Digital Commons Network^™

Ultra-Rare Functional Variants Reveal Early-Onset Breast Cancer Risk Genes And Pathways In The Uk Biobank And All Of Us Research Program, Chen Wang, Panagiotis Katsonis, Yi Li, Lawrence A Donehower, Olivier Lichtarge

Faculty, Staff and Students Publications

Breast cancer (BRCA) affects one in eight women, and while past studies have identified susceptibility genes and variants, those driving early-onset disease remain opaque. We introduce EA-Pathways, a control-free association method that aggregates ultra-rare germline coding variants weighted by Evolutionary Action to detect functional impact distribution biases in genes and pathways. In UK Biobank women with BRCA, EA-Pathways prioritized candidate risk genes across pathways enriched in known familial genes. Ultra-rare, high-impact variants in these genes were BRCA specific, and variants from eight pathways were associated with 2-year-earlier disease, including homology-directed DNA repair, TP53, and pexophagy pathways. The early-onset effect replicated …

Pharmacogenomic-Guided Prescribing And Polypharmacy Across Age Groups In Obsessive-Compulsive Disorder: A Retrospective Study, Rachel A Schwartz, Nicolette Weisensel, Martin E Franklin, Madeline M Hartig, Maharaj Singh, Sreya Vadapalli

Faculty, Staff and Students Publications

Background: This study evaluated medication utilization in children, adolescents, and adults with obsessive-compulsive disorder (OCD), a chronic psychiatric condition characterized by intrusive thoughts and repetitive behaviors. Although first-line treatments include selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT), the heterogeneous biological underpinnings contribute to suboptimal outcomes, with 40-60% of individuals not responding to SSRIs. This complex phenotype often leads to psychotropic polypharmacy, which may be mitigated by incorporating combinatorial pharmacogenomic (PGx) testing into protocol-based care to identify potential gene-drug interactions.

Methods: A retrospective review was conducted of individuals with OCD aged 8 to 65 years who received either …

Multi-Site Dms Probing Reveals Higher-Order Structure Of Rna-Protein Complexes In Living Cells, Anthony Hoang, Joshua Meehan, Ritwika Bose, David Mitchell, David H Price, Calla M Olson, Chase A Weidmann, Anthony M Mustoe

Faculty, Staff and Students Publications

Identifying tertiary structures and protein binding sites in RNA molecules remains a key challenge in RNA biology. We describe multi-site dimethyl sulfate (DMS)-mutational profiling (MaP) (msDMS-MaP), a strategy that enables simultaneous measurement of RNA secondary, tertiary, and quaternary structures via a single DMS chemical probing experiment. Optimized reverse transcription decodes typically invisible DMS N7-methylguanine (N7-G) modifications via a tautomer-induced mutational signature concurrent with N1 and N3 modifications. We show that N7-G reactivity reports on higher-order RNA structures, revealing key functional motifs such as pseudoknots and protein binding sites. Using msDMS-MaP, we find that E. coli ribosomal RNAs encode numerous independently …

Suatu Tinjauan Atas Pemberian Suaka Terhadap Pengungsi Berdasarkan Konvensi Internasional, Yon Riezky Prasetyo

Jurnal Hukum & Pembangunan

Abstract

Kajian Hukum Sengketa Tanah Di Lokasi Transmigrasi Kecamatan Muara Sungkal Kabupaten Lampung Utara Propinsi Lampung, Suparjo Sujadi

Jurnal Hukum & Pembangunan

Abstract

Keuangan Daerah: Berdasarkan Uu No. 32 Tahun 2004 Tentang Pemerintahan Daerah, Harsanto Nursadi

Jurnal Hukum & Pembangunan

Abstract

Master Settlement And Acquisition Agreement (Msaa) Dan Master Refinancing And Note Issuance Agreement (Mrnia) Dalam Perspektif Hukum Perdata (Suatu Tinjauan Singkat), Ari Wahyudi Hertanto

Jurnal Hukum & Pembangunan

Abstract

Komisi Yudisial Sebagai Lembaga Kontrol Terhadap Hakim, Lintong O. Siahaan

Jurnal Hukum & Pembangunan

Abstract

Hukum Rakyat A La Friedrich Karl Von Savignyl, Antonius Cahyadi

Jurnal Hukum & Pembangunan

Abstract

Kekerasan Dalam Rumah Tangga Terhadap Perempuan, Dewi Lestari

Jurnal Hukum & Pembangunan

Abstract

Mahkamah Konstitusi Dan Hak Asasi Manusia Dalam Era Reformasi: Peran Mahkamah Konstitusi Dalam Menyusun Konsepsi Keadilan Transisional Di Indonesia, Muhammad Ajisatria

Jurnal Hukum & Pembangunan

Abstract

Upaya-Upaya Hukum Terhadap Penetapan, Nurul Elmiyah, Suparjo Sujadi

Jurnal Hukum & Pembangunan

Abstract

Peranan Partai Politik Menyerap Aspirasi Masyarakat Dan Hukum Politik Yang Tidak Semantik, Ramly Hutabarat

Jurnal Hukum & Pembangunan

Abstract

Analisis Sistem Pemerintahan Dalam Uud Negara Republik Indonesia Tahun 1945 Pra Dan Pasca Perubahan, Serta Pelaksanaannya Dalam Praktek Ketatanegaraan, Fatmawati Fatmawati

Jurnal Hukum & Pembangunan

Abstract

Lembaga, Badan, Dan Komisi Negara Independen (State Auxiliary Agencies) Di Indonesia: Tinjauan Hukum Tata Negara, Hendra Nurtjahjo

Jurnal Hukum & Pembangunan

Abstract

Pemilihan Presiden Langsung Dan Calon Independen Dalam Pemilihan Presiden Dan Pemilihan Kepala Daerah, Teddy Anggoro

Jurnal Hukum & Pembangunan

Abstract

Islam Dan Persaingan Ideologi Di Parlemen (Studi Kasus: Pro Kontra Pemasukan "Tujuh Kata” Piagam Jakarta Ke Da/Am Konstitusi Pada Masa Reformasi), Pan Mohamad Faiz

Jurnal Hukum & Pembangunan

Abstract

Hak Asasi Manusia: Diskresi Kepolisian Dan Restorative Justice Di Indonesia Dalam Rangka Penegakan Hukum Dan Ketertiban Sosial, Muhammad Mustofa

Jurnal Hukum & Pembangunan

Abstract

Prinsip Military Necessity Dalam Hukum Internasional Humaniter, Hersapta Mulyono

Jurnal Hukum & Pembangunan

Abstract

Pendapat Hukum Dalam Transaksi Komersial, D. Sidik Suraputra

Jurnal Hukum & Pembangunan

Abstract

Mahkamah Konstltusi Dan Penegakan Hukum Dan Ham Di Indonesia, Mutiara Hikmah

Jurnal Hukum & Pembangunan

Abstract

A Novel Geospatial Tool For Assessing Risks And Opportunities For Conversion Of Ccr Closures Into Productive Solar Energy Generation Sites, Marc Theisen

World of Coal Ash Proceedings

Closure of Coal Combustion Residuals (CCR) surface impoundments and landfills offers unique opportunities for conversion to solar power sites with the potential to offset costs of post-closure care via generation of clean electricity. In 2023 the US Environmental Protection Agency (EPA) collaborated with the National Renewable Energy Laboratory (NREL) to create a report entitled “Coal Ash Disposal Sites and Opportunities for Solar Photovoltaic Development” (EPA Publication #540-S-23-004). The purpose of this document was to identify closed CCR units and provide key factors for their potential for solar photovoltaic (PV) development. In 2022, the EPA’s RE-Powering Initiative identified 772 current CCR …

The Modern Hydraulic Containment System: Using Automation, Telemetry And Data Dashboarding To Meet Client And Regulatory Objectives At A Coal Combustion Residual (Ccr) Site, Brian Hennings, Christopher Glidden, Vic Modeer, J. Austin Bond

World of Coal Ash Proceedings

The site, a former coal-fired power plant in southern Illinois, generated coal combustion residuals (CCR) such as bottom ash and fly ash stored in surface impoundments. Adjacent to the Ash Pond, boron was detected in groundwater above the state standard of 2 mg/L. In late 2025, a groundwater extraction system was installed to control hydraulic conditions and prevent boron migration offsite until source control measures are completed. The system is expected to operate for up to 11 years. Three-dimensional groundwater modelling was used to support system design, helping to identify optimal well locations and flow rates for effective containment. Components, …

Strategic Workforce Solutions In The Coal Ash Industry, Stuart Keeter

World of Coal Ash Proceedings

The coal ash industry stands at a pivotal moment, shaped by legacy environmental events, evolving engineering standards, and a rapidly shifting workforce landscape. This session explores the strategic talent challenges facing consultants, civil engineering firms, and utilities in 2026 and beyond. Drawing from data sources including MRI, LaborIQ, AGC, and the U.S. Bureau of Labor Statistics, the presentation highlights: • The impact of historic coal ash incidents (TVA Kingston, Duke Dan River) on industry best practices. • The convergence of civil, environmental, and power sectors in driving remediation and innovation. • Alarming workforce trends, including the retirement of 12,000 professionals …

Establishing A Roadmap For The Planning, Design, And Construction Of A Water Treatment System For A Ccr Unit Closure, Mariah Schroeder, Matthew Balance

World of Coal Ash Proceedings

The treatment of water from a CCR unit is an important step in the closure strategy for surface impoundments to comply with 40 CFR §257.102(d)(2)(i) of the CCR rule. The unwatering and dewatering of a surface impoundment is a necessary first step in ensuring that the eventual closure of the unit will meet the requirements for closure in place described in 40 CFR §257.102(d). Depending on the operational conditions and requirements of the plant, the NDPES discharge limits, and the impacted water quality, the water treatment system needs can vary greatly. This presentation will outline a roadmap for assessment, evaluation, …

Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur

World of Coal Ash Proceedings

American Electric Power (AEP) is closing and restoring a legacy Coal Combustion Residuals (CCR) site in Ohio that once held a power plant that pioneered innovative steam generation technology. The plant was closed in 1975. Today, the legacy CCR site is being transformed back to natural, sustainable vegetation. To comply with and close the Stormwater Pollution Prevention Plan (SWPPP) permit, permanent stabilization is required on the site. AEP, one of the largest electric companies in the country, holds a core principle to respect the environment through creative sustainable solutions. AEP connected with Profile Products, the world’s largest manufacturer and supplier …

Horizontal Wells For Ccr Applications – Results And Lessons Learned, David Bardsley

World of Coal Ash Proceedings

No abstract provided.

Closure Of A Process Water Impoundment, Todd Stong, Shane Stockdill, Erin Hunter

World of Coal Ash Proceedings

Rainbow Energy Center’s (REC’s) Coal Creek Station manages process water in various engineered impoundments across the facility. As part of the ongoing life of the plant, one of the site process water ponds has been decommissioned to allow for construction of a new coal combustion residuals (CCR) impoundment within the same footprint. In order to transition from a non-CCR impoundment to construction of a CCR impoundment, the existing impoundment was closed and decommissioned in 2025. The composite-lined process water impoundment intended for closure previously operated from the early 1990s. To effectively close the impoundment, a closure verification plan was developed …

Future Strategies For Beneficial Use Harvesting, Gabe Lang, Patrick Kiser

World of Coal Ash Proceedings

TVA is the largest public power company in the U.S. and has historically operated a fleet of 12 coal-fired plants as part of their diverse generating portfolio. To date, eight of the coal plants have been retired and the remaining four plants are projected to shut down in the next couple of decades. The decommissioning of these plants is driving a transition to harvesting of ponded and landfilled CCR’s to continue to support ready-mix concrete and other industries that enable infrastructure development. However, the regional market demand limits the ability to initiate widespread harvesting activities during near-term CCR Unit closure …

An Australian Case - Harvesting And Processing Salt Water Sluiced Dam Coal Ash For Use In Conventional Concrete, Massimo Capasso

World of Coal Ash Proceedings

The Cement & Concrete sector account for 8% of the worlds emissions . "hard to abate" sector is the substitution out of highly emissive cement with very low emissive SCMs. (Industry by-products) In the region of South Australia , 100% of SCM's are imported at great cost, no sovereign "Australian Standard" sources are locally available. The focus of this study is on the local Pt.Augusta dam ash, a dam repository that remains since the station closure in 2016. The uniqueness of this study is that , like many unused dam repositories globally, seawater was used to sluice coal ash at …