Digital Commons Network^™

Dispelling The Malaria-Typhoid Co-Infection Myth In Nigeria. A Literature Review, Olawale Akinola

Dartmouth Library Staff Publications

Malaria and typhoid fever are public health concerns in Nigeria, with high prevalence rates. The perception of a widespread co-infection between these diseases may be misleading, due to limitations in diagnostic methods, particularly the Widal test for typhoid fever. This literature review examines the prevalence of malaria-typhoid co-infection in Nigeria and identifies factors contributing to misdiagnosis, including non-specific symptoms, limited diagnostic resources, and the diagnostic accuracy of tests employed. Additionally, the review discusses the implications of misdiagnosis, such as the overuse of broad-spectrum antibiotics leading to a rising incidence of antimicrobial resistance. Strategies to address this issue are explored, emphasizing …

Abortion Hostility And The Earned Income Tax Credit, Beatrix Jordan

Honors Scholar Theses

The future of abortion access in the United States is uncertain. Preceding
Dobbs v. Women’s Health, many states enacted abortion policy considered hostile, culminating in strict or even total bans once Roe v. Wade fell. The purpose of this paper is to investigate one facet of the economic outcomes associated with changes in abortion policy. In order to do this I examine the relationship between hostile abortion policy and average reimbursements for the federal earned income tax credit (EITC). I construct a panel dataset which spans 2013 to 2022, with 510 observations: one for each state, for each year. By …

M’Ma, Charlotte Rose Eshelman

Theses

As I wrestle with myself, I wrestle with my mother. Both my mother and I survived domestic abuse as children, my mother again as an adult. Our bodies carry our trauma, her body carried mine, and someday, my body will carry my children. M’ma contemplates what we do with what we’re given, how trauma is inherited and passed down to the next generation through the body, and the complex intimacy of the mother-child relationship. I express and project my questions about my future children, my relationship with and understanding of my mother, and of myself in anticipation of being a …

Beyond Patents: Incentive Strategies For Ocean Plastic Remediation Technologies, Jacob Stotser

Duke Law & Technology Review

With a garbage truck’s worth of plastic being dumped in the ocean each minute, there is a dire need for effective technological solutions aimed at mitigating the marine plastic pollution problem. However, the reliance of the U.S. patent system on market demand to incentivize this type of innovation has proven insufficient in light of the peculiarities of “green” technologies. To remedy this, this article proposes a multi-faceted incentivization approach that looks beyond the U.S. Patent and Trademark Office to stimulate the development of remediation technologies through comprehensive regulatory interventions, the establishment of prize funds and other alternative incentive mechanisms, and …

Optimal Environmental And Economic Performance Trade-Offs For Fifth Generation District Heating And Cooling Network Topologies With Waste Heat Recovery, Michael D. Murphy

Publications

Network topology greatly influences both the economic and environmental performance of fifth generation district heating and cooling (5GDHC) systems. In this study the optimal trade-offs between the environmental and economic performance of 5GDHC network topologies for a five-building district with waste heat recovery were explored. A life cycle assessment method was used to calculate the total life cycle CO2 emissions (LCCO2) associated with the installation and operation of various network topologies. Twelve months of empirical data from a data center cooling system were analyzed to assess its suitability for integration into a 5GDHC system. The most suitable method for utilizing …

Graduate Recital: Gibson Swalley, Violin; Younhee Choi, Piano; April 27, 2024, Gibson Swalley, Younhee Choi

School of Music Programs

Kemp Recital Hall
April 27, 2024
Saturday Evening
7:30 p.m.

Blastomas Of The Digestive System In Adults: A Review, Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu

School of Medicine Faculty Publications

Blastomas, characterized by a mixture of mesenchymal, epithelial, and undifferentiated blastematous components, are rare malignant neoplasms originating from precursor blast cells. This review focuses on digestive system blastomas in adult patients, including gastroblastoma, hepatoblastoma, and pancreatoblastoma. Gastroblastoma is a biphasic, epitheliomesenchymal tumor, with only sixteen cases reported to date. In addition to the characteristic histology, metastasis-associated lung adenocarcinoma transcript 1 - glioma-associated oncogene homolog 1 gene fusion is typical, although recently novel ewing sarcoma breakpoint region 1 - c-terminal binding protein 1 and patched 1 - glioma-associated oncogene homolog 2 fusions have been described. Hepatoblastoma is exceptionally rare in adults …

An Approach To Catholic Marriage For The K'Ho People Of The Diocese Of Da Lat, Vietnam, Duc Van Nguyen

School of Theology and Seminary Graduate Papers/Theses

One of the challenges for the priests providing pastoral care to the K'Ho people in the Diocese of Da Lat, Vietnam, is to help them preserve their culture and customs while remaining faithful to the teachings of the Church. Sometimes conflicts arise; for example, they often hold a wedding before celebrating the Sacrament of Marriage. This paper proposes an approach to the Sacrament of Matrimony while respecting the traditional marriage customs of the K'Ho people in the Diocese of Da Lat, Vietnam. The paper includes three parts: (1) The traditional marriage customs of the K’Ho people; (2) The challenges of …

Ensemble Concerts: Symphonic Winds, April 27, 2024, F. Mack Wood, Christopher Bulding, Ben Stiers

School of Music Programs

Center for the Performing Arts
April 27, 2024
Saturday Evening
8:00 p.m.

Histone Proteoform Analysis Reveals Epigenetic Changes In Adult Mouse Brown Adipose Tissue In Response To Cold Stress, Hari Krishna Yalamanchili, Scott A Ochsner, Gladys E Zapata, Nitesh R Mehta, Neil J Mckenna, Nicolas L Young, Alli M Nuotio-Antar

Faculty, Staff and Students Publications

BACKGROUND: Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for the treatment of obesity and diabetes. Our preliminary analyses of RNA-Seq data uncovered many nodes representing epigenetic modifiers that are altered in BAT in response to chronic thermogenic activation. Thus, we hypothesized that chronic thermogenic activation broadly alters epigenetic modifications of DNA and histones in BAT.

RESULTS: Motivated to understand how BAT function is regulated epigenetically, we developed a novel method for the first-ever unbiased top-down proteomic quantitation of histone modifications in BAT and validated our results with a …

Graph-Based Learning, Jason Gronn

Honors Projects

An educational approach to teaching students based on prerequisite knowledge they may or may not have is presented. This approach represents educational content in the form of a graph, where edges link each topic to the prerequisites of that topic. A proof-of-concept website is created based on this approach, where qualitative results are observed and a number of conclusions are drawn. Some of the findings are that, while it can prevent users from being confused by lacked prior knowledge, the users may instead be confused by the presentation of the graph structure. The work finds that the approach is workable, …

Rainbowcake: Mitigating Cold-Starts In Serverless With Layer-Wise Container Caching And Sharing, Hanfei Yu, Rohan Basu Roy, Christian Fontenot, Devesh Tiwari, Jian Li, Hong Zhang, Hao Wang, Seung Jong Park

Computer Science Faculty Research & Creative Works

Serverless Computing Has Grown Rapidly as a New Cloud Computing Paradigm that Promises Ease-Of-Management, Cost-Efficiency, and Auto-Scaling by Shipping Functions Via Self-Contained Virtualized Containers. Unfortunately, Serverless Computing Suffers from Severe Cold-Start Problems - -Starting Containers Incurs Non-Trivial Latency. Full Container Caching is Widely Applied to Mitigate Cold-Starts Yet Has Recently Been Outperformed by Two Lines of Research: Partial Container Caching and Container Sharing. However, Either Partial Container Caching or Container Sharing Techniques Exhibit their Drawbacks. Partial Container Caching Effectively Deals with Burstiness While Leaving Cold-Start Mitigation Halfway; Container Sharing Reduces Cold-Starts by Enabling Containers to Serve Multiple Functions While Suffering …

Bidirectional Relationships Between Nicotine Vaping And Maladaptive Eating Behaviors Among Young Adults., H Isabella Lanza, Kailey Waller, Lalaine Sevillano

School of Social Work Faculty Publications and Presentations

Past research indicates that young adult cigarette smokers are at risk of engaging in maladaptive eating behaviors (MEBs); however, whether this relationship extends to nicotine vaping is unclear. The current study assessed bidirectional associations between four types of MEBs and nicotine vaping among young adults.

Efficient Gene Knockout And Genetic Interaction Screening Using The In4mer Crispr/Cas12a Multiplex Knockout Platform, Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Medina Colic, John G Doench, Traver Hart

Faculty, Staff and Student Publications

Genetic interactions mediate the emergence of phenotype from genotype, but technologies for combinatorial genetic perturbation in mammalian cells are challenging to scale. Here, we identify background-independent paralog synthetic lethals from previous CRISPR genetic interaction screens, and find that the Cas12a platform provides superior sensitivity and assay replicability. We develop the in4mer Cas12a platform that uses arrays of four independent guide RNAs targeting the same or different genes. We construct a genome-scale library, Inzolia, that is ~30% smaller than a typical CRISPR/Cas9 library while also targeting ~4000 paralog pairs. Screens in cancer cells demonstrate discrimination of core and context-dependent essential genes …

Utility Of Clinical Next Generation Sequencing Tests In Kit/Pdgfra/Sdh Wild-Type Gastrointestinal Stromal Tumors, Ryan A Denu, Cissimol P Joseph, Elizabeth S Urquiola, Precious S Byrd, Richard K Yang, Maria Alejandra Zarzour, Dejka M Araujo, Vinod Ravi, Elise F Nassif Haddad, Michael S Nakazawa, Shreyaskumar Patel, Wei-Lien Wang, Alexander J Lazar, Neeta Somaiah

Faculty, Staff and Student Publications

Objective: The vast majority of gastrointestinal stromal tumors (GISTs) are driven by activating mutations in KIT, PDGFRA, or components of the succinate dehydrogenase (SDH) complex (SDHA, SDHB, SDHC, and SDHD genes). A small fraction of GISTs lack alterations in KIT, PDGFRA, and SDH. We aimed to further characterize the clinical and genomic characteristics of these so-called "triple-negative" GISTs.

Methods: We extracted clinical and genomic data from patients seen at MD Anderson Cancer Center with a diagnosis of GIST and available clinical next generation sequencing data to identify "triple-negative" patients.

Results: Of …

Examining The Effect Of Genes On Depression As Mediated By Smoking And Modified By Sex, Dmitry Prokopenko, John E Hokanson, Michael H Cho, Christoph Lange, Karin F Hoth, Sharon M Lutz

Faculty, Staff and Student Publications

Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis to test the indirect or mediated effect of SNPs on broad depression through the log of pack-years of cigarette smoking, adjusting for age, sex, current smoking status, and genetic ancestry (via principal components). In secondary analyses, we adjusted …

Tailoring Fxr Modulators For Intestinal Specificity: Recent Progress And Insights, Amanda Morrison, Bahaa Elgendy

2020-Current year OA Pubs

While FXR has shown promise in regulating bile acid synthesis and maintaining glucose and lipid homeostasis, undesired side effects have been observed in clinical trials. To address this issue, the development of intestinally restricted FXR modulators has gained attention as a new avenue for drug design with the potential for safer systematic effects. Our review examines all currently known intestinally restricted FXR ligands and provides insights into the steps taken to enhance intestinal selectivity.

Community-Linked Field Experience Pilot, Mia Palombo

Student Research Symposium

This IRB-approved study explores the possibilities of a teacher education program engaged with and rooted in the community. The project follows a partnership between a university and a community organization whose mission is to meet the needs of k-12 multilingual students. Pre-service teachers complete their field experience in an innovative community-based setting, and receive mentoring from a teacher on staff focused on developing skills and understanding how learning is nurtured outside traditional classroom settings. This partnership serves a dual purpose, meeting the needs of the community organization and those of pre-service interns who have demands on their time, which make …

Subversion Of Traditional Gender Roles In Macbeth, Olivia Eubanks

Merge

No abstract provided.

Diminishing Graduate Student-Teacher Power Dynamics Through Care And Vulnerability, Takhmina Shokirova, Lisa Ruth Brunner

Feminist Pedagogy

In this critical reflection, we discuss the concepts of ‘care’ (hooks, 1994) and ‘vulnerability’ (Cano Abadía, 2021) as they relate to the student-teacher power dynamics instructors often face – consciously or not – in graduate-level post-secondary contexts. We suggest that, when practiced together, care and vulnerability offer ways to diminish power imbalances between instructors and students.

The Left Must Rediscover Free Speech And Academic Freedom, Albena Azmanova, Enzo Rossi

Emancipations: A Journal of Critical Social Analysis

The conflict in Gaza has brought to a boil the systematic threat to academic freedom and freedom of speech in Western liberal democracies. This neo-McCarthyism can only be countered by a united front not only within the Left, but across the left-right ideological divide.

On The Political Economy Of Knowledge-Production - An Interview With Richard Wolff, Maria Cernat

Emancipations: A Journal of Critical Social Analysis

With her interview with Marxian economist Richard Wolff, Maria Cernat launches the two-part series on the political economy of knowledge production.

Hypocritical Management Studies, Khang Lê

Emancipations: A Journal of Critical Social Analysis

The assertion “critical management studies is dead. It died a long time ago” (O’Doherty and Jones, 2005, p. 6) has aged poorly. Critical Management Studies lives on, stronger than ever. The term itself even gets title case capitalization. Responding to the call to “investigate the production of theories that pose as radical without challenging the status quo”, I offer my critique of Critical Management Studies. Critical Management Studies provides critical perspectives on established management theories and practices. It aims to encourage micro-emancipations and propose radical alternatives for organizational life. However, I argue that, in the current backdrop of neoliberal academia, …

The Drivers Of Academic Novelty In Digital Capitalism: Job Insecurity, Mental Illness And Time Poverty, Adalberto Fernandes

Emancipations: A Journal of Critical Social Analysis

The present-day digital capitalist academy increases novel academic results by leveraging factors such as precarious academic employment, time poverty, and mental illness. This paradigm reveals a confluence that turns seemingly negative aspects into productive elements. The consequence of this hypothesis is that by enhancing work, time and mental health conditions, there may be a reduction in the number of novelties, with an enhancement of academic's role as producers of truth.

The Contradiction Between Use-Value And Exchange-Value: Ecology, Imperialism, And The Telos Of Production, Larry Alan Busk, Elizabeth Portella

Emancipations: A Journal of Critical Social Analysis

This article elaborates and defends a critique of capitalism which, despite its appearance in various bodies of work, has not been named or systematically differentiated. The critique locates a contradiction between production for use-value and production for exchange-value, or a contradiction in what we call “the telos of production.” While maintaining that it has some basis in Marx’s work, we defend this model as preferable to the critique of capitalism based strictly on the exploitation of labor (which we call the “exploitation-exclusive critique”). We attempt to show this by applying the two approaches to the empirical realities of the ecological …

The Symbolic Capital Of The Neoliberal University, Chad Lavin

Emancipations: A Journal of Critical Social Analysis

The paper examines the concerns about the enduring value of liberal education in the broader context of a shift from a liberal to a neoliberal society. While so much literature on “the neoliberal university” tends to characterize neoliberalism as a hostile force invading the sacred space of the university, the knowledge comprising neoliberalism is in large part the product of research coming out of universities. Using the concept of symbolic capital to explore the role of university researchers in developing and consecrating neoliberal ideas, the paper argues that even in this era of heightened skepticism toward experts and expertise, university …

What Comes After The Critique Of The Corporate University? Toward A Syndicalist University, Clyde W. Barrow

Emancipations: A Journal of Critical Social Analysis

For the past three decades, university faculty have produced a cascade of contemporary protest literature that routinely criticizes the knowledge factory, academic capitalism, managed professionals, college for sale, the university in ruins, the corporate corruption of higher education, and University, Inc. University faculty are regularly warned about the fall of the faculty, the last professors, and the last intellectuals. This article reviews the historical development of the corporate and neoliberal university, but it takes the next step of asking what is to be done after the critique of the corporate university. It calls on faculty to engage in a variety …

Walk, Don't Run For Employee Wellness, Francesca Citro, Danielle Cassidy, Maura Bednarcik

Academic Festival

There are a multitude of factors that have an impact on individuals’ physical activity. Specifically, implementing walking initiatives has proven to be beneficial when it comes to workplace wellness and can contribute to the increased physical activity level among employees in the workplace. The implementation of wearables and walking treadmills are one of many ways to initiate the increase of physical activity among employees.

Machine Learning Model For Os Detection, Victor Ginart Belmonte, Ravjeet Chahal

Academic Festival

This poster shows the development of a deep learning model for OS detection. We begin by explaining the objectives and applications of the model. Then we show the methods used to create it, along with its results. Finally, we discuss the results, problems and future improvements.

How Mini Grants Impact Student Learning, Jenna D'Angelo, Karen Hansen

Academic Festival

As recipients of the Robert Noyce Teacher Scholarship, we have been lucky enough to get the opportunity to provide our clinical classrooms and school, both located at the Discovery Interdistrict Magnet School, with materials and/ or resources that foster growth in STEM education. Before our acceptance into the Noyce Program, neither of us were aware of what a mini grant was, how to apply for one, nor how it can be beneficial to the school's community. This learning was possible through our application and acceptance of mini grants that we developed and presented during the end of the Fall 2023 …