Digital Commons Network^™

Beyond The Switch: Identifying Gli2-Associated Secretory Targets For Igm Regulation In Waldenström’S Macroglobulinemia, Trevor Charles Chapman

Master's Theses and Capstones

Waldenström’s Macroglobulinemia (WM) is a rare non-Hodgkin lymphoma characterized by the increased presence of monoclonal IgM circulating in the blood and the infiltration of lymphoplasmacytic cells into the bone marrow. WM cells are heterogeneous, sharing features of both B-lymphocytes and plasma cells while not being able to terminally differentiate. Our labs’ previous work established that inhibiting and knocking down the GLI2 transcription factor effectively reduces IgM secretion in three different WM cell lines. This observed phenotype was discovered to operate through IL-6Rα signaling but whether IgM was regulated transcriptionally was not assessed. GLI2 was initially hypothesized to regulate IgM production …

Shared And Unique Neural Correlates Of Sign And Spoken Language Production: An Ale Meta-Analysis, Grace Robertson

Master's Theses and Capstones

This coordinate-based meta-analysis aimed to identify brain areas that are uniquely active in sign language production during single word/sign production tasks using Activation Likelihood Estimation (ALE). Evidence from a pooled ALE of all studies revealed a shared network between sign and spoken language for language, specifically lexical, syntactic, and semantic selection and retrieval, motor planning and execution, sensorimotor integration, phonological working memory, and visual and multimodal processing. The ALE subtraction (sign language > spoken language) did not reveal any significant clusters above the corrected threshold. However, visual inspection of an uncorrected map revealed that regions responsible for language, spatial attention and …

Advancing Bathymetric Lidar Nearshore Mapping With Self-Supervised Learning, Joseph Wilder

Master's Theses and Capstones

The application of AI/ML to shallow bathymetric mapping with airborne lidar remains limited by a lack of high-quality labeled datasets, extreme spatial variability, and noise introduced by environmental conditions and hardware limitations. These issues reduce the generalizability of traditional statistical approaches for extracting bathymetric points from lidar point clouds, with additional challenges for supervised neural networks arising due to the amount and quality of labeled data required to properly capture broad seafloor characteristics. Recent advances in point cloud machine learning methods have the potential to improve conventional bathymetric processing workflows. This work examines modern self-supervised learning (SSL) methods for bathymetric …

Conserved Spatial Proximity And Immune-Linked Evolution Of Lncrnas From Protein-Coding Genes In Vertebrates, Sahar Jamialahmadi

Master's Theses and Capstones

Long non-coding RNAs (lncRNAs) are widespread components of vertebrate genomes, yet theevolutionary principles governing their genomic positioning, origin, and functional associations remain incompletely understood. Here, we performed a comparative genomic analysis across 96 vertebrate species to investigate the spatial relationship between lncRNAs and protein-coding genes, their evolutionary trajectories within gene families, and their functional and genomic contexts.

We show that lncRNAs are consistently positioned in close proximity to protein-codinggenes across vertebrates, with distance distributions significantly deviating from random genomic placement in all species examined. Despite this non-random organization, genome-wide lncRNA–mRNA distance distributions were highly conserved across species. Ancestral state reconstruction …

Bio 23 Human Anatomy & Physiology I Syllabus, Rujin Tian

Open Educational Resources

The syllabus for BIO 23 contains a course description, course objectives, course readings divided by week and a link to an OER textbook.

Unified Deep Learning Techniques For Spatial Detection And Temporal Forecasting Across Visual Domains, John Olawale Olamofe

All Dissertations

This dissertation proposed a unified deep learning framework for spatial detection and temporal forecasting across visual domains, designed to address limited supervision, class imbalance, and scale variability. The framework was structured around four complementary principles: Domain-Aware Input Rebalancing, Representation-Centric Learning, Diversity-Driven Robustness, and Transfer Across Scale and Modality, which together enabled robust visual representation learning across heterogeneous data sources.

Domain-Aware Input Rebalancing mitigates non-uniform and sparse data distributions by actively reshaping inputs before learning via class-aware augmentation, sampling, resolution manipulation, and super-resolution. This principle underpins object detection in overhead satellite imagery (xView), dense urban aerial scenes (CADOT), temporally sparse NDVI …

The Bridge To Becoming An Educator: An Analysis Of Educator Preparation Programs And Their Effects On Stakeholders, Myltazaire Kynshasha Crayton

All Dissertations

This qualitative study examined how national, state, and institutional policies impact teacher certification processes and influence the experiences of stakeholders in educator preparation programs (EPPs), including administrators, professors, and teacher candidates. Guided by Astin’s Input-Environment-Output (I-E-O) model, this research examined how inputs such as policy mandates, institutional culture, and candidate demographics interact with educational environments to produce diverse outcomes in teacher preparation, certification, and retention. Data were collected through semistructured interviews, questionnaires, document analysis, and policy review across two university EPPs, one in Texas and one in Arkansas. Findings revealed that inconsistencies in policy interpretation, financial and academic barriers, and …

Bio 24 Human Anatomy And Physiology Ii, Rujin Tian

Open Educational Resources

The syllabus for BIO 24 contains a course description, course objectives, course readings divided by week and a link to an OER textbook.

Is Bruen The New Usery?, Tonja Jacobi, Cory Conley

William & Mary Law Review

In 2022, in New York State Rifle & Pistol Ass’n v. Bruen, the Supreme Court revolutionized the Second Amendment, achieving the long-held conservative goal of limiting gun restrictions by imposing an expansive, originalist view of the right to bear arms. However, within just three years, Bruen is showing cracks. Lower court judges are struggling mightily to apply it and are expressing their frustrations in exceptionally frank ways. And already the Supreme Court, in Rahimi v. United States, was forced to reconsider its approach. The Court has been here before, when it tried to revitalize the Tenth Amendment in …

Digital Deterrence Through Financial Controls: Anti-Money Laundering Laws, Lawfare, And The Prc Cyber Threat, Owen T. Tremblay

William & Mary Law Review

This Note argues that anti-money laundering (AML) laws have the potential to serve as powerful tools in disrupting and degrading the support networks that enable and sustain PRC offensive cyber operations. [...] Part I provides an overview of the PRC’s cyber force structure and the national objectives it seeks to achieve through state-sponsored cyber operations. Part II examines the existing legal mechanisms employed to combat PRC MCA [Malicious Cyber Activity], including criminal charges, sanctions, export controls, investment restrictions, civil lawsuits, and other regulatory measures. Part III introduces AML laws as an additional tool in the legal and regulatory toolkit used …

Unconstitutional Cruelty, Michael R. Ulrich

William & Mary Law Review

Despite the long history of transgender people and transgender care, state legislatures suddenly rushed to pass a wave of bans on gender-affirming medical care for trans youth over a three-year period beginning in 2021—an alarming surge within a flurry of legal attacks on the transgender community. In analyzing the constitutionality of these bans, courts and scholars have focused their attention on how to characterize the nature of the rights implicated, and therefore the level of scrutiny warranted. This focus reacts to, and often follows, the current Supreme Court majority’s approach to questions about the rights of historically oppressed and marginalized …

Prefrontal Engagement In Cognitive Flexibility Across Paradigms, Katarina Kalajzic

Honors Scholar Theses

Cognitive flexibility is an executive function that involves dynamically adapting behavior in the face of changing environmental circumstances to achieve a particular goal. Disrupted in numerous psychiatric disorders such as Alzheimer’s disease, schizophrenia, OCD, and depression, the neural correlates of cognitive flexibility are not well understood. However, the prefrontal cortex (PFC) is strongly implicated in executive function and attentional control processes. Thus, we sought to examine the neural circuitry involved in distinct cognitive flexibility tasks – the attentional set-shifting task and the probabilistic 2-armed bandit task. Through optogenetic suppression, we targeted pyramidal neurons of the rodent medial prefrontal cortex, an …

Impact Of Biomass Type On Hydrocarbon Yield And Chain Length Distribution Produced Via Fischer-Tropsch Synthesis, Nicholas R. Hawe

Honors Scholar Theses

This paper investigates the relationship between biomass composition and hydrocarbon yield as well as chain length distribution produced by Fischer-Tropsch synthesis. Through an Aspen Plus model, the conversion of three different biomasses – digestate, sawdust, and corn stover – into hydrocarbon fuel was simulated. The model converts biomass into gaseous and liquid hydrocarbons via various unit operations and reactions. Simulation results highlight the product distribution and hydrocarbon output, allowing for an analysis of hydrocarbon yield and comparison of chain length distributions amongst the three biomasses. Overall, the simulation showed biomass composition had no significant impact on hydrocarbon yield or chain …

Awareness Of Green Infrastructure Projects Near Johnson Creek Restoration Sites In Portland, Oregon, Kate R. Cullinan, Anita T. Morzillo

Honors Scholar Theses

Green infrastructure plays an increasingly important role in managing stormwater and improving human connection to nature in urban areas. My objective was to examine resident awareness of green infrastructure (GI) projects near Johnson Creek restoration sites in the City of Portland, Oregon. Using a mail survey, residents reported their awareness of local water features undergoing restoration. Geographic Information Systems analysis was used to measure the distance, by both street network and Euclidian distance, from each respondent’s residence to the closest active green infrastructure water feature project. Linear regression was used to determine the relationships between the three dependent variables and …

Ai In Wonderland, Bodj Oliver Alngohuro

Honors Scholar Theses

Studies in sound symbolism have revealed a baseline preference for people to associate certain sounds with certain concepts. The Bouba/Kiki effect, for instance, reveals a preference for individuals to associate “Bouba” with a round shape and “Kiki” with a sharp shape (Köhler 1929). Other studies have revealed other associations with certain sounds and names with concepts, such as “Mil” referring to something small and “Mal” referring to something big (Sidhu and Pexman, 2017). This study looks at LLMs and how they compare to humans concerning intuitions for certain names based on sound symbolism.

The Confluence Of Literacy And Child Welfare: The Impact Of Poverty & Adult Literacy And A Proposal For University Partnerships With Local Libraries To Close The Gaps Of Low Literacy Among Underserved Communities, Arianna E. Clouser

Honors Scholar Theses

A literature review about the connection of low adult literacy rates, poverty, and other barriers to education and literacy resources was conducted. The literature review uncovered that children living in underserved communities and experiencing poverty, have a lack of access to education and literacy resources, impacting their literacy skills that transferred into their adulthood. Information was gathered through research of online and scholar articles. A literacy kit event was conducted to make literacy kits to donate to public libraries in need of books. Interviews of local librarians was conducted to gained insight of their efforts to supporting children’s literacy and …

Sacrifice In The Name Of Balance: The Role And Rights Of Lesser Powers At The Congress Of Vienna, Jacob Flinchbaugh

Honors Scholar Theses

This paper examines the relationship between the great powers at the Congress of Vienna, 1814-1815, and the weaker states for whom they attempted to dictate decisions. By looking at critics of the Congress, a pattern of debate between advocates of balance of power and advocates of national sovereignty becomes apparent. Beginning with debates regarding the Congress’ organizational structure, disagreements between figures such as Viscount Castlereagh and Prince Talleyrand focused on disputes about the authority the leaders of the great powers attempted to wield. Subsequent decisions regarding the Netherlands, Poland, and the Ottoman Empire further illustrate awareness and controversy about the …

Munificence: The History And Legacy Of The Munson Steamship Line, 1865–1955, Nicholas C. Benda

Honors Scholar Theses

This paper provides an overview of the Munson Steamship Line, an American steamship company founded by Captain Walter David Munson. A veteran of the American Civil War, Captain Munson visited Cuba following the war’s conclusion and became involved in Cuba’s oil and sugar industries, gradually becoming involved in the international sugar shipping trade. An 1890 innovation in shipboard technology and its impact on the Cuban American molasses trade was a moment that established a multi-generational maritime empire, officially incorporating the Munson Steamship Line shortly after the American intervention in the Cuban War of Independence and expanding throughout the Atlantic. His …

Pathogenic Leptospira Adherence To Epithelial Cells: A Comparison Between Different Hosts Based On Outcome Of Disease, Imaan G. Masood

Honors Scholar Theses

Leptospirosis is a neglected zoonotic disease with global distribution caused by infection with pathogenic spirochetes of the genus Leptospira. Bacterial adherence to host cells is considered a crucial step in leptospiral infection and dissemination. However, the role of host-specific cellular interactions in disease outcome remains poorly understood. In this study, the adherence of pathogenic Leptospira interrogans serovar Manilae strain L495 and saprophytic Leptospira biflexa serovar Patoc I to kidney epithelial cell lines was investigated. The differing cell lines modeled reservoir, subclinical and acute disease hosts. Infection of rat kidney (RK3E), mouse kidney (TCMK-1), and hamster kidney cells (HaK) were evaluated …

Too Big To Fail Or Built To Survive? Government Intervention And Corporate Resilience In The Global Automotive Industry During The 2007–2009 Financial Crisis, Reagan A. Waurishuk

Honors Scholar Theses

The 2007-2009 financial crisis displayed how many industries lacked sustainability during times of market volatility. It revealed structural vulnerabilities, especially in the global automotive industry. This case study and analysis intend to examine why certain major automakers were able to survive the crisis without bankruptcy, such as Ford, Toyota, Honda, and BMW AG, while other competitors required company-wide restructuring and government assistance. This research investigates the extent and timing of government support. It also investigates the influence of these loans on firm rebound rates and whether the companies that were provided with aid were prioritized based on size or weakness. …

Multiplexing Reductive Alkylation Of Peptides For Quantitative Proteomics, Kevin C. Souza

Honors Scholar Theses

Reductive alkylation is a robust and commonly used labeling technique for quantifying proteins and peptides in complex samples using mass spectrometry. This technique involves the attachment of alkyl groups to an amino group at the N-terminus and lysine residues of a peptide, causing a mass shift that is detectable using mass spectrometry. This work aims to explore the application of reductive alkyl labeling in multiplexed quantitative proteomics. The first part of the study investigates the effectiveness of the labeling of peptides using a variety of aldehydes via reductive alkylation. The aldehydes were chosen, such that they provided various degrees of …

When Mac Shouldn’T Smile Back: Anthropomorphic Logo And Effect On Consumer Perceptions Of Generative Artificial Intelligence, Ainsley E. Ballard

Honors Scholar Theses

Drawing on prior research suggesting that anthropomorphic design can increase trust, liking, and perceived competence, this research investigates whether these effects extend to generative artificial intelligence logos. A three-group between-subjects study was conducted to examine how varying levels of logo anthropomorphization influenced consumer perceptions of an artificial intelligence brand. In being assigned to one of three logo conditions, humanoid (high anthropomorphism), animalistic (moderate anthropomorphism), or nature/geometric (low anthropomorphism), participants evaluated the new logo across multiple dimensions, including liking, brand fit, trustworthiness, and willingness to buy. Contrary to the initial hypothesis, the low anthropomorphism condition consistently received the most positive ratings, …

Factors Affecting Pedestrian-Vehicle Conflicts: An Empirical Analysis, Christo D. Jamo

Honors Scholar Theses

The number of pedestrian deaths increased by 78% between 2009 and 2023, while other motor vehicle crash deaths increased by 13% in the same period [1]. To identify potential pedestrian safety measures, this study analyzed the effects of location-based demographics, pedestrian phasing type, and other physical infrastructure and behavior variables on the probability of pedestrian-vehicle conflicts at signalized intersections, which is a surrogate measure of crash risk. Data were collected from 55 intersections in Connecticut, and the pedestrian-vehicle interactions were classified by severity based on the Swedish Traffic Conflict Technique: undisturbed passage, potential conflict, minor conflict, or serious conflict. Because …

Gender-Neutral Insurance Reform In The United States: Actuarial Challenges In Pricing And Reserving, Matthew O'Connor

Honors Scholar Theses

This paper examines whether gender remains an appropriate rating variable in the U.S. insurance industry. Gender has historically been used across several lines of insurance because it has demonstrated predictive value in areas such as mortality, claim frequency, and health utilization. However, the continued use of gender creates challenges as insurance systems attempt to accommodate individuals who do not fall within traditional male/female binary classifications.

The paper first reviews the current state of gender use in U.S. insurance, including examples from auto, health, life, and annuity markets. It then considers equity and ethical concerns, particularly the tension between actuarial fairness …

Inosine Accelerates Cancer Cell Killing By The Experimental Antifolate Ucp1162: Implications For Novel Combination Treatments, Reshma Ramesh, Charles Giardina, Alan Kuo

Honors Scholar Theses

Antifolates disrupt one-carbon metabolism (OCM), which stops nucleotide synthesis and therefore slows down cell proliferation. Our experimental antifolate, UCP1162, stops de novo purine synthesis and thymidine synthesis by targeting the OCM pathway. We investigated whether the downstream metabolites of OCM pathway: methionine, thymidine, and inosine, affect the cell death caused by UCP1162 using MV4-11 leukemia cells. Thymidine was found to partially rescue MV4-11 cells from UCP1162, in contrast, inosine was found to accelerate the cell death caused by UCP1162. These cytotoxic effects of UCP1162 alone and in combination with inosine were irreversible, as removal of treatment did not restore cell …

Policing The Bench: Why State Legislatures Target Judicial Ethics Commissions, Emily R. Grayson

Honors Scholar Theses

This thesis examines the factors driving state legislatures to restructure judicial ethics commissions. Although judicial autonomy is foundational to the American legal system, these reforms signal a growing legislative willingness to exert direct influence over the bench. With a particular focus in Texas and Georgia, this study compares the variables that shape reforms and the common themes that are present in the legislative debates. Using Devlin and Wildeman’s (2021) framework as a guide, the specific arguments made by legislators regarding these reforms are examined in an effort to understand how they justified or contested the changes. By analyzing legislative discourse …

The Germinal Center Blueprint For Spatial Immune Mapping And Antibody Discovery In Breast Cancer Sentinel Lymph Nodes, Angel Shah

Honors Scholar Theses

Sentinel lymph nodes are the first nodes that receive drainage from a tumor and are commonly used to evaluate whether cancer has begun to spread, but they also provide an important window into how a patient’s immune system is reacting to tumor-derived antigens. This project examines immune activity within SLNs, with particular attention to germinal centers, where B cells mature, undergo clonal expansion and somatic hypermutation, and generate improved antibody responses. Using a combination of spatially mapped immune marker staining, rapid sampling of reactive germinal centers, cytokine profiling, and single-cell/single-nucleus RNA sequencing, the study aims to characterize the localization, activation …

From Prescription To Plate: Redefining The Pharmacist’S Role In Food Is Medicine Initiatives, Aleena R. Thomas

Honors Scholar Theses

Produce prescription (PRx) programs are an emerging Food is Medicine intervention designed to address diet-related chronic diseases and food insecurity by integrating healthcare delivery with access to fruits and vegetables. Diet-related conditions such as type 2 diabetes, hypertension, and cardiovascular disease represent a major public health burden in the United States, particularly among populations with limited access to nutritious food. Despite growing evidence supporting PRx programs, pharmacists -- who routinely manage these conditions and monitor outcomes -- are underutilized in program implementation. The objective of this project is to translate the public health aspects of PRx programs into an accessible, …

Diagnostic Ability Of Rate Of Torque Development For Patellofemoral Pain, Arun Loganathan, Neal R. Glaviano Phd, Sungwan Kim Phd

Honors Scholar Theses

Context: Patellofemoral pain (PFP) is a highly prevalent condition (22.7% in general population) that significantly impacts the quality of life of those who suffer from it. However, there is no gold standard test to diagnose it yet, leading to inconsistencies with treatment as well as delayed intervention. Rate of torque development (RTD) is a neuromuscular measure that has shown strong connections to PFP.

Objective: The purpose of this study is to determine the diagnostic ability of RTD for PFP.

Design: Cross-sectional.

Setting: Laboratory.

Participants: Thirty-five individuals with PFP (24 males and 11 females, 22.7 ± 3.7 years, 1.67 ± 0.1 …

Validation Of A Real-Time Pcr Laboratory Developed Test For The Detection Of Pneumocystis Jirovecii In Bronchoalveolar Lavage Samples, Caitlyn Moon

Honors Scholar Theses

Pneumocystis jirovecii is an opportunistic, host-obligate fungal pathogen responsible for causing P. jirovecii pneumonia (PJP) in humans. PJP is treated with trimethoprim-sulfamethoxazole (TMP-SMX), a strong broad-spectrum antibiotic that carries risk of renal and hepatotoxicity. Therefore, rapid diagnosis or exclusion of PJP is crucial to ensure PJP-positive patients receive effective treatment and PJP-negative patients avoid unnecessary antibiotics. Unlike most microorganisms, P. jirovecii cannot be cultured, presenting complications for the typical methods of diagnosing fungal pathogens. Historically, the gold standard for diagnosis was direct microscopic examination with stains such as methenamine silver and calcofluor white, but this diagnostic technique requires highly skilled …