Digital Commons Network^™

Mirabai: The Making Of A Saint, Nancy M. Martin

Religious Studies Faculty Books and Book Chapters

This book traces the narrative genealogy of the immensely popular Indian saint Mirabai from the earliest manuscript references to her through colonial and nationalist formations to scholarly and popular portrayals in the decades leading up to Indian independence. This iconic sixteenth-century woman is renowned for her unwavering love of God, her disregard for social hierarchies and gendered notions of honor and shame, and her challenge thereby to familial, feudal, and religious authorities. Though verifiable historical facts regarding her life are few, stories about her have multiplied across social, linguistic, regional, and religious boundaries. With attention to who is telling which …

The Vices Of Virtues: Making Room For Moral Testimony In The Life Of The Virtuous Person, Maria Waggoner

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation sheds light on new and unacknowledged difficulties that we face in striving to be (more) virtuous. By making use of empirical literature from moral, affective, and perceptual learning, I explore the potential cognitive and psychological relationships between having a virtue in one context and the tendency to exhibit vices in another. I do this by showing how morally good behavioral habits can also lead to morally inappropriate actions, when a virtuous moral perceptual system can give rise to moral illusions, and when our basic evaluative affective responses differ in their degree of sensitivity, leading to having some virtues …

The Transformation Of Congressional Policy Making In A Partisan Era, Patrick Rickert

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores the transformation of Congressional politics away from traditional practices and the consequences of those changes. In the House of Representatives, I consider this with respect to the party and chamber rule changes introduced by the new Republican majority after the 1994 election, while in the Senate I use the lens of paired voting to evaluate how the Senate has evolved. The first chapter discusses the literature on party government and theorizes how parties have used committees to achieve their goals. Chapters 2 and 3 center how Speaker Newt Gingrich used rule changes to alter the relationship between …

Gene Signature Reveals Decreased Sox10-Dependent Transcripts In Malignant Cells From Immune Checkpoint Inhibitor-Resistant Cutaneous Melanomas, Timothy J. Purwin, Signe Caksa, Ahmet Sacan, Claudia Capparelli, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Evidence is mounting for cross-resistance between immune checkpoint and targeted kinase inhibitor therapies in cutaneous melanoma patients. Since the loss of the transcription factor, SOX10, causes tolerance to MAPK pathway inhibitors, we used bioinformatic techniques to determine if reduced SOX10 expression/activity is associated with immune checkpoint inhibitor resistance. We integrated SOX10 ChIP-seq, knockout RNA-seq, and knockdown ATAC-seq data from melanoma cell models to develop a robust SOX10 gene signature. We used computational methods to validate this signature as a measure of SOX10-dependent activity in independent single-cell and bulk RNA-seq SOX10 knockdown, cell line panel, and MAPK inhibitor drug-resistant datasets. Evaluation …

Carrie Tingley Hospital Records & William Minear Papers: Seed Funding Project, Laura J. Hall, Jonathan M. Pringle

Posters and Presentations

No abstract provided.

20230725_Staff Pick For Quick Nursing Evidence Summaries, Lisa M. Acuff

HSLIC Blog Post

No abstract provided.

Sarcoma: Know The Signs And Symptoms, Staff

Browse All News

No abstract provided.

Crafting The Image Of Pelayo: Identity And State-Building In Early Medieval Asturian Chronicles, Erica Buchberger

History Faculty Publications

In the late ninth century, a series of chronicles from the Christian kingdom of Asturias staked a claim on Visigothic identity, and thus ancestral legitimacy to rule in Iberia, for Asturias and its kings. Connecting Pelayo, the first king of the Asturian kingdom, to the last Visigothic kings and crafting his image as an ideal Goth and Christian was essential to this process. Informed by scholarship on “borderlands” and boundary-making, this article demonstrates how the chroniclers renegotiated the parameters of Gothic identity to impose the idea of a strict border between legitimate and illegitimate, good Catholic and heretic, and loyalty …

Adaptive Gps Antenna Array Beam Nulling Effectiveness Under Varying Antenna Element Positioning, Aadesh Neel

Electrical and Computer Engineering ETDs

Global Positioning System (GPS) is an essential part of modern life but is susceptible to same frequency jamming. GPS jamming can add excessive noise to a received low power signal and have the capability to change or completely distort information being sent through the GPS signal. Adaptive antenna arrays have long since been a solution to mitigating GPS jamming via beamnulling algorithms. However, there is little research on the effectiveness of these beamnulling algorithms under varying element positioning. In this work, an adaptive antenna array, consisting of Right-Hand Circularly Polarized (RHCP) nearly square GPS antenna elements, was constructed and tested …

The Influence Of Mixing Duct Length And Phase Of Flight On Wall Temperatures Of A Rocket Based Combined Cycle Engine In Ejector And Air-Augmented Modes, Jonathan Grow

Doctoral Dissertations and Master's Theses

Rocket Based Combined Cycle (RBCC) engines have been theorized as a possible means of powering launch vehicles and high-speed atmospheric vehicles. By incorporating aspects of both air-breathing and rocket propulsion, RBCC engines promise up to a 230 % increase in specific impulse over traditional chemical rocket propulsion by entraining a secondary flow of atmospheric air and mixing it with the exhaust of a rocket motor. Students within the Embry-Riddle Future Space Explorers and Developers Society (ERFSEDS) identified a
problem of excessive heating and structural failure of the mixing duct during launch and transonic flight of a student-built flight test vehicle. …

How Enhancers Regulate Wavelike Gene Expression Patterns, Christine Mau, Heike Rudolf, Frederic Strobl, Benjamin Schmid, Timo Regensburger, Ralf Palmisano, Ernst Hk Stelzer, Leila Taher, Ezzat El-Sherif

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

A key problem in development is to understand how genes turn on or off at the right place and right time during embryogenesis. Such decisions are made by non-coding sequences called ‘enhancers.’ Much of our models of how enhancers work rely on the assumption that genes are activated de novo as stable domains across embryonic tissues. Such a view has been strengthened by the intensive landmark studies of the early patterning of the anterior-posterior (AP) axis of the Drosophila embryo, where indeed gene expression domains seem to arise more or less stably. However, careful analysis of gene expression patterns in …

The Importance Of An Onboarding Process For Librarian Success, Sonali Sugrim

Publications and Research

Starting a new job comes with its unique challenges. New librarians are expected to develop an understanding of their roles, often with no guidance. For assorted reasons, including staffing, time, and lack of planning, many libraries do not have an onboarding process. This article explores from a librarian’s perspective the key ingredients needed when starting a new job in this hybrid environment, with a focus on the importance of an onboarding process that prioritizes effective communication, documentation of institutional knowledge, and the long-term success of librarians. This article is a call for library leadership to do more to ensure librarians …

Insight Into The Optimization Of Implementation Time In Cob Construction: Field Test And Compressive Strength Versus Drying Kinetics, K Touati, Sahmarany B Al, Guern M Le, Mendili Y El, F Streiff, S Goodhew

School of Art, Design and Architecture

Mastering construction times is of paramount importance in making vernacular earth construction techniques attractive to modern clients. The work presented here is a contribution towards the optimization of the construction time of cob buildings. Therefore, this paper follows the evolution of a cob’s mechanical properties during its drying process in the case of a double-walling CobBauge system. Laboratory tests and in situ measurements were performed, and further results were described. Volumetric water content sensors were immersed in the walls of a CobBauge prototype building during its construction. The evolution of the cob layer’s compressive strength and Clegg Impact Value (CIV) …

Dual Targeting Of Cdk4/6 And Bcl-2 Exhibits A Potent Antitumor Effect On Mantle Cell Lymphoma, Yuxuan Che, Yang Liu, Yijing Li, Joseph M Mcintosh, Alexa Jordan, Wei Wang, Heng-Huan Lee, Jingling Jin, Yixin Yao, Zhongming Zhao, Vivian Changying Jiang, Michael Wang

Faculty, Staff and Student Publications

No abstract provided.

Agrp Neurons Are Not Indispensable For Body Weight Maintenance In Adult Mice, Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R Arenkiel, Yan Zhang, Qingchun Tong, Cheng Zhan

Faculty, Staff and Student Publications

In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in adults, and consistently, acute inhibition of AgRP neurons is known to reduce short-term food intake. Here, we adopted complementary methods to achieve nearly complete ablation of arcuate AgRP/NPY neurons in adult mice and report that lesioning arcuate AgRP/NPY neurons in adult mice causes no apparent alterations in ad libitum feeding or body weight. Consistent with previous studies, loss of AgRP/NPY neurons blunts fasting refeeding. Thus, our studies show …

Impact Of Type Of Induction Therapy On Outcomes In Older Adults With Aml After Allogeneic Stem Cell Transplantation, Nicholas J Short, Faustine Ong, Farhad Ravandi, Graciela Nogueras-Gonzalez, Tapan M Kadia, Courtney D Dinardo, Gautam Borthakur, Betul Oran, Gheath Al-Atrash, Rohtesh Mehta, Elias J Jabbour, Musa Yilmaz, Ghayas C Issa, Abhishek Maiti, Richard E Champlin, Hagop Kantarjian, Elizabeth J Shpall, Uday Popat

Faculty, Staff and Student Publications

Although venetoclax-based lower-intensity regimens have greatly improved outcomes for older adults with acute myeloid leukemia (AML) who are unfit for intensive chemotherapy, the optimal induction for older patients with newly diagnosed AML who are suitable candidates for hematopoietic stem cell transplant (HSCT) is controversial. We retrospectively analyzed the post HSCT outcomes of 127 patients ≥60 years of age who received induction therapy at our institution with intensive chemotherapy (IC; n = 44), lower-intensity therapy (LIT) without venetoclax (n = 29), or LIT with venetoclax (n = 54) and who underwent allogeneic HSCT in the first remission. The 2-year relapse-free survival …

Deep Learning-Based Tem Image Analysis For Fully Automated Detection Of Gold Nanoparticles Internalized Within Tumor Cell, Amrit Kaphle, Sandun Jayarathna, Hem Moktan, Maureen Aliru, Subhiksha Raghuram, Sang Hyun Cho

Faculty, Staff and Student Publications

Transmission electron microscopy (TEM) imaging can be used for detection/localization of gold nanoparticles (GNPs) within tumor cells. However, quantitative analysis of GNP-containing cellular TEM images typically relies on conventional/thresholding-based methods, which are manual, time-consuming, and prone to human errors. In this study, therefore, deep learning (DL)-based methods were developed for fully automated detection of GNPs from cellular TEM images. Several models of "you only look once (YOLO)" v5 were implemented, with a few adjustments to enhance the model's performance by applying the transfer learning approach, adjusting the size of the input image, and choosing the best optimization algorithm. Seventy-eight original …

Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Matthew W Mccarthy, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly, Activ-1 Im Study Group Members

Faculty, Staff and Student Publications

IMPORTANCE: Immune dysregulation contributes to poorer outcomes in COVID-19.

OBJECTIVE: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.

DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and …

The Mastery Lifestyle Intervention To Reduce Biopsychosocial Risks For Pregnant Latinas And African Americans And Their Infants: Protocol For A Randomized Controlled Trial, Asim C Akbulut, Armand M Jaminon, Ehsan Natour, Roberto Lorusso, Joachim E Wildberger, Barend Mees, Geert Willem Schurink, Michael J Jacobs, Jack Cleutjens, Ingrid Krapels, Alexander Gombert, Jos G Maessen, Ryan Accord, Tammo Delhaas, Simon Schalla, Leon J Schurgers, Elham Bidar

Faculty, Staff and Student Publications

Current management guidelines for ascending thoracic aortic aneurysms (aTAA) recommend intervention once ascending or sinus diameter reaches 5-5.5 cm or shows a growth rate of >0.5 cm/year estimated from echo/CT/MRI. However, many aTAA dissections (aTAAD) occur in vessels with diameters below the surgical intervention threshold ofMoreover, during aTAA repair surgeons observe and experience considerable variations in tissue strength, thickness, and stiffness that appear not fully explained by patient risk factors. To improve the understanding of aTAA pathophysiology, we established a multi-disciplinary research infrastructure: The Maastricht acquisition platform for studying mechanisms of tissue-cell crosstalk (MAPEX). The explicit scientific focus of the …

Flux-Quanta Injection For Nonreciprocal Current Control In A Two-Dimensional Noncentrosymmetric Superconducting Structure, Serafim Teknowijoyo, Sara Chahid, Armen Gulian

Mathematics, Physics, and Computer Science Faculty Articles and Research

We designed and experimentally demonstrated a four-terminal superconducting device, a “quadristor,” that can function as a nonlatching (reversible) superconducting switch from the diode regime to the resistive state by application of a control current much smaller than the main transport current. The device uses a vortex-based superconducting-diode mechanism that is switched back and forth via the injection of flux quanta through auxiliary current leads. Our finding opens a new research area in the field of superconducting electronics.

Alemtuzumab And Cxcl9 Levels Predict Likelihood Of Sustained Engraftment After Reduced-Intensity Conditioning Hct, Ashley V Geerlinks, Shalini Shenoy, Et Al.

2020-Current year OA Pubs

Overall survival after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) using alemtuzumab, fludarabine, and melphalan is associated with high rates of mixed chimerism (MC) and secondary graft failure (GF). We hypothesized that peritransplantation alemtuzumab levels or specific patterns of inflammation would predict these risks. We assessed samples from the Bone Marrow Transplant Clinical Trials Network 1204 (NCT01998633) to study the impact of alemtuzumab levels and cytokine patterns on MC and impending or established secondary GF (defined as donor chimerism <5% after initial engraftment and/or requirement of cellular intervention). Thirty-three patients with hemophagocytic lymphohistiocytosis (n = 25) and other IEIs (n = 8) who underwent HCTs with T-cell-replete grafts were included. Patients with day 0 alemtuzumab levels ≤0.32 μg/mL had a markedly lower incidence of MC, 14.3%, vs 90.9% in patients with levels >0.32 μg/mL (P = .008). Impending or established secondary GF was only observed in patients with day 0 alemtuzumab levels …

Atr Protects Ongoing And Newly Assembled Dna Replication Forks Through Distinct Mechanisms, Wendy Leung, Antoine Simoneau, Sneha Saxena, Jessica Jackson, Parasvi S Patel, Mangsi Limbu, Alessandro Vindigni, Lee Zou

2020-Current year OA Pubs

The ATR kinase safeguards genomic integrity during S phase, but how ATR protects DNA replication forks remains incompletely understood. Here, we combine four distinct assays to analyze ATR functions at ongoing and newly assembled replication forks upon replication inhibition by hydroxyurea. At ongoing forks, ATR inhibitor (ATRi) increases MRE11- and EXO1-mediated nascent DNA degradation from PrimPol-generated, single-stranded DNA (ssDNA) gaps. ATRi also exposes template ssDNA through fork uncoupling and nascent DNA degradation. Electron microscopy reveals that ATRi reduces reversed forks by increasing gap-dependent nascent DNA degradation. At new forks, ATRi triggers MRE11- and CtIP-initiated template DNA degradation by EXO1, exposing …

Microbiota-Produced Indole Metabolites Disrupt Mitochondrial Function And Inhibit Cryptosporidium Parvum Growth, Lisa J Funkhouser-Jones, Rui Xu, Georgia Wilke, Yong Fu, Lawrence A Schriefer, Heyde Makimaa, Rachel Rodgers, Elizabeth A Kennedy, Kelli L Vandussen, Thaddeus S Stappenbeck, Megan T Baldridge, L David Sibley

2020-Current year OA Pubs

Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children in resource-poor settings. To explore microbial influences on susceptibility, we screened 85 microbiota-associated metabolites for their effects on Cryptosporidium parvum growth in vitro. We identify eight inhibitory metabolites in three main classes: secondary bile salts/acids, a vitamin B

Membrane Stretch As The Mechanism Of Activation Of Piezo1 Ion Channels In Chondrocytes, Alireza Savadipour, Robert J Nims, Neda Rashidi, Jaquelin M Garcia-Castorena, Ruhang Tang, Gabrielle K Marushack, Sara J Oswald, Wolfgang B Liedtke, Farshid Guilak

2020-Current year OA Pubs

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce injurious levels of biomechanical strain in articular chondrocytes and mediate cell death. However, the mechanisms of channel gating in response to high cellular deformation and the strain thresholds for activating PIEZO channels remain unclear. We coupled studies of single-cell compression using atomic force microscopy (AFM) with finite element modeling (FEM) to identify the biophysical mechanisms of PIEZO-mediated calcium (Ca

Accelerating Cryptic Pocket Discovery Using Alphafold, Artur Meller, Soumendranath Bhakat, Shahlo Solieva, Gregory R Bowman

2020-Current year OA Pubs

Cryptic pockets, or pockets absent in ligand-free, experimentally determined structures, hold great potential as drug targets. However, cryptic pocket openings are often beyond the reach of conventional biomolecular simulations because certain cryptic pocket openings involve slow motions. Here, we investigate whether AlphaFold can be used to accelerate cryptic pocket discovery either by generating structures with open pockets directly or generating structures with partially open pockets that can be used as starting points for simulations. We use AlphaFold to generate ensembles for 10 known cryptic pocket examples, including five that were deposited after AlphaFold's training data were extracted from the PDB. …

Utility Of Targeted Gene Sequencing To Differentiate Myeloid Malignancies From Other Cytopenic Conditions, Amy E Dezern, Robert S Fulton, Matthew J Walter, Et Al.

2020-Current year OA Pubs

The National Heart, Lung, and Blood Institute-funded National MDS Natural History Study (NCT02775383) is a prospective cohort study enrolling patients with cytopenia with suspected myelodysplastic syndromes (MDS) to evaluate factors associated with disease. Here, we sequenced 53 genes in bone marrow samples harvested from 1298 patients diagnosed with myeloid malignancy, including MDS and non-MDS myeloid malignancy or alternative marrow conditions with cytopenia based on concordance between independent histopathologic reviews (local, centralized, and tertiary to adjudicate disagreements when needed). We developed a novel 2-stage diagnostic classifier based on mutational profiles in 18 of 53 sequenced genes that were sufficient to best …

Momelotinib Long-Term Safety And Survival In Myelofibrosis: Integrated Analysis Of Phase 3 Randomized Controlled Trials, Srdan Verstovsek, Stephen T Oh, Et Al.

2020-Current year OA Pubs

Momelotinib is the first inhibitor of Janus kinase 1 (JAK1) and JAK2 shown to also inhibit activin A receptor type 1 (ACVR1), a key regulator of iron homeostasis, and has demonstrated improvements in splenomegaly, constitutional symptoms, and anemia in myelofibrosis (MF). This long-term analysis pooled data from 3 randomized phase 3 studies of momelotinib (MOMENTUM, SIMPLIFY-1, and SIMPLIFY-2), representing MF disease from early (JAK inhibitor-naive) to late (JAK inhibitor-experienced) stages. Patients in the control arms (danazol in MOMENTUM, ruxolitinib in SIMPLIFY-1, and best available therapy in SIMPLIFY-2) could cross over to receive momelotinib at the end of the 24-week randomized …

Alemtuzumab And Cxcl9 Levels Predict Likelihood Of Sustained Engraftment After Reduced-Intensity Conditioning Hct, Ryan Fleischmann, Michael A Pulsipher, Mary Eapen, James A Connelly, Catherine M Bollard, Sung-Yun Pai, Christine N Duncan, Leslie S Kean, K Scott Baker, Lauri M Burroughs, Jeffrey R Andolina, Shalini Shenoy, Philip Roehrs, Rabi Hanna, Julie-An Talano, Kirk R Schultz, Elizabeth O Stenger, Howard Lin, Adi Zoref-Lorenz, Kenneth L Mcclain, Michael B Jordan, Tsz-Kwong Man, Carl E Allen, Rebecca A Marsh

Faculty, Staff and Students Publications

Overall survival after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) using alemtuzumab, fludarabine, and melphalan is associated with high rates of mixed chimerism (MC) and secondary graft failure (GF). We hypothesized that peritransplantation alemtuzumab levels or specific patterns of inflammation would predict these risks. We assessed samples from the Bone Marrow Transplant Clinical Trials Network 1204 (NCT01998633) to study the impact of alemtuzumab levels and cytokine patterns on MC and impending or established secondary GF (defined as donor chimerism < 5% after initial engraftment and/or requirement of cellular intervention). Thirty-three patients with hemophagocytic lymphohistiocytosis (n = 25) and other IEIs (n = 8) who underwent HCTs with T-cell–replete grafts were included. Patients with day 0 alemtuzumab levels ≤0.32 μg/mL had a markedly lower incidence of MC, 14.3%, vs 90.9% in patients with levels >0.32 μg/mL (P = .008). Impending or established secondary GF was only observed in patients with day …

Omega-3 Fatty Acids And Risk For Atrial Fibrillation: Big Fish Or Small Fry?

Faculty, Staff and Students Publications

No abstract provided.

Understanding Veteran Perceptions About Mental Health And Its Treatment, Quinn Turner Stoddard

Dissertations and Theses

Mental health illnesses are a growing issue for a large part of the country, and veterans in particular are vulnerable to the numerous negative effects they pose. Despite the high number of people that may benefit from treatment, a variety of issues with trust, stigma, and attitudes may act as barriers to care utilization. In response, this study investigated the perceptions that veterans within the Pacific Northwest hold in regards to mental health treatment as well as their intentions to seek it out should they require it. Using the integrated model of behavioral prediction (IMBP), data was gathered about veterans’ …