Digital Commons Network^™

Chronic Overlapping Pain Conditions And Long-Term Opioid Treatment, Maria Ukhanova, Robert W Voss, Miguel Marino, Nathalie Huguet, Steffani R Bailey, Daniel M Hartung, Jean O'Malley, Irina Chamine, John Muench

Faculty, Staff and Student Publications

OBJECTIVES: One in 5 people in the United States lives with chronic pain. Many patients with chronic pain experience a subset of specific co-occurring pain conditions that may share a common pain mechanism and that have been designated as chronic overlapping pain conditions (COPCs). Little is known about chronic opioid prescribing patterns among patients with COPCs in primary care settings, especially among socioeconomically vulnerable patients. This study aims to evaluate opioid prescribing among patients with COPCs in US community health centers and to identify individual COPCs and their combinations that are associated with long-term opioid treatment (LOT).

STUDY DESIGN: Retrospective …

An Actionable Step: Evaluating The Impact Of A Text-Based Vocabulary Intervention To Support Middle School Emergent Bilinguals’ Vocabulary Growth, Annisha R. H. Susilo

Graduate Doctoral Dissertations

Research over the last two decades has shown middle school EBs are at risk for academic failure due to compounded systematic challenges that prevented them from acquiring reading proficiency level required to succeed in academic setting (Bowman-Perrott et al., 2010; Deussen et al., 2017; Sheng et al., 2011; Slama, 2012). EBs face shortages of qualified teachers, lack of access to quality instruction, and lack of appropriate assessment tools (Carnoy & Garcia, 2017; Sanchez, 2017; Umansky, 2016). This crisis is particularly acute for middle schoolers, as academic content often requires extensive reading. Middle school EBs are falling behind academically in comparison …

Impacts Of Attribution Style On Academics, Personal Relationships, And Extracurricular Activities: A Mixed Methods Study Of Learned Helplessness In Secondary Students, Joslyn Vendola

Graduate Doctoral Dissertations

The phenomenon of learned helplessness is the state in which an individual no longer views their outcomes as contingent upon their effort in response to previous failure outcomes and stressful events which were out of their control. Learned helplessness symptoms are often observed amongst students who experience other challenges simultaneously, such as low academic achievement, emotional disability (ED) diagnosis, and/or low-socioeconomic status (low-SES). The existing LH research focuses on identification, labeling, and offering interventions, such as learned optimism (LO) and attribution retraining. The lack of qualitative data, specifically student input, is a gap in the current body of research that …

Propranolol Reduces Ifn-Γ Driven Pd-L1 Immunosuppression And Improves Anti-Tumour Immunity In Ovarian Cancer, M Falcinelli, G Al-Hity, S Baron, M Mampay, M C Allen, M Samuels, W Jones, C Cilibrasi, Renee L Flaherty, G Giamas, P H Thaker, M S Flint

2020-Current year OA Pubs

The immune system plays an important role in controlling epithelial ovarian cancer (EOC). EOC is considered to be a "cold tumour," a tumour that has not triggered a strong response by the immune system. However, tumour infiltrating lymphocytes (TILs) and the expression of programmed cell death ligand (PD-L1) are used as prognostic indicators in EOC. Immunotherapy such as PD-(L)1 inhibitors have shown limited benefit in EOC. Since the immune system is affected by behavioural stress and the beta-adrenergic signalling pathway, this study aimed to explore the impact of propranolol (PRO), a beta-blocker, on anti-tumour immunity in both in vitro and …

Genomic Complexity Predicts Resistance To Endocrine Therapy And Cdk4/6 Inhibition In Hormone Receptor-Positive (Hr+)/Her2-Negative Metastatic Breast Cancer, Andrew A Davis, Jingqin Luo, Rama Suresh, Foluso O Ademuyiwa, Caron Rigden, Timothy P Rearden, Katherine Clifton, Katherine Weilbaecher, Ashley Frith, Tracy Summa, Brittney Haas, Shana Thomas, Leonel F Hernandez-Aya, Lindsay L Peterson, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

PURPOSE: Clinical biomarkers to identify patients unlikely to benefit from CDK4/6 inhibition (CDK4/6i) in combination with endocrine therapy (ET) are lacking. We implemented a comprehensive circulating tumor DNA (ctDNA) analysis to identify genomic features for predicting and monitoring treatment resistance.

EXPERIMENTAL DESIGN: ctDNA was isolated from 216 plasma samples collected from 51 patients with hormone receptor-positive (HR+)/HER2-negative (HER2-) metastatic breast cancer (MBC) on a phase II trial of palbociclib combined with letrozole or fulvestrant (NCT03007979). Boosted whole-exome sequencing (WES) was performed at baseline and clinical progression to evaluate genomic alterations, mutational signatures, and blood tumor mutational burden (bTMB). Low-pass whole-genome …

Polygenic Risk Score Penetrance & Recurrence Risk In Familial Alzheimer Disease, Min Qiao, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

OBJECTIVE: To compute penetrance and recurrence risk using a genome-wide PRS (including and excluding the APOE region) in families with Alzheimer's disease.

METHODS: Genotypes from the National Institute on Aging Late-Onset Alzheimer's Disease Family-Based Study and a study of familial Alzheimer's disease in Caribbean Hispanics were used to compute PRS with and without variants in the 2 MB region flanking APOE. PRS was calculated in using clumping/thresholding and Bayesian methods and was assessed for association with Alzheimer's disease and age at onset. Penetrance and recurrence risk for carriers in highest and lowest PRS quintiles were compared separately within APOE-ε4 carriers …

A Novel Deep Learning, Camera, And Sensorbased System For Enforcing Hand Hygiene Compliance In Healthcare Facilities, Samyak Shrimali, Christof Teuscher

Electrical and Computer Engineering Faculty Publications and Presentations

Hospital-acquired infections are a major cause of death worldwide, and poor hand hygiene compliance is a primary reason for their spread. This paper proposes an artificial intelligence, microcontroller, and sensor-based system that monitors and improves staff hand hygiene compliance at various critical points in a hospital. The system uses a Convolutional Neural Network (CNN) to detect and track if staff have followed the WHO hand rub/hand wash guidelines at alcohol dispensers, hospital sinks, and patient beds. The system also uses RFID tags, vibration motors, LEDs, and a central server to identify staff, alert them of their cleaning requirements, monitor their …

A Pwm Method For Reducing Dv/Dt And Switching Losses In Two-Stage Power Converters, Mahima Gupta, Abhijeet Prem

Electrical and Computer Engineering Faculty Publications and Presentations

Today's semiconductor devices are accompanied by high switching frequencies (> kilo-hertz) and small transition times (< micro-seconds). Such fast transition times are accompanied by undesirable effects such as voltage overshoots at the load terminals, ground leakage currents, wide-band electromagnetic noise, etc. With the advent of wide band-gap devices, several applications are moving towards higher switching frequency operation with at-least an order of magnitude reduction in transition times. While these characteristics are considered necessary to break the next-generation barriers in power density, efficiency and applicability, the undesirable effects due to faster transitions are expected to present obstacles. This work proposes a PWM approach to modify the shape of the switching voltages to overcome the disadvantages of the fast transition times without any increase in switching losses. In fact, several of the switching transitions feature ZVS operation, resulting in reduced switching losses. The paper discusses the analytical details of the approach using a simple DC-DC boost-buck converter and extends it to a DC to three-phase AC converter using the principles of space vector modulation. The paper presents detailed simulation and comparative results in terms of voltage over-shoots over long cables, loss calculations and electromagnetic noise. Results from a laboratory-scale working prototype confirm the benefits of the proposed approach in terms of EMI and loss reduction.

Low-Cost Microstereolithography 3d Printing With Microfluidic Microsampling Applications, Lauren Twombly

Chemistry & Biochemistry Undergraduate Honors Theses

The growing field of stereolithography 3D printing has welcomed a new age ofmicrofluidic device fabrication techniques. When compared to previous planar fabrication techniques such as soft-lithography, stereolithography 3D printing offers highly automated procedures, reduced fabrication times, and greater complexity of device features. To date, the greatest tradeoff for 3D printing in microfluidic device fabrication is poorer resolution when compared to soft-lithography which can produce feature sizes on the nanometer scale. The poorer resolution of 3D printing limits the feasible size of features. While highly sophisticated 3D printers are capable of achieving sub 10 μm resolution, these instruments are incredibly expensive …

Expression, Characterization, And Investigation Of The Thermal Stability Of Fibroblast Growth Factor (Fgf) 19, Ridhikaanth Kalaiselvan

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast growth factors are a family of cell signaling proteins that have the ability to bind to heparin and are involved in a wide range of physiological functions, such as angiogenesis, cell differentiation, cell proliferation, cell morphogenesis, and wound healing. Fibroblast growth factor (FGF) 19 is a signaling protein belonging to this large family of fibroblast growth factors (FGFs). FGF19 has a pronounced effect on various biological processes, including cell proliferation, cholesterol and lipid catabolism, and glucose homeostasis. As such, FGF19 is known to play an integral role in regulating many metabolic diseases, which piques the interest of the science …

Detection Of Nitrogen Dioxide Via Graphene-Enhanced Raman Scattering, Spencer Hazeslip

Chemistry & Biochemistry Undergraduate Honors Theses

This paper presents the development of a nitrogen dioxide (NO₂) sensor that utilizes the phenomenon of graphene-enhanced Raman scattering (GERS). The sensor consists of monolayer graphene on a silicon wafer, functionalized noncovalently with Copper(II) 2,9,16,23-tetra-tert-butyl-29H,31H-phthalocyanine (CuTTPc) via the solution soaking method. A custom sensing chamber was constructed to enable Raman spectra to be collected during NO₂ exposure. The response of the sensor was found to be linear between 10 and 100 ppm NO₂, indicating that it could be used for both detection and quantification. Furthermore, the sensor was shown to be reusable after …

Carbon Dioxide Reduction On Large Area Liquid Metal Gallium-Indium Electrocatalysts, Thomas Hollis

Chemistry & Biochemistry Undergraduate Honors Theses

Carbon dioxide (CO₂) is widely known as a greenhouse gas that contributes to global warming due to the burning of fossil fuels. The carbon dioxide reduction reaction (CO₂RR) is widely studied to reutilize CO₂ to useful products, including methane, ethane, and carbon monoxide. This project studies the use of liquid metal gallium-indium as an electrocatalyst to perform CO₂ reduction to carbon monoxide (CO) or possibly solid carbon in various solutions. Gallium-indium is characterized and studied through its “wetting” properties and adhesion to substrate foil through the measurement of contact angles inside solution. These liquid …

A Characterization Of The Quadruple Mutant Of The Fgf1-Fgf2 Heterodimer, Kenlee Claborn

Chemistry & Biochemistry Undergraduate Honors Theses

Human Fibroblast Growth Factor (FGF) was first identified as a protein whose function was to aid in cell proliferation, but now, FGF has been determined to consist of over 23 different proteins in 7 different subfamilies with three different types of cell-signaling purposes.¹ In the first subfamily are the two most notable and studied proteins, Fibroblast Growth Factor 1 (FGF1) and Fibroblast Growth Factor 2 (FGF2). Respectively, they are known for their unique capabilities of cell proliferation/mitogenesis and angiogenesis.² To induce the cell-signaling pathway that leads to the function of these proteins, FGF1 and FGF2 binds to their …

Design Of A Hyperstable Endocrine Acting Fibroblast Growth Factot, Sara Armstrong

Chemistry & Biochemistry Undergraduate Honors Theses

A novel chimera protein, consisting of the C-terminus of Fibroblast Growth Factor (FGF) 21 and super FGF1, a mutant of the wild-type FGF1, was studied. The protein retained the stability of sFGF1 and the endocrine acting behaviors and binding efficiency of FGF21, so that it could be more practical for therapeutic uses as a wound healing and angiogenic agent. sFGF1- FGF21 was expressed and purified before utilizing various biophysical techniques to measure its stability, secondary and tertiary characteristics, and metabolic activity.

An Investigation On The Effect Of Conserved Hinge Histidine On Influenza Hemagglutinin(Ha2) Protein Conformation Using Md Simulations, Nada Tolba

Chemistry & Biochemistry Undergraduate Honors Theses

Hemagglutinin is a protein on the surface of Human Influenza Viruses.¹ It is composed of two glycopolypeptide domains, the HA1 and HA2 domains. Previous studies have found that across different strains of Influenza viruses, HIS435 residues remain conserved.⁴ In studies where mutations occurred in hinge-site histadine residues, the Influenza virus was inactive.⁴ These investigations indicated a significant role of HIS435 (hinge-site histadines) in virulence. Four systems were created using Molecular dynamics (MD) simulations. Each system was composed of an Isolated HA2 trimer solvated in a 150 mM NaCl rectangular water box at 310 K under isobaric and …

Digital Privacy For Reproductive Choice In The Post-Roe Era, Aziz Z. Huq, Rebecca Wexler

Faculty Scholarship

The overruling of Roe v. Wade has unleashed a torrent of regulatory and punitive activity restricting previously lawful reproductive options. But the turn to the expansive criminal law and new schemes of civil liability creates novel concerns, quite distinct from the pre-Roe landscape a half-century ago. Reproductive choice, and its nemesis, turn upon information. For pregnant people, deciding on a choice of medical care entails a search for advice and services. Information is at a pre­mium for them. Meanwhile, efforts to regulate abortion began with clinic closings. But they will quickly extend to civil actions and criminal indictments of patients, …

Expression, Purification, And Characterization Of Fibroblast Growth Factor 19, Elizabeth Ford

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast growth factors (FGFs) are a family of signaling proteins with diverse biological functions. Fibroblast growth factor 19 (FGF19) regulates several vital physiological processes, including bile acid, glucose, and lipid homeostasis. However, its therapeutic potential is limited by its structural instability. The purpose of this study is to express, purify, and characterize recombinant FGF19 to build the foundation for the creation of stable mutants, which can be used to treat a variety of common diseases including type 2 diabetes, atherosclerosis, and nonalcoholic fatty liver disease. The parameters for overexpression in Escherichia coli were optimized according to optical density, inducer concentration, …

Developing Methods For Pattern Transfer In Photoelectrochemical Lithography, Ashlyn Descarpentrie

Chemistry & Biochemistry Undergraduate Honors Theses

The microprocessor industry has historically been driven by the goal of shrinking devices. To create features small enough to fit on such devices, photolithography has conventionally been used in the micropatterning of noble metal surfaces. Photolithography is a complicated and expensive process that involves a cleanroom, metallization processes, and photoresist. While this investment makes sense for high revenue applications, a number of microelectronic devices do not require nanometer-scale patterned features. Examples of such applications include specific types of antennae, sensing electrodes, and photocatalysts. Photolithography for these devices is thus too costly in both money and energy. The Coridan lab has …

Studying The Phosphorylation Of Isocitrate Dehydrogenase In Humans, Hannah Smith

Chemistry & Biochemistry Undergraduate Honors Theses

Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. While there are three isoforms of isocitrate dehydrogenase (IDH1, IDH2, and IDH3), this research will focus on IDH1. The phosphorylation of isocitrate dehydrogenase is a process that has been linked to the formation of both luminal-like and basal-like breast cancer. Despite these correlations, the mechanisms that cause breast cancer development are unknown. To examine this, an enzyme activity assay for each phosphorylation variant and crystallization were conducted. The results of these indicate that phosphorylation at each site (IDH1-T77, IDH1-S188, …

Predictive Ecology And Management Of Phyllosphere Microbial Communities Through Cross-Scale Synthesis, David W. Armitage, Morgan E. Carter, Robin A. Choudhury, Mitja Remus-Emsermann, Cindy E. Morris, Johan H. Leveau, Linda L. Kinkel, José Pablo Dundore-Arias

School of Earth, Environmental, & Marine Sciences Faculty Publications

Here we summarize the main takeaways from a symposium and hybrid virtual and in-person participatory discussion focused on the challenges of scale in understanding the ecology and management of phyllosphere microbial communities. We provide an overview of the confounding effects of spatial scale on inference in microbial ecology, the spatial organization of microbial interactions in the phyllosphere, advances and remaining gaps in measuring phyllosphere colonization across scales, and the epidemiology in the phyllosphere. We hope to motivate further discussion and the development and adoption of creative approaches to solving the challenges of scale to enhance fundamental understanding and practical management …

Mitigating The Associations Of Kidney Dysfunction With Blood Biomarkers Of Alzheimer Disease By Using Phosphorylated Tau To Total Tau Ratios, Shorena Janelidze, Nicolas R Barthélemy, Yingxin He, Randall J Bateman, Oskar Hansson

2020-Current year OA Pubs

IMPORTANCE: Chronic kidney disease (CKD) has been associated with increased plasma concentrations of phosphorylated tau (p-tau) 217 and p-tau181, which potentially decreases their usefulness in the diagnostic workup of Alzheimer disease (AD).

OBJECTIVE: To investigate associations of CKD with plasma ratios of p-tau217 and p-tau181 to the corresponding unphosphorylated peptides in AD.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included patients with mild cognitive impairment (cohort 1; enrollment in 2000-2005) and replication in cohort 2 from the Swedish BioFINDER-2 study, including both cognitively unimpaired individuals and those with cognitive impairment (enrollment in 2017-2022). All participants were from 2 memory clinics …

Unesco World Heritage: Striving For Utopia Through Universal Value, Caleb Phillips

Honors Theses

With this thesis, I take a critical look at the UNESCO World Heritage Convention and its mission to foster international unity through the creation of World Heritage Sites. The World Heritage Convention was created with good intentions, but in attempting to actualize its original objectives, the Convention has strayed from its goals. By looking at the events leading up to the creation of the World Heritage Convention, the Convention itself, and the various measures carried out by the Convention since its creation, it is clear that the UNESCO World Heritage Convention still has work to do to achieve its utopian …

Physical Function Across The Lifespan In Adults With Multiple Sclerosis: An Application Of The Short Physical Performance Battery, Brenda Jeng, Petra Šilić, Rachel E. Bollaert, Brian M. Sandroff, Robert W. Motl

Exercise Science Faculty Research and Publications

Background

Multiple sclerosis (MS) typically has its onset in early and middle adulthood, but the population is steadily becoming more dominated by older adults. One of the primary consequences of both MS and aging involves declines of lower extremity physical function and mobility. This cross-sectional study compared physical function status based on Short Physical Performance Battery (SPPB) summary and component scores between persons with MS and healthy controls across 6 age groups. We further examined associations between SPPB summary scores and component scores as well as associations between summary scores and measures of physical and cognitive function for identifying the …

Creating Persistent Law Review Article Links With Digital Object Identifiers, Valeri Craigle, Benjamin J. Keele, Aaron Retteen

Faculty Scholarship

A case study for how to use digital object identifiers (DOIs) to make online journals more accessible and improve their site user reports.

Gamestopped: How Robinhood’S Gamestop Trading Halt Reveals The Complexities Of Retail Investor Protection, Neal Newman

Faculty Scholarship

Should brokers have the unfettered right to restrict investor trading? GameStop, a brick-and-mortar video game retailer, had been experiencing declining revenues since 2016. However, GameStop saw its share price climb almost 1000 percent in the span of a one- week period from January 21, 2021 to January 27, 2021 due to retail investors buying significant amounts of GameStop shares during that period. Melvin Capital, a hedge fund, ended up losing billions as they were betting that GameStop shares would lose value instead of increase—a practice referred to as short selling. On January 28, 2021, brokers inexplicably halted trading on GameStop …

Mass E-Carceration: Electronic Monitoring As A Bail Condition, Sara Zampierin

Faculty Scholarship

Over the past decade, the immigration and criminal legal systems have increasingly relied on electronic monitoring as a bail condition; hundreds of thousands of people live under this monitoring on any given day. Decisionmakers purport to impose these conditions to release more individuals from detention and to maintain control over individuals they perceive to pose some risk of flight or to public safety. But the data do not show that electronic monitoring successfully mitigates these risks or that it leads to fewer individuals in detention. Electronic monitoring also comes with severe restrictions on individual liberty and leads to harmful effects …

Immigration Law's Missing Presumption, Fatma Marouf

Faculty Scholarship

The presumption of innocence is a foundational concept in criminal law but is completely missing from quasi-criminal immigration proceedings. This Article explores the relevance of a presumption of innocence to removal proceedings, arguing that immigration law has been designed and interpreted in ways that disrupt formulating any such presumption to facilitate deportation. The Article examines the meaning of “innocence” in the immigration context, revealing how historically racialized perceptions of guilt eroded the notion of innocence early on and connecting the missing presumption to persistent associations between people of color and guilt. By analyzing how a presumption of innocence is impeded …

Fishing And Fisheries Under International Water Law: A Dialogue Between Professor Gabriel Eckstein And Professor Paul Stanton Kibel, Gabriel Eckstein, Paul Stanton Kibel

Faculty Scholarship

On April 10 and 11, 2023, the Center on Urban Environmental Law (CUEL) at Golden Gate University School of Law hosted a two-day webinar on International Law Aspects of Fisheries and Hydropower in Europe. To open the webinar, Professor Gabriel Eckstein (of Texas A&M University School of Law) and Professor Paul Stanton Kibel (of Golden Gate University School of Law) participated in a keynote dialogue titled Fishing and Fisheries under International Water Law. What follows is a transcription of this dialogue between Professor Eckstein and Professor Kibel.

(Nearly) All Roads Lead To Polarization: Cognitive Dissonance And The Inverse Relationship Between Polarization And Trivialization In The 2016 And 2020 Elections, Austin D. Eubanks

Graduate Theses and Dissertations

The present study investigated cognitive dissonance theory—in particular, outcome-based dissonance, i.e., dissonance experienced from facing an outcome inconsistent with ones’ choice (in this case, preferring the candidate who lost the election)—in electoral contexts using the 2016 and 2020 American National Election Studies data (ns = 3,648 and 7,453, respectively). The particularly negative context of the 2016 and 2020 elections offered an opportunity to make a novel direct empirical comparison of choice valence between “hard/positive choices” (i.e., between two “good” alternatives) and “hard/negative choices” (i.e., between two “bad” alternatives) using real-world data. Results showed that after the election, respondents who preferred …

Poesis And Sympathy: Community Through Craftsmanship, Braden Dodds Taylor

Graduate Theses and Dissertations

A community is no more than a mass of individuals that is held together by the objects that connect them. The independent spaces occupied by a craftsman or consumer become dependent on their counterparts. These connected environments create the ecosystem of the community. Objects originating from the craftsmen of the community allow for sympathy to flourish. When these objects are created by well-educated craftsmen of the community, they originate with natural understanding, further extending their reach. While nonnatural things such as plastic items have an intrinsic connection to modern life, they do not encourage folk to connect with others in …