward Litton, Jacquita S. Affandi, Courtney Ryder, Bobby Porykali, Brea Grant, Kenneth Yakubu, Colin Garlett, Camila A. Kairuz Santos

Journal of the Australian Indigenous HealthInfoNet

Background: Gaining informed consent is a critical step before any medical procedure, and before taking part in medical research. Cultural differences in concepts of health and healing, communication, language, and racism, can play a part in forming barriers to gaining informed consent for Aboriginal and Torres Strait Islander people. For Aboriginal and Torres Strait Islander people, a lack of informed consent can worsen distrust and contribute to continuing health disparities. This protocol describes a study aimed at providing a better understanding of informed consent experiences of Aboriginal and Torres Strait Islander people undergoing heart surgery and participating in research. This …

Aboriginal Men’S Business: A Literature Review Of Factors Affecting Aboriginal Men Accessing Sexual Health Services, Daniel Dawson, Daniel Mcdonough, Rachel Reilly, James A. Charles

Journal of the Australian Indigenous HealthInfoNet

Introduction: Aboriginal men are relatively young, with a median age of 22 years, nearly half that of their non-Aboriginal counterparts. Aboriginal men also have the highest mortality rates and have the lowest life expectancy. Sexually Transmissible Infection (STI) rates are extremely overrepresented in lower socio-economic groups, including minority populations. STI rates among Aboriginal communities are significantly higher when compared to the non-Aboriginal population.

Aims: In the context of multiple factors impinging on the sexual health of Aboriginal men, we sought to conduct a comprehensive review of the literature for the purpose of developing a framework through which needs and actions …

What Works For Aboriginal And Torres Strait Islander Men? A Systematic Review Of The Literature, Jack R. Menges, Marie L. Caltabiano, Alan Clough

Journal of the Australian Indigenous HealthInfoNet

Aboriginal and Torres Strait Islander men experience significantly higher rates of suicide, trauma, alcohol related deaths and unemployment than other Australian men. Despite significant levels of government intervention, rates of family violence, unemployment and incarceration continue to increase in Aboriginal and Torres Strait Islander communities. As a subset of the Aboriginal and Torres Strait Islander population, there has been a lesser focus on how to meaningfully improve the wellbeing of Aboriginal and Torres Strait Islander men. This systematic review seeks to understand what interventions, programs and activities are successful in improving the wellbeing of Aboriginal and Torres Strait Islander men …

Intersectionality Based Policy Analysis Of How Racism Is Framed In Medical Education Policies Guiding Aboriginal Health Curriculum, Petah Atkinson, Marilyn Baird, Karen Adams

Journal of the Australian Indigenous HealthInfoNet

Introduction: Racism has a profound impact on health inequities for Aboriginal and Torres Strait Islander people. Australian medical schools are required to include Aboriginal and Torres Strait Islander health curriculum in their medical courses and policies have been developed to support this work.

Methods: The research question was: how is racism framed in medical education policies guiding Aboriginal and Torres Strait Islander health curriculum for entry-level medical courses? Applying an Indigenous Research Paradigm and Intersectionality Based Policy Analysis, three key policies were analysed: Australian Medical Council (AMC) Standards for Assessment and Accreditation of Primary Medical programs; Aboriginal and Torres Strait …

Scoping The Potential Of A Noongar Re-Entry Peer Navigator Model, Jane Anderson

Journal of the Australian Indigenous HealthInfoNet

The Noongar people of the South West of Western Australia (WA) continue to seek self-determination and empowerment to ensure their families are able to meet cultural, economic and social needs. Their aspirations, however, are thwarted by a significant number of their members who are incarcerated and the adverse consequences of imprisonment on families. In the meantime, the WA prison system is yet to respond to the unique needs of Noongar prisoners transitioning out of the prison system. The article reviews the literature to develop the idea of a Noongar re-entry peer navigator (PN) model. In this model, select Noongar people …

‘It’S Us, Or Maybe No One’: Yarning With Aboriginal Social And Emotional Wellbeing Workers From The Kimberley Region Of Western Australia, Zaccariah Cox, Emma Carlin, Kate Derry, Pat Dudgeon

Journal of the Australian Indigenous HealthInfoNet

Objective

Social and Emotional Wellbeing (SEWB) describes the holistic model of health and wellbeing advocated for by Aboriginal and Torres Strait Islander peoples. This research explored the experiences of Aboriginal peoples employed in SEWB service delivery to identify enablers, challenges, and requirements of growing a sustainable, and empowered SEWB workforce.

Methods

We used a yarning methodology with seven Aboriginal SEWB workers located at Aboriginal Community Controlled Health Organisations across the Kimberley region of Western Australia.

Results

Three key SEWB service delivery themes were identified: 1) Role of cultural identity; 2) Barriers and enablers of SEWB service provision; 3) Building the …

Editorial, Neil M. Drew, Darren Deves, Hannah Tarrant

Journal of the Australian Indigenous HealthInfoNet

No abstract provided.