Digital Commons Network^™

Herpes Simplex Virus Type 1 R-Loops Are Targets For Apobec-Mediated Mutagenesis, Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel Deweerd, Abby M Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi

2020-Current year OA Pubs

APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic, and APOBEC3 enzymes do not edit HSV-1 without an R-loop; mutagenesis occurs when R-loops and APOBEC3 enzymes interact. These findings identify endogenous R-loops formed during the HSV-1 life cycle as focal vulnerabilities and highlight R-loop-APOBEC3 coupling as a mechanism for antiviral mutagenesis.

Maddicks V. 106-108 Convent Bcr, Llc

All Decisions

The Appellate Division affirmed the denial of tenants' motion, seeking a declaration of a rent overcharge scheme. The motion, improperly brought under CPLR 906(1) and thus treated as one for summary judgment, was denied because tenants failed to provide all necessary documentary evidence, such as leases and underlying records for claimed improvements, to meet their prima facie burden. The court noted that while an attorney affirmation is permissible for admissible documents, personal knowledge is required for unrefutable facts. The court also clarified that post-2024 legislative amendments (L 2024, ch 95) eliminated the common law fraud standard and tenant affidavit requirement …

The Link April 14, 2026, Access To Justice Institute

The Link Newsletter

No abstract provided.

Synthetic Lethality Of Decitabine Plus Atr Inhibition For Tp53-Mutated Aml, Jeremy T Baeten, Sumedha Agashe, Imene Tabet, Jack T Wooldridge, Amber Carter, Jamie N Butler, Christopher A Miller, Nicole Helton, Annabel Quinet, Kimberly B Johansson, Yichan Yang, Geoffrey L Uy, Alessandro Vindigni, Daniel C Link

2020-Current year OA Pubs

TP53 mutations are found in 10% to 15% of myeloid neoplasms and are associated with a dismal prognosis. Although hypomethylating agents (HMAs), such as decitabine, are active in TP53-mutated myeloid neoplasms (TP53-MN), mutation clearance is rarely complete and nearly all patients relapse. Molecular determinants of response to HMAs in TP53-MN are poorly understood. Here, we show that decitabine induces replicative stress with decreased replication fork progression, induction of single-strand DNA breaks, and activation of the ataxia telangiectasia mutated-Rad3-related (ATR) pathway. Resolution of decitabine-induced replication stress is impaired in TP53-mutated acute myeloid leukemia (AML) cells, representing a potential therapeutic vulnerability. Indeed, …

Resource-Aware Cooperative Perception For Autonomous Driving, Matthew Magee

Theses

In recent years, many new vehicles equipped with autonomous driving capabilities have been deployed around the world, but they still have a number of failure cases. One proposed solution to improve performance in these scenarios is cooperative perception, a paradigm in which vehicles communicate with other vehicles and nearby sensors to collect additional perception information about the environment. Prior work has demonstrated that cooperative perception can be accomplished with the high accuracy and low latency needed for autonomous driving. However, state-of-the-art systems rely on unrealistic assumptions about the conditions of the network connections between participating nodes and the compute resources …

Advancing Hand Therapy Practice Through Specialized Clinical Reasoning And Patient Education, Candace Heinlein

Capstone Projects

This doctoral capstone experience (DCE) was completed at Corewell Health Grand Rapids Hospitals Hand Therapy Clinic and focused on two ACOTE concentration areas including advanced clinical practice skills and education. The experience combined hands-on clinical practice in a specialized outpatient hand therapy setting with the development of high-quality client education materials and home exercise programs (HEPs). Objectives were created to address identified needs through the creation of client education handouts, development of diagnosis-specific Medbridge HEP templates, and creation of training resources to improve therapist efficiency with Medbridge use. Outcomes of the project included improved access to evidence-based educational materials, reduced …

Dalam Rangka Pembangunan Ekonomi : Sudah Saatnya Ahli Hukum Lebih Berperan, Hendarmin Djarab

Jurnal Hukum & Pembangunan

Abstract

Perjanjian-Perjanjian Internasional Indonesia Mengenai Perlindungan Penanaman Modal, Prof. Dr. Mr. S. Gautama

Jurnal Hukum & Pembangunan

Abstract

Kedudukan Hukum Pidana Adat Dalam Hukum Pidana Nasional (Sumbangan Pemikiran Bagi Pembentukan Kuhp Nasional), I. Sriyanto

Jurnal Hukum & Pembangunan

Abstract

Kebijakan Yang Diperjanjikan (Beleidosovereenkomst), H.M. Laica Marzuki

Jurnal Hukum & Pembangunan

Abstract

Lembaga Swadana Sebagai Model Pengelolaan Keuangan Negara, Arifin P. Soeria Atmadja

Jurnal Hukum & Pembangunan

Abstract

Feasibility Of Digital Environment In Al-Madinah Al-Munawaroh Schools And Teachers Attitudes Towards It, Khaled Muraya Alqahtani

University of Bisha Journal for Educational Sciences

This study aimed to identify the availability of a digital environment in Madinah schools and teachers’ attitudes towards it. The study employed a descriptive-analytical approach using a questionnaire, one of the most widespread and commonly used research tools across various scientific fields. It is more effective in terms of saving time and reducing costs, and it allows for data collection from a larger number of individuals compared to other methods. A simple random sampling of 213 male and female secondary school teachers in Madinah was selected to represent the study sample. The study’s findings indicate that the digital environment in …

Forms Of Bullying That Affect The Academic Achievement Of Eighth-Grade Students According To Data From The Timss 2023 International Study: A Comparative Study Of Saudi Arabia, Japan, And Finland, Dr. Ali Hamoud Alharbi

University of Bisha Journal for Educational Sciences

This research aimed to identify the most common forms of bullying experienced by eighth-grade students, according to data from the TIMSS 2023, and those with the greatest impact on academic achievement, in Saudi Arabia, Japan, and Finland. The sample included all students who participated in the TIMSS 2023 study, totaling 15,667 students. The descriptive method, employing both causal-comparative and correlational approaches, was used to achieve the study’s objectives. The results showed that the most common form of bullying in Saudi Arabia, Japan, and Finland was “listening to hurtful things about one’s appearance,” with rates of 35.5%, 12.1%, and 24%, respectively. …

Requirements For Developing A Knowledge Economy At Majmaah University, Dr. Nada Khalid Hamad Al-Sayyari

University of Bisha Journal for Educational Sciences

The current study aimed to identify the requirements for developing the knowledge economy at Majmaah University from the perspective of faculty members, focusing on six key areas: (strategic leadership requirements, teaching and learning requirements, research and innovation requirements, partnership and community outreach requirements, infrastructure and technology requirements, and human capacity development requirements). To achieve the objectives of the study, the researcher adopted a descriptive approach using a survey method and used a questionnaire as a data collection tool. The study concluded with results that revealed a hierarchical order of requirements for the development of the knowledge economy according to the …

The Contribution Of The Department Of Da’Wah And Islamic Culture Courses At Umm Al-Qura University In Promoting Intellectual Moderation: A Descriptive Analytical Study, Arwa Ali Mohammed Al-Yazidi

UB Journal for Humanities

This study, titled “The Contribution of the Courses of the Department of Da‘wah and Islamic Culture at Umm Al-Qura University to Promoting Intellectual Moderation,” examines the role of the Department in fostering intellectual moderation and protecting youth from contemporary ideological deviations. Using a descriptive-analytical approach, the study includes an introduction, a theoretical framework, two main sections, and a conclusion. The theoretical framework clarifies the concept of intellectual moderation and highlights the role of universities in promoting balanced thought and strengthening intellectual and national security. The first section introduces the Department and its objectives, explaining how its curricula contribute to safeguarding …

Performing Professional Persona On Whatsapp: Gendered Self-Presentation And Authority Negotiation Among Saudi Women At Work, Meshari Ali Al-Sairi

UB Journal for Humanities

Drawing on Goffman’s concept of persona as a strategic and situational performance, the study examines written responses elicited through guided workplace scenarios designed to simulate high-stakes professional interaction on WhatsApp. The study adopted a qualitative, interpretive, discourse-pragmatic research design. The sample of the study included 30 women and 10 men employed in academic or administrative roles at the University of Bisha, and data were collected through semi‑structured, DCT‑style guided written prompts tailored to WhatsApp communication. Findings outlined three recurring persona patterns in women’s responses which are not interpreted as individual communication styles, but as systematic and adaptive responses to the …

Demographic Characteristics Of Migrants To Khamis Mushait City, Hassan Abdullah Mari Alamri

UB Journal for Humanities

This study examines the demographic characteristics of migrants to Khamis Mushait City, to reveal their motives, and their relationship to their original homeland. The study relied on the field survey method using the sample method in data collection, and the descriptive analytical method based on the quantitative method, through the use of statistical methods (measures of central tendency, and Pearson correlation coefficient). The findings indicate that the majority of migrants are male with university-level education, and that more than half are between 25 and 65 years of age. The results further show that the most salient reasons for migration to …

Aspek-Aspek Hukum Pidana Dari Pemalsuan Dan Penyalahgunaan Kartu Kredit, Loebby Loqman

Jurnal Hukum & Pembangunan

Abstract

Pembangunan Hukum Dalam Perspektif Moral, Ichtijanto Sa.

Jurnal Hukum & Pembangunan

Abstract

Aspek Yuridis Pembebasan Tanah, Boedi Harsono

Jurnal Hukum & Pembangunan

Abstract

Pengelolaan Uang Negara Dalam Era Tinggal Landas, Jusuf L. Indradewa

Jurnal Hukum & Pembangunan

Abstract

Tinjauan Tentang Tanggung Gugat Ex Pasal 1365 Bw Bagi Pencemar Lingkungan, Ari Purwadi

Jurnal Hukum & Pembangunan

Abstract

Pendekatan Socio-Yuridis Terhadap Kasus Kecelakaan Kerja, Setelah Dua Puluh Tahun Undang-Undang No.1 Tahun 1970, Aminuddin Kasim, M. Yasin Nahar

Jurnal Hukum & Pembangunan

Abstract

Tanah Terlantar Dalam Perspektif Hukum Adat, Hukum Islam Dan Yurlsprudensi, Sudirman Saad

Jurnal Hukum & Pembangunan

Abstract

Pembredelan Pers Di Indonesia Pasca Pencabutan Pembatalan Siupp, Satya Arinanto

Jurnal Hukum & Pembangunan

Abstract

Mengkaji Peran Operasi Pemeliharaan Perdamaian Pbb Sebagai Baglan Upaya Menciptakan Perdamaian Dunia, Adji Samekto

Jurnal Hukum & Pembangunan

Abstract

An Analysis Of Teacher Talk In A Senior High School In Palu, Central Sulawesi Through The Use Of Self-Evaluation Of Teacher Talk (Sett), Moh. Abraham Akbar Eisenring, Margana

Jurnal Pendidikan Humaniora

This present research tended to analyze the teacher talk performed by the English teachers in a Senior High School in Palu, Central Sulawesi through the use of Self-Evaluation of Teacher Talk (SETT). This research employed a case study research design, in the nature of qualitative research. Random sampling technique was used in determining the research’s participants. From the results of the research, it was found that the English teachers implemented all of the fourteen interactional strate- gies of SETT. Besides, the teachers and students’ perceptions were also investigated.

Drawing-Based Story Telling Influence On Children Language Development And Social Aspect, Hariddha Yuni Sulistyaningrum, Imanuel Hitipeuw, Triyono Triyono

Jurnal Pendidikan Humaniora

Language and social development of children plays an important role in influencing further development. The objectives of this research are to determine the effect of drawing based on story- telling toward language development and social development of children age 5–6 years. Single subject research with reversal design ABAB was used in this experimental research. Four kindergarten children identified having language and social problems became the subjects. The observation was used to col- lect data. In addition, the data were put into graphs to be analyzed by using visual inspection. The results showed that drawing activities based on story telling could …

Strategies Of Cultural Integration In Successful Merger-Companies, Achmad Supriyanto, Burhanuddin

Jurnal Pendidikan Humaniora

This research aimed to discover strategies in integrating a new culture within the merger companies. The strategies have elements including values, phases, leader role, and the system of cul- tural integration construction. This research used a meta-analysis with an expose facto research de- sign. Findings indicate new cultural integrations were carried out by many companies through demon- strating internal and external values. Integrations are implemented through ‘pre, process, and post- merger’. The most important in the preliminary stage is started by benchmarking, leading entire stages, and keeping a balance of collaboration between human and non-human aspects as well as leader …

Teachers’ Beliefs About Communicative Language Teaching (Clt) And The Implementation In Classroom Practices, Trifita Setyaningrum

Jurnal Pendidikan Humaniora

This study aims at investigating the match between beliefs and classroom practices about communicative language teaching (CLT). Survey design through questionnaire for professional teachers of English and guided interviews is employed in this study. The 25 questionnaire items revealed the teachers’ belief about CLT and the classroom practices based on its characteristics, i.e.: overall goals, relationship of form and function, fluency-accuracy, focus on real-world contexts, autonomy and stra- tegic involvement, teacher roles, and student roles. The data were gathered, reduced, grouped, and verified. The results showed that the highest discrepancy is on the aspect of fluency-accuracy.