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Investigation Of Patients' Use Of Non-Pharmacological Substances In Dental Pain Management, Neslihan Yılmaz Çırakoğlu, Özgenur Kaya Aug 2026

Investigation Of Patients' Use Of Non-Pharmacological Substances In Dental Pain Management, Neslihan Yılmaz Çırakoğlu, Özgenur Kaya

Journal of Dentistry Indonesia

Background: Dental pain is a complex condition influenced by biological, biochemical, environmental, and psychological factors. Before seeking professional care, many patients attempt to relieve dental pain using self-administered, non-medical agents. This study aimed to investigate patients’ use of non-pharmacological substances in dental pain management and to identify factors influencing these practices.

Methods: The questionnaire consisted of four sections addressing demographic characteristics, oral hygiene habits, pain characteristics, and pain-relief agents. Categorical variables were analyzed using Pearson’s chi-square test. Categorical data are presented as frequencies and percentages, while continuous data are expressed as mean ± standard deviation and median values. …


Flaxseed Ethanolic Extract Modulates Β-Catenin And Dkk1 Expressions During Osteoblast Differentiation Of Dental Pulp-Derived Stem Cells, Nur Sazwi Nordin, Khairani Idah Mokhtar, Omar Abdul Jabbar Abdul Qader, Basma Ezzat Mustafa, Widya Lestari, Deny Susanti Darnis, Thirumulu Ponnuraj Kannan, Azlina Ahmad, Solachuddin Jauhari Arief Ichwan Aug 2026

Flaxseed Ethanolic Extract Modulates Β-Catenin And Dkk1 Expressions During Osteoblast Differentiation Of Dental Pulp-Derived Stem Cells, Nur Sazwi Nordin, Khairani Idah Mokhtar, Omar Abdul Jabbar Abdul Qader, Basma Ezzat Mustafa, Widya Lestari, Deny Susanti Darnis, Thirumulu Ponnuraj Kannan, Azlina Ahmad, Solachuddin Jauhari Arief Ichwan

Journal of Dentistry Indonesia

Background: WNT signaling regulates osteogenic differentiation of mesenchymal stem cells (MSC) through the canonical WNT pathway. β-catenin; an important molecule of WNT pathway, and DKK1; a WNT antagonist, play important roles in regulating bone formation. Although flaxseed (Linum usitatissimum) has various health benefits, including promoting bone health, our previous study showed that flaxseed ethanolic extract (FEE) reduced the osteoblast differentiation potential of stem cells from human exfoliated deciduous teeth (SHED). This study aimed to determine the effects of FEE on WNT pathway-related molecules, β-catenin and DKK1, during osteoblast differentiation of SHED.

Methods: RNA at Day 7, 14, …


Orthodontic Camouflage Treatment Of A Severe Class Iii Skeletal Pattern With Anterior Open Bite: A Case Report, Dikeledi Maureen Letsholo, Mandla Dominic Nyakale, Mosimane Peter Silas Sethusa Aug 2026

Orthodontic Camouflage Treatment Of A Severe Class Iii Skeletal Pattern With Anterior Open Bite: A Case Report, Dikeledi Maureen Letsholo, Mandla Dominic Nyakale, Mosimane Peter Silas Sethusa

Journal of Dentistry Indonesia

Background: Class III malocclusion combined with anterior open bite (AOB) is one of the most challenging occlusal problems to treat. The objective of this article was to report a case of an adult female patient diagnosed with Class III malocclusion combined with an anterior open bite and a hyperdivergent facial pattern.

Case Report: Camouflage orthodontic treatment with the extraction of maxillary and mandibular first premolars was used to treat the patient. Anterior teeth were retracted maximally against the Nance holding arch and fixed lingual arch appliances, and box elastics were used to close AOB. At the end of …


Loralee Clark, Loralee Clark, Loralee Clark Aug 2026

Loralee Clark, Loralee Clark, Loralee Clark

Virginia Poets Database: A Literary and Educational Resource

No abstract provided.


The Correlation Between Medication Adherence, Blood Glucose Levels, And Quality Of Life In Patients With Type 2 Diabetes Mellitus At Ciamis Regional Hospital, Amyla Putri Nurul Nazmi, Nur Rahayuningsih, Lusi N Aug 2026

The Correlation Between Medication Adherence, Blood Glucose Levels, And Quality Of Life In Patients With Type 2 Diabetes Mellitus At Ciamis Regional Hospital, Amyla Putri Nurul Nazmi, Nur Rahayuningsih, Lusi N

Pharmacology and Clinical Pharmacy Research

Type 2 diabetes mellitus is a chronic condition requiring continuous treatment, including patient adherence to prescribed medication. This study aimed to explore the relationship between medication adherence, blood glucose levels, and quality of life in patients with type 2 diabetes mellitus at Ciamis Regional Hospital, conducted from January to March 2025, the research employed a quantitative, prospective cross-sectional design involving 49 hospitalized patients. Data included blood glucose levels (RPG, FPG, 2hPG), medication adherence measured using the Medication Adherence Report Scale (MARS-5), and quality of life assessed via the Diabetes Quality of Life-Brief Clinical Inventory (DQOL-BCI). The chi-square test was used …


The Phytochemical Content And Antibacterial Activity Of Purified Extract Of Mangifera Indica L. Against Gram Positive Pathogen, Dewi Andini Kunti Mulangsri, Masduki Faqih, Sugar Arifin, Mutiara Trie Sieya Agustin Aug 2026

The Phytochemical Content And Antibacterial Activity Of Purified Extract Of Mangifera Indica L. Against Gram Positive Pathogen, Dewi Andini Kunti Mulangsri, Masduki Faqih, Sugar Arifin, Mutiara Trie Sieya Agustin

Pharmacology and Clinical Pharmacy Research

The purified extract of arum manis mango leaves contained flavonoid compounds by TLC methods and antibacterial activity against Gram-positive and negative pathogens. This research aimed to identify and determine the phytochemical content (mangiferin and flavonoids content) and antibacterial activity against other Gram-positive pathogens. Purification of ethanol extract of arum manis mango leaves by liquid-liquid fraction method. Determination of total flavonoid content and identification of mangiferin used respectively by aluminum chloride and Thin Layer Chromatography method. The disk diffusion method was used to assay antibacterial activity against S. epidermidis, and B. subtilis bacteria with the concentration of the sample such …


Cost Effectiveness Analysis Of Psychopharmaca Therapy Combination Compared With Psychopharmaca Therapy And Ect Combination In Schizoaffective Inpatients At The Rsj Provinsi Jawa Barat, Yasmin Fadillah, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi Aug 2026

Cost Effectiveness Analysis Of Psychopharmaca Therapy Combination Compared With Psychopharmaca Therapy And Ect Combination In Schizoaffective Inpatients At The Rsj Provinsi Jawa Barat, Yasmin Fadillah, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi

Pharmacology and Clinical Pharmacy Research

Mental disorders constitute an economic burden on health, estimated at USD 2.5 trillion in 2010 and expected to increase to USD 6 trillion by 2030. Treatment of schizoaffective disorder involves a combination of medication and psychotherapy. Pharmacoeconomics is an important consideration in drug selection. This study aims to determine the cost-effectiveness of psychopharmaca therapy combination compared with psychopharmaca therapy and ECT combination in schizoaffective inpatients at the RSJ Provinsi Jawa Barat. Data collection was conducted retrospectively from patient medical records for the period December 2023–December 2024. Total costs, based on a health perspective, include psychopharmaca drug costs, inpatient care costs, …


Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang Aug 2026

Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang

Pharmacology and Clinical Pharmacy Research

Ischemic stroke is a health problem that causes death and neurovascular disability worldwide. The inflammatory response due to infection can increase ischemic stroke and increase brain damage through changes in blood pressure, coagulation, immune response, and endothelial function. This study aims to evaluate the rationality of antibiotic use on clinical outcomes in ischemic stroke patients. This study used a cross-sectional design. Retrospective data were taken from the medical records of Jayapura Regional Hospital for the period January 1, 2023, to May 31, 2025. The study subjects were all patients who suffered ischemic stroke and received antibiotics. Evaluation of the rationality …


Retrospective Analysis Of Antimicrobial Resistance Patterns In Gram-Positive And Gram-Negative Blood Isolates, Helman Kurniadi, Timbul Partogi Haposan Simorangkir, Ros Sumarny, Fitria Heldiana Aug 2026

Retrospective Analysis Of Antimicrobial Resistance Patterns In Gram-Positive And Gram-Negative Blood Isolates, Helman Kurniadi, Timbul Partogi Haposan Simorangkir, Ros Sumarny, Fitria Heldiana

Pharmacology and Clinical Pharmacy Research

Bloodstream infections are an important cause of morbidity and mortality, while antimicrobial resistance limits treatment options. This retrospective study evaluated bacterial distribution and antimicrobial susceptibility in blood cultures at RSPAD Gatot Soebroto, Jakarta, using microbiology and medical record data from January-December 2019. Clinically significant isolates were included, while duplicates and contaminants were excluded. Identification and susceptibility testing followed standard procedures and CLSI 2019 guidelines. Data were analyzed descriptively. Among 482 isolates, 246 (51.0%) were Gram-positive and 236 (49.0%) were Gram-negative. The Gram-positive isolates were mainly coagulase-negative staphylococci, including Staphylococcus epidermidis (62, 25.2%), S. hominis (61, 24.8%), and S. haemolyticus (50, …


Analysis Of Pharmacotherapy And Non-Pharmacotherapy Burden From The Ina-Cbgs Package For Cesarean Section Surgery At The Regional General Hospital Dr. Soedarso In 2023, Ananda Rizky Awwaliyah, Nurmainah Nurmainah, Ridha Ulfah Aug 2026

Analysis Of Pharmacotherapy And Non-Pharmacotherapy Burden From The Ina-Cbgs Package For Cesarean Section Surgery At The Regional General Hospital Dr. Soedarso In 2023, Ananda Rizky Awwaliyah, Nurmainah Nurmainah, Ridha Ulfah

Pharmacology and Clinical Pharmacy Research

The prevalence of cesarean sections has been increasing each year. Previous studies show that the cost of medications and medical supplies for cesarean patients accounts for one-third of the total care costs. In the era of National Health Insurance (NHI), medications and medical supplies are considered operational expenses for hospitals rather than sources of income. This condition requires proper medication management and the use of medical supplies. This study aims to analyze the percentage of pharmacotherapy and non-pharmacotherapy, including the types and quantities of medications as well as disposable medical supplies used on patients undergoing cesarean section procedures at the …


Alexithymia In Substance Use Disorders: A Scoping Review Of Therapeutic Approaches, Pratami Diah Herliani, Shelly Iskandar, Angela Vera Herman Efendi Aug 2026

Alexithymia In Substance Use Disorders: A Scoping Review Of Therapeutic Approaches, Pratami Diah Herliani, Shelly Iskandar, Angela Vera Herman Efendi

Pharmacology and Clinical Pharmacy Research

Alexithymia, defined as the inability to recognize and express emotions, has a high prevalence (40–50%) among individuals with substance use disorders (SUD), particularly alcohol use disorder, and is associated with poorer clinical outcomes. Despite this, comprehensive mapping of psychotherapeutic interventions targeting this condition within the SUD population remains limited. This study aimed to systematically map the therapeutic approaches investigated to address alexithymia among individuals with substance use disorders and to summarize the reported outcomes. A scoping review was conducted in accordance with the PRISMA-ScR guidelines using systematic literature searches in the PubMed and Scopus databases. Relevant studies were screened based …


Illinois Model Programs Of Study Guide: Digital Technology (Draft For Public Comment), Education Systems Center Aug 2026

Illinois Model Programs Of Study Guide: Digital Technology (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft is available for public comment through September 30, 2026. Share your public comment at:

https://forms.gle/VDKeCdf5HycEerMr7


Illinois Model Programs Of Study Guide: Education (Draft For Public Comment), Education Systems Center Aug 2026

Illinois Model Programs Of Study Guide: Education (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft is available for public comment through September 30, 2026. Share your public comment at:

https://forms.gle/VDKeCdf5HycEerMr7


Illinois Model Programs Of Study Guide: Physical Health (Draft For Public Comment), Education Systems Center Aug 2026

Illinois Model Programs Of Study Guide: Physical Health (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft is available for public comment through September 30, 2026. Share your public comment at:

https://forms.gle/VDKeCdf5HycEerMr7


Using Clustering Techniques And Mitre Att&Ck Threat Interpretation To Detect Anomalies In Modbus/Tcp For Industrial Control Systems, Shivanjali Khare, Tirthankar Ghosh, Jhansi Sreya Jagarapu, Atharva Haridas Sagare Aug 2026

Using Clustering Techniques And Mitre Att&Ck Threat Interpretation To Detect Anomalies In Modbus/Tcp For Industrial Control Systems, Shivanjali Khare, Tirthankar Ghosh, Jhansi Sreya Jagarapu, Atharva Haridas Sagare

Journal of Cybersecurity Education, Research and Practice

Recent attacks on America's critical infrastructure have drawn increased attention on securing industrial control systems and operational technology in power plants, utility companies, and other sectors providing public services. Attack detection and mitigation strategies on these systems have shown promising results using machine learning and other statistical baselining techniques, mostly using supervised learning and classification. Unsupervised learning using cluster analysis and other techniques remain mostly unexplored. In this paper, we propose multi-layered feature extraction and hybrid clustering framework to detect fine-grained nested attack patterns in Modbus-over-TCP traffic. Operating under the assumption of known number of distinct network categories, our approach …


Clinic-In-A-Box: A Portable, Software-Defined Cyber Range For Realistic, Scenario-Based Cybersecurity Training, Ethan Chumley, Aaron Nair, Royce Yaezenko, Joshua Payne, Veronika Kyles, Paul Wagner, Robert J. Honomichl, Ryan Straight, Shengjie Xu Aug 2026

Clinic-In-A-Box: A Portable, Software-Defined Cyber Range For Realistic, Scenario-Based Cybersecurity Training, Ethan Chumley, Aaron Nair, Royce Yaezenko, Joshua Payne, Veronika Kyles, Paul Wagner, Robert J. Honomichl, Ryan Straight, Shengjie Xu

Journal of Cybersecurity Education, Research and Practice

Realistic, hands-on cybersecurity training has traditionally depended on fixed infrastructure such as dedicated lab hardware, cloud subscriptions, or permanent network connectivity, limiting where and how often it can be delivered. This paper presents the design and implementation of a portable, scenario-based cybersecurity training platform housed in a single travel case and built from commodity hardware, type-1 hypervisor virtualization, containerized service orchestration, and software-defined networking. The platform clones, isolates, and resets complete lab environments on demand, allowing the same physical system to support repeated classroom, workshop, or field deployments with minimal manual reconfiguration. Training scenarios are grounded in generated organizational profiles …


Between Digital Transformation And Regulatory Vacuum: Cybersecurity Of Public Services In Mozambique, Faztudo Languisse Eng. Aug 2026

Between Digital Transformation And Regulatory Vacuum: Cybersecurity Of Public Services In Mozambique, Faztudo Languisse Eng.

Journal of Cybersecurity Education, Research and Practice

The rapid expansion of digital public services in Mozambique—including e-government platforms, digital health systems, and electronic tax administration—has outpaced the development of a coherent legal framework for cybersecurity. While Law No. 3/2017 (Electronic Transactions Law) of 9 January 2017 introduced foundational data-protection principles, Mozambique long lacked a dedicated cybersecurity regulatory authority, mandatory security standards, and formal incident-notification mechanisms. This regulatory vacuum exposed critical public services to escalating cyber risks as digital transformation was actively promoted as a development priority. This article examines the legal and institutional gaps in Mozambique's cybersecurity governance framework prior to the 2026 Cybersecurity and Cybercrime Laws, …


Middle Class Affordability In The Mountain West, 2023, Kian Parikh, Krish Sharma, Mohit Pande, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr. Aug 2026

Middle Class Affordability In The Mountain West, 2023, Kian Parikh, Krish Sharma, Mohit Pande, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet presents 2023 data on the share of middle-class households that can afford basic necessities in the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The Brookings Institution report, “In every corner of the country, the middle class struggles with affordability,” provides metropolitan-level estimates across all 50 U.S. states and the District of Columbia. This fact sheet focuses on middle class affordability data for the largest metro area in each Mountain West state and, where available, explores middle class affordability by race and ethnicity.


Concepts For Supporting Indigenous And Tribal Information And Research Needs, Sharon Hausam Aug 2026

Concepts For Supporting Indigenous And Tribal Information And Research Needs, Sharon Hausam

Faculty Publications

This is a working paper produced as part of National Science Foundation project #2115169, “Transforming Rural-Urban Systems: Trajectories for Sustainability in the Intermountain West,” known as the “Intermountain West Transformation Network” (TN), led by the University of New Mexico with institutional partners at three additional universities in New Mexico, two in Arizona, and one each in Utah, Colorado, and Washington. The TN’s Indigenous and Tribal engagement was supported through a contract with Dr. Sharon Hausam, additional work by Aaron M. Canter, coordination with Dr. Lani Tsinnajinnie, and an Advisory Committee on Indigenous Information Needs primarily comprised of Indigenous representatives in …


The Rider (2026-08-31), Daniela Chapa-Reyes Aug 2026

The Rider (2026-08-31), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 2


Implementing A Routine Fall Risk Assessment In Older Adults In An Inpatient Psychiatric Setting, Amaka Obi Aug 2026

Implementing A Routine Fall Risk Assessment In Older Adults In An Inpatient Psychiatric Setting, Amaka Obi

Walden Dissertations and Doctoral Studies

The purpose of the project was to implement and evaluate a structured fall risk assessment process that promoted the early identification of patients at increased risk for falls and supported interventions designed to prevent fall-related events. A pre- and post-implementation evaluation design was used to assess the intervention's effectiveness by comparing fall rates before and after implementation of the standardized assessment protocol. De-identified data obtained from the electronic health record (EHR) were analyzed using descriptive statistics to evaluate changes in fall incidence and protocol adherence. The project findings demonstrated that provider-led, standardized fall-risk assessments improved screening compliance, provider adherence, and …


Staff Education To Increase Knowledge And Awareness Of Sexually Transmitted Diseases, Alie Sholola Sahid Aug 2026

Staff Education To Increase Knowledge And Awareness Of Sexually Transmitted Diseases, Alie Sholola Sahid

Walden Dissertations and Doctoral Studies

Background STIs or sexually transmitted diseases (STDs) are consequential public health emergencies that affect millions of people globally and have long-term health implications (Garcia et al., 2024). STIs are infections that are passed from one person to another through sexual contact with the most common types of STIs include chlamydia, trichomoniasis, general herpes, and human papillomavirus (HPV). It is estimated that each year, more than 20% of the U.S. population has had an STI, with around 26.2 million cases per year (Centers for Disease Control and Prevention [CDC], 2024a). The common types of STIs include chlamydia, trichomoniasis, general herpes, and …


Optimizing Advanced Ehr And Enhanced Data-Sharing And Reporting In Rural Health Clinics, Adaeze Honesta Duru Aug 2026

Optimizing Advanced Ehr And Enhanced Data-Sharing And Reporting In Rural Health Clinics, Adaeze Honesta Duru

Walden Dissertations and Doctoral Studies

Rural clinics continue to face several barriers in utilizing advanced electronic health record (EHR) features, including interoperability, data sharing, and care coordination. The purpose of this integrative review was to investigate strategies to overcome barriers to the use of advanced EHRs and enhance data-sharing and reporting capabilities in rural clinics. The review question emphasized viable strategies for overcoming barriers to advanced EHR utilization and enhancing data-sharing and reporting capabilities in rural clinics. The consolidated framework for implementation research provided a conceptual model for understanding the various facets of EHR optimization. A literature search initially resulted in 135 relevant articles. After …


Spiraling Up, Spiraling Down: A Multi-Level Study Of Social Value Creation And Community Capitals In A Mexican Social Enterprise, Karla M. Corres Luna Aug 2026

Spiraling Up, Spiraling Down: A Multi-Level Study Of Social Value Creation And Community Capitals In A Mexican Social Enterprise, Karla M. Corres Luna

Graduate Doctoral Dissertations

This dissertation examines how a social enterprise creates social value and, through the same intervention, erodes it in the communities it serves. Research on social entrepreneurship has theorized value largely from the organizational viewpoint, measured it at a single point in time, and rested on an unexamined aggregation assumption: that gains delivered to individual households sum into well-being at the level of the community. This study holds that assumption up to community-level, participant-centered evidence. Through three qualitative studies of a participatory housing model implemented by a social enterprise in two informal settlements in Querétaro, México, it analyzes social value creation …


Equitable Access To Literacy Assessment And Instruction For Students With Cerebral/Cortical Visual Impairment, Tammy Reisman Aug 2026

Equitable Access To Literacy Assessment And Instruction For Students With Cerebral/Cortical Visual Impairment, Tammy Reisman

Graduate Doctoral Dissertations

Students with Cerebral/Cortical Visual Impairment (CVI) represent a growing population of learners whose visual difficulties originate in the brain rather than the eyes. As understanding of CVI has evolved, questions have emerged regarding the most appropriate approaches to literacy assessment and instruction. While some educational approaches emphasize maximizing visual functioning, increasing evidence supports the integration of compensatory skills and multiple sensory channels to improve literacy access. Understanding current literacy assessment and instructional practices is essential to ensuring equitable educational opportunities for students with CVI.

The purpose of this mixed-methods study was to examine current literacy assessment and instructional practices for …


Redefined: Understanding The Experience Of Black Joy Among Black Youth, Kaela A. Yamini Aug 2026

Redefined: Understanding The Experience Of Black Joy Among Black Youth, Kaela A. Yamini

Graduate Doctoral Dissertations

The study of Black joy is a newer concept and, therefore, reflected in a small but growing body of literature. Many scholars have reflected on the theoretical nature of Black joy and how it can appear across settings, e.g., academically, occupationally, communally, and internally, but very few studies have examined this phenomenon empirically. Several definitions of Black joy have emerged in connection to history and suffering; however, there is still a notable lack of agreement among researchers. Despite thatall conceptualizations acknowledge how this emotional experience is much greater than the pain associated with it and highlight its ability …


“Nothing About Us Without Us”: Examining Sense Of Belonging And College Success Through The Experiences Of Students With Autism Spectrum Disorder, Courtney E. Mulligan Aug 2026

“Nothing About Us Without Us”: Examining Sense Of Belonging And College Success Through The Experiences Of Students With Autism Spectrum Disorder, Courtney E. Mulligan

Graduate Doctoral Dissertations

Sense of belonging has become an increasingly important indicator of student engagement, persistence, and success in higher education. Despite this, limited research has explored how college students with autism experience and define belonging while at college. As increasing numbers of students with autism pursue postsecondary education, institutions face a growing need to better understand the factors that influence student experiences and outcomes. The purpose of this mixed-methods study was to investigate the experiences of sense of belonging among current college students with autism and identify the factors that contribute positively or negatively to this experience to inform more inclusive higher …


The Negotiated Identities Of Refugee-Background Women During Resettlement, Iuliia Fakhrutdinova Aug 2026

The Negotiated Identities Of Refugee-Background Women During Resettlement, Iuliia Fakhrutdinova

Graduate Doctoral Dissertations

Refugee-background women experience unique challenges while resettling in the U.S. as they navigate complicated transnational gender roles, education gaps, migration trauma, learning a new language, and literacy in the adaptation process during resettlement, which can derail the productive paths they are on. Therefore, ignoring refugee-background women’s unique experiences and failing to understand their identities prevents our society from doing social justice and creating a space for a smooth adaptation to the new context. Language plays a paramount role in identity formation, as it moves away from the belief that identity is an essential concept. For refugee-background women during resettlement, their …


Innovating A Crustacean Embryo Toxicity (Cet) Assay For Screening Environmental Contaminants, Irina A. Polunina-Proulx Aug 2026

Innovating A Crustacean Embryo Toxicity (Cet) Assay For Screening Environmental Contaminants, Irina A. Polunina-Proulx

Graduate Doctoral Dissertations

Environmental pollutants can disrupt normal developmental processes, leading to neurobehavioral and developmental abnormalities. Toxicity tests are important for evaluating environmental contaminants; however, standard assays are often time- and cost-intensive and typically require large numbers of vertebrate animals. These limitations highlight the need to reduce reliance on vertebrate testing and to develop New Approach Methodologies that provide comparable results while improving efficiency and cost-effectiveness. This research utilizes a novel screening assay to evaluate developmental toxicity using Hyalella azteca. H. azteca is a freshwater amphipod widely used as a model organism for sediment toxicity in ecotoxicology, yet its embryos have been minimally …


Home, Neighborhood, And Community Environments And Social Isolation In Later Life: Joint Associations And Their Moderation By Life-Course Socioeconomic Mobility, Jeein Law Aug 2026

Home, Neighborhood, And Community Environments And Social Isolation In Later Life: Joint Associations And Their Moderation By Life-Course Socioeconomic Mobility, Jeein Law

Graduate Doctoral Dissertations

Social isolation is a major public health concern among older adults, yet less is known about how multilevel residential environments shape isolation among those aging in place. Guided by the Socio-Ecological Model, Person–Environment Fit, and a life-course perspective, this dissertation examined whether micro-level home hazards, meso-level neighborhood social cohesion and physical disorder, and macro-level census-tract structural conditions were associated with social isolation. It also examined whether life-course socioeconomic mobility moderated the associations between home and neighborhood environments and social isolation.

This dissertation used two nationally representative longitudinal studies of U.S. older adults. Aims 1 and 2 used the National Health …