Digital Commons Network^™

Suppressing Saints And Suffering Sinners: An Analysis Of Reductive Tropes Through The 2025 Film Sinners, Kaila Palmer

Electronic Theses and Dissertations

Ryan Coogler’s 2025 horror film Sinners is set in a predominantly Black Mississippi community during the Jim Crow era and explores the vulnerability and hypervisibility of Black people. Vampires and Klansmen fixate on Black bodies, treating them as consumable and dispensable sources. Prior to its Amazon Prime debut and extended theatrical run, Sinners grossed over $300 million, signaling its cultural impact and contribution to reshaping representations of Black identity in cinema. As part of Coogler’s broader array of Black storytelling, the film disrupts entrenched stereotypes by emphasizing character depth rather than caricature.

This paper analyzes the characters Annie and the …

Global Impact Of Germline Structural Variation On The Cancer Proteome, Fengju Chen, Yiqun Zhang, Luis F Paulin, Darshan S Chandrashekar, Sooryanarayana Varambally, Fritz J Sedlazeck, Chad J Creighton

Faculty, Staff and Students Publications

Proteome and transcriptome data combined can help assess the relevance of non-coding germline variants. Here, we combine germline Structural Variants (SVs) with mass spectrometry-based proteomics on tumors from 1637 cancer patients spanning various tumor tissues of origin to determine the extent SV breakpoint patterns involve differential protein expression of nearby genes. Rare and singleton SVs disrupting protein expression of known cancer susceptibility genes collectively involve 6% of patients. About 24% of the hundreds of genes with SV-associated non-coding cis-regulatory alterations at the mRNA level are similarly associated at the protein level. Both rare and common SVs may associate with differential …

Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu

Faculty, Staff and Students Publications

Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.

Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …

International Consensus On The Evaluation And Management Of Hypothalamic Hamartomas: Results From A Modified Delphi Survey, Nathan T Cohen, Xiaotong Li, Madison M Berl, Chima O Oluigbo, Hiroshi Shirozu, Samuel F Berkovic, Margaret Zacharin, Wirginia Maixner, Andreas Schulze-Bonhage, Kerstin Klotz, Nicola Specchio, Sarah Ferrand-Sorbets, Christine Bulteau, Alexis A Arzimanoglou, Jean Regis, J Helen Cross, Martin M Tisdall, Hanna Richardson, Arthur Cukiert, Cristine Cukiert, Julia Jacobs, Elizabeth J Donner, Phillip L Pearl, John F Kerrigan, Angus A Wilfong, Kevin C J Yuen, Dennis J Dlugos, Daniel Curry, Irfan Ali, John Ragheb, Lisa Soeby, Erica Webster, William D Gaillard

Faculty, Staff and Students Publications

Background and objectives: Hypothalamic hamartomas (HH) are rare brain lesions associated with epilepsy and numerous comorbidities. Worldwide treatment is varied. There is a paucity of high-quality evidence to guide treatment. This study aimed to establish expert consensus on the evaluation and management of HH.

Methods: A modified Delphi survey was designed by the Medical Advisory Board of Hope for Hypothalamic Hamartomas and was conducted among 17 International League Against Epilepsy level II epilepsy surgery centers. The survey included 257 questions in round 1 and 81 refined questions in round 2, covering domains of diagnosis, imaging, medical and surgical treatment, neuropsychological …

Artificial Intelligence In Low-Dose Computed Tomography Lung Cancer Screening: Clinical Integration, Validation, And Translational Challenges, Valeria Vanessa Varela Betancourt, Archana Acharya, Nusrat Jahan, Udit Kapahi, Insharah Khalid, Syed Maaz Shah, Hassan Ibrahim, Bushra Nawaz, Shazma Shayan, Maia Valls Palacios Reese, Sheeza Nadeem, Manju Rai

Student Publications

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Low-dose computed tomography (LDCT) screening has demonstrated significant mortality reduction in high-risk populations; however, its widespread implementation is limited by high false-positive rates, inter-reader variability, and substantial workflow burden. Artificial intelligence (AI) has emerged as a promising adjunct to address these challenges by enhancing diagnostic consistency, efficiency, and risk stratification in LDCT-based screening. This narrative review aims to synthesize current evidence on AI methodologies, clinical applications, validation studies, and translational challenges in LDCT-based lung cancer screening. A structured literature search was conducted across PubMed, Scopus, …

Spartan Daily, April 14, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 32

1627-1635 Amsterdam Ave. Llc V. Wolfe

All Decisions

The court granted summary judgment dismissing this nonpayment petition because the subject building requires a certificate of occupancy but does not have one. Open Department of Buildings violations served as prima facie evidence of the deficiency, which the landlord did not dispute. Relying on the controlling Court of Appeals precedent in Chazon, LLC v Maugenest, the court dismissed decisions the landlord cited to the contrary as outliers.

Equitable Estimation Of Accurate High Injury Networks (Hins) For Vulnerable Road Users, Anurag Pande, Anandamayee Majumdar, Lucas Roman Kantorowski

Mineta Transportation Institute

To improve traffic safety, communities first need to know where serious crashes are actually happening. High-Injury Networks are designed to identify these locations, but they are usually built using only police-reported crash data. This research asks: Are we missing crashes—and injuries—by relying on police data alone? The research team first demonstrates that data from Emergency Medical Services and those from official databases differ substantially, and neither data set captures the full extent of collisions in a community. Following that analysis, the research team concluded that a new data source may help complete this. Toward that end, the research team scraped …

From Disaster To Decision: Spatial And Temporal Patterns In Disaster-Affected Voting, Jake L. Shaw

Dissertations

This dissertation examines how natural disasters shape electoral behavior in gubernatorial and presidential elections in the United States, with particular attention to geographic proximity, disaster severity, and partisan accountability. Using county-level gubernatorial and presidential election returns from 2016 to 2022, it analyzes the electoral effects of hurricanes, wildfires, and tornadoes through three frameworks: direct disaster impact, near-distance exposure, and disaster severity. Employing the difference-in-differences and fixed effects models across more than 31,000 county-year observations, the study finds that natural disasters can significantly reduce incumbent party vote share and voter turnout, particularly in gubernational elections. Results further demonstrate that electoral effects …

Semiochemicals And Odorant Receptors Underlying Potato Cultivar Susceptibility And Resistance To Potato Tuber Moth, Ruipeng Chen, Wangtao Hu, Qin Hu, Junjie Yan, Jiao Yin, Fathiya M. Khamis, Yulin Gao, Walter S. Leal

All Peer-Reviewed Publications

Infestation of potato by the potato tuber moth (Phthorimaea operculella) varies markedly among cultivars, yet the chemical and molecular mechanisms underlying this variation remain poorly understood. Here, we combine field surveys, chemical ecology, functional genomics, and structural modeling to reveal how cultivar-specific volatile profiles shape moth oviposition behavior and pest outcomes. Field and laboratory assays identified marked differences in adult attraction, oviposition, and larval damage among potato cultivars, which correlated with distinct blends of emitted volatile organic compounds (VOCs). Behavioral analyses revealed that among other VOCs, trans-nerolidol and β-ionone act as attractants, whereas 3-carene and benzyl tiglate function as oviposition …

The Effects Of Dietary Protein Manipulation On Operant Demand, Brianna R. Lilly

LSU Master's Theses

Previous work with dietary protein restriction in rodents has demonstrated that rodents fed a low protein diet exhibit physiological effects such as lower rates of weight gain and increased levels of circulating fibroblast growth factor 21 (FGF21). Dietary protein restriction also produces behavioral effects. Compared to rodents that are not protein-restricted, rodents that are protein-restricted exhibit increased food intake and higher preference for a protein vs. carbohydrate solution. Additionally, protein-restricted rodents will respond at higher levels for a protein reinforcer than non-restricted rodents. The current study assessed the effect of dietary protein restriction on operant protein demand during and after …

The Link April 14, 2026, Access To Justice Institute

The Link Newsletter

No abstract provided.

Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein

Capstone Projects

This doctoral capstone experience (DCE) was completed at Corewell Health Grand Rapids Hospitals Hand Therapy Clinic and focused on two ACOTE concentration areas including advanced clinical practice skills and education. The experience combined hands-on clinical practice in a specialized outpatient hand therapy setting with the development of high-quality client education materials and home exercise programs (HEPs). Objectives were created to address identified needs through the creation of client education handouts, development of diagnosis-specific Medbridge HEP templates, and creation of training resources to improve therapist efficiency with Medbridge use. Outcomes of the project included improved access to evidence-based educational materials, reduced …

Mastery By Mistakes: Reframing Failure In Higher Education Skill-Based Teaching And Assessment, Maura Metheny

JWU Dissertations & Theses

Experiencing a mistake, error or failure while learning generates an additional inquiry process that activates prior knowledge and increases retention of subsequent feedback and new material (Kapur, 2008). The use of errors to guide practice has been shown to lead to skill-mastery and expertise (Ericsson et al., 1993). When classrooms are psychologically safe environments where penalty-free exploration and knowledge application are encouraged, students gain a deeper understanding of the content (Tulis, 2013). This qualitative exploratory descriptive study aimed to understand the ways that undergraduate faculty in skill-based disciplines involve errors, mistakes and failures in teaching and …

Enhanced Dietary Monitoring Using Fecal Genomics For Childhood Malnutrition Interventions, Ammara Aqeel, Najeeha T Iqbal, Sanam Iram Soomro, Sheraz Ahmed, Teresa K Mcdonald, Olivia Osborne, Sharon Jiang, Nolan Ives, Kazi Ahsan, Fayaz Umrani, Michael J Barratt, Jeffrey I Gordon, Syed Asad Ali, Lawrence A David

2020-Current year OA Pubs

Ready-to-use therapeutic and supplementary foods (RUTF/RUSF) are a primary treatment for childhood malnutrition in Community Management of Acute Malnutrition (CMAM) programs. However, measuring intervention compliance is labor intensive and unreliable. We applied FoodSeq, a fecal genomic dietary assessment biomarker, in malnourished infants (3-15 months) from Matiari, Pakistan. FoodSeq identified a significant increase in the abundance of DNA from chickpea, a primary RUSF ingredient, during RUSF administration and captured region-specific complementary feeding practices, including age-inappropriate feeding practices such as wide-spread tea consumption. Our findings highlight the potential of dietary genomics as an empirical and scalable tool for compliance monitoring and dietary …

Synthetic Lethality Of Decitabine Plus Atr Inhibition For Tp53-Mutated Aml, Jeremy T Baeten, Sumedha Agashe, Imene Tabet, Jack T Wooldridge, Amber Carter, Jamie N Butler, Christopher A Miller, Nicole Helton, Annabel Quinet, Kimberly B Johansson, Yichan Yang, Geoffrey L Uy, Alessandro Vindigni, Daniel C Link

2020-Current year OA Pubs

TP53 mutations are found in 10% to 15% of myeloid neoplasms and are associated with a dismal prognosis. Although hypomethylating agents (HMAs), such as decitabine, are active in TP53-mutated myeloid neoplasms (TP53-MN), mutation clearance is rarely complete and nearly all patients relapse. Molecular determinants of response to HMAs in TP53-MN are poorly understood. Here, we show that decitabine induces replicative stress with decreased replication fork progression, induction of single-strand DNA breaks, and activation of the ataxia telangiectasia mutated-Rad3-related (ATR) pathway. Resolution of decitabine-induced replication stress is impaired in TP53-mutated acute myeloid leukemia (AML) cells, representing a potential therapeutic vulnerability. Indeed, …

Und Leads Implementation Team Meeting Agenda — April 14, 2026, University Of North Dakota

LEADS Implementation Documents

Agenda for the April 14, 2026 meeting of the UND LEADS Implementation Team. The agenda includes subgroup reports, final review of Affinity recommendations, Discovery recommendation development, and discussion of matters arising related to UND LEADS implementation.

Herpes Simplex Virus Type 1 R-Loops Are Targets For Apobec-Mediated Mutagenesis, Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel Deweerd, Abby M Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi

2020-Current year OA Pubs

APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic, and APOBEC3 enzymes do not edit HSV-1 without an R-loop; mutagenesis occurs when R-loops and APOBEC3 enzymes interact. These findings identify endogenous R-loops formed during the HSV-1 life cycle as focal vulnerabilities and highlight R-loop-APOBEC3 coupling as a mechanism for antiviral mutagenesis.

Dalam Rangka Pembangunan Ekonomi : Sudah Saatnya Ahli Hukum Lebih Berperan, Hendarmin Djarab

Jurnal Hukum & Pembangunan

Abstract

Perjanjian-Perjanjian Internasional Indonesia Mengenai Perlindungan Penanaman Modal, Prof. Dr. Mr. S. Gautama

Jurnal Hukum & Pembangunan

Abstract

Kedudukan Hukum Pidana Adat Dalam Hukum Pidana Nasional (Sumbangan Pemikiran Bagi Pembentukan Kuhp Nasional), I. Sriyanto

Jurnal Hukum & Pembangunan

Abstract

Kebijakan Yang Diperjanjikan (Beleidosovereenkomst), H.M. Laica Marzuki

Jurnal Hukum & Pembangunan

Abstract

Lembaga Swadana Sebagai Model Pengelolaan Keuangan Negara, Arifin P. Soeria Atmadja

Jurnal Hukum & Pembangunan

Abstract

Feasibility Of Digital Environment In Al-Madinah Al-Munawaroh Schools And Teachers Attitudes Towards It, Khaled Muraya Alqahtani

University of Bisha Journal for Educational Sciences

This study aimed to identify the availability of a digital environment in Madinah schools and teachers’ attitudes towards it. The study employed a descriptive-analytical approach using a questionnaire, one of the most widespread and commonly used research tools across various scientific fields. It is more effective in terms of saving time and reducing costs, and it allows for data collection from a larger number of individuals compared to other methods. A simple random sampling of 213 male and female secondary school teachers in Madinah was selected to represent the study sample. The study’s findings indicate that the digital environment in …

Forms Of Bullying That Affect The Academic Achievement Of Eighth-Grade Students According To Data From The Timss 2023 International Study: A Comparative Study Of Saudi Arabia, Japan, And Finland, Dr. Ali Hamoud Alharbi

University of Bisha Journal for Educational Sciences

This research aimed to identify the most common forms of bullying experienced by eighth-grade students, according to data from the TIMSS 2023, and those with the greatest impact on academic achievement, in Saudi Arabia, Japan, and Finland. The sample included all students who participated in the TIMSS 2023 study, totaling 15,667 students. The descriptive method, employing both causal-comparative and correlational approaches, was used to achieve the study’s objectives. The results showed that the most common form of bullying in Saudi Arabia, Japan, and Finland was “listening to hurtful things about one’s appearance,” with rates of 35.5%, 12.1%, and 24%, respectively. …

Requirements For Developing A Knowledge Economy At Majmaah University, Dr. Nada Khalid Hamad Al-Sayyari

University of Bisha Journal for Educational Sciences

The current study aimed to identify the requirements for developing the knowledge economy at Majmaah University from the perspective of faculty members, focusing on six key areas: (strategic leadership requirements, teaching and learning requirements, research and innovation requirements, partnership and community outreach requirements, infrastructure and technology requirements, and human capacity development requirements). To achieve the objectives of the study, the researcher adopted a descriptive approach using a survey method and used a questionnaire as a data collection tool. The study concluded with results that revealed a hierarchical order of requirements for the development of the knowledge economy according to the …

The Contribution Of The Department Of Da’Wah And Islamic Culture Courses At Umm Al-Qura University In Promoting Intellectual Moderation: A Descriptive Analytical Study, Arwa Ali Mohammed Al-Yazidi

UB Journal for Humanities

This study, titled “The Contribution of the Courses of the Department of Da‘wah and Islamic Culture at Umm Al-Qura University to Promoting Intellectual Moderation,” examines the role of the Department in fostering intellectual moderation and protecting youth from contemporary ideological deviations. Using a descriptive-analytical approach, the study includes an introduction, a theoretical framework, two main sections, and a conclusion. The theoretical framework clarifies the concept of intellectual moderation and highlights the role of universities in promoting balanced thought and strengthening intellectual and national security. The first section introduces the Department and its objectives, explaining how its curricula contribute to safeguarding …

Performing Professional Persona On Whatsapp: Gendered Self-Presentation And Authority Negotiation Among Saudi Women At Work, Meshari Ali Al-Sairi

UB Journal for Humanities

Drawing on Goffman’s concept of persona as a strategic and situational performance, the study examines written responses elicited through guided workplace scenarios designed to simulate high-stakes professional interaction on WhatsApp. The study adopted a qualitative, interpretive, discourse-pragmatic research design. The sample of the study included 30 women and 10 men employed in academic or administrative roles at the University of Bisha, and data were collected through semi‑structured, DCT‑style guided written prompts tailored to WhatsApp communication. Findings outlined three recurring persona patterns in women’s responses which are not interpreted as individual communication styles, but as systematic and adaptive responses to the …

Demographic Characteristics Of Migrants To Khamis Mushait City, Hassan Abdullah Mari Alamri

UB Journal for Humanities

This study examines the demographic characteristics of migrants to Khamis Mushait City, to reveal their motives, and their relationship to their original homeland. The study relied on the field survey method using the sample method in data collection, and the descriptive analytical method based on the quantitative method, through the use of statistical methods (measures of central tendency, and Pearson correlation coefficient). The findings indicate that the majority of migrants are male with university-level education, and that more than half are between 25 and 65 years of age. The results further show that the most salient reasons for migration to …

Aspek-Aspek Hukum Pidana Dari Pemalsuan Dan Penyalahgunaan Kartu Kredit, Loebby Loqman

Jurnal Hukum & Pembangunan

Abstract