Digital Commons Network^™

Plasma Proteomic Patterns Show Sex Differences In Early Concentric Left Ventricular Remodeling, Anne-Mar Van Ommen, Ernest Diez Benavente, N. Charlotte Onland-Moret, Gideon B. Valstar, Maarten J. Cramer, Frans H. Rutten, Arco J. Teske, Roxana Menken, Leonard Hofstra, Igor I. Tulevski, Nancy Sweitzer, G. Aernout Somsen, Hester M. Den Ruijter

2020-Current year OA Pubs

BACKGROUND: Concentric remodeling (cRM) can precede heart failure with preserved ejection fraction (HFpEF), a condition prevalent in women.

METHODS: Patients (n=60 593, 54.2% women) visiting outpatient clinics of Cardiology Centers of the Netherlands were analyzed for cRM, HFpEF development, and mortality risk. We studied risk factors for relative wall thickness both sex-stratified and in women and men combined. Biomarker profiling was performed (4534 plasma proteins) in a substudy involving 557 patients (65.4% women) to identify pathways involved in cRM.

RESULTS: cRM was present in 23.5% of women and 27.6% of men and associated with developing HFpEF (HR, 2.15 [95% CI, …

A Motor Association Area In The Depths Of The Central Sulcus, Michael A Jensen, Harvey Huang, Gabriela Ojeda Valencia, Bryan T Klassen, Max A Van Den Boom, Timothy J Kaufmann, Gerwin Schalk, Peter Brunner, Gregory A Worrell, Dora Hermes, Kai J Miller

2020-Current year OA Pubs

Cells in the precentral gyrus directly send signals to the periphery to generate movement and are principally organized as a topological map of the body. We find that movement-induced electrophysiological responses from depth electrodes extend this map three-dimensionally throughout the gyrus. Unexpectedly, this organization is interrupted by a previously undescribed motor association area in the depths of the midlateral aspect of the central sulcus. This 'Rolandic motor association' (RMA) area is active during movements of different body parts from both sides of the body and may be important for coordinating complex behaviors.

Multicenter Randomized Trial Of Carpal Tunnel Release With Ultrasound Guidance Versus Mini-Open Technique, Kyle R Eberlin, Benjamin P Amis, Thomas P Berkbigler, Christopher J Dy, Mark D Fischer, James L Gluck, F Thomas D Kaplan, Thomas J Mcdonald, Larry E Miller, Alexander Palmer, Paul E Perry, Marc E Walker, James F Watt

2020-Current year OA Pubs

BACKGROUND: Comparative studies of carpal tunnel release with ultrasound guidance (CTR-US) vs. mini-open CTR (mOCTR) are limited, prompting development of this randomized trial to compare efficacy and safety of these techniques.

RESEARCH DESIGN AND METHODS: Patients were randomized (2:1) to CTR-US or mOCTR, treated by experienced hand surgeons (median previous cases: 12 CTR-US; 1000 mOCTR), and followed for 3 months.

RESULTS: Among 149 randomized patients, 122 received CTR-US (

CONCLUSIONS: The efficacy and safety of CTR-US were comparable to mOCTR despite less previous surgical experience with CTR-US. The choice of CTR technique should be determined by shared decision-making between patient …

Accelerated Infliximab Infusion Safety And Tolerability Is Non-Inferior To Standard Infusion Protocol In Inflammatory Bowel Disease Patients: A Randomized Controlled Study, Suha Abushamma, Ted Walker, Kevin Garza, Ling Chen, Darren Nix, Chien-Huan Chen

2020-Current year OA Pubs

BACKGROUND AND AIM: Infliximab is typically given over an infusion time of 2 hours, leading to a significant burden in inflammatory bowel disease (IBD) patients. We aimed to determine the safety and cost-effectiveness of an accelerated infliximab infusion of 1 hour, compared with the standard 2-hour infusion.

METHODS: Open-label randomized trial where IBD patients receiving maintenance infliximab infusions were randomly assigned to 1- and 2-hour infusion groups, corresponding to study and control groups, respectively. The primary outcome was the rate of infusion reactions. Secondary outcomes were assessment of the effect of premedications and immunomodulators on the rate of infusion reactions, …

Glp-1r Agonists Demonstrate Potential To Treat Wolfram Syndrome In Human Preclinical Models, Vyron Gorgogietas, Cris Brown, Fumihiko Urano, Et Al.

2020-Current year OA Pubs

AIMS/HYPOTHESIS: Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss and neurodegeneration. Considering the unmet treatment need for this orphan disease, this study aimed to evaluate the therapeutic potential of glucagon-like peptide 1 receptor (GLP-1R) agonists under wolframin (WFS1) deficiency with a particular focus on human beta cells and neurons.

METHODS: The effect of the GLP-1R agonists dulaglutide and exenatide was examined in Wfs1 knockout mice and in an array of human preclinical models of Wolfram syndrome, including WFS1-deficient …

Coping Strategies And Symptoms Of Mental Health Disorders Among People With Hiv Initiating Hiv Care In Cameroon, Angela M Parcesepe, Lindsey M Filiatreau, Amanda Gomez, Peter Vanes Ebasone, Anastase Dzudie, Brian W Pence, Milton Wainberg, Marcel Yotebieng, Kathryn Anastos, Eric Pefura-Yone, Denis Nsame, Rogers Ajeh, Denis Nash

2020-Current year OA Pubs

Little is known about the coping strategies used among people with HIV (PWH), especially in sub-Saharan Africa, and the extent to which adaptive or maladaptive coping strategies are associated with symptoms of mental health disorders. We interviewed 426 PWH initiating HIV care in Cameroon and reported the prevalence of adaptive and maladaptive coping strategies, overall and by presence of symptoms of depression, anxiety, and PTSD. Log binominal regression was used to estimate the association between each type of coping strategy (adaptive or maladaptive) and symptoms of each mental health disorder, separately. Adaptive and maladaptive coping strategies were commonly reported among …

Sell, Paul Stuart, Collection, 1887-1981, Special Collections, Leonard H. Axe Library

Finding Aids

Dr. Paul Stuart Sell was a longtime dentist, practicing in Independence, Kansas, and an avid musician. This collection of materials includes photographs, sheet music, songs and song books he used to play at events, and miscellaneous artifacts.

The Paul Stuart Sell Collection is divided into three series: Photograph, Music and Miscellaneous.

The Photograph series contains photographs of Paul Sell at various stages of his life, and of his father, John Sell. There are photographs of his store, Cherryvale, and the Girard Fire Department.

The Music series includes eleven pieces of sheet music that he composed. There are sixteen different song …

Para-Inguinal Hernia; Presentation, Diagnosis And Surgical Treatment, A Case Report, Maha Mourad, Bilal Kharbutli

Surgery Articles

INTRODUCTION: Para-inguinal, or peri-inguinal, hernias are a rare type of hernia of the inguinal region that present in a similar fashion to but do not anatomically correspond to inguinal or femoral hernia pathologies. Surgeons should be aware of this rare pathology, diagnostic imaging and surgical treatment approaches including minimally invasive techniques. In this paper, we discuss the different groin region hernias and describe the first case reported of a successful TEP repair of a para-inguinal hernia.

PRESENTATION OF THE CASE: 62-year-old-female who presented to the clinic with symptomatic large right groin bulge. Examination revealed a large incarcerated right inguinal hernia …

A Review Of Solar Hybrid Photovoltaic-Thermal (Pv-T) Collectors And Systems, Todd Otanicar

Mechanical and Biomedical Engineering Faculty Publications and Presentations

In this paper, we provide a comprehensive overview of the state-of-the-art in hybrid PV-T collectors and the wider systems within which they can be implemented, and assess the worldwide energy and carbon mitigation potential of these systems. We cover both experimental and computational studies, identify opportunities for performance enhancement, pathways for collector innovation, and implications of their wider deployment at the solar-generation system level. First, we classify and review the main types of PV-T collectors, including air-based, liquid-based, dual air–water, heat-pipe, building integrated and concentrated PV-T collectors. This is followed by a presentation of performance enhancement opportunities and pathways for …

"The End Of Learning Is Gracious Living": A Centennial Of Life In Mary Trowbridge Hall, Kalmazoo College, Hunter Lorain Magrum

Historic Preservation Final Projects

No abstract provided.

The Social Value Of Intellectual Property, Alina Ng Boyte

IP Theory

No abstract provided.

Fair Use Failing The First Amendment? How The Parody And Satire Dichotomy May Be Stunting Political Discourse, Megan L. Wheeler

IP Theory

The First Amendment, in certain circumstances, is used as a defense to “protect[] satire and parody as a form of free speech and expression.”2 When it comes to jokes, “[q]uestions . . . have arisen in case law [pertaining to satire typically] concerning libel, emotional distress and copyright infringement.”3 Further, in a right of publicity claim, “[t]he First Amendment clearly protects all but the most intrusive coverage of news, or details of a person’s private life, such as are reported in the tabloid press or talk shows.”4 This demonstrates that humor and satire have a close relationship with the First …

Encouraging Public Access To Pharmaceuticals Through Modified Protection Of Clinical Trial Data, Scott M. Nolan Ii

IP Theory

Part I of this Article investigates the development of pharmaceuticals and clinical trial data with a focus on patent and data protection. Part II evaluates the effects of protection and the challenges it poses to widespread public pharmaceutical access. Part III discusses two scholarly approaches to the public access issue that focus on clinical data protection and their associated challenges. In light of these scholarly works, Part IV suggests a new approach to clinical trial data protection that aims to improve public pharmaceutical access while maintaining the incentives to invent for drug developers.

Water Current, Volume 55, No. 2, Summer 2023

Water Current Newsletter

No abstract provided.

Droughtscape, Summer 2023, National Drought Mitigation Center

DroughtScape: Quarterly Newsletter of the National Drought Mitigation Center (2007–2023)

DroughtScape, Summer 2023

Notre Dame Lawyers Connect: Summer 2023, Notre Dame Law School

Notre Dame Lawyers Connect

Save the Date: Homecoming: September 23 Weekend of the ND-Ohio State Game

ND Law holds third annual Notre Dame Religious Liberty Summit in London

New NDLA Board Members

• Tracy Warren '99 J.D.
• Qiana Lillard '98 B.A., '01 J.D.
• Paul Carvelli '86 B.A., '89 J.D.
• Ken Vorrasi '04 J.D.
• Adam Russ '02 BBA, '05 J.D.
• Giovanni Angles '11 J.D.
• Claudia Tran '17 J.D.

G. Marcus Cole reappointed as dean of Notre Dame Law School

LRAP deadline

‘Off the Court’: ND Law hosts event in New York City with Muffet McGraw and Coquese Washington ’92, ’97 J.D.

Alumni Spotlights

• NDLA Board honors …

Population-Specific Responses In Eastern Oysters Exposed To Low Salinity In The Northern Gulf Of Mexico, Kyle A. Sirovy, Sandra M. Casas, Jerome F. La Peyre, Morgan W. Kelly

Faculty Publications

Eastern oysters, Crassostrea virginica, are facing rapid environmental changes in the northern Gulf of Mexico and can respond to these changes via plasticity or evolution. Plastic responses can immediately buffer against environmental changes, although this buffering may impact the organism’s ability to evolve in subsequent generations. While plasticity and evolution are not mutually exclusive, the relative contribution and interaction between them remains unclear. In this study, we investigated the roles of plastic and evolved responses of C. virginica acclimated to low salinity using a common garden experiment with four populations exposed to two salinities. We used three transcriptomic analyses (edgeR, …

Riverbank Erosion And Char Stability Along The Fluvial-To-Tidal Transition Zone In The Lower Meghna River And Tentulia Channel In The Ganges-Brahmaputra-Meghna Delta, Bangladesh, Leslie A. Valentine, Carol A. Wilson

Faculty Publications

The Ganges-Brahmaputra-Meghna (GBM) delta has been named one of the world's most vulnerable sinking deltas. It is also one of the most dynamic deltas, with the world's highest sediment discharge and third highest water discharge, with semi-diurnal mesoscale (2–4 m) tides. The high fluvial discharge and significant tidal velocities (1–2 m/s) create an expansive fluvial-to-tidal transition zone (FTTZ) along the entire Lower Meghna River (LMR). Within this FTTZ, tidally elongated channel bars, locally called ‘chars’, rapidly evolve due to the high sediment and water discharges. Chars along the LMR have a total population exceeding 5 million people; thus, evaluating the …

Refining 2svca Method For Measuring Telehealth Accessibility Of Primary Care Physicians In Baton Rouge, Louisiana, Lingbo Liu, Jennifer Alford-Teaster, Tracy Onega, Fahui Wang

Faculty Publications

Equity in health care delivery is a longstanding concern of public health policy. Telehealth is considered an important way to level the playing field by broadening health services access and improving quality of care and health outcomes. This study refines the recently developed “2-Step Virtual Catchment Area (2SVCA) method” to assess the telehealth accessibility of primary care in the Baton Rouge Metropolitan Statistical Area, Louisiana. The result is compared to that of spatial accessibility via physical visits to care providers based on the popular 2-Step Floating Catchment Area (2SFCA) method. The study shows that both spatial and telehealth accessibilities decline …

Validation Of The Hierarchical Nature Of The Ao Spine Sacral Classification And The Development Of The Sacral Ao Spine Injury Score, Brian A. Karamian, Gregory D. Schroeder, Mark J. Lambrechts, Jose A. Canseco, Emiliano N. Vialle, Frank Kandziora, Lorin M. Benneker, Rajasekaran Shanmuganathan, F. Cumhur Öner, Klaus J. Schnake, Christopher K. Kepler, Alexander R. Vaccaro

Rothman Institute Papers

STUDY DESIGN: Global cross-sectional survey.

OBJECTIVE: The objective of this study was to validate the hierarchical nature of the AO Spine Sacral Classification System and develop an injury scoring system.

SUMMARY OF BACKGROUND DATA: Although substantial interobserver and intraobserver reliability of the AO Spine Sacral Classification System has been established, the hierarchical nature of the classification has yet to be validated.

METHODS: Respondents numerically graded each variable within the classification system for severity. Based on the results, a Sacral AO Spine Injury Score (AOSIS) was developed.

RESULTS: A total of 142 responses were received. The classification exhibited a hierarchical Injury …

American Community Survey (2021), John Shepard, Jean Winsor, John Butterworth, Alberto Migliore, Daria Domin, Agnes Zalewska

All Institute for Community Inclusion Publications

This Data Note summarizes employment and poverty rates across the US in 2021. These data are compared for people with no disability, people with any disability, and people with a cognitive disability, which indicate that people with disabilities continue to have less success in the labor market, and a greater likelihood of being underemployed, compared to individuals without a disability.

Monitoring The Philippine Economy State Of The Economy Report, Mitzie Irene P. Conchada, Lawrence B. Dacuycuy, Jesus Felipe, Desher Edgar Empeño, Brendan Emmanuel A. Miranda

Angelo King Institute for Economic and Business Studies (AKI)

The Philippine economy recovered from the COVID-19 pandemic during 2022. It posted a very high annual growth rate, 7.6%, although this must be understood in the context of a low base. AKI’s State of the Economy Report focuses on three issues in the context of the new Administration’s 8-Point Socioeconomic Agenda and the Philippine Development Plan 2023-2028: growth, inflation, and the fiscal deficit and national debt. Overall, we have a positive view of the economy over the medium and long-term. However, we argue that:

-The focus of economic policy has to shift decisively toward changing the structure of the economy …

Economic Transformation And Growth In The Philippines: An Analysis Of Political Settlements, Rents, And Deals, Jesus Felipe, Desher Edgar Empeño, Brendan Emmanuel A. Miranda

Angelo King Institute for Economic and Business Studies (AKI)

The main gateway for the Philippines to develop and become an upper-middle-income economy—and eventually, a high-income economy—is to expedite the shift of workers out of agriculture and to produce and export more complex products with a higher income elasticity of demand. The actual growth rate is constrained by the balance-of-payments equilibrium growth rate, about 6%—the maximum the country can attain without incurring balance-of-payments problems. We use the Pritchett-Sen-Werker political-economy framework to analyze the role of different types of firms and the deals environment during successive Philippine administrations until the current one. Due to their economic size and political power, only …

What Russia-Ukraine Conflict May Imply For The Future Of Dollar-Centered Monetary System, Jesus Felipe

Angelo King Institute for Economic and Business Studies (AKI)

AGLOBAL financial summit held in Paris some days ago reached a "new" global pact to help developing countries deal with poverty, climate change and debt. Part of the solution? More "funds," that is, debt. Ironically, nobody at the Paris summit questioned the current monetary system, which is at the root of the debt problem.

Coincidentally, a recent article in the journal Real-World Economics Review (http://www.paecon.net/PAEReview/issue104/Spano) argues that one of the potential consequences of the Russia-Ukraine war could be the demise of the US dollar as the international unit of account. If this materializes, the international monetary system may change significantly. …

Dollars And Sense Newsletter - Summer 2023 Issue, Nova Southeastern University

Dollars & Sense Newsletter

No abstract provided.

Diaasq: A Benchmark Of Conversational Aspect-Based Sentiment Quadruple Analysis, Bobo Li, Hao Fei, Fei Li, Yuhan Wu, Jinsong Zhang, Shengqiong Wu, Jingye Li, Yijiang Liu, Lizi Liao, Tat-Seng Chua, Donghong Ji

Research Collection School Of Computing and Information Systems

The rapid development of aspect-based sentiment analysis (ABSA) within recent decades shows great potential for real-world society. The current ABSA works, however, are mostly limited to the scenario of a single text piece, leaving the study in dialogue contexts unexplored. To bridge the gap between fine-grained sentiment analysis and conversational opinion mining, in this work, we introduce a novel task of conversational aspect-based sentiment quadruple analysis, namely DiaASQ, aiming to detect the quadruple of target-aspect-opinion-sentiment in a dialogue. We manually construct a large-scale high-quality DiaASQ dataset in both Chinese and English languages. We deliberately develop a neural model to benchmark …

Norfolk Integrated Waste-Energy Framework, Emma Kurtz, Abigail Schroeder, Jonah Mcdowell

Project Energy Nebraska: Student Projects

Environmental Engagement in the Community projects, spring 2023 A poster titled Norfolk Integrated Waste-Energy Framework for client City of Norfolk, Nebraska and Nebraska Public Power District.

Faculty sponsor: David Gosselin

Multiple Sterile Withdrawals From Iohexol Bottles Does Not Increase Contamination Risk, Caroline Purtill, Manraj Dhesi, Daniel Haber, Nicholas D'Antonio, Noreen J. Hickok, Jeremy I. Simon

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: There is a global shortage of iohexol contrast media, commonly used in epidural injections, as a result of lockdown and decreased production due to COVID-19. Iohexol bottles are designated for single use, which, depending on the vials available, often leads to wasting up to 95% of this limited resource. However, avoiding multiple withdrawals may be unnecessary if withdrawing multiple times using sterile technique does not increase the risk for contamination.

OBJECTIVES: The purpose of our study is to determine whether multiple withdrawals from iohexol injection bottles using a sterile technique poses a greater risk of introducing contaminants than a …

Acorporation, Inc.: Corporate Form As Art Project And Advocacy, Chad Erpelding, Ruth Jebe, Jeff Lingwall

Art, Design & Visual Studies Faculty Publications and Presentations

Development of the corporation was a key turning point in the institutional history of business. The concepts of life beyond the existence of its founders, limited liability, and the ability to accumulate massive amounts of capital through stock ownership changed the nature of commercial practice in the United States and around the world. This has not been without controversy, particularly as large corporations began to capture much of modern economic life. Great economic power has not always meant great responsibility, and concepts of corporate citizenship and legal “personhood” remain subjects of debate. Similarly, how corporations do, or ought to, navigate …

Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle

Theses and Dissertations

In its 2022 commercial market outlook, Boeing forecasted an 80% increase in the global fleet through 2041 compared to 2019 pre-pandemic levels. This sharp rise in demand will drive pressure onto airframe manufacturers to ramp up production and find more efficient ways to design and manufacture airplanes. Complicating this challenge is the industry’s recent transformation from traditional metal-based airframes towards hybrid composite-metal aircraft. While composites have been used in aviation for decades, aircraft manufacturers are still struggling to design and manufacture quality parts at a high rate. Automated Fiber Placement (AFP) is one of the main manufacturing techniques used to …