Digital Commons Network^™

Ndls Communicator: Week Of 05.08.23, Notre Dame Law School

NDLS Communicator

The Latest News

• ND London Law students learn constitutional law from two Supreme Court justices
• These law schools sent the most grads to federal clerkships
• Roger Alford testified before the Senate Judiciary Committee last Wednesday on the topic of competition in digital advertising.
• David Pruitt was appointed to the Indiana Coalition for Court Access. The Coalition for Court Access coordinates all Indiana Supreme Court related programs designed to provide civil legal aid to those with limited financial resources. The Coalition includes judges, law school representatives, civil legal aid and pro bono providers, and Indiana State Bar Association and Foundation members. …

Theory, Simulation, And Experiments On A Magnetically Insulated Transmission Line Terminated By A Bremsstrahlung Diode, Troy Clay Powell

Electrical and Computer Engineering ETDs

Foundational concepts necessary for power flow analysis of a self-magnetically insulated transmission line (MITL) are introduced in theoretical form and several developments to the theory are described. These include cold-cathode electron emission physics, self-magnetic insulation physics, self-limited MITL current, and relativistic secondary ion production from anode surfaces. Modeling these physics is performed using EMPIRE, an electromagnetic particle-in-cell code.

Self-limited MITL current theory described numerically by Pointon is developed here in analytic form and is then used to drive simulations to compare to experiments that were performed in EMPIRE. Carefully calibrated current sensors from HERMES-III experiments show good agreement with EMPIRE …

Establishing Big Sagebrush Seedlings On The Colorado Plateau, Kari E. Veblen, Eric Thacker, Mark Larese-Casanova, Kyle Nehring, Mike Duniway, Colby Brungard

All Current Publications

Factors such as soil type and precipitation vary across rangeland landscapes, and these factors affect restoration outcomes and ultimately mean that “one size fits all” management strategies are not effective across large, complex landscapes. Big sagebrush (Artemisia tridentata) is a foundational rangeland species that is important to wildlife habitat across the western U.S. On the Colorado Plateau, sagebrush is important browse for ungulates, such as mule deer and pronghorn, which motivates a great deal of restoration effort. However, most scientific knowledge of big sagebrush comes from the Great Basin, and we know much less about how to restore sagebrush on …

Criminal Defense Clinic Hosts German Students For Exploration Of The American Criminal Legal System, Tuhfa Begum ’23

NYLS Community News

No abstract provided.

Characteristics, Treatment, And Outcomes Of Real-World Talazoparib-Treated Patients With Germline Brca-Mutated Advanced Her2-Negative Breast Cancer, Reshma Mahtani

All Publications

Background: Talazoparib is a poly (adenosine diphosphate-ribose) polymerase inhibitor approved for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative, locally advanced or metastatic breast cancer (LA/mBC), with approval based on the EMBRACA trial. To date, there are no published data on talazoparib use in the real-world United States (USA) setting.

Patients and methods: Characteristics, treatment patterns, and clinical outcomes of real-world US patients with gBRCAm HER2-negative LA/mBC treated with talazoparib monotherapy were collected via retrospective chart review and summarized using descriptive statistics.

Results: Among 84 eligible patients, 35.7% had hormone receptor-positive tumors and 64.3% …

Henderson Library Gets A Glow Up, Georgia Southern University

Library Publications (1999-2023)

• Henderson Library Gets a Glow Up

Microclimate Enhancement In Arid Climate, Paras Bharat Nandu

Theses

In summary, the four primary variables for human comfort - air temperature, wind speed, humidity, and mean radiant temperature - can be analyzed using solar analysis and computational fluid dynamics on computer-aided software. This allows for quick calculations and the ability to measure the effects of sun and wind on building design. Historically, designers relied on judgment for passive design decisions, but now with the help of software, sustainable architectural design solutions can be achieved. This includes utilizing proven passive techniques that have existed since ancient times but are often overlooked in favor of energy-consuming mechanical systems. This thesis challenges …

The Impact Of Digital Transformation On Human Resources During The Pandemic Covid-19, Hind Rashid Alessa

Theses

Technological advancement in human resources and the adoption of artificial intelligence, analytics, and machine learning help HR leaders become strategic leaders. Automation helps in engaging employees and improving their work experience. Human resource is an important part of an organization and before covid epidemic the human resource department works manually and in an office environment completely. However, due to covid-19 pandemic has raised the demand for working online and implementing digital transformation ways. There is a high demand for working virtually or what is called hybrid working, simple-to-use technology that can be accessible at anytime from anywhere. Human resource employees …

Design And Development Of A Movable Multi-Functional Display, Junjie Zhou

Theses

COVID-19 has altered lives and work. Travel restrictions and social distance requirements compel remote communication. My design will help the youth group communicate remotely in various situations. I identified two primary forms of remote communication for people separated by interviews and questionnaires: direct communication based on video calls and interactive entertainment based on online games and streaming media. I summarized long-distance communication issues and user needs in further research. Video calling is the most popular method for those who need to interact directly. Video calling does have certain drawbacks, though, like the inability to actively choose one's point of view …

Pacing After Tavr: Just Give Me The Beat, But Improve The Instruments., Steven J Yakubov, Anish Amin

Heart and Vascular Articles

No abstract provided.

Locally Monochromatic Two-Step Nonlinear Trident Process In A Plane Wave, S. Tang, B. King

School of Engineering, Computing and Mathematics

In many-cycle plane waves at intermediate intensities, the nonlinear trident process can be well approximated by the two sequential steps of nonlinear Compton scattering of a polarized real photon followed by its transformation into an electron-positron pair via nonlinear Breit-Wheeler pair creation. We investigate this two-step process in the intermediate intensity regime by employing the locally monochromatic approximation for each step and numerically evaluating resulting expressions. When photon polarization is included, it is found to produce an order 10% decrease in the trident rate: the importance of polarization increases at lower intensities, and decreases at higher intensities. Its importance persists …

Phase Ib And Expansion Study Of Gemcitabine, Nab-Paclitaxel, And Ficlatuzumab In Patients With Metastatic Pancreatic Cancer, Kimberly Perez, Koushik Das, Et Al.

2020-Current year OA Pubs

BACKGROUND: In preclinical pancreatic ductal adenocarcinoma (PDAC) models, inhibition of hepatocyte growth factor (HGF) signaling using ficlatuzumab, a recombinant humanized anti-HGF antibody, and gemcitabine reduced tumor burden.

METHODS: Patients with previously untreated metastatic PDAC enrolled in a phase Ib dose escalation study with 3 + 3 design of 2 dose cohorts of ficlatuzumab 10 and 20 mg/kg administered intravenously every other week with gemcitabine 1000 mg/m2 and albumin-bound paclitaxel 125 mg/m2 given 3 weeks on and 1 week off. This was followed by an expansion phase at the maximally tolerated dose of the combination.

RESULTS: Twenty-six patients (sex, 12 male:14 …

2023 North Haverhill Fair 4-H Pint-Size Pet Showcase, Extension

UNH Cooperative Extension

No abstract provided.

Advantages Of Whole Genome Sequencing In Mitigating The Helicobacter Pylori Antimicrobial Resistance Problem, Kartika Afrida Fauzia, Ricky Indra Alfaray, Yoshio Yamaoka

Faculty, Staff and Students Publications

Helicobacter pylori antimicrobial resistance is a critical public health issue. Typically, antimicrobial resistance epidemiology reports include only the antimicrobial susceptibility test results for H. pylori. However, this phenotypic approach is less capable of answering queries related to resistance mechanisms and specific mutations found in particular global regions. Whole genome sequencing can help address these two questions while still offering quality control and is routinely validated against AST standards. A comprehensive understanding of the mechanisms of resistance should improve H. pylori eradication efforts and prevent gastric cancer.

Dna Supercoiling-Induced Shapes Alter Minicircle Hydrodynamic Properties, Radost Waszkiewicz, Maduni Ranasinghe, Jonathan M Fogg, Daniel J Catanese, Maria L Ekiel-Jeżewska, Maciej Lisicki, Borries Demeler, Lynn Zechiedrich, Piotr Szymczak

Faculty, Staff and Students Publications

DNA in cells is organized in negatively supercoiled loops. The resulting torsional and bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes. This interplay between negative supercoiling, looping, and shape influences how DNA is stored, replicated, transcribed, repaired, and likely every other aspect of DNA activity. To understand the consequences of negative supercoiling and curvature on the hydrodynamic properties of DNA, we submitted 336 bp and 672 bp DNA minicircles to analytical ultracentrifugation (AUC). We found that the diffusion coefficient, sedimentation coefficient, and the DNA hydrodynamic radius strongly depended on circularity, loop length, and degree of …

Tfeb And Tfe3 Drive Kidney Cystogenesis And Tumorigenesis, Chiara Di Malta, Angela Zampelli, Letizia Granieri, Claudia Vilardo, Rossella De Cegli, Laura Cinque, Edoardo Nusco, Salvatore Pece, Daniela Tosoni, Francesca Sanguedolce, Nicolina Cristina Sorrentino, Maria J Merino, Deborah Nielsen, Ramaprasad Srinivasan, Mark W Ball, Christopher J Ricketts, Cathy D Vocke, Martin Lang, Baktiar Karim, Luisa Lanfrancone, Laura S Schmidt, W Marston Linehan, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

Birt-Hogg-Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss-of-function pathogenic variants in the gene encoding the tumor-suppressor protein folliculin (FLCN). FLCN acts as a negative regulator of TFEB and TFE3 transcription factors, master controllers of lysosomal biogenesis and autophagy, by enabling their phosphorylation by the mechanistic Target Of Rapamycin Complex 1 (mTORC1). We have previously shown that deletion of Tfeb rescued the renal cystic phenotype of kidney-specific Flcn KO mice. Using Flcn/Tfeb/Tfe3 double and triple KO mice, we now show that both Tfeb …

Country-Level Gender Inequality Is Associated With Structural Differences In The Brains Of Women And Men, André Zugman, Luz María Alliende, Vicente Medel, Richard A.I. Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkevičiūtė, Laila Asmal, Anderson M. Winkler

School of Medicine Publications

Significance

Gender inequality is associated with worse mental health and academic achievement in women. Using a dataset of 7,876 MRI scans from healthy adults living in 29 different countries, we here show that gender inequality is associated with differences between the brains of men and women: cortical thickness of the right hemisphere, especially in limbic regions such as the right caudal anterior cingulate and right medial orbitofrontal, as well as the left lateral occipital, present thinner cortices in women compared to men only in gender-unequal countries. These results suggest a potential neural mechanism underlying the worse outcome of women in …

Polarized Localization Of Phosphatidylserine In The Endothelium Regulates Kir2.1, Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson

2020-Current year OA Pubs

Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain elusive. The goal of this study is to investigate how lipid regulation of endothelial Kir2.1 - an inwardly rectifying potassium channel that regulates membrane hyperpolarization - contributes to vasodilation in resistance arteries. First, we show that phosphatidylserine (PS) localizes to a specific subpopulation of myoendothelial junctions (MEJs), crucial signaling microdomains that regulate vasodilation in resistance arteries, and in silico data have implied that PS may compete with phosphatidylinositol …

Impact Of Early Relapse Within 24 Months After First-Line Systemic Therapy (Pod24) On Outcomes In Patients With Marginal Zone Lymphoma: A Us Multisite Study, Narendranath Epperla, Lauren Shea, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

Progression of disease within 24 months (POD24) from diagnosis in marginal zone lymphoma (MZL) was shown to portend poor outcomes in prior studies. However, many patients with MZL do not require immediate therapy, and the time from diagnosis-to-treatment interval can be highly variable with no universal criteria to initiate systemic therapy. Hence, we sought to evaluate the prognostic relevance of early relapse or progression within 24 months from systemic therapy initiation in a large US cohort. The primary objective was to evaluate the overall survival (OS) in the two groups. The secondary objective included the evaluation of factors predictive of …

Coastal Survey Data For Perranporth Beach And Start Bay In Southwest England (2006–2021), R. J. Mccarroll, N. G. Valiente, M. Wiggins, T. Scott, G. Masselink

School of Biological and Marine Sciences

Records of beach morphologic change and concurrent hydrodynamic forcing are needed to understand how coastlines in different environments change over time. This submission contains data for the period 2006 to 2021, for two contrasting macrotidal environments in southwest England: (i) cross-shore dominated, dissipative, sandy Perranporth Beach, Cornwall; and (ii) longshore-dominated, reflective gravel beaches within Start Bay, Devon. Data comprise monthly to annual beach profile surveys, annual merged topo-bathymetries, in addition to observed and numerically modelled wave and water levels. These data provide a valuable resource for modelling the behaviour of coastal types not covered by other currently available datasets.

An Analysis Of All-Cause Mortality On Patients With Sickle Cell Disease And Kidney Disease Using Propensity Score Matching, Adam Garrison

Electronic Theses and Dissertations

In this work, we provide an overview of the Cox proportional hazards model for time to event or survival analysis and the notion of propensity score matching to deal with confounding factors. A full analysis is reported in Chapter 2 concerning mortality for in-center dialysis patients with sickle cell disease to demonstrate the application of a general analysis strategy that has some logistical benefits over more traditional approaches to accounting for confounding variables. We also provide some insight and discussions on the challenges and future research questions that will emerge when trying to implement this strategy as a monitoring tool …

Optical Phased Array For Lidar Systems At Blue Wavelengths, Long H. Nguyen

Theses

Optical Phased Array has become a popular solution for light detection and rang- ing (lidar) due to its compact size, steering ability without physical moving parts, and integration with conventional CMOS manufacturing processes. With the rising demand in advanced driver assistance systems (ADAS) and surveying in agriculture and oceanography industries, there is a need for a durable, high performing, and integrable lidar module. For that, a suitable integrated OPA is required to carry sufficient power and have large steering angle at a particular wavelength range. This thesis is specifically focused on blue wavelengths for use in applications such as aug- …

Measuring Diffusion Through Carbon Nanotube Arrays With Fluorescent Spectroscopy, Michael Machold

Theses

Carbon nanotube (CNT) arrays are emerging as versatile nanostructures that can be used in many applications including gene transfection technology. To understand the transport of molecules through an array of CNTs, diffusion of molecules was studied experimentally and analytically. A procedure using fluorescent spectroscopy was developed to measure the concentration change of fluorescein salt in a two-reservoir system separated by a CNT array. Experiments were conducted to measure how changing the initial concentration gradient and reservoir volume size impacted the diffusivity of the system. For 2 mL reservoirs, diffusivities were measured between 2.56*10^(-11) m^2/s and 3.51*10^(-11) m^2/s. Diffusivities were measured …

Rbm47 Regulates Intestinal Injury And Tumorigenesis By Modifying Proliferation, Oxidative Response, And Inflammatory Pathways, Saeed Soleymanjahi, Valerie Blanc, Elizabeth A. Molitor, David M. Alvarado, Yan Xie, Vered Gazit, Jeffrey W. Brown, Kathleen Byrnes, Ta-Chiang Liu, Jason C. Mills, Matthew A. Ciorba, Deborah C. Rubin, Nicholas O. Davidson

2020-Current year OA Pubs

RNA-binding protein 47 (RBM47) is required for embryonic endoderm development, but a role in adult intestine is unknown. We studied intestine-specific Rbm47-knockout mice (Rbm47-IKO) following intestinal injury and made crosses into ApcMin/+ mice to examine alterations in intestinal proliferation, response to injury, and tumorigenesis. We also interrogated human colorectal polyps and colon carcinoma tissue. Rbm47-IKO mice exhibited increased proliferation and abnormal villus morphology and cellularity, with corresponding changes in Rbm47-IKO organoids. Rbm47-IKO mice adapted to radiation injury and were protected against chemical-induced colitis, with Rbm47-IKO intestine showing upregulation of antioxidant and Wnt signaling pathways as well as stem cell and …

Draft Final 2023 Residential Metals Abatement Program (Rmap) Clark Park Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Perspectives On Non-Prescription Antibiotic Use Among Hispanic Patients In The Houston Metroplex, Lindsey Laytner, Patricia Chen, Susan Nash, Michael K Paasche-Orlow, Richard Street, Roger Zoorob, Barbara Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

BACKGROUND: Non-prescription antibiotic use includes taking an antibiotic without medical guidance (e.g., leftovers, from friends/relatives, or purchased without a prescription). Non-prescription use contributes to antimicrobial resistance, adverse drug reactions, interactions, superinfection, and microbiome imbalance. Qualitative studies exploring perspectives regarding non-prescription use among Hispanic patients are lacking. We used the Kilbourne Framework for Advancing Health Disparities Research to identify factors influencing patients' non-prescription use and organize our findings.

METHODS: Our study includes Hispanic primary care clinic patients with different types of health insurance coverage in the Houston metroplex who endorsed non-prescription use in a previous survey. Semistructured interviews explored the factors …

Enabling Extreme Low Power Mode Based On Bluetooth Quality Reports, Feng-Jui Kuo

Defensive Publications Series

Unchecked power consumption at low battery levels can hasten the shutdown of a device, causing inconvenience to the user. This disclosure describes an extreme low power mode for devices that have Bluetooth capabilities. At low battery levels, statistics of recent activities and current consumption of the Bluetooth controller, as obtained from Bluetooth quality reports (BQR), are used to adaptively select energy appropriate Bluetooth modes. In the extreme low power mode, the audio codec can be switched to one that minimizes current consumption; the frequency of Bluetooth/BLE advertising and scanning can be reduced; the frequency of BLE advertising reports can be …

Highly Flexible Cni-Agnostic Server Agent With Support For Dual-Tor Ecmp And Control Plane High Availability, Gautam Venkataramanan, Mandeep Singh Dhami

Defensive Publications Series

Techniques are presented herein that support a Border Gateway Protocol (BGP) daemon that may advertise routes and attract any traffic towards a server. Aspects of the presented techniques support dual-top of rack (ToR) equal cost multipath (ECMP) routing and Kubernetes (K8s) control plane application programming interface (API) server high availability (HA) without being tied to any particular Container Network Interface (CNI) implementation.

Hemingway In Spain, Doug Ramspeck

Valparaiso Fiction Review

No abstract provided.

Saints Preserve Us In Hot Young Stuff, Parker Desautell

Valparaiso Fiction Review

No abstract provided.