Digital Commons Network^™

Sudden Acquired Retinal Degeneration Syndrome In Canine Patients, Morgan Powell

Honors College Theses

Sudden Acquired Retinal Degeneration Syndrome (SARDS) is a perplexing and debilitating ocular condition that affects canine patients primarily in the form of the sudden onset of total vision loss. Veterinary literature will be reviewed to discuss the basic anatomy of the canine eye and retina, as well as to investigate various diagnostic techniques to evaluate ophthalmic function and hypotheses of the pathogenesis of SARDS. The complexity of this disease and the absence of research leads to veterinarians and clients grappling with unanswered questions. This research surveys veterinarians to gain a perspective of the rareness of the disease, the most frequent …

Anti-Press Bias: A Response To Andersen Jones And West's Presuming Trustworthiness, Erin C. Carroll

Georgetown Law Faculty Publications and Other Works

Professors RonNell Andersen Jones and Sonja R. West’s Presuming Trustworthiness is a deeply depressing read. That is what makes it so good. The article is a clear-eyed, data-driven approach to assessing just how endangered the legal status of the free press is. Given the universality of the agreement that a free press is central to democracy, Andersen Jones and West’s message is vital. Presuming Trustworthiness should raise alarms.

In response, I hope this essay can serve as a bullhorn. I want to amplify what Andersen Jones and West’s research and data bear out. Not only has the Supreme Court ceased …

Molybdenum Alkylidyne Complexes With Phenoxide Ligands For Alkyne Metathesis, Marvin L. Stewart Jr

LSU Doctoral Dissertations

Abstract

Alkyne metathesis is a powerful synthetic tool, which provides easy access to complex organic molecules in a single-step. It is a dynamic covalent reaction that scrambles alkynes, carbon-carbon triple bonds (C≡C). Molybdenum- or tungsten-alkylidyne (Mo≡C, W≡C) complexes are typically used as catalyst to cleave and reform alkyne bonds. Our goal has been to gain a deeper understanding of the intrinsic differences between functional ligands by the development of novel phenoxide ligands.

In chapter 2 we explore the detailed synthesis of novel phenoxide podand ligands in an effort to identify their mo-alkylidyne complexes. We were able to synthesize a variety …

Dopamine Release Neuroenergetics In Mouse Striatal Slices, Msema Msackyi, Yuanxin Chen, Wangchen Tsering, Ninghan Wang, Hui Zhang

Department of Neuroscience Faculty Papers

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Dopamine (DA) neurons in the substantia nigra pars compacta, which have axonal projections to the dorsal striatum (dSTR), degenerate in PD. In contrast, DA neurons in the ventral tegmental area, with axonal projections to the ventral striatum, including the nucleus accumbens (NAcc) shell, are largely spared. This study aims to uncover the relative contributions of glycolysis and oxidative phosphorylation (OxPhos) to DA release in the striatum. We measured evoked DA release in mouse striatal brain slices using fast-scan cyclic voltammetry applied every two minutes. Blocking OxPhos resulted in a greater …

Dual Functional Magnetic Nanoparticles Conjugated With Carbon Quantum Dots For Hyperthermia And Photodynamic Therapy For Cancer, Mounika Choppadandi, Kondi Soumya, Sumanta Ghosh, Aishwarya Balu, Tanvi Shingote, Srivalliputtur Sarath Babu, Vani Sai Prasanna, Somasundaram Arumugam, Ravichandiran Velyutham, Murali M. Yallapu, Govinda Kapusetti

School of Medicine Publications

The global incidence of cancer continues to rise, posing a significant public health concern. Although numerous cancer therapies exist, each has limitations and complications. The present study explores alternative cancer treatment approaches, combining hyperthermia and photodynamic therapy (PDT). Magnetic nanoparticles (MNPs) and amine-functionalized carbon quantum dots (A-CQDs) were synthesized separately and then covalently conjugated to form a single nanosystem for combinational therapy (M-CQDs). The successful conjugation was confirmed using zeta potential, Fourier transform infrared spectroscopy (FT-IR), and UV-visible spectroscopy. Morphological examination in transmission electron microscopy (TEM) further verified the conjugation of CQDs with MNPs. Energy dispersive X-ray spectroscopy (EDX) revealed …

Autonomy Relation To Student's Motivation In Stem, Halle Patton

Honors Projects

The purpose of this research project is to investigate how giving students autonomy can affect the way they learn and participate in a STEM environment. Autonomy-Supportive Teaching occurs when students take ownership throughout the entire learning process, becoming more actively engaged and motivated due to the personal responsibility that they feel to learn. Our education system is primarily made up of teacher-centered environments. However, the change to student-centered learning could be revolutionary. By making educational environments geared towards student interest and choice, it could increase both motivation and internalization– two factors that make a successful student. Research was conducted in …

Associations Between Stress, Health Behaviors, And Quality Of Life In Young Couples During The Transition To Survivorship: Protocol For A Measurement Burst Study, Dalnim Cho, Michael Roth, Susan K Peterson, Kristofer Jennings, Seokhun Kim, Sairah Ahmed, Carlos Barcenas, Y Nancy You, Kathrin Milbury

Faculty, Staff and Student Publications

BACKGROUND: Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in their developmental transitions. Cancer treatment can also cause adverse long-term effects, chronic conditions, psychological issues, and decreased quality of life (QoL) among young adults. Despite numerous health benefits of health behaviors (eg, physical activity, healthy eating, no smoking, no alcohol use, and quality sleep), young adult cancer survivors report poor health behavior profiles. Determining the associations of stress (either cancer-specific or day-to-day stress), health behaviors, and QoL as young adult survivors transition to survivorship is key to understanding and enhancing these survivors' health. …

Evolution Of Chromosome-Arm Aberrations In Breast Cancer Through Genetic Network Rewiring, Elena Kuzmin, Toby M Baker, Tom Lesluyes, Jean Monlong, Kento T Abe, Michael Schwartz, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park

Faculty, Staff and Student Publications

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module …

Six-Year Follow-Up And Subgroup Analyses Of A Phase 2 Trial Of Venetoclax For Del(17p) Chronic Lymphocytic Leukemia, Stephan Stilgenbauer, Eugen Tausch, Andrew W Roberts, Matthew S Davids, Barbara Eichhorst, Peter Hillmen, Johannes Schetelig, Sebastian Böttcher, Arnon P Kater, Yanwen Jiang, Michelle Boyer, Relja Popovic, Majd T Ghanim, Michael Moran, Wendy J Sinai, Xifeng Wang, Nabanita Mukherjee, Brenda Chyla, William G Wierda, John F Seymour

Faculty, Staff and Student Publications

Chromosome 17p deletion (del[17p]) is associated with poor prognosis in patients with chronic lymphocytic leukemia (CLL). Venetoclax is approved for treatment of previously untreated and relapsed/refractory (R/R) CLL, including patients with del(17p), based on the open-label, multicenter, phase 2 M13-982 trial (NCT01889186). Here, we detail the 6-year follow-up analysis for M13-982. A total of 158 patients with previously untreated (n = 5) or R/R (n = 153) del(17p) CLL received 400 mg venetoclax daily after initial ramp-up until progressive disease. After a median follow-up of 70 months, the best objective response rate (ORR) was 77% (21% complete remission …

Topographical And Cell Type-Specific Connectivity Of Rostral And Caudal Forelimb Corticospinal Neuron Populations, Rui M Costa

Faculty, Staff and Student Publications

Corticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse assortment of cells with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, the full diversity of spinal neurons targeted by CFA and RFA CSNs is uncharted. Here, we use anatomical and RNA sequencing methods to show that CSNs synapse onto a remarkably selective group of spinal cell types, favoring inhibitory populations that regulate motoneuron activity and gate sensory feedback. CFA and RFA CSNs target similar spinal neuron types, …

Ccr2+ Monocytes Replenish Border-Associated Macrophages In The Diseased Mouse Brain, Meijie Wang, Long-Jun Wu

Faculty, Staff and Student Publications

Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this population of cells is maintained is not well understood. Using two-photon microscopy and multiple lineage-tracing strategies, we determine that CCR2+ monocytes are significant contributors to BAM populations following disruptions of CNS homeostasis in adult mice. After BAM depletion, while the residual BAMs possess partial self-repopulation capability, the CCR2+ monocytes are a critical source of the repopulated BAMs. In addition, we demonstrate the existence of CCR2+ …

Aerodynamic Design And Analysis Of A Modified 2006 Mazda Miata, William N. Recher

Honors College Theses

Aerodynamic forces developed by automobiles have destabilizing effects at high speed. These forces tend to skew toward a vehicle’s rear which can present safety concerns, especially for rear-wheel-drive automobiles like the Mazda Miata. To address oversteer and high-speed instability, a vehicle’s design can be tailored to bring about aerodynamic balance and improve traction. LiDAR was used to bring the physical automobile into the digital space. Then, a splitter and diffuser were added to reduce the magnitude of the destabilizing forces. Next, the size and shape of the rear-wing required to balance the vehicle was calculated using a combination of parameters …

Blissful (Dis)Comfort, Mei Kiengsiri

Theses

From personal anecdotes and past experiences, “Blissful (Dis)comfort” confronts, celebrates, and humorizes my Thai culture and family dynamics through light, sound, and the subversion of everyday objects. This thesis explores the personal, intimate, and even vulnerable sides of my childhood and personal relationships, as well as their reflections on technical challenges and solutions to everyday electronic devices. The body of work rejects the expectations of cause and effect, logical consequences, and reactions, blending in the child-like sense of wonder, discovery, and play with more complex themes of nostalgia and family.

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Ever-Advancing To World Revolution: Soviet Children's Literature From 1925 To 1927, Amy Daniel

The Thetean: A Student Journal for Scholarly Historical Writing

During the third all-Russia congress of the Russian Young Communist League in 1920, speaking to revolutionary youth, Vladimir Lenin laid out what he saw as the mission of the youth leagues and described his new vision of children's education: "The entire purpose of training, educating and teaching the youth of today should be to imbue them with communist ethics . . . [which] stems from the interests of the class struggle of the proletariat." Even before the end of the Russian Civil War, Lenin was conscious that to build communism, he first had to teach it to the youth. In …

The Dynastic Duo: A Tale Of Two Monarchs, John Martin

The Thetean: A Student Journal for Scholarly Historical Writing

With good reason, Sparta is often considered on of the most influential classical Greek poleis. The Spartans led the combined military forces of Greece during the Second Persian Invasion of 480 BCE, and led the Peloponnesian League for over a hundred years. They brought down the Athenian Empire and ruled much of Greece, until they themselves were defeated by the Thebans. Their success is usually attributed to the unique nature and strength of their army. However, there is another key, but often overlooked, contributing factor to Spartan predominance: its unique system of government, ruled by rwo kings. This diarchy enabled …

"Something Sounder, Nobler, And Greater": Neo-Gothic Architecture And National Identity In Confederation-Era Canada, Susannah Morrison

The Thetean: A Student Journal for Scholarly Historical Writing

The morning of 1 September, 1860 was unseasonably warm for Cananda, but the heat did not deter the thousands of spectators gathered on the southern banks of the Ottawa River to catch a glimpse of the young prince of Wales. As the crowning moment of Prince Albert's royal visit to Canada, the eighteen-year-old prince laid the cornerstone for the new government buildings in Ottawa. Keen to use the Prince's tour as an opportunity to show the colony off at its finest, Canada's leaders had outdone themselves in organizing an unabashedly imperial public reception for their future king. The Union Jack …

"A Sufficient Security": British Public Discourse On Proposals For Reconciliation With The Thirteen American Colonies, 1778-1780, Katie Richards

The Thetean: A Student Journal for Scholarly Historical Writing

"The storm of their malice is now ready to burst upon our heads," wrote John Cartwright of the allied relationship between British North America and France, Britain's "ancient enemy." With the signing of the Alliance Treaty on February 6, 1778, the French began officially extending their support to the thirteen American colonies fighting for independence from Great Britain. Such an alliance was bound to provoke many responses within England. In his pamphlet "The Memorial of Common-Sense," Cartwright wrote that the very act of France entering into a treaty with the American colonies admitted those colonies to the rank of independent …

The Boys Behind The Backwoods Bigots: A Microhistory Examination Of The 1950s Ku Klux Klan, Erin Schill Facer

The Thetean: A Student Journal for Scholarly Historical Writing

On January 18, 1958, A young Baptist preacher named James finalized his preparations for an important rally to be held that night. He was bolstered by the anticipation of hundreds, if not thousands, of fellow activists uniting in solidarity for their shared cause. They planned to rally peacefully for their God-given rights and the protection of those whom they loved-but, fearful of violent resistance, they requested federal protection.' As the sun set, James, along with a few friends, drove out to the large field he had rented for the rally on the outskirts of a small town in North Carolina. …

Chasing Freedom Runaway Slaves And Soldiers During The War Of 1812, Lane Lisonbee

The Thetean: A Student Journal for Scholarly Historical Writing

On the morning of September 14, 1814, Francis Scott Key made an indelible contribution to United States patriotism. Through the night he had witnessed the British bombardment of the American Fort McHenry while aboard the H.M.S. Tonnant, a British ship on which he had been detained after helping to negotiate the release of an American prisoner of war. He and his companion, Colonel John Stuart Skinner, had anxiously kept their eyes on the flag flying over the fore, and when in the early light of day they could see chat the stars and stripes stripes of che American banner …

Friction And Fog: The Chaotic Nature Of Defeat For The B.E.F. In The Fall Of France, Carson Teuscher

The Thetean: A Student Journal for Scholarly Historical Writing

Bursting from the thick Ardennes Forest on the morning of May 10, 1940, Hitler's Panzer armies pounded across the French countryside. Not only did his armies strike through what Marshal Petain had deemed the "Impenetrable Ardennes," in doing so German forces bypassed the Maginot Line, France's most formidable defenses. As they poured through the gap, other German armies simultaneously attacked Belgium, sweeping downward through the Low Countries to merge with the primary thrust towards Paris.

Blacks Depicted As A Symbol Of European Power Through The Ages, Lydia Breksa

The Thetean: A Student Journal for Scholarly Historical Writing

Only twenty-seven years ago, Japanese marketeing experts explained that viewers of their advertisements "respond favorably to blacks because they seem more full of energy than whites," and "appear to have a wild side chat seems beyond normal human strength."' In 1988 Japan, this Western-inspired image was not uncommon.2 Such depictions of blacks did not come from thin air. Blacks have been portrayed in European art in various ways throughout history; however, there are recurring themes that persist even today. Such portrayals not only represent society's perceptions but also strengthen them. As such, a study of how European art depicted blacks …

The Economy: The Heart Of The Brazilian Quilombo, Benjamin Passey

The Thetean: A Student Journal for Scholarly Historical Writing

Over Centuries of slavery in Brazil, thousands escaped enslavement in search of freedom and a new life. Fugitive slaves seldom survived more than a few days on the run before they were captured and returned to their masters. Those who avoided capture made their way to one of the many fugitive slave settlements called quilombos, hidden throughout the Brazilian countryside.

Karl May's Amerika: German Intellectual Imperialism, Seth Cannon

The Thetean: A Student Journal for Scholarly Historical Writing

What is America? European misconceptions with regard to the Americas can be traced back to the beginning of transoceanic contact in 1492. From Columbus to the Spaghetti Westerns of the 20th century, Europeans have taken America, their "West," and manipulated and sculpted ic. A plethora of contradictory voices have contributed to the construction of a complicated and paradoxical Western mych. Each voice offered a different vision of the West. The versions are grounded in a shared Western setting, but the stories are dramatically different, even foreign. Such transnational perceptions of the American West have attracted the attention of several contemporary …

Elmer: The Shepherd Statesman, Cathy Hulse

The Thetean: A Student Journal for Scholarly Historical Writing

Plato quoted Socrates when he said that "The unexamined life is not worth living," He referred to self-examination for the purpose of self-improvement. In a broader sense, it is also important to study the lives of others to identify ways to improve ourselves. Life is a shared experience no matter where or in what era our individual paths lie. Today's society is often fascinated by extreme heroics or infamous people. It gives unbalanced attention to glamorous, athletic, or wealthy celebrities. Despite this trend, valuable wisdom can be learned from the lives of common folks.

Foreword, Taylor Rice

The Thetean: A Student Journal for Scholarly Historical Writing

Last year I had the distinct privilege of serving as an editor for this fine publication. As the year was brought to a close, Elise Peterson, last volumes Editor-in-Chief, asked me if I would like to stay on with the 7hetean and be its next Editor-in-Chief. I readily agreed, though I was not convinced I was fully qualified. Elise left big shoes to be filled.

Front Matter

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Cash For Conservation: Payments For Ecosystem Service Programs And Forest Loss, John Shandra

Sustainability Seminar Series

According to the World Bank, 1.1 million square miles of tree cover were cleared from 2001 to 2020. Approximately 90% of forests were cleared in low- and middle-income nations. This loss is equivalent to a 7% reduction in tree cover and corresponds with 107 trillion metric tons of carbon dioxide emissions being released into the atmosphere. To limit forest loss, low and middle-income nations often implement payment for ecosystem service programs. By 2020, over 550 programs were active globally, accounting for an estimated $36–42 billion in annual transactions between users and providers. However, we not aware of any cross-national research …

Disturbance Observer-Based Control For Pmsg-Based Wind Turbine Considering Unbalanced Grid Conditions, Moayad Maher Alanani

Thesis/ Dissertation Defenses

A typical permanent magnet synchronous generator (PMSG)-based wind turbine system consists of an electrical generator, machine-side converter (MSC), grid-side converter (GSC), dc-link capacitor, and a passive filter such as L filter or LCL filter to connect the GSC to the host grid. When the wind turbine operates under unbalanced grid voltages, a negative sequence component is introduced to the system. This negative sequence voltage can pose challenges for classical controllers to ensure an efficient control of the PMSG-based wind turbine system. On one hand, when the control objective is to ensure injecting sinusoidal and balanced three-phase currents to the grid, …

Experimental Investigation Of Various Hydrogen Knock Limit Extension Strategies On A Hydrogen-Gasoline Dual Fuel Spark Ignition Engine, Sanad Puthan Purayil

Thesis/ Dissertation Defenses

Hydrogen is a clean and carbon free substitute with the ability to significantly cut down the harmful emissions while enhancing the energy efficiency of internal combustion engines (ICE) typically powered by conventional fossil fuels. Hydrogen is the most abundant element which can be easily obtained from sources like water and biomass. The wide flammability range and high laminar flame velocity outstands hydrogen from other fuels. However, hydrogen fueled engines are more prone to abnormal combustion like knock and backfire due to its low ignition energy and high adiabatic flame temperature. To avoid backfire, several well-developed approaches have been reported. Unlike …