Digital Commons Network^™

Novel Paradigm For Ai-Driven Scientific Research: From Ai4s To Intelligent Science, Feiyue Wang, Qinghai Miao

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Techno-Economic Security: Key Issues, Evolution Mechanism And Evaluation Framework, Yanlin Cheng, Tao Dai, Yuye Ding, Danyang Zhao

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the context of the new round of scientific and technological revolution and industrial transformation, the related issues of techno-economic security have become the focus of major countries and regions. From the perspective of discipline construction, basic theory has been studied on key questions such as why, what, and how to evaluate. This study analyzes the importance and urgency, puts forward key issues of techno-economic security that should be paid attention to at different levels, such as technology, enterprise, industry, and country or region. A mechanism framework of the occurrence and evolution of techno-economic security is constructed, which is composed …

Understand Interactive Relationship Between S&T Security And Economic Security, Establish S&T Security Monitoring And Early Warning System, Qiuyi Guo, Guangrong You

Bulletin of Chinese Academy of Sciences (Chinese Version)

The overall concept of national security is an open strategic thought system, which is constantly developing with the practice of national security. Science and technology (S&T) security and economic security are both important areas of national security. They are important components of national security to support and safeguard overall national security. This study analyzes the interactive relationship between S&T security and economic security, and puts forward some suggestions to accelerate the development of S&T security monitoring and early warning system in view of the risks and challenges to ensure S&T security in the process of realizing high-quality development.

Research On Risk Identification Framework Of Future Technology—Based On Perspective Of Techno-Economic Security, Jie Chen, Zhongqi Wu, Tao Dai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the background of a new round of scientific and technological revolution and industrial transformation, the future technology represented by disruptive technology and emerging technology has become the focus of attention and game among countries. The future technology is not only related to taking the lead in future development, enhancing national strength and competitiveness, but also related to whether the economy and national security can be maintained. Based on the perspective of techno-economic security, this study analyzes the connotation and characteristics of future technology, puts forward the ‘three stages and three levels’ economic security influential mechanism of future technology, and …

Breakthrough Mechanism Of “Stuck Neck” Technology: “Situation-Strategy” Asymmetric Matching Perspective, Rongjian Yu, Yaping Wang, Yizhi Zhao, Wei Bai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the dual background of the impact of the epidemic and anti-globalization, the technical problem of “stuck neck” is a major practical problem that China urgently needs to solve. Existing researches lack a structured theoretical framework to solve the technical problem of “stuck neck”, and overlooked the analysis of the situation-dependent mechanism of “stuck neck” technologies. This study evaluates the technical situation from the two dimensions of the technical capability base and the dynamic of the technical paradigm, constructs a “stuck neck” technology cracking strategy matrix from the technical category and technology track, integrates the two categories of the technical …

Risks And Insights From Technological Friction Of The United States And China For Companies In China, Hongwei Wang, Duosi Chen, Huihui Zhang, Yuxuan Bai

Bulletin of Chinese Academy of Sciences (Chinese Version)

In recent years, the United States has seriously hindered the development of science and technology in China by implementing a series of measures such as export controls, economic sanctions, and cooperation restrictions, and United States-China technological frictions have brought a series of major problems related to technological and economic security to Chinese industries and enterprises. Based on the existing research, the study analyzes the current situation of China’s science and technology security, the impact of technological friction on enterprises of China and the United States as well as enterprises of other countries, and puts forward policy recommendations in terms of …

Industrialization Of Tall Wheatgrass For Construction Of “Coastal Grass Belt”, Hongwei Li, Qi Zheng, Jianlin Wang, Hongyong Sun, Kexin Zhang, Hongman Fang, Xuerong Xing, Weicai Yang, Xiaofeng Cao, Xiaojing Liu, Haichun Jing, Kang Chong, Zhensheng Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Tall wheatgrass (Elytrigia elongata) is a perennial cool-season bunchgrass with high productivity and tolerance to salt and alkali, waterlogging, and drought. Since first introduced into China in 1950s, tall wheatgrass has long been used as a wild parent for distant hybridization with wheat (Triticum aestivum). During 1980s─1990s, a few tall wheatgrass varieties were introduced to China as forage grass, nonetheless, currently they are still not widely cultivated and no variety was certificated. In 2020, Zhensheng Li put forward a proposal to construct “Coastal Grass Belt” on saline and alkaline soils in the Circum-Bohai sea region, which provides an opportunity for …

Research On Construction Method Of Ubiquitous Operating System Open Source Ecosystem Based On Internet Of Everything, Meng Wang, Weidong Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Building an independent, healthy, and sustainable open source ecosystem is a key link in the development and application of ubiquitous operating system. Aiming at the Internet of Everything, combined with the new characteristics of ubiquitous operating system, this study summarizes the constituent elements and system model of ubiquitous operating system open source ecosystem, and puts forward the construction method of ubiquitous operating system open source ecosystem. This study provides new ideas to promote the iterative innovation of ubiquitous operating system, integrate the isolated island of ubiquitous operating system open source ecosystem, and promote the preliminary practice and collaborative development of …

Research On Offshore Wind Energy Classification: Bottlenecks And Countermeasures, Chongwei Zheng, Chongyin Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Offshore wind energy resource is a key support for the “carbon peak and carbon neutrality”. However, offshore wind energy development still faces the international bottleneck of reasonable energy classification, which is urgently needed in the overall arrangement and accurate site selection. Firstly, this study systematically reviewed the research progress of offshore wind energy classification scheme at home and abroad, and analyzed the six aspects that need to be improved in the traditional energy classification scheme: without comprehensive consideration of resource characteristics, environmental risks and cost-effectiveness, without significant regional difference of energy classification, unable to meet the needs of diversified tasks, …

Introduction On 2022 Top Ten Scientific Advances In China

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Cover 3

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Learning In A Virtual Environment To Improve Type 2 Diabetes Outcomes: Randomized Controlled Trial, Constance M Johnson, Gail D'Eramo Melkus, Louise Reagan, Wei Pan, Sathya Amarasekara, Katherine Pereira, Nancy Hassell, Sarah Nowlin, Allison Vorderstrasse

Faculty, Staff and Student Publications

Background: Given the importance of self-management in type 2 diabetes mellitus (T2DM), a major aspect of health is providing diabetes self-management education and support. Known barriers include access, availability, and the lack of follow through on referral to education programs. Virtual education and support have increased in use over the last few years.

Objective: The purpose of the Diabetes Learning in a Virtual Environment (LIVE) study was to compare the effects of the LIVE intervention (educational 3D world) to a diabetes self-management education and support control website on diet and physical activity behaviors and behavioral and metabolic outcomes in adults …

Gpu Accelerated Solvers For Toeplitz Systems, Atherton George Mook

Honors Capstone Projects and Theses

No abstract provided.

Application Of Batman In The Analysis Of Proton Nuclear Magnetic Resonance Spectra Of Urine Samples To Determine Metabolite Concentrations Of Diabetes Susceptible Rats, Gabrielle Aline Morris

Honors Capstone Projects and Theses

No abstract provided.

Six Students Join Calhoun Racial Justice Fellowship, Seattle University School Of Law

News Center Articles

No abstract provided.

Norm C. Mayhew, Petitioner / Appellant V. Utah Labor Commission, Darrell W. Anderson Construction, Inc, And/Or Workers Compensation Fund, Respondents / Appellees : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Labor Commission of Utah

Michele L. Halstenrud, Hans M. Scheffler, Attorneys for Respondents/ Appellees Darrell W. Anderson Construction, Inc. and Worker's Compensation Fund, Christopher C. Hill, Attorney for Respondent / Appellee Utah Labor Commission

Michael Gary Belnap, Virginius Dabney, Stony V. Olsen, Attorneys for Petitioner/Appellant Norm C. Mayhew

First- Versus Third-Generation Egfr Tyrosine Kinase Inhibitors In Egfr-Mutated Non-Small Cell Lung Cancer Patients With Brain Metastases, Ahmad Ozair, Atulya Khosla, Shreya Saxena, Manmeet Ahluwalia

All Publications

Introduction: Up to 50% of non-small cell lung cancer (NSCLC) harbor EGFR alterations, the most common etiology behind brain metastases (BMs). First-generation EGFR-directed tyrosine kinase inhibitors (EGFR-TKI) are limited by blood-brain barrier penetration and T790M tumor mutations, wherein third-generation EGFR-TKIs, like Osimertinib, have shown greater activity. However, their efficacy has not been well-studied in later therapy lines in NSCLC patients with BMs (NSCLC-BM). We sought to compare outcomes of NSCLC-BM treated with either first- or third-generation EGFR-TKIs in first-line and 2nd-to-5th-line settings. Methods: A retrospective review of NSCLC-BM patients diagnosed during 2010–2019 at Cleveland Clinic, Ohio, US, a quaternary-care center, …

A Primer For The Student Joining The General Thoracic Surgery Service Tomorrow: Primer 2 Of 7., Colin C. Yost, Rohun Bhagat, David Blitzer, Clauden Louis, Jason Han, Fatima G Wilder, Robert A Meguid

Student Papers, Posters & Projects

This medical student primer discusses general thoracic surgery, which involves treating pathologies involving all structures in the thorax except the heart, thoracic aorta, great vessels, and spine.

2023 Nyls Diversity Panel And Reception, Albanian American Law Students Association, Asian American Law Students Association, Black Law Students Association, First Generation Professionals, Italian Law Students Association, Jewish Law Students Association, Latin American Law Students Association, Legal Association For Women, Muslim Law Students Association, Outlaws, South Asian Law Students Association, The Student Bar Association, Office Of Diversity, Equity, And Inclusion

Student Organizations

April 20, 2023

2023 April 20 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

A Cross-National Investigation Of Human Trafficking Exploitation, Aniyah D. Richardson

Honors College Theses

Human trafficking is a prevalent business, generating up to an estimated annual profit of $150 billion dollars globally (International Labour Organization [ILO], 2014). Although human trafficking is a global phenomenon, an element that has not received considerable empirical attention has been nuances between trafficking that occurs within a singular country (i.e., domestic trafficking) and that which occurs between multiple countries (i.e., international trafficking). The current study utilized cross-national data from the Counter Trafficking Data Collaborative’s (CTDC) Global Synthetic Dataset (GSD) to compare demographic profiles of victims trafficked domestically and internationally. Incorporating measures of gender, age, country of citizenship, country of …

Join Or Die: How Deontological Moral Intuitions Complicate Cooperation Amid The Covid-19 Pandemic, Alessandro Del Ponte

Political Science Faculty Articles and Research

Tackling COVID-19 requires universal collective action: everyone must play their part to reduce the spread of the virus and quell the pandemic. Yet, some people obstinately refuse to cooperate, irrespective of the consequences for themselves and others. In this note, I illustrate a key element of human psychology that hampers cooperation amid the pandemic: deontological moral intuitions. Deontological morality prescribes that moral taboos must be followed no matter the consequences. This means that people who consider Covid vaccines a moral taboo are prepared to suffer virtually any consequence rather than take the vaccine. I discuss the evolutionary basis of deontological …

Law School News: Joyce And Bill Cummings Of Cummings Foundation To Deliver Keynote Address At Rwu Commencement 4-20-2023, Jill Rodrigues

Life of the Law School (1993- )

No abstract provided.

Comparative Genomic Study Of Streptococcus Anginosus Reveals Distinct Group Of Urinary Strains, Ananya Prasad, Adriana Ene, Sandra Jablonska, Jingjie Du, Alan J. Wolfe, Catherine Putonti

Biology: Faculty Publications and Other Works

Streptococcus anginosus is a prevalent member of the human flora. While it has been found in the microbiota of "healthy" asymptomatic individuals, it has also been associated with genitourinary tract infections and bacteremia. Based upon multilocus sequence analysis, two subspecies and two genomosubspecies have been characterized for the species. We previously conducted whole-genome sequencing of 85 S. anginosus isolates from the urinary tract. Here, we present genomic analysis of this species, including isolates from the urinary tract as well as gut and fecal, vaginal, oral, respiratory, and blood and heart samples. Average nucleotide identity and core genome analysis revealed that …

Deployment Of Real-Time Natural Language Processing And Deep Learning Clinical Decision Support In The Electronic Health Record: Pipeline Implementation For An Opioid Misuse Screener In Hospitalized Adults, Majid Afshar, Sabrina Adelaine, Felice Resnik, Marlon P. Mundt, John Long, Margaret Leaf, Theodore Ampian, Graham J. Wills, Benjamin Schnapp, Michael Chao, Randy Brown, Cara Joyce, Brihat Sharma, Dmitry Dligach, Elizabeth S. Burnside, Jane Mahoney, Matthew M. Churpek, Brian W. Patterson, Frank Liao

Biostatistics Collaborative Core: Faculty Publications and Other Works

Background: The clinical narrative in electronic health records (EHRs) carries valuable information for predictive analytics; however, its free-text form is difficult to mine and analyze for clinical decision support (CDS). Large-scale clinical natural language processing (NLP) pipelines have focused on data warehouse applications for retrospective research efforts. There remains a paucity of evidence for implementing NLP pipelines at the bedside for health care delivery.

Objective: We aimed to detail a hospital-wide, operational pipeline to implement a real-time NLP-driven CDS tool and describe a protocol for an implementation framework with a user-centered design of the CDS tool.

Methods: The pipeline integrated …

Could Musical Theatre Be Worthy Of Literary Analysis? (Or, An Attempt At Dismantling The Cultural Hierarchy), Sarah Meierdirks

Honors Theses

Could Musical Theatre Be Worthy of Literary Analysis?

Cultural hierarchy, or the perception that different forms of art relate to each other in terms of higher or lower sophistication, has commanded the way we view art for centuries. Artforms which the cultural hierarchy deems to be “higher” are often given more attention, respect, and appreciation in academia, but can be less accessible both physically and mentally to the masses, while artforms deemed to be “lower” tend to be simpler and more fun, making them have a more popular appeal. The tendency for art that is either simple or fun to …

A Socially Innovative Curriculum For An Afterschool Program, Shelinda T. Knight Davenport

Masters Projects

ABSTRACT

Since the colonial days in what is now known as America, there has been the social problem of racism. Racism has always been and remains a cancer in America’s culture. From racism, a deep hatred has spawned for other races. To the extremes, it has led to violence and murder, and most Americans believe it is more prevalently outspoken today than it has been in the last 20 years (Schaefer & Edwards, 2022). This thesis project consists of a Disrupting Racism curriculum for approximately 3rd grade, which is situated in the literature on racism and education. Grounded in culturally …

Nivolumab Plus Ipilimumab Versus Extreme Regimen As First-Line Treatment For Recurrent/Metastatic Squamous Cell Carcinoma Of The Head And Neck: The Final Results Of Checkmate 651, Robert I Haddad, Kevin Harrington, Makoto Tahara, Robert L Ferris, Maura Gillison, Jerome Fayette, Amaury Daste, Piotr Koralewski, Bogdan Zurawski, Miren Taberna, Nabil F Saba, Milena Mak, Andrzej Kawecki, Gustavo Girotto, Miguel Angel Alvarez Avitia, Caroline Even, Joaquin Gabriel Reinoso Toledo, Alexander Guminski, Urs Müller-Richter, Naomi Kiyota, Mustimbo Roberts, Tariq Aziz Khan, Karen Miller-Moslin, Li Wei, Athanassios Argiris

Faculty, Staff and Student Publications

PURPOSE: CheckMate 651 (ClinicalTrials.gov identifier: NCT02741570) evaluated first-line nivolumab plus ipilimumab versus EXTREME (cetuximab plus cisplatin/carboplatin plus fluorouracil ≤ six cycles, then cetuximab maintenance) in recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).

METHODS: Patients without prior systemic therapy for R/M SCCHN were randomly assigned 1:1 to nivolumab plus ipilimumab or EXTREME. Primary end points were overall survival (OS) in the all randomly assigned and programmed death-ligand 1 combined positive score (CPS) ≥ 20 populations. Secondary end points included OS in the programmed death-ligand 1 CPS ≥ 1 population, and progression-free survival, objective response rate, and duration …

An Altered Extracellular Matrix-Integrin Interface Contributes To Huntington’S Disease-Associated Cns Dysfunction In Glial And Vascular Cells, Sarah J Hernandez, Ryan G Lim, Tarik Onur, Mark A Dane, Rebecca Smith, Keona Wang, Grace En-Hway Jean, Andrea Reyes-Ortiz, Kaylyn Devlin, Ricardo Miramontes, Jie Wu, Malcolm Casale, David Kilburn, Laura M Heiser, James E Korkola, David Van Vactor, Juan Botas, Katherine L Thompson-Peer, Leslie M Thompson

Faculty, Staff and Students Publications

Astrocytes and brain endothelial cells are components of the neurovascular unit that comprises the blood-brain barrier (BBB) and their dysfunction contributes to pathogenesis in Huntington's disease (HD). Defining the contribution of these cells to disease can inform cell-type-specific effects and uncover new disease-modifying therapeutic targets. These cells express integrin (ITG) adhesion receptors that anchor the cells to the extracellular matrix (ECM) to maintain the integrity of the BBB. We used HD patient-derived induced pluripotent stem cell (iPSC) modeling to study the ECM-ITG interface in astrocytes and brain microvascular endothelial cells and found ECM-ITG dysregulation in human iPSC-derived cells that may …