Digital Commons Network^™

Traf3-Ewsr1 Signaling Axis Acts As A Checkpoint On Germinal Center Responses, Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Hongjiao Wang, Jing Wang, Shuli Zhao, Zuliang Jie

Faculty, Staff and Student Publications

The formation of germinal centers (GCs) is crucial for humoral immunity and vaccine efficacy. Constant stimulation through microbiota drives the formation of constitutive GCs in Peyer's patches (PPs), which generate B cells that produce antibodies against gut antigens derived from commensal bacteria and infectious pathogens. However, the molecular mechanism that regulates this persistent process is poorly understood. We report that Ewing Sarcoma Breakpoint Region 1 (EWSR1) is a brake to constitutive GC generation and immunoglobulin G (IgG) production in PPs, vaccination-induced GC formation, and IgG responses. Mechanistically, EWSR1 suppresses Bcl6 upregulation after antigen encounter, thereby negatively regulating induced GC B …

Psilocybin-Assisted Psychotherapy For Cancer-Related Anxiety And Depression, Dan Yaniv, Lois Michelle Ramondetta, Lorenzo Cohen, Moran Amit

Faculty, Staff and Student Publications

No abstract provided.

Pediatric Firearm Injury Epidemiology At A Level 1 Trauma Center From 2019 To 2021: Including Time Of The Covid-19 Pandemic, Irma T Ugalde

Faculty, Staff and Student Publications

BACKGROUND: Firearms are a leading cause of death in children. The demand for firearms increased following COVID-19 "stay-at home orders" in March 2020, resulting in record-breaking firearm sales and background checks. We aim to describe the changes in pediatric firearm-related injuries, demographics, and associated risk factors at a Level 1 trauma center in Houston before and during the COVID 19 pandemic.

RESULTS: The total number of pediatric firearm-related injury cases increased during March 15th to December 31st, 2020 and 2021 compared to the same time period in 2019 (104 verses 89 verses 78). The demographic group most affected across years …

Ocean-Based Climate Action And Human Rights Implications Under The International Climate Change Regime, Elisa Morgera, Mitchell Lennan, Kati Kulovesi, Bianca G La, Holly J. Niner, Ellycia Harrould-Kolieb, Piva E Recio, Jeremy Hills, Mara Ntona, Alana Malinde Sn Lancaster, Mia Strand, Bernadette Snow, Kira Erwin, Lynne Shannon, Sian Rees, Kieran Hyder, Georg Engelhard, Kerry Howell

School of Biological and Marine Sciences

After drawing attention to the crucial role of marine biodiversity, including that of deep-sea ecosystems, in current scientific understanding of the ocean-climate nexus, this article highlights the limited extent to which the international climate change regime has so far addressed the ocean. The focus then shifts to how the international climate change regime could contribute to the protection of marine biodiversity as part of mitigation, adaptation and finance, taking into account human rights impacts and standards, drawing a comparison with REDD+. The article concludes with an original proposal, inspired by the Climate and Clean Air Coalition, to develop urgent, synergistic …

Quantitative Flow Ratio As A Continuous Predictor Of Myocardial Infarction, Miao Chu, Zhongwei Sun, Kefei Dou, Shengxian Tu, Lei Song, Shubin Qiao, Bo Xu

Faculty, Staff and Student Publications

Background: The quantitative flow ratio (QFR) identifies functionally ischaemic lesions that may benefit more from percutaneous coronary intervention (PCI) than from medical therapy.

Aims: This study investigated the association between QFR and myocardial infarction (MI) as affected by PCI versus medical therapy.

Methods: All vessels requiring measurement (reference diameter ≥2.5 mm and existence of at least one stenotic lesion with diameter stenosis of 50-90%) in the FAVOR III China (5,564 vessels) and PANDA-III trials (4,471 vessels) were screened and analysed for offline QFR. The present study reported clinical outcomes on a per-vessel level. Interaction between vessel treatment and QFR as …

Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel

Faculty, Staff and Student Publications

Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64 genes among 556 metabolic HCC cases and 643 cancer-free controls with metabolic conditions. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for multiple comparisons. Gene-burden tests were used for rare variant associations. Analyses were performed in …

Anomaly Detection In The Molecular Structure Of Gallium Arsenide Using Convolutional Neural Networks, Timothy Roche, Aihua W. Wood, Philip Cho, Chancellor Johnstone

Faculty Publications

This paper concerns the development of a machine learning tool to detect anomalies in the molecular structure of Gallium Arsenide. We employ a combination of a CNN and a PCA reconstruction to create the model, using real images taken with an electron microscope in training and testing. The methodology developed allows for the creation of a defect detection model, without any labeled images of defects being required for training. The model performed well on all tests under the established assumptions, allowing for reliable anomaly detection. To the best of our knowledge, such methods are not currently available in the open …

Victim Protection And The Dynamic Situation Of Human Trafficking: Indonesia Experience, Nathalina Naibaho

Indonesian Journal of International Law

Human trafficking is a global issue. It can arise in the context of national and/or transnational acts and are regulated by national and transnational criminal law mechanisms. However, in trafficking in person cases there are links between human trafficking and other related crimes such as drugs trafficking. Meanwhile, Indonesia has enacted laws which provide mandatory protection for victims of human trafficking. It also has mandatory drug laws which, in some cases, subject to the death penalty. This legislative conflict together with investigative and prosecutorial failure risks the conviction of human trafficked victims who are used as drug dealers in organized …

Frights And Forests: The Hellish Landscape Of The Dark Forest, From Sleepy Hollow To The Forest Of Arden, Minna Nizam

Online Midwinter Seminar (OMS)

This paper seeks to explore forest settings in fantasy, and its hellish landscapes. From the headless horseman in Washington Irving’s The Legend of Sleepy Hollow, to the frights and horrors of mythical creatures in fantasy settings placed in forests. The purpose of this study is to dive deep into the fear of the forest, its early days in storytelling, to more modern renditions. Sources used will be primarily books, and texts within books, such as The Legend of Sleepy Hollow, The Lord of the Rings, and much more.

Mythopoeic Awards Discussion, David Lenander, David Emerson

Online Midwinter Seminar (OMS)

No abstract provided.

Seven Minutes In Hell: Hells In Fantasy Games, Nyssa Gilkey

Online Midwinter Seminar (OMS)

Join Nyssa Gilkey on a tour through several different fantasy video game depictions of hell. We’ll spend about seven (-ish) minutes looking around each hell or underworld before moving on, touring Helheim in God of War and God of War: Ragnarok, Hades and Elysium as portrayed in Assassin’s Creed: Odyssey DLC, and the Duat of ancient Egypt in Assassin’s Creed: Origins DLC. With sufficient time and interest, we can tour other fantasy depictions of hell. Participants will be able to ask questions and discuss throughout the journey.

The Image Of Satan In Evangelical Children’S Fantasy, Melody Green

Online Midwinter Seminar (OMS)

Over the last few decades, niche publishers have presented several children’s fantasy series marketed as being “in the tradition of Lewis and Tolkien.” These publishers, however, are neither British, nor are they Anglican or Catholic. They are instead American Evangelical organizations, providing a space for faith-informed stories that wander somewhere between allegory and parable. Within the pages of these texts can be found not only the expected Christ-figures, but there are also Satan-figures and hellish landscapes much more likely to reflect concepts from Dante, Milton, and medieval witch-hunting guides than from the Bible, the text that evangelicals claim to be …

Hell As An Exploration Of Sin: A Comparison Of Alan Moore’S Providence To Dante’S Inferno, Zachary Rutledge

Online Midwinter Seminar (OMS)

In Alan Moore’s graphic novel Providence, Robert Black travels Lovecraftian New England and suffers a series of horrifying encounters—each an allusion to a Lovecraft story. These encounters contain direct references to various sins and taboos, thereby making explicit much of the sublimated sexuality in Lovecraft’s works. Therefore, Black’s journey constitutes not only a trip through Lovecraft’s mythology but also reads as a cataloguing of sins reminiscent of Dante’s passage through the levels of sin in Inferno. This paper identifies and explores the similarities between Dante and Black as examples of those who descend to the underworld along with a …

Political Demons: Society As Hell In Hellblazer And Sandman, Andrew Burt

Online Midwinter Seminar (OMS)

In the Hellblazer and Sandman comic book universes, hell depends on the writer’s worldview and often on the decade in which they are writing, appearing as a twisted version of a dreary regular world. Thus, this hell is often related to the contemporary Western political and cultural landscape as seen through Judeo-Christian conceptions of hell, demonology, and fears of everlasting torment and damnation, just like Dante’s Inferno and many other representations for centuries. In creating a hell that mirrors the modern world and accounts for contemporary folklore about the supernatural, the creators humanize the character’s quests and reify the fruitlessness …

Panel: The Rings Of Power Season 1: Underworlds, Overworlds, And Ocean Worlds, Tim Lenz, Leah Hagan, Grace Moone, Pablo Guss

Online Midwinter Seminar (OMS)

Now that the first of five planned seasons of Amazon’s big budget Second Age adaptation The Lord of the Rings: The Rings of Power has aired, we will provide a retrospective of Season 1. We will compare Tolkien’s Second Age writings with the realized version in the show, including how the writers and showrunners have interpreted certain specific passages from the texts, and where significant departures were made for sake of adaptation. We will highlight themes of the season, as well as specific characters, relationships, and settings that have resonated with audiences, and speculate on where the series could potentially …

Green Infrastructure Intervention To Improve Waste And Water System In Urban Areas, Muthiah Hakim Hadini, Farah Bulqis Muzakar, Nurlina Yustiningrum, Nicole Hall, Peicong Li, Freya Ward, Ova Candra Dewi, Coriesta Dian Sulistiani, Andrew Flynn

Smart City

The increase in waste generation and water use in urban areas may lead to local flooding that is dangerous for health if it is not appropriately managed by waste and water systems in urban infrastructure. Sponge City is a concept that utilizes Green Infrastructures (GIs) to manage waste and water systems while still maintaining open and public spaces function. This study aims to review the waste and water infrastructure systems in Depok, Indonesia which are compared with Gainesville in the United States, America and Cardiff, United Kingdom, to give recommendations for preventing flooding in urban areas. Analysis is done by …

Development Of A Kmno4 Catalyst-Infused Fuel Grain For H2o2 Hybrid Thruster Ignition Enhancement, Ryan Thibaudeau, Stephen A. Whitmore

Small Satellite Conference

Utah State University's patented High Performance Green Hybrid Propulsion (HPGHP) technology leverages unique dielectric breakdown properties of 3D-printed acrylonitrile butadiene styrene (ABS), allowing re-start, stop, and reignition. HPGHP works most reliably using gaseous oxygen (GOX) as the oxidizer but has experienced ignition reliability and latency issues when replaced high test hydrogen peroxide (HTP), which has a significantly higher storage density. This deficiency results from HTP's high decomposition energy barrier. Traditionally, inline external catalyst beds or GOX pre-lead burns are used to overcome this energy barrier to achieve ignition; however, the extra hardware required for these systems have inhibited their adoption …

Who The Hell Is Helen Of Sparta?, Nyssa Gilkey

Online Midwinter Seminar (OMS)

The rising popularity of Greek mythology is due in some part to female authors such as Madeline Miller and Natalie Haynes lending a fresh perspective to the Homeric tradition. However, these female authors tend to actually reduce the importance of one of the most important female characters of the Trojan War: Helen. Helen of Sparta has been an enigma to writers throughout the last 3000 years, her story changing with each iteration and era. Since Homer’s Iliad, the most beautiful woman in the world has been victim and villain, strong and weak willed. She has chosen husbands, and been …

Pullman’S Problematic Paradise: Dissolving Into Dust, David E. Isaacs

Online Midwinter Seminar (OMS)

In the His Dark Materials trilogy, Phillip Pullman has openly positioned himself as the anti-C.S. Lewis who attempts to embed the gospel of atheism through his fantasy novels. Pullman recasts classics such as Paradise Lost and Blake’s The Marriage of Heaven & Hell so that humans triumph over the oppressive Authority by learning that sinning is simply enjoying life. This paper will specifically explore Pullman’s depictions of the underworld and his alternative vision of Hell, Purgatory, and Heaven in The Amber Spyglass, examining Pullman’s attempts to assure readers that by rejecting Christian views of the final translation, one can …

Hellish Landscapes In J.R.R. Tolkien’S Legendarium, Willow Dipasquale

Online Midwinter Seminar (OMS)

J.R.R. Tolkien’s Legendarium is rich with magical and mythological elements—enchanted rings, powerful wizards, stories told long ago—and near-Biblical struggles of good over evil, power over life and death, and the inexorable passage of time. The Halls of Mandos in Valinor even have echoes of the “afterlife,” serving as a liminal place for the spirits of Elves to await their next destination. Interestingly, though, a “hell” in the classic sense (that is, a spiritual region of eternal torment and suffering) does not seem to truly exist in Tolkien’s imagined worlds. However, Tolkien does fill those worlds with hellish landscapes: Utumno and …

Planes Of Oblivion In The Elder Scrolls, Michael Barros

Online Midwinter Seminar (OMS)

The planes of Oblivion from The Elder Scrolls (TES) series are not explicitly Hell; they are any dimensions of reality which are not under control of the Aedra, the benevolent spiritual entities. As a result, these planes may be totally unknown, pleasant, chaotic, or horrifying, depending on who is in charge, reflecting the personality of its ruler. These planes are at the heart of the franchise, and the intrusion of the planes of Oblivion and its inhabitants is a constant in the series. The planes of Oblivion are a reimagining of Hell as a place of potential, rather than evil. …

Thermal And Radiation Design Considerations For Cubesats In Low Lunar Orbit, Bruno Mattos, Lucas Anderson, Randy Jost, Charles Swenson, Denis Vieira, Renan Menezes

Small Satellite Conference

NASA's Artemis program is turning the attention back to the Moon. As an example of Artemis I, CubeSats can now be inserted into lunar orbits by ridesharing. Designers must become familiarized with the additional technical challenges of operating far away from the usual low Earth orbit (LEO) condition, especially regarding the lunar radiation and thermal environments. This paper analyzes the thermal environment loads for a spacecraft operating in a low lunar orbit (LLO) at 100km altitude with a fixed nadir-pointing orientation. A simplified thermal model is presented to assess the impact of the surfaces' thermal-optical properties and internal thermal resistances …

Lessons Learned From Operations Planning And Preparation For Equuleus Launched Toward The Moon By Sls Artemis-1, Shintaro Nakajima, Yosuke Kawabata, Ryota Fuse, Ryu Funase

Small Satellite Conference

EQUULEUS (EQUilibriUm Lunar-Earth point 6U Spacecraft) will be the world's smallest spacecraft to explore around the Earth–Moon Lagrange point, which was launched on November 16, 2022, by NASA's SLS (Space Launch System) Artemis-1. The primary mission of spacecraft is a trajectory control experiment, and its objective is to develop and demonstrate trajectory control techniques within the Sun-Earth-Moon region by flying to a libration orbit around the Earth-Moon Lagrange point L2 (EML2) along a low-energy transfer. EQUULEUS must perform a maneuver before the lunar flyby to stay within the Sun-Earth-Moon region. To perform DV1, we need to calculate and optimize the …

Autonomous Docking System For Assembly And Reconfiguration In Space For Small Satellites, Atheel Redah, Felix Sittner, Saurav Paudel, Sergio Montenegro

Small Satellite Conference

As the number of orbiting satellites has rapidly increased in the last few years, the need of space elements that can perform autonomous rendezvous and docking maneuvers with other orbiting elements for different application such as self-assembly and reconfiguration in space are become more pressing. The TAMARIW project is intended to demonstrate such capability for small satellites. This paper describes the project and the modules being developed to realize its objectives at the time of writing. It will also present the technologies and systems intended to be used for performing safe autonomous undocking/docking maneuvers. Additionally, the testing platforms being built …

Space Demonstration Of Two-Layer Pop-Up Origami Deployable Membrane Reflectarray Antenna By 3u Cubesat Origamisat-2, Gen Nakayama, Motoki Moritani, Takashi Tomura, Hiraku Sakamoto, Shuhei Koike, Taichi Oshino, Yoshiki Mitsumoto, Kazuki Nagai, Sora Kanamaru, Takumi Sato, Haruki Kurokawa, Soma Saito, Atsuki Ochi, Delburg Mitchao, Shinya Tamura, Yuki Takeda, Toranosuke Yanagi, Koichi Kidani, Kota Toyoda, Suk So Yeon, Mitsuhiko Yasuhara, Koudai Suzuki, Riku Maeda, Sota Kume, Atsushi Shirane, Kenichi Okada

Small Satellite Conference

3U CubeSat OrigamiSat-2 demonstrates a 50-cm × 50-cm two-layer pop-up Origami deployable membrane reflectarray antenna in space. The membrane has small stowage volume and high gain even though it has low flatness because of a large enough antenna area to cover its un-flatness. C-band transmitter is equipped in the CubeSat and offers 20-Mbps amateur satellite communication. In 3U size, a 1-m length deployable gravity gradient mast and magnetic torquer are equipped to stabilize and control its attitude. A camera is attached to the satellite to measure the shape of the membrane antenna. OrigamiSat-2 was selected as the Innovative Satellite Technology …

Windform® Xt 2.0 Use As 3u Cubesat Primary Structure, Amanda Stark, Andrew Paddock, Thuan Nguyen, Kurt Woodham

Small Satellite Conference

CubeSats provide a platform for small-scale space research and technology demonstration at reduced complexity, cost, and development time. These advantages drove the NASA Langley Research Center (LaRC) to develop and launch the GPX2 3U CubeSat to explore the viability of using Commerical Off-The-Shelf (COTS) differential Global Position System (dGPS) in low earth orbit. To reduce manufacturing costs and increase design flexibility, the project chose additive manufactured Windform® XT 2.0 as the primary bus material rather than traditional subtractive manufactured (milled) metal. The bus is a two-part, Selective Laser Sintered, 3D-print structure consisting of a single-piece, five-walled chassis and single-walled cover. …

The Lightsail 2 Solar Sailing Mission Summary, David A. Spencer, John M. Bellardo, Bruce Betts, Justin Mansell, Barbara Plante

Small Satellite Conference

The LightSail 2 mission concluded a 3-year mission in November 2022, having successfully demonstrated controlled solar sailing in low-Earth orbit using a CubeSat platform. Flight data show that LightSail 2 successfully controlled its orientation relative to the Sun, with sustained periods of apogee raising and increasing orbital energy. The LightSail 2 solar sail was 5.6 m on a side and has a total deployed area of 32 m². Four independent triangular aluminized Mylar® sail sections 4.6 microns thick were Z-folded and stowed into four sail bays. The sail segments were deployed by four 4 m Triangular Retractable And Collapsible booms …

Persephone Bites: Consumption In The Underworld, Erin Sledd

Online Midwinter Seminar (OMS)

If you know one thing about Persephone, it is that she was abducted by Hades, held captive, and ate pomegranate seeds in the Underworld. Although Demeter rescued her daughter, she had to return for several months each year as a consequence of consuming the “Fruit of the Underworld.” But tasting those succulent ruby red seeds was not the first time she succumbed to desire—according to the Homeric Hymn to Demeter II, the first thing Persephone “bites” is a lure. Hades sets a trap: a flower with “one hundred stems of fragrant blossoms.” When Persephone grasps a stalk of this …

Only In Dying Life: The Production Of Hope And Peace, Taylor Johnson Guinan

Online Midwinter Seminar (OMS)

Unlike fantasy authors of previous generations like C.S. Lewis and J.R.R. Tolkien who wrote depictions of an afterlife that mirrored their personal faiths, modern children’s fantasy authors of the last thirty years, such as Neil Gaiman, Ursula K. Le Guin, Phillip Pullman, Rick Riordan, J.K. Rowling, Jonathan Stroud, and Garth Nix, often merely use religious concepts as a way to depict the land of the dead. In their depictions, the land of the dead is a dark, terrible, and uninviting place. However, rather than ending on that dark point, these authors transition from fear to a sense of peace, acceptance, …

Through Sauron’S Eye: Hell, Arda Unmarred, Arda Marred, And Arda Healed According To The Maia Formerly Known As Mairon, Cameron Bourquein

Online Midwinter Seminar (OMS)

From the beginning of Tolkien scholarship Mordor has been analyzed in light of its Hellish iconography; from the perspective of the narrative voice, what constitutes “Hell” in Middle-earth may seem clear. But what is Hell to Mordor’s chief inhabitant? What is Hell in Sauron’s Eye? The Rings of Power has brought Sauron into the spotlight by interpreting him not as depersonalized evil but as a character in his own right. Actor Charlie Vickers has shared how he developed this character for the screen, adapting characteristics taken directly from Tolkien’s own writings: Sauron’s love of order and his desire to “heal” …