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A Dynamic Model Of The Pi3k/Akt/Pten Axis In Pathological Microglial Phenotype, Rohan Sethi Apr 2023

A Dynamic Model Of The Pi3k/Akt/Pten Axis In Pathological Microglial Phenotype, Rohan Sethi

Undergraduate Research and Engagement Symposium

Microglia, which are immune cells of the CNS, are critical to maintaining the integrity of nervous system and are stimulated into action after detection of damaged/dying cells and foreign pathogens. Recent literature has implicated the role of dysregulated PI3K/AKT dynamics in promoting inflammatory microglia that chronically promote damaging neuroinflammation in neurodegenerative disease. I have designed a computational model that can help elucidate the intrinsic biochemical mechanisms and kinetics of the PI3K/AKT pathway that govern the microglial states. I plan to use the in-silico model to study the therapeutic potential of manipulating this pathway’s biochemical kinetics to slow neurodegenerative disease progression.


Maternal Effects On Long Bone Length, Mohammed Abdul Samad Apr 2023

Maternal Effects On Long Bone Length, Mohammed Abdul Samad

Undergraduate Research and Engagement Symposium

Past studies have given the heritability of long bones but have not taken maternal effects into consideration. The goal of this research is to identify the proportion of maternal effects in that heritability and the level of influence that it has on offspring. This will use the information of a parent and offspring generation of mice to create a model that can identify the maternal effects apart from direct effects. The results will give a map for identifying the loci for maternal effects that indirectly influence long bones. This will give estimates for variation of offspring for certain populations.


Back Matter (Volume 4, Issue 1), Grayson Carter Apr 2023

Back Matter (Volume 4, Issue 1), Grayson Carter

Sehnsucht: The C. S. Lewis Journal

No abstract provided.


Internet Links: Updated, Grayson Carter Apr 2023

Internet Links: Updated, Grayson Carter

Sehnsucht: The C. S. Lewis Journal

No abstract provided.


Kindle Reviews, Sørina Higgins Apr 2023

Kindle Reviews, Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

No abstract provided.


Review Of Looking For The King: An Inklings Novel, Annelise Holwerda Apr 2023

Review Of Looking For The King: An Inklings Novel, Annelise Holwerda

Sehnsucht: The C. S. Lewis Journal

Annelise Holwerda: Review of David C. Downing, Looking for the King: An Inklings Novel (San Francisco, 2010). 278 pages. $15.96. ISBN 9781586175146.


Book Announcements And Short Reviews, Sørina Higgins Apr 2023

Book Announcements And Short Reviews, Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

No abstract provided.


Review Of Death And Fantasy: Essays On Phillip Pullman, C.S. Lewis, George Macdonald, And R.L. Stevenson, Kirstin Jeffrey Johnson Apr 2023

Review Of Death And Fantasy: Essays On Phillip Pullman, C.S. Lewis, George Macdonald, And R.L. Stevenson, Kirstin Jeffrey Johnson

Sehnsucht: The C. S. Lewis Journal

Kirstin Jeffrey Johnson: Review of William Gray, Death and Fantasy: Essays on Philip Pullman, C. S. Lewis, George MacDonald, and R. L. Stevenson (Newcastle upon Tyne, 2008). 136 pages. $24.99. ISBN 9781847188717.


Review Of War Of The Fantasy Worlds: C.S. Lewis And J.R.R. Tolkein On Art And Imagination, Charles Franklyn Beach Apr 2023

Review Of War Of The Fantasy Worlds: C.S. Lewis And J.R.R. Tolkein On Art And Imagination, Charles Franklyn Beach

Sehnsucht: The C. S. Lewis Journal

Charles Franklyn Beach: Review of Martha C. Sammons, War of the Fantasy Worlds: C. S. Lewis and J. R. R. Tolkien on Art and Imagination (Santa Barbara, 2010). xv + 237 pages. $44.95. ISBN 9780313362828.


Review Of Encyclopedia Of Contemporary Christian Fiction: From C.S. Lewis To Left Behind, Stephen F. Hayes Apr 2023

Review Of Encyclopedia Of Contemporary Christian Fiction: From C.S. Lewis To Left Behind, Stephen F. Hayes

Sehnsucht: The C. S. Lewis Journal

Stephen F. Hayes: Review of Nancy M. Tischler, Encyclopedia of Contemporary Christian Fiction: From C. S. Lewis to Left Behind (Santa Barbara, 2009). 352 pages. $96. ISBN 9780313345685.


Review Of The Hidden Story Of Narnia: A Book-By-Book Guide To C.S. Lewis' Spiritual Themes, Stephen Yandell Apr 2023

Review Of The Hidden Story Of Narnia: A Book-By-Book Guide To C.S. Lewis' Spiritual Themes, Stephen Yandell

Sehnsucht: The C. S. Lewis Journal

Stephen Yandell: Review of Will Vaus, The Hidden Story of Narnia: A Book-by-Book Guide to C. S. Lewis’ Spiritual Themes (Cheshire, Connecticut, 2010). ii + 135 pages. $19.97. ISBN 9781936294022.


Review Of The Narnia Code: C.S. Lewis And The Secret Of The Seven Heavens, Sørina Higgins Apr 2023

Review Of The Narnia Code: C.S. Lewis And The Secret Of The Seven Heavens, Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Sørina Higgins: Review of Michael Ward, The Narnia Code: C. S. Lewis and the Secret of the Seven Heavens (Carol Stream, Illinois, 2010). 193 pages, including “For Further Reading” and Discussion Guide. $13.99. ISBN 9781414339658.


Review Of C.S. Lewis On The Fullness Of Life: Longing For Deep Heaven, Sanford Schwartz Apr 2023

Review Of C.S. Lewis On The Fullness Of Life: Longing For Deep Heaven, Sanford Schwartz

Sehnsucht: The C. S. Lewis Journal

Sanford Schwartz: Review of Dennis J. Billy, C. S. Lewis on the Fullness of Life: Longing for Deep Heaven (Mahwah, New Jersey, 2009). 125 pages. $14.95. ISBN 9780809145430.


Review Of The Feeling Intellect: Reading The Bible With C.S. Lewis, David G. Clark Apr 2023

Review Of The Feeling Intellect: Reading The Bible With C.S. Lewis, David G. Clark

Sehnsucht: The C. S. Lewis Journal

David G. Clark: Review of Roger J. Newell, The Feeling Intellect: Reading the Bible with C. S. Lewis (Eugene, Oregon, 2010). xi + 115 pages. $16.00. ISBN 9781608991389.


Review Of A Sword Between The Sexes? C.S. Lewis And The Gender Debates, Sørina Higgins Apr 2023

Review Of A Sword Between The Sexes? C.S. Lewis And The Gender Debates, Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Sørina Higgins: Review of Mary Stewart Van Leeuwen, A Sword between the Sexes? C. S. Lewis and the Gender Debates (Grand Rapids, 2010). 264 pages. $19.99. ISBN 9781587432088.


Review Of Shadows And Chivalry: Pain, Suffering, Evil And The Goodness In The Works Of George Macdonald And C.S. Lewis, P. H. Brazier Apr 2023

Review Of Shadows And Chivalry: Pain, Suffering, Evil And The Goodness In The Works Of George Macdonald And C.S. Lewis, P. H. Brazier

Sehnsucht: The C. S. Lewis Journal

P.H. Brazier: Review of Jeff McInnis, Shadows and Chivalry: Pain, Suffering, Evil and Goodness in the Works of George MacDonald and C. S. Lewis (Eugene, Oregon, 2008). 307 pages. $39.00. ISBN 9781556356650.


Review Of C.S. Lewis And Philosopher: Truth, Goodness And Beauty, James P. Helfers Apr 2023

Review Of C.S. Lewis And Philosopher: Truth, Goodness And Beauty, James P. Helfers

Sehnsucht: The C. S. Lewis Journal

James P. Helfers: Review of David Baggett, Gary R. Habermas, and Jerry L. Walls, eds., C. S. Lewis as Philosopher: Truth, Goodness and Beauty (Downers Grove, Illinois, 2008). 268 pages. $23.00. ISBN 9780830828081.


Review Of C.S. Lewis: A Philosophy Of Education, Charles W. Connell Apr 2023

Review Of C.S. Lewis: A Philosophy Of Education, Charles W. Connell

Sehnsucht: The C. S. Lewis Journal

Charles W. Connell: Review of R. Loomis and Jacob P. Rodriguez, C. S. Lewis: A Philosophy of Education (New York, 2009). 246 pages, 9 illustrations. $80. ISBN 9780230605770.


Review Of C.S. Lewis And Philosophy As A Way Of Life, Victor Reppert Apr 2023

Review Of C.S. Lewis And Philosophy As A Way Of Life, Victor Reppert

Sehnsucht: The C. S. Lewis Journal

Victor Reppert: Review of Adam Barkman, C. S. Lewis and Philosophy as a Way of Life (Allentown, Pennsylvania, 2009). 624 pages. $45.00. ISBN 9780972322164.


Review Of Our Of My Bone: The Letters Of Joy Davidman, Suzanne Bray Apr 2023

Review Of Our Of My Bone: The Letters Of Joy Davidman, Suzanne Bray

Sehnsucht: The C. S. Lewis Journal

Suzanne Bray: Review of Don W. King, ed., Out of My Bone: The Letters of Joy Davidman (Grand Rapids, 2009). xxxi + 421 pages. 22 b&w photos. $28.00. ISBN 9780802863997.


Review Of Charles Williams And His Contemporaries, Stephen Barber Apr 2023

Review Of Charles Williams And His Contemporaries, Stephen Barber

Sehnsucht: The C. S. Lewis Journal

Stephen BarberReview of Suzanne Bray and Richard Sturch, eds., Charles Williams and His Contemporaries (Newcastle upon Tyne, 2009). xi + 160 pages. $52.99. ISBN 9781443805650.


Review Of Mere Christians: Inspiring Stories Of Encounters With C.S. Lewis, Will Vaus Apr 2023

Review Of Mere Christians: Inspiring Stories Of Encounters With C.S. Lewis, Will Vaus

Sehnsucht: The C. S. Lewis Journal

Will Vaus: Review of Andrew Lazo and Mary Anne Phemister, eds., Mere Christians: Inspiring Stories of Encounters with C. S. Lewis (Grand Rapids, 2009). 222 pages. $14.99. ISBN 9780801071843.


Review Of Conversations With C.S. Lewis: Imaginative Discussions About Life, Christianity And God, Lyle W. Dorsett Apr 2023

Review Of Conversations With C.S. Lewis: Imaginative Discussions About Life, Christianity And God, Lyle W. Dorsett

Sehnsucht: The C. S. Lewis Journal

Lyle W. Dorsett: Review of Robert Velarde, Conversations with C. S. Lewis: Imaginative Discussions about Life, Christianity and God (Downers Grove, Illinois, 2008). 192 pages. $15.00. ISBN 9780830834839.


Review Of William Murdock, The Inklings At Christmastide, Bruce R. Johnson Apr 2023

Review Of William Murdock, The Inklings At Christmastide, Bruce R. Johnson

Sehnsucht: The C. S. Lewis Journal

Bruce R. Johnson: Review of William Murdock, The Inklings at Christmastide (Queen Creek, Arizona, 2009). 115 pages. $12.95. ISBN 9780984289219.


Review Of C.S.Lewis, The C.S. Lewis Bible, Gregory M. Anderson Apr 2023

Review Of C.S.Lewis, The C.S. Lewis Bible, Gregory M. Anderson

Sehnsucht: The C. S. Lewis Journal

Gregory M. Anderson: Review of C. S. Lewis, The C. S. Lewis Bible (San Francisco, 2010). xxxi + 1529 pages, including several indices and a concordance. $34.99. ISBN 9780061982088.


Review Of The Great Divorce (Play), Sørina Higgins Apr 2023

Review Of The Great Divorce (Play), Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Review of C. S. Lewis, The Great Divorce. Starring Anthony Lawton. Adapted for the stage by Anthony Lawton. Produced by the Lantern Theater Company. Performed at St. Stephen’s Theater, Philadelphia, Pennsylvania, on December 12, 2010 as part of “Between Heaven and Hell: The Anthony Lawton Festival.”


Review Of C.S. Lewis And Don Giovanni Calabria, The Latin Letters Of C.S. Lewis, Nikolay Epplée Apr 2023

Review Of C.S. Lewis And Don Giovanni Calabria, The Latin Letters Of C.S. Lewis, Nikolay Epplée

Sehnsucht: The C. S. Lewis Journal

Nikolay Epplée: Review of C. S. Lewis and Don Giovanni Calabria, The Latin Letters of C. S. Lewis, ed. and trans. by Martin Moynihan (South Bend, 2009). 125 pages. $12.00. ISBN 9781587314551.


Review Of Freud's Last Session (Play), Sørina Higgins Apr 2023

Review Of Freud's Last Session (Play), Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Review of Mark St. Germain, Freud’s Last Session. Starring Mark H. Dold and Martin Rayner. Produced by The Barrington Stage Company. Performed at The Marjorie S. Deane Little Theater, New York, New York, on November 21, 2010.


Review Of The Screwtape Letters (Play), Sørina Higgins Apr 2023

Review Of The Screwtape Letters (Play), Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Review of C. S. Lewis, The Screwtape Letters. Starring Anthony Lawton and Kim Carson. Adapted for the stage by Anthony Lawton. Produced by the Lantern Theater Company. Performed at St. Stephen’s Theater, Philadelphia, Pennsylvania, on May 30, 2010.


Plastic Flute, D. S. Martin Apr 2023

Plastic Flute, D. S. Martin

Sehnsucht: The C. S. Lewis Journal

No abstract provided.