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Implications Of Toll-Like Receptor 10 Mutants In Cell Signaling, Sonali Joshi

Undergraduate Honors Theses

Our innate immune system serves the important purpose of quickly recognizing microbial pathogens and providing the first line of defense against infection. Toll-Like Receptors (TLRs) are one class of receptors responsible for enacting our bodies’ innate immune responses. Specifically, TLR10 is an extremely under-researched receptor. Some naturally occurring mutations in TLR10 have been linked with a worsening prognosis of rheumatoid arthritis, with previous research uncovering a mutant form of TLR10 that impairs innate immune system-controlled inflammatory responses. However, other research has found that wild-type forms of TLR10 also contribute to pro-inflammatory pathways in healthy cells. To better understand the wild-type …

Computational Modeling Of Superconductivity From The Set Of Time-Dependent Ginzburg-Landau Equations For Advancements In Theory And Applications, Iris Mowgood

Computational and Data Sciences (PhD) Dissertations

A full review of the research conducted and published during my PhD studies in Computational and Data Sciences at Chapman University, under the advisement of Dr. Armen Gulian, are presented. Using the set of time-dependent Ginzburg-Landau (TDGL) equations with inclusion of the interference current and the non-equilibrium phonon term, we modeled the dynamics of superconductors in various theory revealing states and practical purposes. A review of the history and phenomenon of superconductivity, including modern applications, is introduced. The Josephson effect and associated Josephson junction are discussed for comparison to our analogous results with the 1-D superconducting wire. The mathematics of …

Tennessee Jail Summary Report, May 2023, Tennessee. Department Of Correction.

Jail Summary Reports

No abstract provided.

From Grain To Main And Following Fish, Nathan Huynh

Standard Theses

Two story maps. One is about the rice-to-shrimp agricultural transition in Vietnam from the 1970s-1990s. The other is about Senegalese fishermen climate migrants and their impact on Spain.

Abundance Of Plankton Taxa And Their Effects On The Planktonic Community In Lake Auburn., Dylan Ernest Larose

Standard Theses

Lake Auburn, the source of Lewiston and Auburn drinking water, is a dimictic mesotrophic lake located in Auburn Maine. The lake’s pristine nature allows for water, under strict guidelines, to be processed for drinking without the need or requirement for filtration. The lake must maintain relatively clear water in order to continue to be a filterless drinking water supply. Past water treatments have been undertaken to maintain clear water. A closer look was taken at the community dynamics of Lake Auburn’s plankton in an effort to better predict when costly and disturbing water treatments should be administered. Over fifty taxa …

A Comparative Analysis Of Groundwater Vulnerability And Pfas Contamination In Maine, Eli Boesch Dining

Standard Theses

As more information is learned regarding the long-term health effects of per- and polyfluoroalkyl substances (PFAS), increasing regulatory measures are being taken to protect the public from these chemicals. States like Maine are on the forefront of such legislation, banning land-applied biosolids in 2022 for fear of PFAS contamination, with plans to halt sales of all unnecessary PFAS products in the state by 2030. The state has conducted some testing of groundwater supplies, but the near-ubiquitous nature of PFAS in manufacturing indicates contamination may be widespread. To prioritize testing in Maine’s most vulnerable aquifers, a groundwater susceptibility map has been …

8,000 Years Of Forests In Maine: A Story Told By The Eastern Hemlock, Sugar Maple, And American Chestnut, Catherine (Cici) Conroy

Standard Theses

Forests have dominated Maine’s landscapes since the recession of the Laurentide Ice Sheet. The outmigrations of glaciers gave way to a tundra environment, later transforming into the northern hardwood forests. Trees such as the Eastern hemlock, sugar maple, American chestnut, Eastern white pine, and brown ash form unique relationships with plants, fungi, animals, and humans. This paper examines the unique history of Maine’s forests from 8,000 years ago to today, emphasizing the changes brought by European colonization. Big history argues that history should be studied at large time scales, ranging from thousands to even millions or billions of years. It …

Understanding And Quantifying Phosphorus Transport From Septic Systems To Lake Auburn, Evan Ma

Standard Theses

Rural areas often use septic systems to treat household wastewater, which may pose a phosphorus (P) loading risk to nearby water bodies if systems fail or if the soil types are unsuitable for P retention. In the Lake Auburn watershed, septic systems may be a source of phosphorus loading to Lake Auburn, an unfiltered drinking water supply. Site evaluations from municipal permits reveal patterns of septic system locations and soil types in septic drain fields. Many septic drain fields have shallow depths to groundwater or a restrictive layer, which may lead to inadequate P retention in the soil. Areas with …

Management Recommendations To Facilitate Wild And Farmed Scallop Fishery Co-Existence In The Gulf Of Maine, Alysse E. Cleasby

Standard Theses

The established Atlantic sea scallop (Placopecten magellanicus) inshore fishery and the growing scallop aquaculture industry compete for access to marine space and scallop larval resources in the Gulf of Maine. Entities concerned with scallop resource management (Maine Department of Marine Resources and fisheries-focused NGOs) are interested in solutions to facilitate wild-aquaculture co-existence. One such NGO, the Maine Center for Coastal Fisheries (MCCF), launched a collaborative research project in 2022 to determine the abundance and distribution of scallop larvae along the Maine coast, involving scallop fishermen and farmers in the process to begin co-existence conversations. Using this project as a case …

Determining The Effectiveness Of Rosemary Essential Oil On The Shelf Life Of Ground Beef Under Different Lighting Conditions, Jordan Looper

Animal Science Undergraduate Honors Theses

The objective of this study was to determine the effectiveness of rosemary extract on the shelf life of ground beef patties under different retail display conditions. Ground beef patties were produced from an 85% lean and 15% fat blend purchased from a local grocery retailer, finely ground through a 0.953 cm plate and separated into 151.2 g patties (n=64). Patties were randomly assigned into a control group (no antioxidants added) or a 0.20% concentration rosemary extract group. Patties were individually packaged using polyvinyl chloride overwrap. Antioxidant and control patties were randomly assigned into one of two lighting intensity …

Psychometric Evaluation Of Phq–9 And Gad–7 Among Community Health Volunteers And Nurses/Midwives In Kenya Following A Nation-Wide Telephonic Survey, Sabina Odero, Paul Mwangi, Rachel Odhiambo, Brenda Nzioka, Constance Shumba, Eunice Ndirangu, Amina Abubakar

Institute for Human Development, East Africa

Background: Nurses/midwives and Community Health Volunteers (CHVs) are exposed to chronic stressors putting them at risk of developing mental health problems. This has been exacerbated by the COVID-19 pandemic. There is limited empirical evidence of the burden of mental health problems among health care workers partly due to the lack of adequately standardized and validated measures for use among health care workers in Sub-Saharan Africa. This study aimed to perform the psychometric evaluation of the PHQ-9 and GAD-7 administered to nurses/midwives and CHVs across 47 counties in Kenya.

Methods: Between June and November 2021, a national survey on mental well-being …

Connecting The Dots For Contextual Information Retrieval, Pei-Chi Lo

Dissertations and Theses Collection (Open Access)

There are many information retrieval tasks that depend on knowledge graphs to return contextually relevant result of the query. We call them Knowledgeenriched Contextual Information Retrieval (KCIR) tasks and these tasks come in many different forms including query-based document retrieval, query answering and others. These KCIR tasks often require the input query to contextualized by additional facts from a knowledge graph, and using the context representation to perform document or knowledge graph retrieval and prediction. In this dissertation, we present a meta-framework that identifies Contextual Representation Learning (CRL) and Contextual Information Retrieval (CIR) to be the two key components in …

Integrated Deterrence And Cyberspace: Selected Essays Exploring The Role Of Cyber Operations In The Pursuit Of National Interest, Joseph L. Billingsley, Heidi K. Kerg , Usn, Jim Q. Chen, Michael Navicky, Benjamin Tkach, J.D. Work

Strategic Monographs

This edited volume represents an important contribution to our thinking on cyberspace and national security. It also serves as one example of an enduring and fruitful relationship between the U.S. Cyber Command (USCYBERCOM) and the College of Information and Cyberspace (CIC) at the National Defense University (NDU).

Treatment Of Posterior Tibial Tendon Dysfunction: A Case Study, Baylee Ann Reiser

Physical Therapy Scholarly Projects

Background and Purpose. Posterior tibial tendon dysfunction (PTTD) is a progressive and debilitating disease that can lead to bony involvement or deformity. Common symptoms of PTTD include medial ankle and foot pain and acquired flat foot deformity. The purpose of this case study is to examine physical therapy interventions in a patient with chronic PTTD.

Case Description. This case study describes the 15-week physical therapy management in an outpatient clinic for a 34-year-old female with unstaged PTTD presenting with pain, decreased range of motion, strength deficits and muscle imbalance, impaired balance, and impaired gait. The patient lived a …

Rehabilitation Of A Patient Diagnosed With Dermatomyositis In A Skilled Nursing Facilty: A Case Report, Chance D. Halvorson

Physical Therapy Scholarly Projects

Background and Purpose: Dermatomyositis is a disease of unknown origin that results in skin rashes and muscle wasting that can lead to significant respiratory issues and loss of function. This case report describes the response following functional training in a bedridden patient who recently reported to a skilled nursing facility.

Case Description: The patient was a 78-year-old male who was previously diagnosed with dermatomyositis that rapidly progressed after being hospitalized for over 4 months. The patient had a complicated past medical history and a difficult socioeconomic background.

Intervention: The plan of care was focused around promoting independence …

The Correlation Between The Season Of Birth And Early Child Development In Healthy Children: Evidence From The Midwestern Region Of The United States: A Pilot Study, Elizabeth G. Bodensteiner

Physical Therapy Scholarly Projects

Background and Purpose: Research has been conducted in countries like Japan and China assessing the impact of various factors on gross motor development. One variable that has been researched and discussed within studies in other countries is the relationship between gross motor development and birth season. This study aimed to address the impact of birth season on gross motor development, specifically within the Midwestern region of the United States. There is limited research regarding this topic within the Midwestern region of the United States.

Materials and Methods: Parents of 114 children completed self-reports on their children’s gross and …

Association Of Generalized Joint Hypermobility And Occurrence Of Musculoskeletal Injury In Physical Therapy And Occupational Therapy Students, Katie A. Harris

Physical Therapy Scholarly Projects

Background: Previous studies have found a higher rate of hypermobility among physical and occupational therapy students compared to the rate of hypermobility within the general public. Hypermobility has been linked to increased injury rates. This raises the question of the influence hypermobility has on injury type and recurrence.

Purpose: The goal of this study was to examine the rate of hypermobility and injury history among physical and occupational therapy students. The injury type and frequency of those with hypermobility was compared to those without hypermobility to determine if there was a relationship. The Foot Posture Index was used …

Outpatient Physical Therapy Treatment Of Patient With Spondylosis: A Case Study, Paige B. Kropuenske

Physical Therapy Scholarly Projects

Background and Purpose: In the United States low back pain (LBP) is one of the leading causes for individuals to reach out to health care professionals. LBP is often associated with a diagnosis of spondylosis. Spondylosis is present in about 80% of peoples in the United States. The prevalence of spondylosis continues to increase without a definite cure or form of treatment. Overall, exercise and intervention have proven to decrease symptoms of pain of those with spondylosis. However, success of treatment may see large variables in success. Further research into specific treatment interventions may be warranted to decrease chronic …

Periacetabular Osteotomy With Tibial Derotation And Fai Repairs As A Treatment For Symptomatic Hip Dysplasia In An Athlete: A Case Study, Marlie M. Maanum

Physical Therapy Scholarly Projects

Background and Purpose: This case study details a 16-year-old patient following periacetabular osteotomy surgery with labral repair and tibial derotation. In reading this case, you will learn about interventions performed and ideas to consider for any patient hoping to return to sports following orthopedic procedures.

Case Description: Throughout the rehabilitation there was a large focus on the patient returning to sports, specifically basketball. The physical therapy prescription focused on mobility and strengthening of the entire lower extremity due to this surgery’s aggressive nature at the ankle and hip joint. It is accepted throughout the orthopedic world that there …

The Effect Of Physical Therapy Intervention On Fatigue, Balance, Depression And Quality Of Life In Clients Following Medical Treatment For Cancer: A Pilot Study, Mckenna N. Johnson

Physical Therapy Scholarly Projects

People who are diagnosed with cancer and undergo radiation or chemotherapy treatment are at great risk for developing long-term side effects such as fatigue, balance deficits, depression, and decreased quality of life months and even years following treatment. With approximately 16.9 million people in the United States with a history of invasive cancer, and an expected steady increase in this number in the coming years, a better understanding of these side effects and how they can be treated would be instrumental for health care professionals. The purpose of this study was to test the effect of exercise intervention on fatigue, …

Connecting Eastern And Western Massachusetts With High Speed Rail, Mary Piecewicz, An Pham

School of Professional Studies

No abstract provided.

Building A Representative Workforce: How We Can Help Our Gateway Cities Recruit And Retrain Employees Reflective Of Their Communities, Jessica Lynn Feldman, Andrew J. Russo

School of Professional Studies

No abstract provided.

2023-May-01-Etsu/Norc Study Finds Rural People Face Greater Challenges To Substance Use Disorder Treatment, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – In early May, 11 cadets at East Tennessee State University received their commission as second lieutenants. Hailing from across the Southeast, these recent ETSU graduates joined a proud tradition – one that has been happening on campus for 70 years.

This year marks seven decades since what was then East Tennessee State College held its first commissioning ceremony in 1953.

“As we consider the past 70 years, ETSU’s Army ROTC program has not just been a source of outstanding officers for the United States military,” said Lt. Col. Kent Monas, a professor of military science at ETSU. …

2023-May-01-Discovering His Place In Politics, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (May 2023) – Aiden Graybeal felt drawn to politics from an early age.

“I’ve always been a weird political kid,” he said, “and there aren’t a lot of opportunities to explore that in high school and elementary school. My parents don’t know anything about politics – they don’t care to – so I had to do this all on my own. When I came to college, a friend said, ‘Hey, I’m going to do this TISL thing. Have you heard of this?’ I discovered there’s this whole world I was missing out on – all these things I’d …

2023-May-01-Etsu's Rotc Celebrates 70 Years, University Marketing And Communication, East Tennessee State University

ETSU News

A new analysis from the East Tennessee State University/NORC Rural Health Equity Research Center finds that people living in rural areas of the United States face greater challenges accessing substance use disorder (SUD) treatment than people living in urban areas.

The ETSU/NORC Rural Health Research Center is a partnership between the Addiction Science Center and Center for Rural Health Research, in the ETSU College of Public Health.

The study shows that rural residents are four-and-a-half times more likely than urban residents to be admitted to inpatient treatment through a court order or by law enforcement and nine times less likely …

2023-May-01-Eye Toward The Underserved, These 66 Will Change The World, University Marketing And Communication, East Tennessee State University

ETSU News

The Class of 2023 at East Tennessee State University Bill Gatton College of Pharmacy received their doctoral hoods this morning, officially becoming part of the college’s 14th graduating class. 

The Hooding and Commencement ceremony was held in the ETSU Martin Center for the Arts, where 66 student pharmacists earned the Doctor of Pharmacy degree.  

This ceremony, which was live-streamed at youtube.com/@etsupharmacy for those unable to attend, was part of ETSU’s commencement weekend. 

Dr. Debbie Byrd, dean of ETSU Bill Gatton College of Pharmacy, thanked the graduating class for the mark they left on the college. 

“We are so pleased you …

Intouch Week Of May 1, 2023, New York Medical College

InTouch

• Academic Excellence Recognized During Alpha Omega Alpha Iota Chapter 2023 Induction Ceremony
• The Department of Environmental Health and Safety Welcomes New Director
• Department of Physical Therapy Hosts 19th Annual Doctoral Project Presentation Day
• NYMC Hosts Ninth Annual Drs. Gabor and Harriette Kaley Endowed Lecture
• GSBMS Grad Aspires to Treat Neurodegenerative Diseases

A Multi-Agent Modeling Social Network Analysis Of Cooperative Learning Groups Within A Simulated Adult Education Classroom Learning Environment, Leverett Bruner

All Dissertations

Illiteracy and a lack of a high school diploma are impediments to a fulfilled and meaningful life. Low or reduced literacy and non-attainment of a high school diploma are significant problems in the United States. Adult education can be a vehicle to address these ever-present issues. A disproportionate number of students in adult education are minorities, members of lower socioeconomic statuses and traditionally marginalized groups who lack effective literacy skills and/or a high school diploma. Adult education and its related entities can serve as a vehicle to address these pervasive issues, but adult education as a program type is a …

Iii-Nitride Triangular Microcantilevers For Multimodal Sensing Applications, Balaadithya Uppalapati

All Dissertations

Micro-electromechanical systems (MEMS)-based sensors have gained significant attention due to their ability to sense, measure, and process various physical, chemical, and biological parameters. The small size of MEMS sensors provides numerous advantages, including low power consumption, high sensitivity, and rapid response time, making them suitable for various applications in healthcare, automotive, aerospace, and consumer electronics.

In the past few years, AlGaN/GaN MEMS devices have been found to offer several advantages over silicon-based MEMS devices. One of the main advantages of AlGaN/GaN MEMS is their high sensitivity to surface stresses and forces due to their high piezoelectric coefficients. This sensitivity allows …

Mesoscale Modeling And Machine Learning Studies Of Grain Boundary Segregation In Metallic Alloys, Malek Alkayyali

All Dissertations

Nearly all structural and functional materials are polycrystalline alloys; they are composed of differently oriented crystalline grains that are joined at internal interfaces termed grain boundaries (GBs). It is well accepted that GB dynamics play a critical role in many phenomena during materials processing or under operating environments. Of particular interest are GB migration and grain growth processes, as they influence many crystal-size dependent properties, such as mechanical strength and electrical conductivity.

In metallic alloys, GBs offer a plethora of preferential atomic sites for alloying elements to occupy. Indeed, recent experimental studies employing in-situ microscopy revealed strong GB solute segregation …