Digital Commons Network^™

Voltage-Sensor–Targeting Modulators Of Iks: Identifying Critical Functional Groups Of C28 Via Electrophysiology And Sar Modeling, Jiacheng Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

I_Ks (KCNQ1/KCNE1) channels are essential for cardiac repolarization, and their dysfunction contributes to arrhythmogenic disorders such as Long QT Syndrome type 1 (LQT1). Pharmacological activation of I_Ks has therefore emerged as a promising therapeutic strategy. C28, a recently identified voltage-sensor–targeting activator, has been shown to markedly shift KCNQ1/KCNE1 voltage dependence and enhance current amplitude, validating the voltage-sensing domain (VSD) as a druggable site. However, the structural determinants that underlie C28’s activity remain incompletely understood. In this study, we aimed to identify critical functional groups of C28 by screening a structurally diverse set of C28-like analogs and evaluating their …

Toward Vehicle-Agnostic Driving Signatures For Cognitive Impairment Prediction From Naturalistic Driving Data, Aadarsha Gopala Reddy

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis studies whether naturalistic driving data can help predict binary Clinical Dementia Rating (CDR) status while accounting for differences across vehicles. The final analytic dataset comprised 26,968 participant-weeks from 304 participants. Weekly driving features were derived from real-world telematics data and combined with four demographic covariates. Primary model comparisons used leave-one-participant-out (LOGO) cross-validation, with one individual held out at a time and pooled participant-level metrics used as the main reporting surface.

The main comparison includes six model families evaluated on the same dataset under a shared LOGO framework. Performance remained modest overall. GRU-DANN had the highest participant-level ROC AUC …

Interaction-Aware Safe Planning For Human-Robot And Multi-Robot Systems, Haoyi Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Robots operating in shared environments must interact safely not only with static obstacles but also with other decision-making agents, including humans and other robots. In such settings, both safety and task completion depend on the ability to reason about interaction. Two major challenges arise. In human-robot interaction, future human behavior depends on latent internal factors, such as attentiveness and behavioral style, that are not directly observable to the robot. In multi-robot systems, decentralized reactive navigation can fail in cluttered environments when reciprocal interactions create deadlocks that prevent progress through narrow passages or bottlenecks. This thesis investigates these two challenges from …

Temperature And Environmental Implications On Ti3c2cl2 Mxene Degradation Process, Yang Yang

McKelvey School of Engineering Graduate Student Theses & Dissertations

MXenes, a rapidly emerging class of two-dimensional transition metal carbides and nitrides, have attracted considerable attention owing to their exceptional electrical, mechanical, and chemical properties. However, the inherent thinness of their atomic structure and the reactivity of their functional groups render MXenes susceptible to environmental degradation, whereby the lattice integrity is compromised and desirable material functionalities are dimin- ished. In this work, ex situ electron microscopy characterisation is performed on Ti₃C₂Cl₂ MXene specimens subjected to controlled gas environments — nitrogen gas (N₂) and air — at annealing temperatures of 200°C and 600°C, with …

Gender And Grades: The Gap In How Men And Women Fear Economic Collapse, Riley O'Connor

Student Scholar Symposium Abstracts and Posters

Due to prescribed gender roles in society and wage gaps, historically, women have had to rely on spouses and family for economic survival. Now, with access to higher education and increased salaries, their economic fears are shifting. In this paper I analyze the extent of the gender gap in the fear of economic and financial collapse of Americans. Using the Chapman Survey of American Fear, an original data set surveying the degree to which American adults fear incidents collected in spring of 2025, men and women of the same education fear economic collapse differently, signifying men fear economic collapse less …

"Silent Or Seen: How Trust Influences Protest Engagement", Adam M. Erdkamp

Student Scholar Symposium Abstracts and Posters

The research question I have chosen for my project is, “In what ways do levels of trust impact whether someone chooses to participate in an in-person protest?” A current problem within this field from previous findings is that research claims there is no consensus on whether trust encourages participation or if distrust drives it. Therefore, while some believe that a minimum level of trust is necessary to participate in politics, others argue that distrust drives citizens to partake in non-institutionalized, radicalized, or in-person protests. My answer to this question is that I believe if people were to have high levels …

Immediate Nerve And Tendon Transfers After Wide Resection Of A Radial Nerve Malignant Peripheral Nerve Sheath Tumor: A Case Report And Surgical Technique, Joanne Zhou, Sai Shreya Kambham, Andrew Fang, Christopher Frey, Michael Macavoy

Faculty, Staff and Student Publications

The authors have reported on immediate nerve and tendon transfers postresection of a radial nerve-based malignant peripheral nerve sheath tumor in a 15-year-old female with neurofibromatosis. The median nerve branch to flexor carpi radialis was transferred to the posterior interosseous nerve, the median nerve branch to flexor digitorum superficialis was transferred to the nerve to extensor carpi radialis brevis, and the pronator teres tendon was transferred to the extensor carpi radialis brevis tendon, with 3-year outcomes reported. Tumor excision, tendon, and nerve transfer yielded negative margins and remission. Functional wrist/finger extension appeared at 6 months and increased until 3 years …

2026-05-06 Campus Store No More? Seattle U Shifts To Online Sales And Future Pop-Ups, Maya Deguzman

The Spectator Online

No abstract provided.

Financial Literacy And Kentucky House Bill 342, Rebecca J. Futrell

Honors College Theses

This study examines the correlation between taking a financial literacy class in high school and an individual’s actual financial literacy. It is inspired by the recent Kentucky House Bill 342, which mandates that a financial literacy class be taken during high school. According to recent studies, Generation Z scores the lowest on a financial literacy index among the past three generations. To address this, many U.S. states have introduced mandatory financial literacy classes in K-12 education. In 2025, Kentucky joined the 30 states that mandated a financial literacy class for a high school diploma. The Kentucky House Bill 342 selects …

Examining The Relationship Between Teachers’ Attitudes And Efficacy For Inclusive Classroom Practices, Dike Ibiam Dick

Journal of Innovation and Teacher Professionalism

This study examined the relationship between teachers’ self-efficacy and their attitudes toward inclusive education in Ondo State, Nigeria. A descriptive survey research design was adopted, and data were collected from 500 primary and secondary school teachers using two standardized instruments: the Sentiments, Attitudes, and Concerns about Inclusive Education Revised (SACIE-R) Scale and the Teacher Efficacy for Inclusive Practice (TEIP) Scale. Data were analyzed using Pearson Product-Moment Correlation, Multiple Linear Regression, and one-way ANOVA. The findings revealed a moderate positive relationship between teachers’ attitudes toward inclusive education and their self-efficacy in behavior management and collaboration, while a weaker positive relationship was …

Stability Of Sufentanil Sublingual Microtablets (Dzuveo) In Extreme Cold Weather Conditions: An Experimental Study, David Mcconnell, Hayley Manners, Paul Sutton, Nicola Gawman, Tim Parham, Jonathon Lowe

School of Geography, Earth and Environmental Sciences

Introduction Extreme cold weather environments are challenging for medication storage and delivery, particularly for injectable analgesics vulnerable to freezing and device failure. These risks may compromise pain management in austere or operational settings where temperature control cannot be maintained. Sufentanil sublingual microtablets (sold in the UK as Dzuveo) provide an oral analgesic option with manufacturer-reported sub-zero stability. Evidence describing the effects of sustained extreme cold exposure and repeated freeze–thaw cycling on chemical stability and delivery system function is limited.Methods We conducted a laboratory study assessing the effect of sustained freezing and repeated freeze–thaw exposure on sufentanil sublingual microtablets (30 µg …

Spinoza And The Reciprocity Of Nature, Kevin S. Jobe

Philosophy Faculty Publications

This paper develops an account of the reciprocity of Nature in Spinoza as a central yet underappreciated dimension of Spinoza’s relational metaphysics. Building on Ziporyn’s interpretation of Spinoza, the paper argues that any understanding of infinity and necessity is incomplete without Spinoza’s relational account of the reciprocity of God or Nature (Deus sive Natura). Through a close analysis of the Ethics, the Principles and Letter 32, the paper shows that for Spinoza all finite things are reciprocally determined by another singular thing to exist in a certain way through the infinite, eternal and equal force [ …

Message From The President, Georgia Southern University

Messages from the President

No abstract provided.

Midweek Memo, Georgia Southern University

Midweek Memo

• Applaud 
• Remember 
• Share 
• Experience 
• Around the Nest

Automated Segmentation And Structural Remodeling Analysis Of Ipsc-Derived Cardiomyocyte, Bahareh Bahmani

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cardiomyopathy is a disease of the heart muscle that can change cell structure, protein organization, and overall heart function. Some forms of cardiomyopathy are genetically inherited, including Hypertrophic Cardiomyopathy (HCM), the most common inherited cardiomyopathy affecting nearly 1 in 200 individuals1,2, and Desmin-Related Cardiomyopathy (DRM), a rarer disease that affects approximately 1 in 2000 individuals3. Changes in cardiomyocytes’ cellular structure define cardiomyopathies, and these changes are typically studied with fluorescence microscopy. However, manual image analysis is slow, labor-intensive, and often gives inconsistent results, especially when images are analyzed by non-experts. This thesis presents an automated computational framework for analyzing cardiomyocyte …

Improving Semantic Precision In Text-To-Image Diffusion Models Via Latent-Space Optimization And Semantically-Parsed Evaluation, Mohammad Rouie Miab

McKelvey School of Engineering Graduate Student Theses & Dissertations

Text-to-image diffusion models can produce visually impressive images from natural-language prompts, but they often fail to satisfy the detailed semantic constraints expressed in compositional prompts. Typical failure modes include omitted objects, merged entities, incorrect quantities, incorrect attribute binding, and leakage of one entity's attributes onto another. This thesis studies the problem of semantic precision in text-to-image generation: how faithfully a generated image satisfies the structured meaning of its prompt.   The thesis makes two linked contributions. First, it presents a training-free inference-time refinement method for diffusion-based image generation. The method operates directly in latent space during denoising and uses noun-phrase-aware cross-attention …

Largest 2-Regular Subgraphs In Complete S-Partite Graphs, Yiyang Jiang

McKelvey School of Engineering Graduate Student Theses & Dissertations

In this thesis, we focus on the class of complete $S$-partite graphs, for $S$ an undirected graph possibly with self-loops, and address the problem of finding largest $2$-regular subgraphs of these graphs, which can be formulated as an integer linear program. Roughly speaking, a complete $S$-partite graph is obtained by replacing every single node of $S$ with a number of nodes, preserving the edge/non-edge relations of $S$. Our motivation in studying largest $2$-regular subgraphs is rooted in the structural systems theory, particularly in the problem of finding largest subnetworks that can sustain controllability or asymptotic stability of the corresponding subsystems. …

Enhancing Community Transitions For Outpatient Behavioral Health Clients, Sylvia Chonya

Walden Dissertations and Doctoral Studies

No abstract provided.

Sustainability Strategies For Solo And Small Medical Practices In Kenya, Milcah Achieng' Odeny

Walden Dissertations and Doctoral Studies

No abstract provided.

Implementation Of The Phq-9 For Early Detection Of Depression In Older Adults, Elsie Kumba Kamara

Walden Dissertations and Doctoral Studies

No abstract provided.

The Moderating Effects Of Body-Mind-Spirit Well-Being On The Relationship Between Diabetes Self-Efficacy And Type 2 Diabetes Self-Management, Carly Snodgrass

Walden Dissertations and Doctoral Studies

No abstract provided.

Examining A Positive Variation Of The Good Behavior Game With Head Start Children At Risk For Child Adversity And Externalizing Behavior Problems., Alexandra Gibson, Courtney P D Goldenberg, Malinda J. Colwell, Amelia E. Talley, Joaquín Borrego, Adam T. Schmidt

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children participating in the Head Start program in the United States are predominantly from underserved groups, have increased rates of child adversity, and are at risk for externalizing behavior problems in the classroom. The Good Behavior Game (GBG) is an effective classroom management strategy for reducing disruptive and off-task classroom behaviors. However, previous research has not examined the GBG within the Head Start context.

METHODS: The current case-controlled study evaluated the effectiveness of the GBG in six Head Start children aged 3-5. Researchers conducted daily classroom behavioral observations of disruptive behaviors, and teachers completed pre- and post-treatment assessments of …

What History Shows: A Structural Account Of Fixed-Point Theory Formation, Griselda Poe

Publications and Research

Theory generation has long been subsumed under categories such as creativity, genius, and innovation. These categories do not distinguish assembly-based conceptual synthesis from fixed-point theory generation.

This paper makes that distinction explicit. The termination condition of assembly is external: data, citation, endorsement, usability. The termination condition of fixed-point theory generation is internal: consistency with internally held constraints, resolution of structural contradiction. The two operate under different processing conditions.

The historical record confirms this distinction. What Darwin, Einstein, Spinoza, and Kant produced was not assembly. Their processes involved unresolved branch retention and decomposition necessity, arriving at internally constrained fixed-point termination. Freud …

Asymmetric Synthesis Of Borylated Amines Via Rhodium Catalyzed Hydroboration Of Allylamine Derivatives: Surprising Role Of Counterions And Accelerators, Rukshani Wickrama Arachchilage

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The Catalytic Asymmetric Hydroboration (CAHB) reaction is a valuable method for synthesizing chiral organoboron compounds. Nevertheless, key mechanistic details, including catalyst activation, ligand effects, and rate-determining steps, are difficult to generalize and remain not fully understood. Building on previous research from the Takacs group, this work explores acyclic N-acyl allylamines as substrates in rhodium-catalyzed hydroboration and investigates the formation of active catalysts from various rhodium precursors, the role of counterions (e.g. BF₄, BArF-), ligand-to-metal ratios, and the impact of external fluoride additives (e.g. TBAT). Hydroboration of acyclic N-acyl allylamines achieves up to 90% yield and 99 : 1 …

Transforming Experience Into Practice: A Portfolio Of Growth, Identity, And Leadership, Ana I. Loli

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This professional portfolio documents the integration of my academic learning, practicum experience, and personal transformation throughout the Master of Social Work program at the University of Montana. Drawing from trauma‑informed, anti-oppressive, and culturally responsive frameworks, I demonstrate competency across micro, mezzo, and macro levels of practice, with particular emphasis on ethical decision-making, ADEI engagement, community assessment, policy analysis, research-informed practice, and collaborative leadership. Through narrative reflections and applied artifacts—including case analyses, simulated clinical sessions, community-based research, organizational evaluation, and leadership implementation—I illustrate how meaning, context, power, history, and possibility shape my approach to social work. This portfolio highlights my development …

Stance Detection On Social Media: The Impact Of Doping On Athlete Reputation, Connor O'Neill

Theses

Doping scandals can have a lasting effect on both athletes' and organizations' reputations, causing athletes to lose money and fans to lose trust in the organizations that govern their favorite sports. This paper investigates the impact a doping scandal can have on an athlete's reputation by  conducting a case study on Jannik Sinner, one of the top tennis players in the world, who ultimately accepted a suspension after testing positive for performance-enhancing drugs, despite being unintentionally exposed. Using data sourced from YouTube comments on tennis-related videos, a fine-tuned Mistral-7B-Instruct-v0.3 model with a classification head was used to carry out stance …

She Absorbs, Jamie Westermeyer

Theses

Drawing from lived experience, this thesis investigates the ways sensitivity, attentiveness, and emotional labor are cultivated over time, specifically within gendered environments that reward endurance and self-containment. The figures in this work exist within moments of tension—straining, compressing, and distorting under pressures that are often invisible yet deeply felt. This work focuses on endurance—how individuals adapt, absorb, and negotiate expectations placed upon them. My figures operate as both personal and collective bodies, embodying experiences that extend beyond being autobiographical. Moments of physical distortion and emotional discomfort coexist within the sculptures, allowing vulnerability and critique to appear simultaneously. Ultimately, the sculptures …

Interventions For Behavioral Symptoms Of Dementia, Christina Khouri, Robert Martin

Advocate GME

No abstract provided.

Professional Blend Xx, Rossie Rf Baker

Professional Practices (ART 399)

Over the years and with lots of considerations photography relating to landscape and nature are crucial to what I as an artist and photographer want to work with.These four photographs were a way for me as an artist to have free range on what I wanted to capture. Not only did I have free range with what I wanted to capture but as well as how I wanted to capture my photographs. At first glance it just seems that there are four photographs of trees. The point is not to just look and see trees but to look and see …

Empowering Junior High School Students’ Collaboration Skills Through Science Learning Using The Secret Mission Game, Rahma Fika Kurnia, Imraatul Mufidah, Dyne Rizki Puspitasari

Journal of Innovation and Teacher Professionalism

This study aimed to empower the collaboration skills of Class VII B students at SMP Laboratorium UM through the implementation of the Game-Based Learning model using the Secret Mission game in science learning on the topic of Physical and Chemical Changes. The study was motivated by the low level of students’ collaboration skills, as indicated by previous classroom assignments that were mostly completed individually rather than collaboratively in groups. The study employed the Lesson Study approach, which consisted of three stages: Plan, Do, and See. During the planning stage, the Lesson Study team collaboratively designed learning modules, game scenarios, instructional …