Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 528091 - 528120 of 5209450

Full-Text Articles in Entire DC Network

Patterns Of Land Use Change, Land Governance, And The Supply Of Ecosystem Services In A Multifunctional Landscape: A Case Study From Upstate Sc, Usa, Mary Grace Albright, Caroline Vickery, Roy Bower, John E. Quinn Jul 2023

Patterns Of Land Use Change, Land Governance, And The Supply Of Ecosystem Services In A Multifunctional Landscape: A Case Study From Upstate Sc, Usa, Mary Grace Albright, Caroline Vickery, Roy Bower, John E. Quinn

Open Access Fund Publications

Urban expansion and development continue to increase globally, threatening rural multifunctional landscapes that provide a diversity of direct and indirect ecological benefits. However, not all landscapes are equally impacted, thus making conservation planning more difficult. We used 8 years of land use and land cover to understand this change in Greenville Co. SC, a region experiencing rapid expansion of development into rural landscapes. Regression models helped explain the relationships between development predictor variables and rural response variables. To explore where these changes were occurring, we determined which size categories of land parcels were the most developed and how this is …


Avoiding Anthropomoralism, Julian Friedland Jul 2023

Avoiding Anthropomoralism, Julian Friedland

Between the Species

The Montreal Declaration on Animal Exploitation, which has been endorsed by hundreds of influential academic ethicists, calls for establishing a vegan economy by banning what it refers to as all unnecessary animal suffering, including fishing. It does so by appeal to the moral principle of equal consideration of comparable interests. I argue that this principle is misapplied by discounting morally relevant cognitive capacities of self-conscious and volitional personhood as distinguished from merely sentient non-personhood. I describe it as a kind of anthropomorphizing moralism which I call anthropomoralism, defined as the tendency to project morally relevant characteristics of personhood onto merely …


Braunstein, Beth, Sophia Maier Garcia Jul 2023

Braunstein, Beth, Sophia Maier Garcia

Bronx Jewish History Project

Beth Anshen Braunstein was born in the Bronx 1954. Both sets of her grandparents immigrated from Russia, with one grandmother stopping in Alexandria, Egypt along the journey and learning Italian, which she used to communicate with Italian families in the Bronx. Her mother’s family lived and had a children’s clothing store on Bathgate Avenue. His father had a store next door and, after they were married, her parents had a health food store off of Pelham Parkway. Braunstein first lived on Bathgate before the family moved to Thieriot Avenue, near Parkchester. In her teenage years she became more religious, attending …


Advance Care Planning In Advanced Heart Failure: A Relational Exploration Of Autonomy, Tieghan Killackey Jul 2023

Advance Care Planning In Advanced Heart Failure: A Relational Exploration Of Autonomy, Tieghan Killackey

Dissertations

Advance care planning (ACP) is the process of understanding and sharing personal values and goals to ensure people with serious illnesses receive healthcare and treatment that is consistent with their goals and preferences. With the increasing number of treatment options available to patients living with advanced heart failure (HF), ACP is regarded as a means of preserving individual autonomy throughout the illness trajectory. Despite significant public awareness campaigns, research and interventions developed to increase participation in ACP, this practice remains severely under-utilized by those who are chronically ill. This gap in practice highlights the need for further exploration of how …


Sheaffer '24 Unwinds Protein Networks In Brain With Computer Science, Chris Francis Jul 2023

Sheaffer '24 Unwinds Protein Networks In Brain With Computer Science, Chris Francis

News and Events (Discontinued Series)

No abstract provided.


Surface-Doped Zinc Gallate Colloidal Nanoparticles Exhibit Ph-Dependent Radioluminescence With Enhancement In Acidic Media, Amar S Kumbhar, Jianguo Wen, Zhiping Luo Jul 2023

Surface-Doped Zinc Gallate Colloidal Nanoparticles Exhibit Ph-Dependent Radioluminescence With Enhancement In Acidic Media, Amar S Kumbhar, Jianguo Wen, Zhiping Luo

Faculty, Staff and Student Publications

As abnormal acidic pH symbolizes dysfunctions of cells, it is highly desirable to develop pH-sensitive luminescent materials for diagnosing disease and imaging-guided therapy using high-energy radiation. Herein, we explored near-infrared-emitting Cr-doped zinc gallate ZnGa2O4 nanoparticles (NPs) in colloidal solutions with different pH levels under X-ray excitation. Ultrasmall NPs were synthesized via a facile hydrothermal method by controlling the addition of ammonium hydroxide precursor and reaction time, and structural characterization revealed Cr dopants on the surface of NPs. The synthesized NPs exhibited different photoluminescence and radioluminescence mechanisms, confirming the surface distribution of activators. It was observed that the colloidal NPs emit …


Midweek Memo, Georgia Southern University Jul 2023

Midweek Memo, Georgia Southern University

Midweek Memo

Applaud

Remember

Share

Experience

You May Have Heard


Newsroom, Georgia Southern University Jul 2023

Newsroom, Georgia Southern University

Newsroom (2006-2023)

Georgia Southern University to Offer New Executive Master’s in Criminal Justice Degree


Therapies For Patients With Coexisting Heart Failure With Reduced Ejection Fraction And Non-Alcoholic Fatty Liver Disease, Jose Arriola-Montenegro, Renato Beas, Renato Cerna-Viacava, Andres Chaponan-Lavalle, Karla Hernandez Randich, Diego Chambergo-Michilot, Herson Flores Sanga, Pornthira Mutirangura Jul 2023

Therapies For Patients With Coexisting Heart Failure With Reduced Ejection Fraction And Non-Alcoholic Fatty Liver Disease, Jose Arriola-Montenegro, Renato Beas, Renato Cerna-Viacava, Andres Chaponan-Lavalle, Karla Hernandez Randich, Diego Chambergo-Michilot, Herson Flores Sanga, Pornthira Mutirangura

Internal Medicine Articles

Heart failure with reduced ejection fraction (HFrEF) and nonalcoholic fatty liver disease (NAFLD) are two common comorbidities that share similar pathophysiological mechanisms. There is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and NAFLD. This manuscript reviews current and potential therapies for patients with coexisting HFrEF and NAFLD. Pharmacological therapies, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, mineralocorticoids receptor antagonist, and sodium-glucose cotransporter-2 inhibitors, have been shown to reduce fibrosis and fat deposits in the liver. However, there are currently no data showing the beneficial effects of sacubitril/valsartan, ivabradine, hydralazine, isosorbide nitrates, …


Analysis Of Syndrome-Based Iterative Decoder Failure Of Qldpc Codes, Kirsten D. Morris, Tefjol Pllaha, Christine A. Kelley Jul 2023

Analysis Of Syndrome-Based Iterative Decoder Failure Of Qldpc Codes, Kirsten D. Morris, Tefjol Pllaha, Christine A. Kelley

Department of Mathematics: Faculty Publications

Iterative decoder failures of quantum low density parity check (QLDPC) codes are attributed to substructures in the code’s graph, known as trapping sets, as well as degenerate errors that can arise in quantum codes. Failure inducing sets are subsets of codeword coordinates that, when initially in error, lead to decoding failure in a trapping set. In this paper we examine the failure inducing sets of QLDPC codes under syndrome-based iterative decoding, and their connection to absorbing sets in classical LDPC codes.


Unraveling Prevalence And Effects Of Deleterious Mutations In Maize Elite Lines Across Decades Of Modern Breeding, Shichao Sun, Baobao Wang, Changyu Li, Gen Xu, Jinliang Yang, Matthew B. Hufford, Jeffrey Ross-Ibarra, Haiyang Wang, Li Wang Jul 2023

Unraveling Prevalence And Effects Of Deleterious Mutations In Maize Elite Lines Across Decades Of Modern Breeding, Shichao Sun, Baobao Wang, Changyu Li, Gen Xu, Jinliang Yang, Matthew B. Hufford, Jeffrey Ross-Ibarra, Haiyang Wang, Li Wang

Department of Agronomy and Horticulture: Faculty Publications

Future breeding is likely to involve the detection and removal of deleterious alleles, which are mutations that negatively affect crop fitness. However, little is known about the prevalence of such mutations and their effects on phenotypic traits in the context of modern crop breeding. To address this, we examined the number and frequency of deleterious mutations in 350 elite maize inbred lines developed over the past few decades in China and the United States. Our findings reveal an accumulation of weakly deleterious mutations and a decrease in strongly deleterious mutations, indicating the dominant effects of genetic drift and purifying selection …


Forensic Investigation Of Small-Scale Digital Devices: A Futuristic View, Farkhund Iqbal, Aasia Jaffri, Zainab Khalid, Aine Macdermott, Qazi Ejaz Ali, Patrick C. K. Hung Jul 2023

Forensic Investigation Of Small-Scale Digital Devices: A Futuristic View, Farkhund Iqbal, Aasia Jaffri, Zainab Khalid, Aine Macdermott, Qazi Ejaz Ali, Patrick C. K. Hung

All Works

Small-scale digital devices like smartphones, smart toys, drones, gaming consoles, tablets, and other personal data assistants have now become ingrained constituents in our daily lives. These devices store massive amounts of data related to individual traits of users, their routine operations, medical histories, and financial information. At the same time, with continuously evolving technology, the diversity in operating systems, client storage localities, remote/cloud storages and backups, and encryption practices renders the forensic analysis task multi-faceted. This makes forensic investigators having to deal with an array of novel challenges. This study reviews the forensic frameworks and procedures used in investigating small-scale …


Emerging Therapies For Antibody-Mediated Rejection In Kidney Transplantation, Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad Jul 2023

Emerging Therapies For Antibody-Mediated Rejection In Kidney Transplantation, Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad

2020-Current year OA Pubs

Despite the advances in immunosuppressive medications, antibody-mediated rejection (AMR) continues to be a major cause of kidney allograft failure and remains a barrier to improving long-term allograft survival. Recently, there have been significant advances in the understanding of the pathophysiological process of AMR, along with the development of new therapeutic options. Additionally, surveillance protocols with donor-derived cell-free DNA and gene profile testing have been established, leading to the early detection of AMR. A multitude of clinical trials are ongoing, opening numerous opportunities for improving outcome in kidney transplant recipients. In this brief review, we discuss the emerging therapies for managing …


Exploring Scenario-Based Assessment Of Students' Global Engineering Competency: Building Evidence Of Validity Of A China-Based Situational Judgment Test, Kirsten A. Davis, Brent Jesiek, David B. Knight Jul 2023

Exploring Scenario-Based Assessment Of Students' Global Engineering Competency: Building Evidence Of Validity Of A China-Based Situational Judgment Test, Kirsten A. Davis, Brent Jesiek, David B. Knight

School of Engineering Education Faculty Publications

Background

Engineers operate in an increasingly global environment, making it important that engineering students develop global engineering competency to prepare them for success in the workplace. To understand this learning, we need assessment approaches that go beyond traditional self-report surveys. A previous study (Jesiek et al., Journal of Engineering Education 2020; 109(3):1–21) began this process by developing a situational judgment test (SJT) to assess global engineering competency based in the Chinese context and administering it to practicing engineers.

Purpose

We built on this previous study by administering the SJT to engineering students to explore what prior experiences related to their …


Islet: Individual-Specific Reference Panel Recovery Improves Cell-Type-Specific Inference, Hao Feng, Guanqun Meng, Tong Lin, Hemang Parikh, Yue Pan, Jeffrey Krischer Jul 2023

Islet: Individual-Specific Reference Panel Recovery Improves Cell-Type-Specific Inference, Hao Feng, Guanqun Meng, Tong Lin, Hemang Parikh, Yue Pan, Jeffrey Krischer

Faculty, Staff and Student Publications

We propose a statistical framework ISLET to infer individual-specific and cell-type-specific transcriptome reference panels. ISLET models the repeatedly measured bulk gene expression data, to optimize the usage of shared information within each subject. ISLET is the first available method to achieve individual-specific reference estimation in repeated samples. Using simulation studies, we show outstanding performance of ISLET in the reference estimation and downstream cell-type-specific differentially expressed genes testing. We apply ISLET to longitudinal transcriptomes profiled from blood samples in a large observational study of young children and confirm the cell-type-specific gene signatures for pancreatic islet autoantibody. ISLET is available at https://bioconductor.org/packages/ISLET …


Tissue-Specific Features Of The T Cell Repertoire After Allogeneic Hematopoietic Cell Transplantation In Human And Mouse, Susan Dewolf, Yuval Elhanati, Katherine Nichols, Nicholas R Waters, Chi L Nguyen, Natasia Rodriguez, Paul A Giardina, Anastasia I Kousa, Hana Andrlová, Nick Ceglia, Teng Fei, Rajya Kappagantula, Yanyun Li, Nathan Aleynick, Priscilla Baez, Rajmohan Murali, Akimasa Hayashi, Nicole Lee, Brianna Gipson, Madhumitha Rangesa, Zoe Katsamakis, Anqi Dai, Amanda G Blouin, Maria Arcila, Ignas Masilionis, Ronan Chaligne, Doris M Ponce, Heather J Landau, Ioannis Politikos, Roni Tamari, Alan M Hanash, Robert R Jenq, Sergio A Giralt, Kate A Markey, Yanming Zhang, Miguel-Angel Perales, Nicholas D Socci, Benjamin D Greenbaum, Christine A Iacobuzio-Donahue, Travis J Hollmann, Marcel R M Van Den Brink, Jonathan U Peled Jul 2023

Tissue-Specific Features Of The T Cell Repertoire After Allogeneic Hematopoietic Cell Transplantation In Human And Mouse, Susan Dewolf, Yuval Elhanati, Katherine Nichols, Nicholas R Waters, Chi L Nguyen, Natasia Rodriguez, Paul A Giardina, Anastasia I Kousa, Hana Andrlová, Nick Ceglia, Teng Fei, Rajya Kappagantula, Yanyun Li, Nathan Aleynick, Priscilla Baez, Rajmohan Murali, Akimasa Hayashi, Nicole Lee, Brianna Gipson, Madhumitha Rangesa, Zoe Katsamakis, Anqi Dai, Amanda G Blouin, Maria Arcila, Ignas Masilionis, Ronan Chaligne, Doris M Ponce, Heather J Landau, Ioannis Politikos, Roni Tamari, Alan M Hanash, Robert R Jenq, Sergio A Giralt, Kate A Markey, Yanming Zhang, Miguel-Angel Perales, Nicholas D Socci, Benjamin D Greenbaum, Christine A Iacobuzio-Donahue, Travis J Hollmann, Marcel R M Van Den Brink, Jonathan U Peled

Faculty, Staff and Student Publications

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains poorly understood. We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5 to 18 tissues per patient) in prospectively collected autopsies of patients with and without graft-versus-host disease (GVHD), a potentially lethal tissue-targeting complication of allogeneic hematopoietic cell transplantation, and in mouse models of GVHD. Anatomic similarity between tissues was a key determinant of TCR repertoire composition within patients, independent of disease or transplant status. The T cells recovered from peripheral blood …


Comprehensive Analysis Of The Prognostic Significance Of The Trim Family In The Context Of Tp53 Mutations In Cancers, Trung Vu, Annaliese Fowler, Nami Mccarty Jul 2023

Comprehensive Analysis Of The Prognostic Significance Of The Trim Family In The Context Of Tp53 Mutations In Cancers, Trung Vu, Annaliese Fowler, Nami Mccarty

Faculty, Staff and Student Publications

The p53 protein is an important tumor suppressor, and TP53 mutations are frequently associated with poor prognosis in various cancers. Mutations in TP53 result in a loss of p53 function and enhanced expression of cell cycle genes, contributing to the development and progression of cancer. Meanwhile, several tripartite motif (TRIM) proteins are known to regulate cell growth and cell cycle transition. However, the prognostic values between TP53 and TRIM family genes in cancer are unknown. In this study, we analyzed the relationship between the


Gender Differences In A Mouse Model Of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging, Brian J Engel, Vincenzo Paolillo, Md Nasir Uddin, Kristyn A Gonzales, Kathryn M Mcginnis, Madhavi Patnana, Gregory J Gores, David Piwnica-Worms, Laura Beretta, Federica Pisaneschi, Seth T Gammon, Steven W Millward Jul 2023

Gender Differences In A Mouse Model Of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging, Brian J Engel, Vincenzo Paolillo, Md Nasir Uddin, Kristyn A Gonzales, Kathryn M Mcginnis, Madhavi Patnana, Gregory J Gores, David Piwnica-Worms, Laura Beretta, Federica Pisaneschi, Seth T Gammon, Steven W Millward

Faculty, Staff and Student Publications

The worldwide incidence of hepatocellular carcinoma (HCC) continues to rise, in part due to poor diet, limited exercise, and alcohol abuse. Numerous studies have suggested that the loss or mutation of PTEN plays a critical role in HCC tumorigenesis through the activation of the PI3K/Akt signaling axis. The homozygous knockout of PTEN in the livers of mice results in the accumulation of fat (steatosis), inflammation, fibrosis, and eventually progression to HCC. This phenotype bears a striking similarity to non-alcoholic steatohepatitis (NASH) which is thought to occupy an intermediate stage between non-alcoholic fatty liver disease (NAFLD), fibrosis, and HCC. The molecular …


Prescribing Patterns Of Fall Risk-Increasing Drugs In Older Adults Hospitalized For Heart Failure, Sarah N Hilmer, Emily B Levitan, Monika M Safford, Parag Goyal Jul 2023

Prescribing Patterns Of Fall Risk-Increasing Drugs In Older Adults Hospitalized For Heart Failure, Sarah N Hilmer, Emily B Levitan, Monika M Safford, Parag Goyal

Faculty, Staff and Student Publications

BACKGROUND: Older adults hospitalized for heart failure (HF) are at risk for falls after discharge. One modifiable contributor to falls is fall risk-increasing drugs (FRIDs). However, the prevalence of FRIDs among older adults hospitalized for HF is unknown. We describe patterns of FRIDs use and examine predictors of a high FRID burden.

METHODS: We used the national biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a prospective cohort recruited from 2003-2007. We included REGARDS participants aged ≥ 65 years discharged alive after a HF hospitalization from 2003-2017. We determined FRIDs -cardiovascular (CV) and non-cardiovascular (non-CV) medications - …


Boldness Is Not Associated With Dynamic Performance Capacity In Hermit Crabs., M Briffa, W Courtene-Jones Jul 2023

Boldness Is Not Associated With Dynamic Performance Capacity In Hermit Crabs., M Briffa, W Courtene-Jones

School of Biological and Marine Sciences

Boldness, the way an individual reacts to risk, is a commonly studied personality trait in animals. Consistent among-individual differences in startle response durations (latency to recover from a startling stimulus) are frequently assumed to reflect variation in boldness. An alternative explanation is that these latencies are not directly driven by variation in responses to information on risk, but by underlying differences in dynamic performance capacities. Here we investigate this possibility by analysing relationships between locomotory speed, a measure of whole-body dynamic performance capacity in hermit crabs, and startle response duration, a repeatable latency measure used as an index of boldness. …


Telehealth Diagnosis Of Autism Spectrum Disorder Through Clinical Cases, Harsimran Grewal Jul 2023

Telehealth Diagnosis Of Autism Spectrum Disorder Through Clinical Cases, Harsimran Grewal

Faculty, Staff and Student Publications

INTRODUCTION: African, Caribbean and Black (ACB) adolescents are disproportionately affected by teen pregnancy in North America. Teen pregnancy poses risks to the quality of life of adolescent boys and girls, including physical, psychosocial and socioeconomic risks. Our review aims to explore this public health concern for ACB adolescents within North America. We aim to identify and analyse available evidence on the incidence and prevalence of, associated factors of and interventions to curtail teen pregnancy involvement (TPI) among ACB adolescent boys and girls in North America. This review will explore TPI, rather than teen pregnancy, to ensure a review of men' …


Clinical Evidence Of Human Pathogens Implicated In Alzheimer’S Disease Pathology And The Therapeutic Efficacy Of Antimicrobials: An Overview Jul 2023

Clinical Evidence Of Human Pathogens Implicated In Alzheimer’S Disease Pathology And The Therapeutic Efficacy Of Antimicrobials: An Overview

Faculty, Staff and Student Publications

A wealth of pre-clinical reports and data derived from human subjects and brain autopsies suggest that microbial infections are relevant to Alzheimer's disease (AD). This has inspired the hypothesis that microbial infections increase the risk or even trigger the onset of AD. Multiple models have been developed to explain the increase in pathogenic microbes in AD patients. Although this hypothesis is well accepted in the field, it is not yet clear whether microbial neuroinvasion is a cause of AD or a consequence of the pathological changes experienced by the demented brain. Along the same line, the gut microbiome has also …


Correction To: ‘Sex Differences In Human Mate Preferences Vary Across Sex Ratios’ (2023) By Walter Et Al., Kathryn V. Walter, Daniel Conroy-Beam, David M. Buss, Kelly Asao, Agnieszka Sorokowska, Piotr Sorokowski, Toivo Aavik, Grace Akello, Mohammad Madallh Alhabahba, Charlotte Alm, Naumana Amjad, Afifa Anjum, Chiemezie S. Atama, Da Duyar, Richard Ayebare, Carlota Batres, Mons Bendixen, Aicha Bensafia, Boris Bizumic, Mahmoud Boussena, Marina Butovskaya, Seda Can, Katarzyna Cantarero, Antonin Carrier, Hakan Cetinkaya, Ilona Croy, Rosa María Cueto, Marcin Czub, Daria Dronova, Seda Dural, I Duyar, Berna Ertugrul, Agustín Espinosa, Ignacio Estevan, Carla Sofia Esteves, Luxi Fang, Tomasz Frackowiak, Jorge Contreras Garduño, Karina Ugalde González, Farida Guemaz, Petra Gyuris, Mária Halamová, Iskra Herak, Marina Horvat, Ivana Hromatko, Chin Ming Hui, Jas Laile Jaafar, Feng Jiang, Konstantinos Kafetsios, Tina Kavčič, Leif Edward Ottesen Kennair, Nicolas Kervyn, Ha Tt Khanh, Imran Ahmed Khilji, Nils C. Köbis, Hoang Moc Lan, András Láng, Georgina R. Lennard, Ernesto León, Torun Lindholm, Trinh Thi Linh, Giulia Lopez, Nguyen Van Luot, Alvaro Mailhos, Zoi Manesi, Rocio Martinez, Sarah L. Mckerchar, Norbert Meskó, Girishwar Misra, Conal Monaghan, Emanuel C. Mora, Alba Moya-Garófano, Bojan Musil, Jean Carlos Natividade, Agnieszka Niemczyk, George Nizharadze, Elisabeth Oberzaucher, Anna Oleszkiewicz, Mohd Sofian Omar-Fauzee, Ike E. Onyishi, Baris Özener, Ariela Francesca Pagani, Vilmante Pakalniskiene, Miriam Parise, Farid Pazhoohi, A Pisanski, K Pisanski, Edna Ponciano, Camelia Popa, Pavol Prokop, N/A Riz Jul 2023

Correction To: ‘Sex Differences In Human Mate Preferences Vary Across Sex Ratios’ (2023) By Walter Et Al., Kathryn V. Walter, Daniel Conroy-Beam, David M. Buss, Kelly Asao, Agnieszka Sorokowska, Piotr Sorokowski, Toivo Aavik, Grace Akello, Mohammad Madallh Alhabahba, Charlotte Alm, Naumana Amjad, Afifa Anjum, Chiemezie S. Atama, Da Duyar, Richard Ayebare, Carlota Batres, Mons Bendixen, Aicha Bensafia, Boris Bizumic, Mahmoud Boussena, Marina Butovskaya, Seda Can, Katarzyna Cantarero, Antonin Carrier, Hakan Cetinkaya, Ilona Croy, Rosa María Cueto, Marcin Czub, Daria Dronova, Seda Dural, I Duyar, Berna Ertugrul, Agustín Espinosa, Ignacio Estevan, Carla Sofia Esteves, Luxi Fang, Tomasz Frackowiak, Jorge Contreras Garduño, Karina Ugalde González, Farida Guemaz, Petra Gyuris, Mária Halamová, Iskra Herak, Marina Horvat, Ivana Hromatko, Chin Ming Hui, Jas Laile Jaafar, Feng Jiang, Konstantinos Kafetsios, Tina Kavčič, Leif Edward Ottesen Kennair, Nicolas Kervyn, Ha Tt Khanh, Imran Ahmed Khilji, Nils C. Köbis, Hoang Moc Lan, András Láng, Georgina R. Lennard, Ernesto León, Torun Lindholm, Trinh Thi Linh, Giulia Lopez, Nguyen Van Luot, Alvaro Mailhos, Zoi Manesi, Rocio Martinez, Sarah L. Mckerchar, Norbert Meskó, Girishwar Misra, Conal Monaghan, Emanuel C. Mora, Alba Moya-Garófano, Bojan Musil, Jean Carlos Natividade, Agnieszka Niemczyk, George Nizharadze, Elisabeth Oberzaucher, Anna Oleszkiewicz, Mohd Sofian Omar-Fauzee, Ike E. Onyishi, Baris Özener, Ariela Francesca Pagani, Vilmante Pakalniskiene, Miriam Parise, Farid Pazhoohi, A Pisanski, K Pisanski, Edna Ponciano, Camelia Popa, Pavol Prokop, N/A Riz

School of Psychology

The correct first affiliation is: Institute of Psychology, University of Wroclaw, Wroclaw 50137, Poland Note that second and third affiliations are correct. The original has now been corrected. Correction to https://doi.org/10.1098/rspb.2021.1115


Pharmaco-Proteogenomic Characterization Of Liver Cancer Organoids For Precision Oncology, Gaohua Wu, Yingcheng Wu, Youpei Lin, Dayun Lu, Yuanli Song, Peng Cui, Zijian Yang, Chen Sang, Guohe Song, Shangli Cai, Yuanchuang Li, Hanqing Lin, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Xiaoming Zhang, Guoqiang Hua, Junqiang Li, Jian Zhou, Zhi Dai, Xiangdong Wang, Li Ding, Pei Wang, Daming Gao, Bing Zhang, Henry Rodriguez, Jia Fan, Hans Clevers, Hu Zhou, Yidi Sun, Qiang Gao Jul 2023

Pharmaco-Proteogenomic Characterization Of Liver Cancer Organoids For Precision Oncology, Gaohua Wu, Yingcheng Wu, Youpei Lin, Dayun Lu, Yuanli Song, Peng Cui, Zijian Yang, Chen Sang, Guohe Song, Shangli Cai, Yuanchuang Li, Hanqing Lin, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Xiaoming Zhang, Guoqiang Hua, Junqiang Li, Jian Zhou, Zhi Dai, Xiangdong Wang, Li Ding, Pei Wang, Daming Gao, Bing Zhang, Henry Rodriguez, Jia Fan, Hans Clevers, Hu Zhou, Yidi Sun, Qiang Gao

Faculty, Staff and Students Publications

Organoid models have the potential to recapitulate the biological and pharmacotypic features of parental tumors. Nevertheless, integrative pharmaco-proteogenomics analysis for drug response features and biomarker investigation for precision therapy of patients with liver cancer are still lacking. We established a patient-derived liver cancer organoid biobank (LICOB) that comprehensively represents the histological and molecular characteristics of various liver cancer types as determined by multiomics profiling, including genomic, epigenomic, transcriptomic, and proteomic analysis. Proteogenomic profiling of LICOB identified proliferative and metabolic organoid subtypes linked to patient prognosis. High-throughput drug screening revealed distinct response patterns of each subtype that were associated with specific …


Babesa Sewage Treatment Plant As A Vital Artificial Wetland Habitat For A Multitude Of Avian Species, Pelden Nima, Mahendra Timsina, Tenzin Jamtsho, Pema Khandu Jul 2023

Babesa Sewage Treatment Plant As A Vital Artificial Wetland Habitat For A Multitude Of Avian Species, Pelden Nima, Mahendra Timsina, Tenzin Jamtsho, Pema Khandu

Research outputs 2022 to 2026

This study aimed to glean basic ecological aspects on diversity and abundance, temporal variation and guild composition of the birds at Babesa Sewage Treatment Plant (STP). The line transect method was used as the sampling technique from November 2021 to October 2022. A total of 80 species belonging to 58 genera, 29 families, and 11 orders were detected, of which three, namely, River Lapwing Vanellus duvaucelii, Falcated Duck Mareca falcata, and Ferruginous Duck Aythya nyroca, are ‘Near Threatened’ with the remaining being ‘Least Concern’. The highest species richness was recorded in the winter (6.29), the highest species diversity in the …


How Unequal Access To Personal And Professional Networks Impacts Success Among Construction Apprentices, Cameron Elliot Arnold Jul 2023

How Unequal Access To Personal And Professional Networks Impacts Success Among Construction Apprentices, Cameron Elliot Arnold

Dissertations and Theses

The construction industry is still primarily white male dominated, and while there is significant research on gendered experiences in the trades, there is not research on experiences and attitudes towards support that occurs outside of the trades across gender and other intersectional identities. My study aims to start filling the gap and answer the questions: How does access to personal and professional networks impact success among Oregon apprentices? How is access to and attitudes towards receiving support impacted by gender and race? To answer these questions this study uses qualitative interviews of Oregon apprentices who completed or terminated in 2018-2019. …


The Greeley Variations, Mary Haidri Jul 2023

The Greeley Variations, Mary Haidri

Dissertations and Theses

Inspired by the works of Charlotte Perkins Gilman, European snake folklore, and "wished-for child" fairy tales, The Greeley Variations features several generations of women and the Victorian house they live in. The novel explores prospective parenthood, maternal legacy, and repeated patterns (visual, genetic, and psychological) as haunting experiences.


Enabling Endpoint Development For Interventional Clinical Trials In Individuals With Angelman Syndrome: A Prospective, Longitudinal, Observational Clinical Study (Freesias), Lynne M Bird, Mariana Bustamante, Rebecca Crean, Shafali Jeste, Robert W Komorowski, Michelle L Krishnan, Meghan T Miller, David Nobbs, Cesar Ochoa-Lubinoff, Kimberly A Parkerson, Alexander Rotenberg, Anjali Sadhwani, Mark D Shen, Lisa Squassante, Wen-Hann Tan, Brenda Vincenzi, Anne C Wheeler, Joerg F Hipp, Elizabeth Berry-Kravis Jul 2023

Enabling Endpoint Development For Interventional Clinical Trials In Individuals With Angelman Syndrome: A Prospective, Longitudinal, Observational Clinical Study (Freesias), Lynne M Bird, Mariana Bustamante, Rebecca Crean, Shafali Jeste, Robert W Komorowski, Michelle L Krishnan, Meghan T Miller, David Nobbs, Cesar Ochoa-Lubinoff, Kimberly A Parkerson, Alexander Rotenberg, Anjali Sadhwani, Mark D Shen, Lisa Squassante, Wen-Hann Tan, Brenda Vincenzi, Anne C Wheeler, Joerg F Hipp, Elizabeth Berry-Kravis

Faculty, Staff and Students Publications

BACKGROUND: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by the absence of a functional UBE3A gene, which causes developmental, behavioral, and medical challenges. While currently untreatable, comprehensive data could help identify appropriate endpoints assessing meaningful improvements in clinical trials. Herein are reported the results from the FREESIAS study assessing the feasibility and utility of in-clinic and at-home measures of key AS symptoms.

METHODS: Fifty-five individuals with AS (aged < 5 years: n = 16, 5-12 years: n = 27, ≥ 18 years: n = 12; deletion genotype: n = 40, nondeletion genotype: n = 15) and 20 typically developing children (aged 1-12 years) were enrolled across six USA sites. Several clinical outcome assessments and digital health technologies were tested, together with overnight 19-lead electroencephalography (EEG) and additional polysomnography (PSG) sensors. Participants were assessed at baseline (Clinic Visit 1), 12 months later (Clinic Visit 2), and during intermittent home visits.

RESULTS: The participants achieved high completion rates for the clinical outcome assessments (adherence: 89-100% [Clinic Visit 1]; 76-91% [Clinic Visit 2]) and varied feasibility of and adherence to digital health …


When Phased Without Water: Biophysics Of Cellular Desiccation, From Biomolecules To Condensates, Shahar Sukenik, Steven Boeynaems Jul 2023

When Phased Without Water: Biophysics Of Cellular Desiccation, From Biomolecules To Condensates, Shahar Sukenik, Steven Boeynaems

Faculty, Staff and Students Publications

The molecular machinery that enables life has evolved in water, yet many of the organisms around us are able to survive even extreme desiccation. Especially remarkable are single-cell and sedentary organisms that rely on specialized biomolecular machinery to survive in environments that are routinely subjected to a near-complete lack of water. In this review, we zoom in on the molecular level of what is happening in the cellular environment under water stress. We cover the various mechanisms by which biochemical components of the cell can dysfunction in dehydrated cells and detail the different strategies that organisms have evolved to eliminate …


Soybean Tolerance To Ultra-Low Doses Of Dicamba: Hormesis Or Not, Luka Milosevic, O. Adewale Osipitan, Jon E. Scott, Stevan Z. Knezevic Jul 2023

Soybean Tolerance To Ultra-Low Doses Of Dicamba: Hormesis Or Not, Luka Milosevic, O. Adewale Osipitan, Jon E. Scott, Stevan Z. Knezevic

Department of Agronomy and Horticulture: Faculty Publications

The widespread use of dicamba across the soybean growing regions of the United States resulted in increased off-target movement of this herbicide to susceptible vegetations. There are speculations that a drift of sublethal (ultra-low) doses of dicamba can enhance soybean growth and yield through a phenomenon called hormesis. Field studies were conducted during 2018 and 2019 to determine whether soybean growth and yield can be enhanced with ultra-low doses (0.0112–56 g ae ha-1) of dicamba, applied at three growth stages (V2, R1 and R2). There was no evidence that the ultra-low doses of dicamba (0.0112–56 g ae ha …