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Articles 529201 - 529230 of 5209161
Full-Text Articles in Entire DC Network
2023-July-18-Etsu Alumni Association Announces New Officers, Directors, University Marketing And Communication, East Tennessee State University
2023-July-18-Etsu Alumni Association Announces New Officers, Directors, University Marketing And Communication, East Tennessee State University
ETSU News
(July 18, 2023) A new slate of officers and directors will lead the ETSU National Alumni Association during the upcoming year.
Tom Tull, an MBA graduate from the East Tennessee State University Class of 1995, has been elected as president. Tull has over 30 years of health care experience and is a longtime member of the Ballad Health team, where he currently serves as vice president and chief experience officer.
Serving as president-elect is Dr. Virginia Bieber, a three-time graduate of ETSU whose degrees include an M.S. in clinical nutrition and an Ed.D. in educational leadership and policy …
Secondary Analysis Of A James Lind Alliance Priority Setting Partnership To Facilitate Knowledge Translation In Degenerative Cervical Myelopathy (Dcm): Insights From Ao Spine Recode-Dcm, Benjamin Davies, Jamie Brannigan, Oliver D. Mowforth, Danyal Khan, Angus G.K. Mcnair, Lindsay Tetreault, Iwan Sadler, Ellen Sarewitz, Bizhan Aarabi, Brian Kwon, Toto Gronlund, Vafa Rahimi-Movaghar, Carl Moritz Zipser, Peter John Hutchinson, Shekar Kurpad, James S. Harrop, Jefferson R. Wilson, James D. Guest, Michael G. Fehlings, Mark R.N. Kotter
Secondary Analysis Of A James Lind Alliance Priority Setting Partnership To Facilitate Knowledge Translation In Degenerative Cervical Myelopathy (Dcm): Insights From Ao Spine Recode-Dcm, Benjamin Davies, Jamie Brannigan, Oliver D. Mowforth, Danyal Khan, Angus G.K. Mcnair, Lindsay Tetreault, Iwan Sadler, Ellen Sarewitz, Bizhan Aarabi, Brian Kwon, Toto Gronlund, Vafa Rahimi-Movaghar, Carl Moritz Zipser, Peter John Hutchinson, Shekar Kurpad, James S. Harrop, Jefferson R. Wilson, James D. Guest, Michael G. Fehlings, Mark R.N. Kotter
Department of Neurosurgery Faculty Papers
OBJECTIVES: To explore whether a James Lind Alliance Priority Setting Partnership could provide insights on knowledge translation within the field of degenerative cervical myelopathy (DCM).
DESIGN: Secondary analysis of a James Lind Alliance Priority Setting Partnership process for DCM.
PARTICIPANTS AND SETTING: DCM stake holders, including spinal surgeons, people with myelopathy and other healthcare professionals, were surveyed internationally. Research suggestions submitted by stakeholders but considered answered were identified. Sampling characteristics of respondents were compared with the overall cohort to identify subgroups underserved by current knowledge translation.
RESULTS: The survey was completed by 423 individuals from 68 different countries. A total …
Radar Processing Techniques For Using The Limesdr Mini As A Short-Range Lfm Radar, Jacob Scott Stratford
Radar Processing Techniques For Using The Limesdr Mini As A Short-Range Lfm Radar, Jacob Scott Stratford
Theses and Dissertations
Drone-mounted ground penetrating radar (GPR) has the capability to investigate terrain that is inaccessible or hazardous to humans. A linear frequency-modulated (LFM) radar with the potential for GPR applications is described based on the LimeSDR Mini software defined radio (SDR). Challenges of the LimeSDR Mini radar include the SDR's lack of support for transmitter-receiver synchronization and high bleedthrough leakage. These issues are overcome through corrective software processing techniques including deconvolution of the SDR's system impulse response and digital feed-through nulling. Feed-through nulling is effective at reducing bleedthrough leakage, achieving a 26 dB reduction in power. Although high noise can confound …
Remembering Martyrdom: Delacroix's Massacre Of Chios As A Site Of Collective Memory, Colette Burton
Remembering Martyrdom: Delacroix's Massacre Of Chios As A Site Of Collective Memory, Colette Burton
Theses and Dissertations
The Massacre of Chios (1824) by Eugéne Delacroix illustrates the titular genocide from the Greek War of Independence. This genocide was a veritable razing of the entire island by Ottoman Turks in 1822. Today, a replica of Delacroix's painting resides on the island inside the entrance of the Chios Byzantine Museum, located in a converted mosque built on the ruins of a Christian church. This site is a case for the existence of non-Western temporalities, including liturgical and Aegean temporalities, as they pertain to the commemoration of the massacre through interaction with the replica. These temporalities are not causal or …
Patients Hospitalized With Acute Heart Failure, Worsening Renal Function, And Persistent Congestion Are At High Risk For Adverse Outcomes Despite Current Medical Therapy, Lauren Cooper, Adam Devore, Jennifer A. Cowger, Sean Pinney, David Baran, Tracy A. Dewald, Tara Burt, Jan B. Pietzsch, Antony Walton, Keith Aaronson, Palak Shah
Patients Hospitalized With Acute Heart Failure, Worsening Renal Function, And Persistent Congestion Are At High Risk For Adverse Outcomes Despite Current Medical Therapy, Lauren Cooper, Adam Devore, Jennifer A. Cowger, Sean Pinney, David Baran, Tracy A. Dewald, Tara Burt, Jan B. Pietzsch, Antony Walton, Keith Aaronson, Palak Shah
Cardiology Articles
INTRODUCTION: Approximately 1/3 of patients with acute decompensated heart failure (ADHF) are discharged with persistent congestion. Worsening renal function (WRF) occurs in approximately 50% of patients hospitalized for ADHF and the combination of WRF and persistent congestion are associated with higher risk of mortality and HF readmissions.
METHODS: We designed a multicenter, prospective registry to describe current treatments and outcomes for patients hospitalized with ADHF complicated by WRF (defined as a creatinine increase ≥0.3 mg/dL) and persistent congestion at 96 h. Study participants were followed during the hospitalization and through 90-day post-discharge. Hospitalization costs were analyzed in an economic substudy. …
Fault Aware Task Scheduling In Cloud Using Min-Min And Dbscan, S. M.F.D.Syed Mustapha, Punit Gupta
Fault Aware Task Scheduling In Cloud Using Min-Min And Dbscan, S. M.F.D.Syed Mustapha, Punit Gupta
All Works
Cloud computing leverages computing resources by managing these resources globally in a more efficient manner as compared to individual resource services. It requires us to deliver the resources in a heterogeneous environment and also in a highly dynamic nature. Hence, there is always a risk of resource allocation failure that can maximize the delay in task execution. Such adverse impact in the cloud environment also raises questions on quality of service (QoS). Resource management for cloud application and service have bigger challenges and many researchers have proposed several solutions but there is room for improvement. Clustering the resources clustering and …
Ursula Shepherd Oral History Interview, Ursula Shepherd
Ursula Shepherd Oral History Interview, Ursula Shepherd
Raymond College
No abstract provided.
Two Killings, One Common Problem: Deaths Of Homeless Men Jordan Neely And Charles Brito Shows They Were Failed, Anna G. Cominsky '05
Two Killings, One Common Problem: Deaths Of Homeless Men Jordan Neely And Charles Brito Shows They Were Failed, Anna G. Cominsky '05
Articles & Chapters
No abstract provided.
Lidar Voxel Segmentation Using 3d Convolutional Neural Networks, Yuval H. Levental
Lidar Voxel Segmentation Using 3d Convolutional Neural Networks, Yuval H. Levental
Theses
Light detection and ranging (lidar) forest models are important for studying forest composition in great detail, and for tracking objects in the understory. In this study we used DIRSIG, a first-principles and physics-based simulation tool, to turn the lidar data into voxels, towards classifying forest voxel types. A voxel is a 3D cube where the dimension represents a certain distance. These voxels are split into categories consisting of background, leaf, bark, ground, and object elements. Voxel content is then predicted from the provided simulated and real National Ecological Observation Network (NEON) data. The inputs are 3D neighborhood cubes which surround …
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis By Modulating Microtubule-Associated Serine/Threonine Kinase-Like/Wnt/Β-Catenin Signaling, Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy Kiran Bastola, Punita Dhawan, Amar B. Singh
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis By Modulating Microtubule-Associated Serine/Threonine Kinase-Like/Wnt/Β-Catenin Signaling, Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy Kiran Bastola, Punita Dhawan, Amar B. Singh
Department of Biochemistry: Faculty Publications
Background: Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths. A positive association between PYCR2 (pyrroline-5-carboxylate reductase-2), a terminal enzyme of proline metabolism, and CRC aggressiveness was recently reported. However, how PYCR2 promotes colon carcinogenesis remains ill understood. Methods: A comprehensive analysis was performed using publicly available cancer databases and CRC patient cohorts. Proteomics and biochemical evaluations were performed along with genetic manipulations and in vivo tumor growth assays to gain a mechanistic understanding. Results: PYCR2 expression was significantly upregulated in CRC and associated with poor patient survival, specifically among PYCR …
Editorial: Rising Stars In Microbial Physiology And Metabolism: 2022, Nicole R. Buan, Ulrike Kappler
Editorial: Rising Stars In Microbial Physiology And Metabolism: 2022, Nicole R. Buan, Ulrike Kappler
Department of Biochemistry: Faculty Publications
This Research Topic was initiated to highlight work by young authors, the rising stars in the field of microbial physiology and metabolism. Microbial physiology and metabolism is an interdisciplinary field of research that seeks to uncover how the metabolic pathways of a cell work together to determine cell fate and function, whether that be growth, replication, pathogenicity, predation, respiration and fermentation, homeostasis or death. Ultimately, researchers like the ones featured here seek to integrate biological information and physicochemical parameters to try to find the underlying rules governing microbial function so that we can understand, predict and design microbes and microbial …
Rewiring Of Aminoacyl-Trna Synthetase Localization And Interactions In Plants With Extensive Mitochondrial Trna Gene Loss, Jessica M. Warren, Amanda K. Broz, Ana Martinez-Hottovy, Christian Elowsky, Alan C. Christensen, Daniel B. Sloan
Rewiring Of Aminoacyl-Trna Synthetase Localization And Interactions In Plants With Extensive Mitochondrial Trna Gene Loss, Jessica M. Warren, Amanda K. Broz, Ana Martinez-Hottovy, Christian Elowsky, Alan C. Christensen, Daniel B. Sloan
School of Biological Sciences: Faculty Publications
The number of tRNAs encoded in plant mitochondrial genomes varies considerably. Ongoing loss of bacterial-like mitochondrial tRNA genes in many lineages necessitates the import of nuclear-encoded counterparts that share little sequence similarity. Because tRNAs are involved in highly specific molecular interactions, this replacement process raises questions about the identity and trafficking of enzymes necessary for the maturation and function of newly imported tRNAs. In particular, the aminoacyl-tRNA synthetases (aaRSs) that charge tRNAs are usually divided into distinct classes that specialize on either organellar (mitochondrial and plastid) or nuclear-encoded (cytosolic) tRNAs. Here, we investigate the evolution of aaRS subcellular localization in …
Unh Named To Money’S 2023 Best Colleges In America List, Keith Testa
Unh Named To Money’S 2023 Best Colleges In America List, Keith Testa
UNH Today Archive
No abstract provided.
Interpreting P Values In 2023, Jennifer K. Homa-Bonell
Interpreting P Values In 2023, Jennifer K. Homa-Bonell
Journal of Patient-Centered Research and Reviews
If recent experiences shared among the biostatistician community are indicative of a sea change in research, then a most-welcome culture shift in dialogue surrounding the proper use and interpretation of the P value, which measures statistical probability, is underway. This editorial strives to offer guidance for researchers who would like to incorporate more comprehensive reporting in their research, namely, a broader discussion that goes beyond looking at the P value by itself and includes effect size estimates, confidence intervals, and clinical implications when interpreting quantitative results. Another evolving development in clinical research is the preferred language when referring …
Previous Health Care Experiences’ Influence On Health Care Perceptions Among Residents In Six Homeless Shelters In Seattle, Washington, July–October 2021, Ashley A. Meehan, Sarah N. Cox, Nicholas B. Thuo, Julia H. Rogers, Amy C. Link, Miguel A. Martinez, Natalie K. Lo, Brian J. Manns, Melissa A. Rolfes, Eric J. Chow, Helen Y. Chu, Emily Mosites, Morhaf Al Achkar
Previous Health Care Experiences’ Influence On Health Care Perceptions Among Residents In Six Homeless Shelters In Seattle, Washington, July–October 2021, Ashley A. Meehan, Sarah N. Cox, Nicholas B. Thuo, Julia H. Rogers, Amy C. Link, Miguel A. Martinez, Natalie K. Lo, Brian J. Manns, Melissa A. Rolfes, Eric J. Chow, Helen Y. Chu, Emily Mosites, Morhaf Al Achkar
Journal of Patient-Centered Research and Reviews
Purpose: The study purpose was to learn and describe 1) where homeless shelter residents receive health care, 2) what contributes to positive or negative health care experiences among shelter residents, and 3) shelter resident perceptions toward health care.
Methods: Semi-structured interviews (SSIs) utilizing purposive sampling and focus group discussions (FGDs) utilizing convenience sampling were conducted at 6 homeless shelters in Seattle-King County, Washington, during July–October 2021. All residents (age ≥ 18) were eligible to participate. SSIs were conducted with 25 residents, and 8 FGDs were held. Thematic analysis was conducted using Dedoose.
Results: Participants received health care …
Calcium Carbonate As A Potential Intervention To Prevent Labor Dystocia: Narrative Review Of The Literature, Sabahat Raees, Marie Forgie, Rita Mitchell, Emily Malloy
Calcium Carbonate As A Potential Intervention To Prevent Labor Dystocia: Narrative Review Of The Literature, Sabahat Raees, Marie Forgie, Rita Mitchell, Emily Malloy
Journal of Patient-Centered Research and Reviews
Anecdotally, there are attestations from clinicians of calcium carbonate being used successfully for laboring people experiencing labor dystocia. The goal of this narrative review was to provide a synopsis of pertinent literature on calcium use in obstetrics to explore the potential benefit of calcium carbonate as a simple and low-cost intervention for prevention or treatment of labor dystocia. To answer how calcium and carbonate physiologically contribute to myometrium contractility, we conducted a literature search of English-language peer-reviewed articles, with no year limitation, consisting of the keywords “calcium,” “calcium carbonate,” “calcium gluconate,” “pregnancy,” “hemorrhage,” and variations of “smooth muscle contractility” and …
Abstracts From The 2023 Health Care Systems Research Network (Hcsrn) Annual Conference, Denver, Colorado
Journal of Patient-Centered Research and Reviews
The Health Care Systems Research Network (HCSRN) is comprised of 20 learning health systems with embedded population-based research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate project findings, explore scientific collaborations, and share insights about conducting research in real-world care delivery settings. Abstracts presented at HCSRN 2023 are published in this issue supplement of Journal of Patient-Centered Research and Reviews, the journal of record for HCSRN’s annual conference proceedings.
External Behavior Of A Logic Program And Verification Of Refactoring, Jorge Fandinno, Zachary Hansen, Yuliya Lierler, Vladimir Lifschitz, Nathan Temple
External Behavior Of A Logic Program And Verification Of Refactoring, Jorge Fandinno, Zachary Hansen, Yuliya Lierler, Vladimir Lifschitz, Nathan Temple
Computer Science Faculty Publications
Refactoring is modifying a program without changing its external behavior. In this paper, we make the concept of external behavior precise for a simple answer set programming language. Then we describe a proof assistant for the task of verifying that refactoring a program in that language is performed correctly.
Examining The Levels Of Compassion Satisfaction Of Critical Care Nurses During The Covid-19 Pandemic, Abigail Mitchell, Alexandra Isabella Yacub
Examining The Levels Of Compassion Satisfaction Of Critical Care Nurses During The Covid-19 Pandemic, Abigail Mitchell, Alexandra Isabella Yacub
Creating Healthy Work Environments (CHWE)
Allowing critical care nurses to recognize factors impacting their work environment and professional quality of life has proven to lessen unpredictable events of compassion fatigue (CF). There is a positive correlation between identifying factors and job satisfaction, retention, and compassion satisfaction resulting in a better quality of care for patients.
Evaluation Of Bio-Friendly Formulations From Siderophore-Producing Fluorescent Pseudomonas As Biocontrol Agents For The Management Of Soil-Borne Fungi, Fusarium Oxysporum And Rhizoctonia Solani, Gaber Attia Abo-Zaid, Ahmed Salah Abdullah, Nadia Abdel-Mohsen Soliman, Ebaa Ebrahim El-Sharouny, Abdulaziz A. Al-Askar, Yiming Su, Ahmed Abdelkhalek, Soraya Abdel-Fattah Sabry
Evaluation Of Bio-Friendly Formulations From Siderophore-Producing Fluorescent Pseudomonas As Biocontrol Agents For The Management Of Soil-Borne Fungi, Fusarium Oxysporum And Rhizoctonia Solani, Gaber Attia Abo-Zaid, Ahmed Salah Abdullah, Nadia Abdel-Mohsen Soliman, Ebaa Ebrahim El-Sharouny, Abdulaziz A. Al-Askar, Yiming Su, Ahmed Abdelkhalek, Soraya Abdel-Fattah Sabry
Civil and Environmental Engineering Faculty Publications
Secretion of siderophores by Pseudomonas aeruginosa F2 and P. fluorescens JY3 was evaluated on chrome azurol S (CAS) agar plates and their inhibitory effect was inspected against Fusarium oxysporum and Rhizoctonia solani. Production of siderophores as biocontrol agents from F2 and JY3 was accomplished in two optimized media. Afterward, cell-free supernatants of the bacterial cultures containing siderophores were used for the preparation of two bio-friendly formulations for the management of F. oxysporum and R. solani under greenhouse conditions. The investigated bacterial isolates, F2 and JY3, showed antagonistic activity in vitro against F. oxysporum and R. solani and produced siderophores …
Regresi Ambang Untuk Mendalami Pengaruh Nonlinier Kekuatan Pasar Terhadap Pinjaman Bank Di Asean-5, Mahjus Ekananda
Regresi Ambang Untuk Mendalami Pengaruh Nonlinier Kekuatan Pasar Terhadap Pinjaman Bank Di Asean-5, Mahjus Ekananda
Jurnal Ekonomi dan Pembangunan Indonesia
Credit distribution has developed rapidly in the ASEAN region and it is largely dominated by the banking sector compared to other financial institutions. This study explores the effects of various changes to the GDP growth regime, firm size, and monetary policy. The objects of this research are commercial banks in ASEAN-5 from year 2010 to 2019. This study utilises the threshold regression method and a single proxy to measure market power. Results of this study found that monetary policy and market forces affect productive credit. Changes in impact that occur are mostly due to different behavior between banks in response …
Topological Comparison Of Some Dimension Reduction Methods Using Persistent Homology On Eeg Data, Eddy Kwessi
Topological Comparison Of Some Dimension Reduction Methods Using Persistent Homology On Eeg Data, Eddy Kwessi
Mathematics Faculty Research
In this paper, we explore how to use topological tools to compare dimension reduction methods. We first make a brief overview of some of the methods often used in dimension reduction such as isometric feature mapping, Laplacian Eigenmaps, fast independent component analysis, kernel ridge regression, and t-distributed stochastic neighbor embedding. We then give a brief overview of some of the topological notions used in topological data analysis, such as barcodes, persistent homology, and Wasserstein distance. Theoretically, when these methods are applied on a data set, they can be interpreted differently. From EEG data embedded into a manifold of high dimension, …
Konig, Irene, Sophia Maier Garcia
Konig, Irene, Sophia Maier Garcia
Bronx Jewish History Project
Irene Konig’s mother was born in Ukraine, coming to the United States at 2 years old, while her father was born on the Lower East Side. Konig grew up with her parents and brother in a one bedroom apartment on Morris Avenue across from Taft High School. At 15 years old, they moved to East 180 St near Tremont Avenue because their apartment building was sinking and condemned by the city, before moving to the Highbridge neighborhood, later. She recalls the Bronx deteriorating, with burning buildings and trash on the streets, as she got older.
On Morris Avenue, the neighborhood …
Around 40 Percent Of Preterm Infants With Bpd-Ph Die Before The Age Of 2. Uab Studies Establish Two Significant Risk Factors Of The Condition., Public Relations
Around 40 Percent Of Preterm Infants With Bpd-Ph Die Before The Age Of 2. Uab Studies Establish Two Significant Risk Factors Of The Condition., Public Relations
Browse All News
No abstract provided.
Rhodium-Catalyzed Asymmetric Synthesis Of P-P And P-C Bonds, Sarah T. Chachula
Rhodium-Catalyzed Asymmetric Synthesis Of P-P And P-C Bonds, Sarah T. Chachula
Dartmouth College Ph.D Dissertations
Chapter 1: Synthesis, Structure, Dynamics, and Enantioface-Selective η3-Benzyl Coordination in the Chiral Rhodium Complexes Rh(diphos*)(η3-CH2Ph) Abstract: The rhodium benzyl complexes Rh(diphos*)(η3-CH2Ph) (1-14, diphos* = chiral bis(phosphine)) were prepared either by treatment of Rh(COD)(η3-CH2Ph) (15, COD = 1,5-cyclooctadiene) with diphos*, or from the reaction of [Rh(diphos*)(Cl)]2 (16- 20) with PhCH2MgCl. For C2-symmetric diphos*, observation of one set of NMR signals for complexes 1-12 suggested that the two diastereomers in which different 3-benzyl enantiofaces were coordinated to rhodium interconverted rapidly on the NMR time scale via suprafacial shifts; observation of five inequivalent aryl 1H NMR signals showed that antarafacial shifts were slow …
Women With Large Vessel Occlusion Acute Ischemic Stroke Are Less Likely To Be Routed To Comprehensive Stroke Centers, Hussain M Azeem, Rania Abdelkhaleq, Louise D Mccullough, Sunil A Sheth, Youngran Kim
Women With Large Vessel Occlusion Acute Ischemic Stroke Are Less Likely To Be Routed To Comprehensive Stroke Centers, Hussain M Azeem, Rania Abdelkhaleq, Louise D Mccullough, Sunil A Sheth, Youngran Kim
Faculty, Staff and Student Publications
Background Prehospital routing of patients with large vessel occlusion (LVO) acute ischemic stroke (AIS) to centers capable of performing endovascular therapy may improve clinical outcomes. Here, we explore whether distance to comprehensive stroke centers (CSCs), stroke severity, and sex are associated with direct-to-CSC prehospital routing in patients with LVO AIS. Methods and Results In this cross-sectional study, we identified consecutive patients with LVO AIS from a prospectively collected multihospital registry throughout the greater Houston area from January 2019 to June 2020. Primary outcome was prehospital routing to CSC and was compared between men and women using modified Poisson regression including …
Integrating Genetics And Metabolomics From Multi-Ethnic And Multi-Fluid Data Reveals Putative Mechanisms For Age-Related Macular Degeneration, Yiheng Chen, Eric Boerwinkle, Robert Kaplan, Bharat Thyagarajan, Martha Daviglus, Charlotte E Joslin, Jianwen Cai, Marta Guasch-Ferré, Deirdre K Tobias, Eric Rimm, Alberto Ascherio, Karen Costenbader, Elizabeth Karlson, Lorelei Mucci, A Heather Eliassen, Oana Zeleznik, John Miller, Demetrios G Vavvas, Rufino Silva, Joan Miller, Frank Hu, Walter Willett, Jessica Lasky-Su, Peter Kraft, J Brent Richards, Stuart Macgregor, Deeba Husain, Liming Liang
Integrating Genetics And Metabolomics From Multi-Ethnic And Multi-Fluid Data Reveals Putative Mechanisms For Age-Related Macular Degeneration, Yiheng Chen, Eric Boerwinkle, Robert Kaplan, Bharat Thyagarajan, Martha Daviglus, Charlotte E Joslin, Jianwen Cai, Marta Guasch-Ferré, Deirdre K Tobias, Eric Rimm, Alberto Ascherio, Karen Costenbader, Elizabeth Karlson, Lorelei Mucci, A Heather Eliassen, Oana Zeleznik, John Miller, Demetrios G Vavvas, Rufino Silva, Joan Miller, Frank Hu, Walter Willett, Jessica Lasky-Su, Peter Kraft, J Brent Richards, Stuart Macgregor, Deeba Husain, Liming Liang
Faculty, Staff and Student Publications
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic genetic and metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16,144 advanced AMD cases and 17,832 controls, we identify 108 putatively causal relationships between plasma metabolites and advanced AMD. These metabolites are enriched in glycerophospholipid metabolism, lysophospholipid, triradylcglycerol, and long chain polyunsaturated fatty acid pathways. Bayesian genetic colocalization analysis and a customized metabolome-wide association approach prioritize putative causal …