Digital Commons Network^™

The Association Between Higher Expression Of Talin-1 And The Reduced Survival Rate In Ovarian Serous Carcinoma Patients, Mina Sharbatoghli, Leili Saeednejad Zanjani, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Medhi Totonchi, Mohsen Asadi-Lari, Zahra Madjd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background & Objective: Talin-1 is a constituent of the multiprotein adhesion complexes that play main role in the formation of tumors and migration in different types of malignancies. The present study aimed to assess expression and prognostic significance of the talin-1 protein in ovarian serous carcinoma (OSC) patients.

Methods: The expression of talin-1 in mRNA and its protein levels were investigated for ovarian cancer (OC) by using bioinformatics tools, including Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Gene Expression Database of Normal and Tumor Tissue 2 (GENT2), and The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN) databases. …

Integrative Software Design For Hospital Information Systems, Esraa M. Hashem, Mahmoud F. Y. Shalaby, Mai S. Mabrouk, Samir.Y. Marzouk

Mansoura Engineering Journal

The Hospital Information System is a huge, integrated system that meets these needs. The primary objective of any hospital information system is to produce high-quality and timely reporting for evidence-based decisions and interventions. The electronic health record is essential in creating uniform data formats and terminology for both corporate and public sector reporting needs. In this study, we design a hospital information system that focuses on the tools, and techniques necessary to improve the gathering, archiving, retrieval, and application of information in biomedicine and the healthcare industry. With the intention of bringing about progress, the idea of a paperless hospital …

Developing A Holistic Outlook Through Art, Jennifer K. Fortuna

The Open Journal of Occupational Therapy

Dr. Guy McCormack, PhD., OTR/L, FAOTA, an occupational therapist and retired academic program director based in Seaside, California, provided the cover art for the Summer 2023 edition of The Open Journal of Occupational Therapy (OJOT). “Tree of Life” is a 20” x 24” painting made from acrylic on panel. McCormack has served as an occupational therapist and educator for nearly 50 years. His career includes many notable clinical and academic achievements. Today, he finds joy in painting landscapes, animals, and abstract compositions. Since his retirement, art has helped McCormack develop a more holistic outlook on life.

Letter To The Editor: Re: Burke, Bundy, & Lane (2023) Article “If Reasoning, Reflection, And Evidence-Based Practice Are Essential To Practice, We Must Define Them”, Angela Benfield, Mark V. Johnston

The Open Journal of Occupational Therapy

The purpose of this letter to the editor is to suggest using modern test theory to support developing empirical definitions of these complex terms.

The Promise Of Occupational Therapy: Occupational Engagement, Daniel Cezar Da Cruz

The Open Journal of Occupational Therapy

Occupational engagement was first described in 1980 by Elizabeth Yerxa. Forty years later, the concept has no consensual definition in the literature. Despite a lack of common agreement, occupational engagement has been used to describe the ultimate goal of occupational therapy in several documents of associations and research articles. The opinion piece discusses the importance and implications of a lack of consensual concept definition for the profession of occupational therapy and focuses on five descriptions of occupational engagement in the literature. The word "promise" expresses the message occupational therapists send through their organizations, institutions, clinical practice, and research to society …

Applying The Ecological Model Of Human Performance And The Slutwalk Movement To Support Those Affected By Rape Culture In The Context Of Occupational Therapy, Angela Klukken, Sally Wasmuth

The Open Journal of Occupational Therapy

Improving the occupational lives of others is at the heart of occupational therapy practice. Advocacy for clientele is central to this improvement, both at individual and structural levels. We argue that interventions in the Ecological Model of Human Performance (EHP) and the social movement theSlutWalk can offer increased opportunity for occupational therapists to address the harmful implications for clients affected by sexual assault and rape culture. In addition, through the principles of the EHP and the SlutWalk, we propose that occupational therapists can have a hand in eradicating the culture that facilitates and tolerates sexual violence. This paper …

The Canadian Occupational Performance Measure (Copm): Critiquing Its Applicability With Indigenous Peoples And Communities, Tara Price, Tara Pride

The Open Journal of Occupational Therapy

Indigenous Peoples experience significant health inequities that must be understood in relation to historical and ongoing colonialism, racism, and discrimination. The occupational therapy profession has claimed commitment to addressing the Truth and Reconciliation Commission (TRC) calls to action, however, the profession is firmly grounded in Euro-Western epistemologies, including its assessments. The purpose of this paper was to assess the Canadian Occupational Performance Measure (COPM) for use with Indigenous clients and communities. Although the COPM uses flexibility through semi-structured interviews and the exclusion of standardized score comparisons, it is mired in colonial underpinnings and has hierarchical therapist-client power dynamics threaded throughout. …

Spirituality And Occupation In Living (Soil) Model: Conceptualizing Occupational Performance Through The Lens Of Spirituality, Clark Patrick Heard

The Open Journal of Occupational Therapy

Spirituality is a multi-faceted concept that includes varied personal, societal, and cultural informers. Despite a relatively high volume of analysis there is significant and ongoing debate about the concept of spirituality in occupational therapy. In particular, this discourse includes questions of relevance, how spirituality might be defined, and what its clinical application might entail.

To date, several models have connected spirituality with occupation but none have supported clinicians in framing occupational performance and occupational performance change in day-to-day clinical practice via a spirituality lens.

This paper describes the Spirituality and Occupation in Living (SOiL) model. This model is designed for …

Teaching Critical Reflection In Occupational Therapy: A Quantitative Pre/Post Evaluation Of Student Learning, Morgan Nelson, Lisa Jaegers, Quinn P. Tyminski, Niki Kiepek, Crystal Dieleman

The Open Journal of Occupational Therapy

This study was designed to answer the question, “Does student recognition of the assumptions underlying occupational therapy practice increase after participation in guided exercises of critical reflection?” The project is grounded in critical occupational therapy (as first named by Whiteford and Townsend) to promote students to reflect actively on dominant disciplinary ideologies and self-reflect on how one’s social positionality impacts understandings of occupational participation. The concept of non-sanctioned occupations was drawn on as a means to facilitate changes in student recognition. A one group, quantitative pre/post design with six open-ended responses was undertaken with master’s-level students (N = 53) at …

Sequential Simulations During Introductory Part-Time Fieldwork: Design, Implementation, And Student Satisfaction, Kaitlin R. Sibbald, Diane E. Mackenzie

The Open Journal of Occupational Therapy

Background: Simulation is used in various ways in occupational therapy education and is recognized as a replacement for some conventional fieldwork hours. However, design and student satisfaction has had limited exploration.

Method: Sequential best practice simulations were designed for Level 1 fieldwork objectives in mental and musculoskeletal practice. The Satisfaction with Simulation Education scale (SSES) and qualitative feedback were used to assess student satisfaction. An exploratory factor analysis was used to validate the SSES in occupational therapy, and a three-factor repeated measures ANOVA was used to determine factors contributing to satisfaction across simulations.

Results: A three-factor model …

Occupational Therapy Curricula Patterns For Acquired Brain Injury-Related Vision Disorders For Entry-Level Programs: A Survey, Laura Schmeiser, Alicia Reiser, Caitlyn Foy

The Open Journal of Occupational Therapy

Occupational therapists are among the first providers to encounter individuals after an acquired brain injury (ABI). Evidence suggests that most occupational therapists learn about ABI-related vision disorders from continuing education and on-the-job training. A better understanding of entry-level curricula patterns for ABI-related vision disorders is important because of their high prevalence and impact on occupational performance. A descriptive online survey was administered to occupational therapy educators at ACOTE-accredited entry-level programs to explore curricula patterns for ABI-related vision disorders. Of 1,391 occupational therapy educators invited to participate, 71 (5%) began the survey, and 66 met the inclusion criteria. Vision screening methods …

Integrating Sleep Promotion Education Into Acute Care Orthopedics Occupational Therapy Practice: A Case Series Study, Rebecca Ludwig, Aaron M. Eakman, Catherine Siengsukon

The Open Journal of Occupational Therapy

Background: The occupation of sleep is frequently under-addressed by occupational therapists with their clients. This may be in part because of a lack of general training on addressing this occupational domain or a lack of education about the basics of sleep. The domain of sleep has been in the Occupational Therapy Practice Framework since 2008. However, it remains unclear how to address the domain of sleep in occupational therapy practice. Therefore, the purpose of this case series is to describe the practical application of sleep promotion education.

Methods: A practicing occupational therapist with sleep training provided sleep promotion …

Use Of A Performance-Based Occupational Therapy Assessment Of Executive Function With The Homeless Population: A Case Report, Emily Raphael-Greenfield, Kimberlee Baltich, Tess Wilson, Rebecca Lowinger

The Open Journal of Occupational Therapy

Background: An estimated 25% of the homeless population has a mental illness, which means that many experience cognitive problems that adversely impact basic and instrumental activities of daily living and goal attainment. This case report focused on the experience of an individual living in transitional housing who was evaluated with a performance-based occupational therapy assessment in the context of community-based interdisciplinary psychosocial care provided by a robust occupational therapy fieldwork program.

Method: This case report generally followed the CARE Case Report Guidelines and highlights the use of a standardized performance-based assessment and follow-up care suggested by test outcomes. …

Feasibility Of A Stress Reduction Program Among Foster Youth In College, Alexis Melinda Ferioli Morin, Jennifer E. Lape

The Open Journal of Occupational Therapy

Background: Foster youth endure traumatic adversities, which can lead to obstacles when transitioning to young adulthood and pursuing postsecondary education. This vulnerable population is required to navigate independent living while also managing stress that commonly arises from postsecondary education.

Method: A pre test, post test pilot design was employed to determine the potential impact and feasibility of an evidenced-based multi-factorial stress management program in reducing foster youth’s perceived stress during postsecondary education. Participants (n = 3) received one, 90-min individual occupational therapy session weekly over 6 weeks. Author-generated stress management surveys along with the Perceived Stress Scale …

Encounters With Ethical Problems During The First 5 Years Of Practice In Occupational Therapy: A Survey, Brenda S. Howard, Michele Govern, Alexandra M. Gambrel, Morgan Haney, Haylee Ottinger, Travis W. Rippe, Alyssa Earls

The Open Journal of Occupational Therapy

Background: Health care professionals face ethical problems in practice, but there is little research on types of ethical problems encountered or ethical problem resolution. This study explored ethical problems encountered by occupational therapists and occupational therapy assistants (OTAs) within the first 5 years of practice.

Method: Investigators sent a survey in cooperation with NBCOT to a sample of 7,800 occupational therapists and OTAs in multiple practice settings who were NBCOT certified within the past five years. The survey covered questions regarding ethical problems encountered in practice, including productivity and related issues, clinical decision-making and professional reasoning, therapeutic relationships, and …

Predictors Of Occupational Competence In People Hospitalized With Chronic Conditions, Melanie Morriss Tkach, Patricia Bowyer, Marsha Neville, Timothy J. Wolf, Gerald Goodman

The Open Journal of Occupational Therapy

Background: Chronic diseases limit participation in meaningful daily activities, roles, and routines, which can negatively impact occupational competence, a sense of self, and life satisfaction, especially when hospitalization is required to manage disease symptoms. Standardized measures of occupational competence and related functional, cognitive, and environmental factors may enhance occupational therapists’ ability to identify potential barriers to and make targeted recommendations for self- and health management in the community.

Method: This cross-sectional study investigated occupational competence in patients hospitalized with chronic conditions. The participants completed measures of occupational competence, values, self-care function, environmental impact, and functional cognition while hospitalized. …

Social Participation And Navigation With Adolescent And Young Adult Brain Tumor Survivors: Usability And Potential Benefits, Gary Bedell, Nicole Porter, Miranda Cullen, Zachary Gould, Stephanie Freeman

The Open Journal of Occupational Therapy

Background: This study examined the usability and potential benefits of Social Participation and Navigation (SPAN), a virtual coaching goal planning intervention, which was modified for adolescent and young adult (AYA) brain tumor survivors who often experience social participation challenges.

Methods: Four AYA brain tumor survivors participated in a brief trial of the modified SPAN consisting of four weekly coaching sessions with trained supervised occupational therapy graduate students and use of a website and web application to assist with goal planning and achievement. The participants rated their social participation and SPAN-specific skills pre/post program. The participants and parents completed 1-week …

Reflections From The Other Side Of Acute Care, Debbie Amini

The Open Journal of Occupational Therapy

An occupational therapist of 40 years experiences a traumatic event during her time in an acute care hospital. She journeys through a host of life-altering experiences, including cognitive decline, delusion, paranoia, and an inability to engage in her desired occupations. While on this journey and during reflections following her return home, she is able to see more clearly how an occupational therapist may have assisted with several of the major concerns she was experiencing, thus improving her well-being and quality of life. She is an Assistant Editor for the Open Journal of Occupational Therapy (OJOT) and this is her story.

The Constitution Of Japan, Harun Alrasjid

Jurnal Hukum & Pembangunan

No abstract provided.

Pissarro's Boulevard Montmartre Paintings As A Cultural Landscape, Hala Ibrahim Mohamed Elsaed

Journal of Art, Design and Music

The term "cultural landscape" describes an area of the Earth that has been altered by human action and is associated with a historic event, activity, person, or other cultural and aesthetic value. This research reveals the role of paintings in protecting cultural landscapes which improve the quality of life, sense of place, and identity for future generations. It also shows the beauty and culture of areas through an experience of a great artist.

The Poetic Beauty Of Resistance, Monsour Owolabi

Writing Beyond the Prison Living Archive

poetry

Human Patient-Derived Brain Tumor Models To Recapitulate Ependymoma Tumor Vasculature., Min D Tang-Schomer, Markus J Bookland, Jack E Sargent, Taylor N Jackvony

Faculty Research 2023

Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient's tumor in vitro. Our data showed that the inclusion of VEGF in serum-free, mixed neural and endothelial cell culture media supported the in vitro growth of all four ependymoma patient samples. The growth was driven by Nestin and Ki67 double-positive cells in a putative cancer stem cell niche, which was manifested as rosette-looking clusters in 2D and spheroids in 3D. The effects of extracellular matrix (ECM) such as collagen …

Social Justice Autobiography, Levester Loggins

Writing Beyond the Prison Living Archive

Essay

Who's Publishing What: There's No Coming Back From This, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Ann Garvin's newest novel, There's No Coming Back from This, revolves around a woman who stows away on the set of a major motion picture and has to solve a crime to keep her secret. Honest, endearing and unabashedly fun, Garvin has a special gift for writing about women who do too much in a world that asks too much from them.

Carbamoylated Erythropoietin-Induced Cerebral Blood Perfusion And Vascular Gene Regulation., Jayanarayanan Sadanandan, Monica Sathyanesan, Yutong Liu, Neeraj K Tiwari, Samuel S Newton

Faculty Research 2023

Cerebral hypoperfusion is associated with enhanced cognitive decline and increased risk of neuropsychiatric disorders. Erythropoietin (EPO) is a neurotrophic factor known to improve cognitive function in preclinical and clinical studies of neurodegenerative and psychiatric disorders. However, the clinical application of EPO is limited due to its erythropoietic activity that can adversely elevate hematocrit in non-anemic populations. Carbamoylated erythropoietin (CEPO), a chemically engineered non-erythropoietic derivative of EPO, does not alter hematocrit and maintains neurotrophic and behavioral effects comparable to EPO. Our study aimed to investigate the role of CEPO in cerebral hemodynamics. Magnetic resonance imaging (MRI) analysis indicated increased blood perfusion …

Preserving Family Artifacts, Ruth E. Bryan

Library Presentations

The Casey County Library is hosting a talk about “Preserving Family Artifacts” on Saturday July 15, 2023 at 11:00 am-Noon. Anyone interested in learning how to care for important family papers, photographs, sound and film recordings, digital information, and books and Bibles are welcome to attend. Ruth E. Bryan, the University Archivist for the University of Kentucky Library’s Special Collections Research Center, will be sharing key steps to keep your family treasures safe for future generations.

Loss Of Pml Nuclear Bodies In Familial Amyotrophic Lateral Sclerosis-Frontotemporal Dementia, Francesco Antoniani, Marco Cimino, Laura Mediani, Jonathan Vinet, Enza M. Verde, Valentina Secco, Alfred Yamoah, Priyanka Tripathi, Eleonora Aronica, Maria Elena Cicardi, Davide Trotti, Jared Sterneckert, Anand Goswami, Serena Carra

Farber Institute for Neuroscience Faculty Papers

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The critical genetic players of ALS and FTD are the TARDBP, FUS and C9orf72 genes, whose protein products, TDP-43, FUS and the C9orf72-dipeptide repeat proteins, accumulate in form of cytoplasmic inclusions. The majority of the studies focus on the understanding of how cells control TDP-43 and FUS aggregation in the cytoplasm, overlooking how dysfunctions occurring at the nuclear level may influence the maintenance of protein solubility outside of the nucleus. However, protein quality control (PQC) systems that maintain protein homeostasis comprise …

Correlation Of Placental Weight With Neonatal Weight And Hba1c In Normal Sudanese Pregnant Ladies In Alban-Jaded Teaching Hospital : Correlation Of Placental Weight With Neonatal Weight And Hba1c, Ibrahim Ali, Asim Osman, Wala Ahmed

Iraqi National Journal of Medicine

Background: The placenta is a life-supporting organ for the growing fetus. Several studies have highlighted the relationship between placental weight and neonatal birth weight; however, the role of glycosylated hemoglobin (HbA1c) has not been addressed. Aim: The study aimed to determine the relationship between the placental weight, neonatal birth weight, and HbA1c at term pregnancy in a Sudanese hospital. Methods: This was a cross-sectional hospital-based study conducted at Al Ban-Jaded Hospital between November and December 2022. Data, including the gestational age at delivery (in weeks), parity, mode of delivery, fetal birth weight, placental weight, fetal gender, and presence or absence …

A World Of Difference: The Fundamental Opposition Between Transhumanist “Welfarism” And Disability Advocacy, Susan B. Levin

Philosophy: Faculty Publications

From the standpoint of disability advocacy, further exploration of the concept of well-being stands to be availing. The notion that “welfarism” about disability, which Julian Savulescu and Guy Kahane debuted, qualifies as helpful is encouraged by their claim that welfarism shares important commitments with that advocacy. As becomes clear when they apply their welfarist frame to procreative decisions, endorsing welfarism would, in fact, sharply undermine it. Savulescu and Kahane's Principle of Procreative Beneficence—which reflects transhumanism, or advocacy of radical bioenhancement—morally requires parents to choose the child who will, in all probability, have “the best life.” Assuming the emergence of potent …

Who's Publishing What: Morning In This Broken World, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Katrina Kittle's poignant novel, Morning in this Broken World, launches Sept. 1. Bestselling novelist Adriana Trigiani describes it as "a novel that celebrates love and hope and why we matter to one another."