Digital Commons Network^™

Social Aspects Of Silent Divorce In Saudi Society: An Empirical Field Study On A Sample Of Families In Riyadh, Intisar N/A Al-Shubaily Dr.

Journal of Arabic Sciences and Humanities

This study aimed at investigating the social aspects of silent divorce in the Saudi society, whereby it focused on three main aspects of the phenomenon, namely: the causes of silent divorce; its manifestations and the most important effects accompanying such form of divorce. In addressing the subject matter, the empirical fieldwork adopted social survey as its method for data collection. A questionnaire was specifically designed and applied on a purposive sample of 188 case. The results study revealed a number of important results most important of which are: 1) For causes of divorce, kin intervention (spouses relatives) in spouses affairs, …

An Acoustic Study Of Zilfaawi Arabic Vowels, Ammar Ahmed Alammar Dr.

Journal of Arabic Sciences and Humanities

The present research provides an acoustic description of vowel quality and quantity in Zilfaawi Arabic (ZA). The vowel duration and the first (F1) and second (F2) formants were measured. Acoustic analysis of the ZA vowels /i/, /i:/, /a/, /a:/, /u/, /u:/, /e:/, /o:/ was performed using eight monosyllabic CVC words. Ten native speakers of ZA each read the carrier phrase five times, producing a total of 400 tokens. This study also examines whether these aspects differ between men and women. The results revealed that the phonemic vowel inventory of this Saudi dialect comprises three short and five long vowels. The …

Perspectives In Melanoma: Meeting Report From The Melanoma Bridge (December 1st–3rd, 2022-Naples, Italy), Paolo A Ascierto, Sanjiv S Agarwala, Allison Betof Warner, Marc S Ernstoff, Bernard A Fox, Jérôme Galon, Brian R Gastman, Jeffrey E Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S Leidner, Roger S Lo, Alexander M Menzies, Olivier Michielin, Poulikos I Poulikakos, Jeffrey S Weber, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

Faculty, Staff and Student Publications

Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). Combinations of these checkpoint therapies with other agents are now being explored to improve outcomes and enhance benefit-risk profiles of treatment. Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. Unfortunately, many patients still progress and …

Loss Of Metabolic Fitness Drives Tumor Resistance After Car-Nk Cell Therapy And Can Be Overcome By Cytokine Engineering, Li Li, Vakul Mohanty, Jinzhuang Dou, Yuefan Huang, Pinaki P Banerjee, Jens G Lohr, Julia Frede, Birgit Knoechel, Luis Muniz-Feliciano, Tamara J Laskowski, Shaoheng Liang, Judy S Moyes, Vandana Nandivada, Rafet Basar, Mecit Kaplan, May Daher, Enli Liu, Ye Li, Sunil Acharya, Paul Lin, Mayra Shanley, Hind Rafei, David Marin, Stephan Mielke, Richard E Champlin, Elizabeth J Shpall, Ken Chen, Katayoun Rezvani

Faculty, Staff and Student Publications

Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is promising, with early-phase clinical studies showing encouraging responses. However, the transcriptional signatures that control the fate of CAR-NK cells after infusion and factors that influence tumor control remain poorly understood. We performed single-cell RNA sequencing and mass cytometry to study the heterogeneity of CAR-NK cells and their in vivo evolution after adoptive transfer, from the phase of tumor control to relapse. Using a preclinical model of noncurative lymphoma and samples from a responder and a nonresponder patient treated with CAR19/IL-15 NK cells, we observed the emergence of NK cell …

Phosphorylated Nuclear Dicer1 Promotes Open Chromatin State And Lineage Plasticity Of At2 Tumor Cells In Lung Adenocarcinomas, Raisa A Reyes-Castro, Shin-Yu Chen, Jacob Seemann, Samrat T Kundu, Don L Gibbons

Faculty, Staff and Student Publications

KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and phosphomimetic Dicer1 contributes to tumorigenesis in mice. Mechanisms through which phospho-DICER1 regulates tumor progression remain undefined. While DICER1 canonically regulates microRNAs (miRNA) and epithelial-to-mesenchymal transition (EMT), we found that phosphorylated nuclear DICER1 (phospho-nuclear DICER1) promotes late-stage tumor progression in mice with oncogenic Kras, independent of miRNAs and EMT. Instead, we observe that the murine AT2 tumor cells exhibit altered chromatin compaction, and cells from disorganized advanced tumors, but not localized tumors, express gastric genes. Collectively, this results in subpopulations of tumor cells transitioning from a restricted alveolar to a broader …

Strongholds Of Liberalism? The Reaction Of Regional Integration Institutions To The Pandemic Trade Crisis, Patrick Holden

School of Law, Humanities and Social Sciences

Regional integration institutions play an important but ambiguous role in the liberal international system, especially when it comes to trade policy. The Covid-19 pandemic generated a trade crisis, which gave them an opportunity to expand their role in a liberal or illiberal direction. An analysis of the framing and policy measures of five key regional institutions in Europe, South America, Africa and Asia will demonstrate whether they were geared towards liberalisation and/or interventionism in early 2020. The European Union stood out for its strong collective action on trade, working out a new balance between interventionism and liberalism. Other institutions hinted …

Using The Sociotechnical Model To Conduct A Focused Usability Assessment Of A Breast Reconstruction Decision Tool, Randi Foraker, Crystal Phommasathit, Kaleigh Clevenger, Clara Lee, Jessica Boateng, Napiera Shareef, Mary C Politi

2020-Current year OA Pubs

INTRODUCTION: BREASTChoice is a web-based breast reconstruction decision aid. The previous clinical trial-prior to the adaptation of this refined tool in which we explored usability-measured decision quality, quality of life, patient activation, shared decision making, and treatment choice. The current usability study was designed to elicit patients' and clinicians' perspectives on barriers and facilitators for implementing BREASTChoice into the clinical workflow.

METHODS: We conducted qualitative interviews with patients and clinicians from two Midwestern medical specialty centers from August 2020 to April 2021. Interviews were first double coded until coders achieved a kappa > 0.8 and percent agreement > 95%, then were coded …

Ifit2 Restricts Murine Coronavirus Spread To The Spinal Cord White Matter And Its Associated Myelin Pathology, Madhav Sharma, Debanjana Chakravarty, Afaq Hussain, Ajay Zalavadia, Amy Burrows, Patricia Rayman, Nikhil Sharma, Lawrence C. Kenyon, Cornelia Bergmann, Ganes C. Sen, Jayasri Das Sarma

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Interferon-induced protein with tetratricopeptide repeats 2, Ifit2, is critical in restricting neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2-deficient (-/-) compared to wild-type (WT) mice results in impaired acute microglial activation, reduced CX3CR1 expression, limited migration of peripheral lymphocytes into the brain, and impaired virus control followed by severe morbidity and mortality. While the protective role of Ifit2 is established for acute viral encephalitis, less is known about its influence during the chronic demyelinating phase of RSA59 infection. To understand this, RSA59 infected Ifit2-/- and Ifit2+/+ (WT) were observed for neuropathological outcomes at day 5 (acute phase) and 30 …

Nanoparticle-Mediated Therapy With Mir-198 Sensitizes Pancreatic Cancer To Gemcitabine Treatment Through Downregulation Of Vcp-Mediated Autophagy, Zhengdong Liang, Osvaldo Vega-Martínez, Sue E Crawford, Mary K Estes, William E Fisher, Changyi Chen, Qizhi Yao

Faculty, Staff and Students Publications

Pancreatic ductal adenocarcinoma (PDAC) remains an extremely aggressive disease characterized by rapidly acquired multi-drug resistance, including to first-line chemotherapeutic agent gemcitabine. Autophagy is a process that is often exploited by cancer and is one of several intrinsic factors associated with resistance to gemcitabine. We have previously found that miR-198 acts as a tumor suppressor in PDAC through the targeting of factors including Valosin-containing protein (VCP). VCP has been reported to play an important role in autophagic flux. In this study, we investigated whether the repression of VCP through miR-198 administration disrupts the autophagy process and sensitizes PDAC cells to gemcitabine …

Proceeding Pro Se: Misguided Limitations On The Prison Mailbox Rule In Cretacci V. Call, Eleanor Ritter

Pepperdine Law Review

Under the “prison mailbox rule,” an inmate’s notice of appeal in either a criminal or civil case is considered filed at the moment the notice is given to prison authorities to be mailed. But the prison mailbox rule originated as a common law rule––having developed in Fallen v. United States and Houston v. Lack––and was not codified in the Federal Rules of Appellate Procedure until 1993. In light of its complex origins, circuit courts have split over to whom and to which types of filings the rule should apply. More specifically, courts have disagreed over whether the prison mailbox rule …

Book Review: Documentary Research In The Social Sciences By Malcolm Tight, Patrick W. Leeport

Essays in Education

Documentary research methods are a critical, yet often overlooked approach to research in the social sciences. Malcolm Tight’s book, Documentary Research in the Social Sciences not only makes the case for the value of documentary research, but serves as a pragmatic introduction to a wide array of different genres within documentary research. The book is suited well to graduate students as well as researchers and practitioners looking to expand their understanding of, and ability to conduct, document-based research.

The Pulse, 1982 Autumn, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on exercise and physical activity, an employee interview is with the supervisor of Telecommunications, parenting classes for new fathers, and updates on personnel.

The Pulse, 1983 Fall, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on Alzheimer's disease, medical insurance and hospital reimbursement, an employee interview with the assistant director of Housekeeping, and updates to personnel.

The Pulse, 1983 Spring, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on treating back pain, hospice services, medical research, an employee interview with a nurse, celebration of National Volunteer Week, and updates to personnel.

The Pulse, 1984 Winter, Advocate Aurora Health

Historical Documents - Combined

Mount Sinai Medical Center, Milwaukee, WI: Internal publication for employees of the Mount Sinai Medical Center. This issue features articles on the new employee assistance program, Mount Sinai's involvement and history with medical students and research, the gift of a tapestry entitled "Compassion", laser technology, radiation therapy, and interviews with eight employees celebrating their 10-year anniversaries.

Effects Of Water Application Rates And Sawdust Biochar On The Physicochemical Properties Of Soil And Performance Of Five Tree Species Used In Urban Landscaping In Ondo, Nigeria, Ayodeji Adeyemi Ogunwole, Samuel Ohikhaena Agele Prof., Oluyemisi Dorcas Ogunwole

Cities and the Environment (CATE)

This study assessed the response to irrigation rate and the minimum irrigation rate for optimum growth of seedlings of five tropical tree species used in urban landscaping in Ondo, Nigeria. The study also evaluated the effects of irrigation rate and sawdust biochar on growth attributes and biochemical constituents of the seedlings and the changes in the physical and chemical properties of the soil on which the tree seedlings were grown. Seedlings of five tree species, Bauhinia monandra, Delonix regia, Terminalia catappa, Dypsis lutescens, and Veitchia merrillii, were subjected to six treatments as follows; The first three treatments comprised of seedlings …

Commentary On Producing Environmental Information From Stakeholder Engagement, Josh Rosa

Cities and the Environment (CATE)

This article provides practice-informed advice, guided by and responsive to theory, for policymakers who seek to improve their environmental policies by generating their own informational value from their interactions with stakeholders. First, the article explains a self-reinforcing opaqueness of conventional environmental policymaking and how this opaqueness disproportionately and cumulatively impacts underrepresented communities. Drawing from the literature of social ecology, political economy, and political methodology, the article adumbrates opaqueness’ contributions to environmental injustice and identifies potential benefits of a more informative approach to stakeholder engagement. Next, the article explains specific methods that policymakers can use to convert stakeholder input into greater …

Land Change Modeler For Evaluating Urbanization Driven By Universities In The Periurban Area Of Yogyakarta City, Indonesia, Sintha P.W. Gunawan, Takashi Machimura, Takanori Matsui Dr., Xiangyun Shi, Chihiro Haga

Cities and the Environment (CATE)

Yogyakarta City and its peri urban areas have experienced a rapid land cover change in the last two decades from non-urban to urban areas. Understanding the driving factors and their level of influence will facilitate well-informed decisions in planning sustainable urbanization. This study formulated a hypothesis that the area hosting a university is most likely to have higher urban area and urbanization rate and verified it by using a land change model (LCM). The LCM which implemented a multi-layer perceptron algorithm using LANDSAT 5 TM in 1999 and 2005 successfully produced a robust land change model with accuracy rate of …

Sustaining Urban Forests In Post-Industrial Cities: Place Attachment, Ecology, And Stewardship Potential, Paige S. Warren, Robert L. Ryan, Brenda K. Bushouse, Krista Harper, Kristina Stinson

Cities and the Environment (CATE)

People value urban green spaces for enjoying nature and socializing with friends, family, and other park users. However, overgrown urban forests without clear access points can be perceived as dark, dangerous, and wild places. As many cities experience reduced budgets, they struggle to maintain green spaces established in more prosperous times. We conducted a descriptive analysis of how constrained parks budgets and subsequent city decisions about maintenance are associated with patterns of forest use, place attachment, and social capital and their impacts on the potential for stewardship of forested parks. We selected Springfield, Massachusetts for our study because it is …

Relationship Between Pedestrian Activity And Avian Body Condition During Fall Migration, Laura Marsh, David A. Aborn

Cities and the Environment (CATE)

Many North American landbirds undergo biannual migrations, which are energetically costly. Quality stopover sites are crucial to avian survival, as they provide opportunities to quickly replenish fat stores, rest, and avoid predation. One component of habitat quality that is often overlooked is the level of pedestrian activity, which birds may interpret as a predatory threat. If intrusion levels are high, birds will flush repeatedly and may not adequately restore energy reserves, which hinders successful migration. We compared body mass index between birds at different intrusion levels, testing the hypothesis that birds near continuous intrusion will be in poorer condition. Results …

Fifteen Years Of Fragmentation And Land Cover Change In India’S Ten Largest Cities – A Google Earth Engine Analysis, Shivani Agarwal, Preeti Rao, Harini Nagendra

Cities and the Environment (CATE)

Urbanization is one of the most transformative drivers of global environmental change today, with India representing one of the fastest urbanizing countries. We map the urban expansion of India’s ten largest cities from 2001 to 2016, through a regression tree classification of Landsat data in Google Earth Engine. Indian cities are growing through sprawl, and simultaneously densifying through in-filling. In Delhi, Mumbai and Pune, urban growth is multinucleated, aggregating to form a larger urban region. However, the dominant pattern in most cities is mono-nucleated growth via edge-expansion. The colonial signature is visible in many cities such as Bangalore, where due …

Community Garden As A Context For Civic Ecology: A Multidisciplinary Project In Restoration And Environmental Education, Mary Leou, Tania Goicoechea, Bethany Kogut

Cities and the Environment (CATE)

This paper describes a civic ecology program called Bees Alive! developed by the NYU Wallerstein Collaborative for Urban Environmental Education & Sustainability over three years to establish a native plant pollinator garden in Greenpoint, Brooklyn, New York. The project brought together a large university, public schools, non-profit organizations and a community garden called Lentol Garden to support wildlife and create an outdoor classroom to educate the public about the importance of pollinators. The garden was utilized as a context for civic ecology, environmental education and stewardship. Theories of place-based education and experiential learning were incorporated in designing this long-term project …

Back Matter

History in the Making

No abstract provided.

Television Review: The Gilded Age, Rossandra Martinez, Daniela Bedolla

History in the Making

No abstract provided.

Book Review: American Exception: Empire And The Deep State, Devin Gillen

History in the Making

No abstract provided.

Thich Nhat Hanh, Erin Herklotz

History in the Making

No abstract provided.

Shireen Abu Akleh, Devin Gillen

History in the Making

No abstract provided.

David Mccullough: Accidental Historian, George “Matt” Patino

History in the Making

No abstract provided.

Infinite Diversity Or Infinite Opportunity: A Look At Star Trek And Its Cultural Influence, Kendra Vaughan

History in the Making

No abstract provided.

Woman Warriors: The Fighting Women Of The Woman King And Black Panther, Rossandra Martinez, Daniela Bedolla

History in the Making

No abstract provided.