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James C. Robinson, Et. Al. V. Fisherbroyles, Llp, Et. Al., Order On Plaintiff's Motion For Sanctions, Eric A. Richardson Aug 2023

James C. Robinson, Et. Al. V. Fisherbroyles, Llp, Et. Al., Order On Plaintiff's Motion For Sanctions, Eric A. Richardson

Superior Court of Fulton County: Metro Atlanta Business Case Division Opinions

No abstract provided.


Purification And Detection Of Antibiotic-Resistant Bacteria From Whole Blood With Nano-Sieve, Xinye Chen Aug 2023

Purification And Detection Of Antibiotic-Resistant Bacteria From Whole Blood With Nano-Sieve, Xinye Chen

Theses

Life-threatening bloodstream infections (BSI), such as sepsis, mainly caused by the body’s syndromic response to pathogen infection, are a major public health concern, leading to ~11 million deaths each year. The identification of sepsis presents significant challenges in the diagnostic process, as the isolation of low concentration pathogens from bodily fluids (e.g., human blood) is extremely demanding, and typically relies on time-consuming and complicated isolation processes. Therefore, this work aims to explore the potential of microfluidics as a powerful tool for rapid purification and concentration of antibiotic-resistant bacteria (ARB) from blood samples, meanwhile developing a molecular diagnostic technology by combining …


Intertemporal Preferences Or (In)Attention To Future Costs: Identifying Factors Influencing Variation In Health Behaviors, Christopher Gustafson Aug 2023

Intertemporal Preferences Or (In)Attention To Future Costs: Identifying Factors Influencing Variation In Health Behaviors, Christopher Gustafson

Cornhusker Economics

When you have the urge to buy a fancy coffee drink at your favorite coffee place, do you think about alternative future uses of the money that you would spend on the drink? If, in the end, you decide to forego buying the drink to save money, you have, by definition, considered what you are giving up now—the drink—in order to have the money later, but many people may not consider the future opportunities they forego when they make decisions now. Research suggests that this asymmetric attention to immediate versus future opportunity costs— the benefits that we give up when …


Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Residential Metals Abatement Program (Rmap) Park Soil Sampling Field Sampling Plan (Fsp) Submittal #12 [Covering Aldersgate United Methodist Church] (Dated July 31, 2023), Nikia Greene Aug 2023

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Residential Metals Abatement Program (Rmap) Park Soil Sampling Field Sampling Plan (Fsp) Submittal #12 [Covering Aldersgate United Methodist Church] (Dated July 31, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Comments For The Draft Residential Metals Abatement Program – Indoor Soil – Investigation Summary Report – Butte High School (Received July 5, 2023), Nikia Greene Aug 2023

Comments For The Draft Residential Metals Abatement Program – Indoor Soil – Investigation Summary Report – Butte High School (Received July 5, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Re: Approval Letter For The Request For Change (Rfc) To The Butte Priority Soils Operable Unit (Bpsou) Revised Request For Change (Rfc)-Brw-2023-02 To The Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Quality Assurance Project Plan (Qapp) For Microbial Analysis And Biotreatability (Dated July 13, 2023), Nikia Greene Aug 2023

Re: Approval Letter For The Request For Change (Rfc) To The Butte Priority Soils Operable Unit (Bpsou) Revised Request For Change (Rfc)-Brw-2023-02 To The Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Quality Assurance Project Plan (Qapp) For Microbial Analysis And Biotreatability (Dated July 13, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Limiting Play-Based Learning In Early Childhood Classrooms: The Impact On Student Engagement, Ashley M. Lesniak Aug 2023

Limiting Play-Based Learning In Early Childhood Classrooms: The Impact On Student Engagement, Ashley M. Lesniak

Masters Projects

Research has revealed the developmental benefits and school readiness skills students gain from play-based child centered learning, yet most early childhood classrooms beyond preschool are seeing less and less play-based learning and more direct instruction of academic skills due to increased accountability put in place by reforms such as No Child Left Behind. The purpose of this project is to inform and remind teachers and administration of the benefits of play-based learning but also to create some curriculum that will integrate more play-based learning into classrooms. Currently, many classrooms do not implement play -based learning due to time, academics, and …


Standardized Testing And Stress In Teachers And Students, Gretchen L. Spoelman-Delong Aug 2023

Standardized Testing And Stress In Teachers And Students, Gretchen L. Spoelman-Delong

Masters Projects

This project demonstrates the relationship between standardized testing and increased stress in both teachers and students. The emphasis placed on standardized testing and therefore potential for increased anxiety and stress for teachers and students is important because stressed and anxious teachers are not going to be teaching to their full potential. Likewise, stressed and anxious students are not going to be able to rise to their full learning potential (Gonzalez et al., 2017). The purpose of this project is to decrease the amount of stress and anxiety that students and teachers feel. This can be accomplished by informing school personnel, …


Brief Of Administrative Law Scholars As Amici Curiae In Opposition To Petitioners' Request For Reversal, Jeffrey Lubbers Aug 2023

Brief Of Administrative Law Scholars As Amici Curiae In Opposition To Petitioners' Request For Reversal, Jeffrey Lubbers

Amicus Briefs & Court Filings

Amici curiae are administrative law scholars from universities around the United States.

They are: • William D. Araiza, Professor of Law and Dean of Brooklyn Law School; • Blake Emerson, Professor of Law at UCLA School of Law; • Jeffrey Lubbers, Professor of Practice in Administrative Law at American University Washington College of Law; • Todd Phillips, Assistant Professor of Business Law at Georgia State University J. Mack Robinson College of Business; and • Beau Baumann, Doctoral candidate at Yale Law School.

Amici have a strong interest in how the Court’s decision will affect the field of administrative law and …


Advancing Decarbonization In Regulated Multifamily Affordable Housing: Key Federal Levers To Achieve Meaningful Change, Housing Sustainability Advisors, Eric Hangen Aug 2023

Advancing Decarbonization In Regulated Multifamily Affordable Housing: Key Federal Levers To Achieve Meaningful Change, Housing Sustainability Advisors, Eric Hangen

Carsey Publications

Decarbonizing affordable rental housing is critical to mitigating climate change and meeting the Biden Administration’s target for a net-zero emissions national economy by 2050. It also offers numerous benefits, including energy cost savings, improved health and well-being, and economic opportunities. However, challenges related to upfront costs, tenant turnover, technical expertise, and policy support must be addressed to accelerate the market’s adoption of decarbonization. Collaboration between governments, policymakers, landlords, tenants, and industry experts is essential to overcome these challenges and achieve a sustainable and equitable future.

We are faced with a historic moment: the Inflation Reduction Act has provided $27 billion …


Gata Now!, Georgia Southern University Aug 2023

Gata Now!, Georgia Southern University

Athletics: News & Publications

No abstract provided.


Gata Now!, Georgia Southern University Aug 2023

Gata Now!, Georgia Southern University

Athletics: News & Publications

No abstract provided.


Nih Selects Marrazzo As Director Of The National Institute Of Allergy And Infectious Diseases, Alicia Rohan Aug 2023

Nih Selects Marrazzo As Director Of The National Institute Of Allergy And Infectious Diseases, Alicia Rohan

Browse All News

No abstract provided.


Chatham Named Director Of Uab Center For Teaching And Learning, Staff Aug 2023

Chatham Named Director Of Uab Center For Teaching And Learning, Staff

Browse All News

No abstract provided.


Alternative Splicing Of Ceacam1 By Hypoxia-Inducible Factor-1Α Enhances Tolerance To Hepatic Ischemia In Mice And Humans, Hirofumi Hirao, Fady M Kaldas, Xiaoyi Yuan, Holger K Eltzschig, Jerzy W Kupiec-Weglinski Aug 2023

Alternative Splicing Of Ceacam1 By Hypoxia-Inducible Factor-1Α Enhances Tolerance To Hepatic Ischemia In Mice And Humans, Hirofumi Hirao, Fady M Kaldas, Xiaoyi Yuan, Holger K Eltzschig, Jerzy W Kupiec-Weglinski

Faculty, Staff and Student Publications

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to environmental stresses, its contributions in organ transplantation have not been appreciated. We have shown that carcinoembryonic antigen-related cell adhesion molecule (Ceacam1; CD66a), a transmembrane biliary glycoprotein expressed in epithelial, endothelial, and immune cells, determines donor liver transplant quality. Here, we studied how AS of Ceacam1 affects ischemia-reperfusion injury (IRI) in mouse and human livers. We found that the short cytoplasmic isoform Ceacam1-S increased during early acute and late resolution phases of warm IRI injury in mice. Transfection of Ceacam1-deficient mouse hepatocytes with adenoviral Ceacam1-S mitigated hypoxia-induced loss of …


Genetic Insights Into Resting Heart Rate And Its Role In Cardiovascular Disease, Yordi J Van De Vegte, Ruben N Eppinga, M Yldau Van Der Ende, Yanick P Hagemeijer, Yuvaraj Mahendran, Albert V Smith, Dan E Arking, Ioanna Ntalla, Emil V Appel, Claudia Schurmann, Jennifer A Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina Mononen, Kirsi Auro, Anne U Jackson, Lawrence F Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Müller-Nurasyid, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Xiuqing Guo, Henry J Lin, Francesca Pavani, Tessel E Galesloot, Raymond Noordam, Yuri Milaneschi, Katharina E Schraut, Marcel Den Hoed, Frauke Degenhardt, Stella Trompet, Marten E Van Den Berg, Giorgio Pistis, Yih-Chung Tham, Stefan Weiss, Xueling S Sim, Hengtong L Li, Peter J Van Der Most, Ilja M Nolte, Leo-Pekka Lyytikäinen, M Abdullah Said, Daniel R Witte, Carlos Iribarren, Lenore Launer, Susan M Ring, Paul S De Vries, Peter Sever, Allan Linneberg, Erwin P Bottinger, Sandosh Padmanabhan, Bruce M Psaty, Nona Sotoodehnia, Ivana Kolcic, Dcct/Edic Research Group, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Beverley Balkau, Claudia T Silva, Christopher H Newton-Cheh, Kjell Nikus, Perttu Salo, Karen L Mohlke, Patricia A Peyser, Heribert Schunkert, Mattias Lorentzon, Jari Lahti, Dabeeru C Rao, Marilyn C Cornelis, Jessica D Faul, Jennifer A Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Konstantin Strauch, Graciela E Delgado, Kent D Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline De Graaf, Renée De Mutsert, Eco J C De Geus, Åsa Johansson, Peter K Joshi, Lars Lind, Andre Franke, Peter W Macfarlane, Kirill V Tarasov, Nicholas Tan, Stephan B Felix, E-Shyong Tai, Debra Q Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia Lindgren, Andrew P Morris, Olli T Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C Morrison, Patricia B Munroe, David P Strachan, Niels Grarup, Ruth J F Loos, Susan R Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif Groop, Nicholas J Wareham, Cornelia M Van Duijn, Mary F Feitosa, Christopher J O'Donnell, Mika Kähönen, Markus Perola, Michael Boehnke, Sharon L R Kardia, Jeanette Erdmann, Colin N A Palmer, Claes Ohlsson, David J Porteous, Johan G Eriksson, Claude Bouchard, Susanne Moebus, Peter Kraft, David R Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, John C Chambers, Jaspal S Kooner, Winfried März, Jerome I Rotter, Andrew A Hicks, J Gustav Smith, Lambertus A L M Kiemeney, Dennis O Mook-Kanamori, Brenda W J H Penninx, Ulf Gyllensten, James F Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J Wouter Jukema, Mark Eijgelsheim, Edward L M Lakatta, Ching-Yu Cheng, Marcus Dörr, Tien-Yin Wong, Charumathi Sabanayagam, Albertine J Oldehinkel, Harriette Riese, Terho Lehtimäki, Niek Verweij, Pim Van Der Harst Aug 2023

Genetic Insights Into Resting Heart Rate And Its Role In Cardiovascular Disease, Yordi J Van De Vegte, Ruben N Eppinga, M Yldau Van Der Ende, Yanick P Hagemeijer, Yuvaraj Mahendran, Albert V Smith, Dan E Arking, Ioanna Ntalla, Emil V Appel, Claudia Schurmann, Jennifer A Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina Mononen, Kirsi Auro, Anne U Jackson, Lawrence F Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Müller-Nurasyid, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Xiuqing Guo, Henry J Lin, Francesca Pavani, Tessel E Galesloot, Raymond Noordam, Yuri Milaneschi, Katharina E Schraut, Marcel Den Hoed, Frauke Degenhardt, Stella Trompet, Marten E Van Den Berg, Giorgio Pistis, Yih-Chung Tham, Stefan Weiss, Xueling S Sim, Hengtong L Li, Peter J Van Der Most, Ilja M Nolte, Leo-Pekka Lyytikäinen, M Abdullah Said, Daniel R Witte, Carlos Iribarren, Lenore Launer, Susan M Ring, Paul S De Vries, Peter Sever, Allan Linneberg, Erwin P Bottinger, Sandosh Padmanabhan, Bruce M Psaty, Nona Sotoodehnia, Ivana Kolcic, Dcct/Edic Research Group, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Beverley Balkau, Claudia T Silva, Christopher H Newton-Cheh, Kjell Nikus, Perttu Salo, Karen L Mohlke, Patricia A Peyser, Heribert Schunkert, Mattias Lorentzon, Jari Lahti, Dabeeru C Rao, Marilyn C Cornelis, Jessica D Faul, Jennifer A Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Konstantin Strauch, Graciela E Delgado, Kent D Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline De Graaf, Renée De Mutsert, Eco J C De Geus, Åsa Johansson, Peter K Joshi, Lars Lind, Andre Franke, Peter W Macfarlane, Kirill V Tarasov, Nicholas Tan, Stephan B Felix, E-Shyong Tai, Debra Q Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia Lindgren, Andrew P Morris, Olli T Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C Morrison, Patricia B Munroe, David P Strachan, Niels Grarup, Ruth J F Loos, Susan R Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif Groop, Nicholas J Wareham, Cornelia M Van Duijn, Mary F Feitosa, Christopher J O'Donnell, Mika Kähönen, Markus Perola, Michael Boehnke, Sharon L R Kardia, Jeanette Erdmann, Colin N A Palmer, Claes Ohlsson, David J Porteous, Johan G Eriksson, Claude Bouchard, Susanne Moebus, Peter Kraft, David R Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, John C Chambers, Jaspal S Kooner, Winfried März, Jerome I Rotter, Andrew A Hicks, J Gustav Smith, Lambertus A L M Kiemeney, Dennis O Mook-Kanamori, Brenda W J H Penninx, Ulf Gyllensten, James F Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J Wouter Jukema, Mark Eijgelsheim, Edward L M Lakatta, Ching-Yu Cheng, Marcus Dörr, Tien-Yin Wong, Charumathi Sabanayagam, Albertine J Oldehinkel, Harriette Riese, Terho Lehtimäki, Niek Verweij, Pim Van Der Harst

Faculty, Staff and Student Publications

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample …


Indwelling Catheter Vs Intermittent Catheterization: Is There A Difference In Uti Susceptibility?, Vera Neumeier, Fabian P Stangl, Joëlle Borer, Collene E Anderson, Veronika Birkhäuser, Oksana Chemych, Oliver Gross, Miriam Koschorke, Jonas Marschall, Shawna Mccallin, Ulrich Mehnert, Helen Sadri, Lara Stächele, Thomas M Kessler, Lorenz Leitner Aug 2023

Indwelling Catheter Vs Intermittent Catheterization: Is There A Difference In Uti Susceptibility?, Vera Neumeier, Fabian P Stangl, Joëlle Borer, Collene E Anderson, Veronika Birkhäuser, Oksana Chemych, Oliver Gross, Miriam Koschorke, Jonas Marschall, Shawna Mccallin, Ulrich Mehnert, Helen Sadri, Lara Stächele, Thomas M Kessler, Lorenz Leitner

2020-Current year OA Pubs

BACKGROUND: Patients with neurogenic lower urinary tract dysfunction (NLUTD) often rely on some type of catheterization for bladder emptying. Intermittent catheterization (IC) is considered the gold standard and is preferred over continuous catheterization, since it is considered to cause fewer urinary tract infections (UTIs) than indwelling catheterization. The main objective of our study was to describe UTI prevalence (at visit) and incidence (within the last 12 months) and urine culture characteristics between patients using an indwelling catheter versus (vs) those performing IC.

METHODS: In this cross-sectional study, we prospectively evaluated from 02/2020 to 01/2021 patients with NLUTD undergoing urine cultures …


Exploring Caregiver Interest In And Preferences For Interventions For Children With Risk Of Asthma Exacerbation: Web-Based Survey, Gabrielle Pogge, David A Fedele, Erika A Waters, Julia Maki, Jean M Hunleth, Sreekala Prabhakaran, Deborah J Bowen, James A Shepperd Aug 2023

Exploring Caregiver Interest In And Preferences For Interventions For Children With Risk Of Asthma Exacerbation: Web-Based Survey, Gabrielle Pogge, David A Fedele, Erika A Waters, Julia Maki, Jean M Hunleth, Sreekala Prabhakaran, Deborah J Bowen, James A Shepperd

2020-Current year OA Pubs

BACKGROUND: Maintaining control of asthma symptoms is the cornerstone of asthma treatment guidelines in the United States. However, suboptimal asthma control and asthma exacerbations among young people are common and are associated with many negative outcomes. Interventions to improve asthma control are needed. For such interventions to be successful, it is necessary to understand the types of interventions that are appealing to caregivers of children with different levels of risk of exacerbation.

OBJECTIVE: This study aimed to evaluate whether caregivers of children with high (vs low) risk of asthma exacerbation show different levels of interest in and preferences for potential …


Quality Assessment Of Life Cycle Inventory Data For Composites, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton Aug 2023

Quality Assessment Of Life Cycle Inventory Data For Composites, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton

School of Engineering, Computing and Mathematics

Environmental sustainability over the life cycle of a product is rising as a key driver in the selection of materials and manufacturing processes. Life cycle assessment (LCA) is increasingly used as a standardised, science-based decision-making support tool to quantify and identify potential environmental impacts through all phases of the product life.A major step involved in completing a Life Cycle Inventory (LCI), and so an LCA study, is the collection, analysis, and quality check of data on the investigated processes, data to quantify the inputs and output (e.g., elementary flow of raw materials, energy, waste, and co-products) of the product system …


Standardizing Congestive Heart Failure Education To Decrease Readmissions, Cyntia Boter Aug 2023

Standardizing Congestive Heart Failure Education To Decrease Readmissions, Cyntia Boter

Master's Projects and Capstones

Background: The setting of this project took place in a small 100-bed community hospital that is a part of a larger healthcare organization in Northern California. The focus of the project was the implementation of standardized education for patients with congestive heart failure (CHF) to lead to an outcome of decreased readmissions. Readmissions to hospitals are costly and effective discharge planning can impact and decrease readmissions.

Problem: The facility in which this project took place has 35 readmissions a year for CHF. It is the third highest DRG and reason for readmissions in 2022. Although there is work in place …


Transformational Leadership Training For Middle Management To Reduce Turnover And Improve Job Satisfaction, Andrea Huntsinger, Andrea Huntsinger Aug 2023

Transformational Leadership Training For Middle Management To Reduce Turnover And Improve Job Satisfaction, Andrea Huntsinger, Andrea Huntsinger

Master's Projects and Capstones

Reduce Turnover and Improve Job Satisfaction

Abstract

Background: The medical center’s Maternal Child Health Department comprises 10 labor and delivery beds, 22 postpartum beds, and a 16-bed Level II NICU. The unit is overseen by six ANMs, a manager, and a director. The unit comprises approximately 160 employees, most being bedside registered nurses (RNs). The hospital prioritizes achieving Magnet status, where nurse job satisfaction is prioritized. The concern is that the department’s culture is not aligning with Magnet guidelines due to a lack of leadership within the unit.

Problem: A review of the department’s ANM team showed an unstable turnover …


Genetic Insights Into Resting Heart Rate And Its Role In Cardiovascular Disease, Yordi J Van De Vegte, Lihua Wang, Dabeeru C Rao, Et Al. Aug 2023

Genetic Insights Into Resting Heart Rate And Its Role In Cardiovascular Disease, Yordi J Van De Vegte, Lihua Wang, Dabeeru C Rao, Et Al.

2020-Current year OA Pubs

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample …


Skp2-Mediated Mlkl Degradation Confers Cisplatin-Resistant In Non-Small Cell Lung Cancer Cells, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu Aug 2023

Skp2-Mediated Mlkl Degradation Confers Cisplatin-Resistant In Non-Small Cell Lung Cancer Cells, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu

Faculty, Staff and Students Publications

Non-small cell lung cancer (NSCLC) is the most prevalent type of cancer and the leading cause of cancer-related death. Chemotherapeutic resistance is a major obstacle in treating NSCLC patients. Here, we discovered that the E3 ligase Skp2 is overexpressed, accompanied by the downregulation of necroptosis-related regulator MLKL in human NSCLC tissues and cell lines. Knockdown of Skp2 inhibited viability, anchorage-independent growth, and in vivo tumor development of NSCLC cells. We also found that the Skp2 protein is negatively correlated with MLKL in NSCLC tissues. Moreover, Skp2 is increased and accompanied by an upregulation of MLKL ubiquitination and degradation in cisplatin-resistant …


In Silico Prediction Of Sirna To Silence The Sars-Cov-2 Omicron Variant Targeting Ba.4, Ba.5, Bq.1, Bq1.1. And Xbb: An Alternative To Traditional Therapeutics, Rahatul Islam, Asif Shahriar, Nour Fatema, Muhammad Ramiz Uddin, Mrityunjoy Acharjee, Md Mukhlesur Rahman Shepon, Avishek Sarkar, Khosnur Jahan Aurin Aug 2023

In Silico Prediction Of Sirna To Silence The Sars-Cov-2 Omicron Variant Targeting Ba.4, Ba.5, Bq.1, Bq1.1. And Xbb: An Alternative To Traditional Therapeutics, Rahatul Islam, Asif Shahriar, Nour Fatema, Muhammad Ramiz Uddin, Mrityunjoy Acharjee, Md Mukhlesur Rahman Shepon, Avishek Sarkar, Khosnur Jahan Aurin

School of Medicine Publications

Background

After the first infection in December 2019, the mutating strains of SARS-CoV2 have already affected a lot of healthy people around the world. But situations have not been as devastating as before the first pandemic of the omicron strains of SARS-CoV2. As of January 2023, five more Omicron offshoots, BA.4, BA.5, B.Q.1, B.Q.1.1 and XBB are now proliferating worldwide. Perhaps there are more variants already dormant that require only minor changes to resurrect. So, this study was conducted with a view to halting the infection afterwards. The spike protein found on the virus outer membrane is essential for viral …


An Sms Text Message-Based Type 2 Diabetes Prevention Program For Hispanic Adolescents With Obesity: Qualitative Co-Design Process, Ayleen Hernandez, Salma M Musaad, Teresia M O'Connor, Debbe Thompson Aug 2023

An Sms Text Message-Based Type 2 Diabetes Prevention Program For Hispanic Adolescents With Obesity: Qualitative Co-Design Process, Ayleen Hernandez, Salma M Musaad, Teresia M O'Connor, Debbe Thompson

Faculty, Staff and Students Publications

BACKGROUND: SMS text message-based interventions are a promising approach for reaching and engaging high-risk youths, such as Hispanic adolescents with obesity, in health promotion and disease prevention opportunities. This is particularly relevant, given that SMS text messaging is widely accessible and available and that adolescents are frequent texters. Including youths in the development of SMS text message content can lead to more acceptable and relevant messaging; however, few studies include this group as cocollaborators.

OBJECTIVE: This study aimed to use a co-design process to inform the development of SMS text messages that promote healthy physical activity (PA) and sleep behaviors …


Collaborative Challenges Between Educational Accessibility Coordinators And Adjunct Faculty In Supporting Autism Spectrum Students, Tamara Faure, Pietro Antonio Sasso Aug 2023

Collaborative Challenges Between Educational Accessibility Coordinators And Adjunct Faculty In Supporting Autism Spectrum Students, Tamara Faure, Pietro Antonio Sasso

New York Journal of Student Affairs

Accessibility of educational accommodations has increased but can be frequently inconsistent for undergraduates with autism spectrum disorder (ASD). The didactic relationship between educational accessibility staff with faculty, who are increasingly adjuncts, facilitates many course-learning accommodations. This descriptive phenomenological study explored the perceptions and professional experiences of educational accessibility coordinators with adjunct faculty in their implementation of learning accommodation for undergraduates with ASD. Findings from this study suggested that accessibility coordinators negotiated expectations of unprepared adjunct faculty and ASD students to address issues throughout the semester.

Coordinators believed ASD students struggled to navigate their experiences with adjunct professors because they were …


Lgbtq Community College Students’ Decreased Sense Of Belonging, Joseph Falco, Michael Sparrow Ed.D. Aug 2023

Lgbtq Community College Students’ Decreased Sense Of Belonging, Joseph Falco, Michael Sparrow Ed.D.

New York Journal of Student Affairs

LGBTQ students experience a lower sense of belonging at community colleges. The correlation between campus and classroom climate and academic success, campus involvement, identity, level of outness, and well-being for LGBTQ students contributes to their decreased sense of belonging. Non-LGBTQ-affirming and non-inclusive community college campuses and classrooms lead to feelings of fear, invisibility, lack of validation, mental health challenges, and poor academic performance for LGBTQ students. An extensive literature review was conducted to determine the root causes around the decreased sense of belonging for LGBTQ students enrolled at community colleges.  Three themes emerged that explained this decreased sense of belonging: …


Increasing Study Abroad Participation Among Historically Excluded Students, Daniel J. Scanlon, Kimberly A. Kline Aug 2023

Increasing Study Abroad Participation Among Historically Excluded Students, Daniel J. Scanlon, Kimberly A. Kline

New York Journal of Student Affairs

Higher education has yet to address the deeper causes of inequities in student participation rates in study abroad programs across student demographics. Factors contributing to inequities include disparities in access to social and cultural capital and neglect of identity-related experiences of racially minoritized and first-generation, historically excluded students. This qualitative study examined faculty and staff experiences in the development of study abroad programs and explored their considerations for the needs of historically excluded students. A consensus among interview participants indicated a significant role for intentionality throughout the processes of program development, recruitment outreach, and preparation of students for the study …


Discovery Of An Introduced Florida Flagfish (Jordanella Floridae) Population In Coastal Mississippi, Robert Ellwanger, Samuel E. Hunt, Calvin R. Rezac, Matthew D. Wagner Aug 2023

Discovery Of An Introduced Florida Flagfish (Jordanella Floridae) Population In Coastal Mississippi, Robert Ellwanger, Samuel E. Hunt, Calvin R. Rezac, Matthew D. Wagner

Southeastern Fishes Council Proceedings

The recent discovery of Jordanella floridae (Florida Flagfish) in Harrison County, Mississippi represents the first known occurrence of the species in the state. Native along the Atlantic and Gulf Coasts of Florida from Jacksonville to Tallahassee, this species has been introduced outside of its range via aquarium introductions. We hypothesize that an aquarium introduction was also the source of the newly discovered population, which has persisted at the location since 2020. Multiple collections of the species have been taken from a small waterbody which has a direct connection to the Tchoutacabouffa River (25mm-47mm TL). While it is unknown if this …


Cookie(X) = 1/2, Lawrence M. Lesser Aug 2023

Cookie(X) = 1/2, Lawrence M. Lesser

Journal of Humanistic Mathematics

This poem applies the concept of expected value, denoted E(X), to the context of any limited resources two parties desire. Usually, "you divide, I choose" keeps pieces equal enough to preempt charges of unfairness. But if one piece is much larger, many distrust the unbiased (in expected value) process of a coin flip giving each person the same chance at the bigger piece and the same cookie amount on average: E(X) = (1/2)p + (1/2)(1-p) = 1/2