Digital Commons Network^™

Rainbowcake: Mitigating Cold-Starts In Serverless With Layer-Wise Container Caching And Sharing, Hanfei Yu, Rohan Basu Roy, Christian Fontenot, Devesh Tiwari, Jian Li, Hong Zhang, Hao Wang, Seung Jong Park

Computer Science Faculty Research & Creative Works

Serverless Computing Has Grown Rapidly as a New Cloud Computing Paradigm that Promises Ease-Of-Management, Cost-Efficiency, and Auto-Scaling by Shipping Functions Via Self-Contained Virtualized Containers. Unfortunately, Serverless Computing Suffers from Severe Cold-Start Problems - -Starting Containers Incurs Non-Trivial Latency. Full Container Caching is Widely Applied to Mitigate Cold-Starts Yet Has Recently Been Outperformed by Two Lines of Research: Partial Container Caching and Container Sharing. However, Either Partial Container Caching or Container Sharing Techniques Exhibit their Drawbacks. Partial Container Caching Effectively Deals with Burstiness While Leaving Cold-Start Mitigation Halfway; Container Sharing Reduces Cold-Starts by Enabling Containers to Serve Multiple Functions While Suffering …

Bidirectional Relationships Between Nicotine Vaping And Maladaptive Eating Behaviors Among Young Adults., H Isabella Lanza, Kailey Waller, Lalaine Sevillano

School of Social Work Faculty Publications and Presentations

Past research indicates that young adult cigarette smokers are at risk of engaging in maladaptive eating behaviors (MEBs); however, whether this relationship extends to nicotine vaping is unclear. The current study assessed bidirectional associations between four types of MEBs and nicotine vaping among young adults.

Efficient Gene Knockout And Genetic Interaction Screening Using The In4mer Crispr/Cas12a Multiplex Knockout Platform, Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Medina Colic, John G Doench, Traver Hart

Faculty, Staff and Student Publications

Genetic interactions mediate the emergence of phenotype from genotype, but technologies for combinatorial genetic perturbation in mammalian cells are challenging to scale. Here, we identify background-independent paralog synthetic lethals from previous CRISPR genetic interaction screens, and find that the Cas12a platform provides superior sensitivity and assay replicability. We develop the in4mer Cas12a platform that uses arrays of four independent guide RNAs targeting the same or different genes. We construct a genome-scale library, Inzolia, that is ~30% smaller than a typical CRISPR/Cas9 library while also targeting ~4000 paralog pairs. Screens in cancer cells demonstrate discrimination of core and context-dependent essential genes …

Utility Of Clinical Next Generation Sequencing Tests In Kit/Pdgfra/Sdh Wild-Type Gastrointestinal Stromal Tumors, Ryan A Denu, Cissimol P Joseph, Elizabeth S Urquiola, Precious S Byrd, Richard K Yang, Maria Alejandra Zarzour, Dejka M Araujo, Vinod Ravi, Elise F Nassif Haddad, Michael S Nakazawa, Shreyaskumar Patel, Wei-Lien Wang, Alexander J Lazar, Neeta Somaiah

Faculty, Staff and Student Publications

Objective: The vast majority of gastrointestinal stromal tumors (GISTs) are driven by activating mutations in KIT, PDGFRA, or components of the succinate dehydrogenase (SDH) complex (SDHA, SDHB, SDHC, and SDHD genes). A small fraction of GISTs lack alterations in KIT, PDGFRA, and SDH. We aimed to further characterize the clinical and genomic characteristics of these so-called "triple-negative" GISTs.

Methods: We extracted clinical and genomic data from patients seen at MD Anderson Cancer Center with a diagnosis of GIST and available clinical next generation sequencing data to identify "triple-negative" patients.

Results: Of …

Examining The Effect Of Genes On Depression As Mediated By Smoking And Modified By Sex, Dmitry Prokopenko, John E Hokanson, Michael H Cho, Christoph Lange, Karin F Hoth, Sharon M Lutz

Faculty, Staff and Student Publications

Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis to test the indirect or mediated effect of SNPs on broad depression through the log of pack-years of cigarette smoking, adjusting for age, sex, current smoking status, and genetic ancestry (via principal components). In secondary analyses, we adjusted …

Tailoring Fxr Modulators For Intestinal Specificity: Recent Progress And Insights, Amanda Morrison, Bahaa Elgendy

2020-Current year OA Pubs

While FXR has shown promise in regulating bile acid synthesis and maintaining glucose and lipid homeostasis, undesired side effects have been observed in clinical trials. To address this issue, the development of intestinally restricted FXR modulators has gained attention as a new avenue for drug design with the potential for safer systematic effects. Our review examines all currently known intestinally restricted FXR ligands and provides insights into the steps taken to enhance intestinal selectivity.

Community-Linked Field Experience Pilot, Mia Palombo

Student Research Symposium

This IRB-approved study explores the possibilities of a teacher education program engaged with and rooted in the community. The project follows a partnership between a university and a community organization whose mission is to meet the needs of k-12 multilingual students. Pre-service teachers complete their field experience in an innovative community-based setting, and receive mentoring from a teacher on staff focused on developing skills and understanding how learning is nurtured outside traditional classroom settings. This partnership serves a dual purpose, meeting the needs of the community organization and those of pre-service interns who have demands on their time, which make …

Subversion Of Traditional Gender Roles In Macbeth, Olivia Eubanks

Merge

No abstract provided.

Diminishing Graduate Student-Teacher Power Dynamics Through Care And Vulnerability, Takhmina Shokirova, Lisa Ruth Brunner

Feminist Pedagogy

In this critical reflection, we discuss the concepts of ‘care’ (hooks, 1994) and ‘vulnerability’ (Cano Abadía, 2021) as they relate to the student-teacher power dynamics instructors often face – consciously or not – in graduate-level post-secondary contexts. We suggest that, when practiced together, care and vulnerability offer ways to diminish power imbalances between instructors and students.

The Left Must Rediscover Free Speech And Academic Freedom, Albena Azmanova, Enzo Rossi

Emancipations: A Journal of Critical Social Analysis

The conflict in Gaza has brought to a boil the systematic threat to academic freedom and freedom of speech in Western liberal democracies. This neo-McCarthyism can only be countered by a united front not only within the Left, but across the left-right ideological divide.

On The Political Economy Of Knowledge-Production - An Interview With Richard Wolff, Maria Cernat

Emancipations: A Journal of Critical Social Analysis

With her interview with Marxian economist Richard Wolff, Maria Cernat launches the two-part series on the political economy of knowledge production.

Hypocritical Management Studies, Khang Lê

Emancipations: A Journal of Critical Social Analysis

The assertion “critical management studies is dead. It died a long time ago” (O’Doherty and Jones, 2005, p. 6) has aged poorly. Critical Management Studies lives on, stronger than ever. The term itself even gets title case capitalization. Responding to the call to “investigate the production of theories that pose as radical without challenging the status quo”, I offer my critique of Critical Management Studies. Critical Management Studies provides critical perspectives on established management theories and practices. It aims to encourage micro-emancipations and propose radical alternatives for organizational life. However, I argue that, in the current backdrop of neoliberal academia, …

The Drivers Of Academic Novelty In Digital Capitalism: Job Insecurity, Mental Illness And Time Poverty, Adalberto Fernandes

Emancipations: A Journal of Critical Social Analysis

The present-day digital capitalist academy increases novel academic results by leveraging factors such as precarious academic employment, time poverty, and mental illness. This paradigm reveals a confluence that turns seemingly negative aspects into productive elements. The consequence of this hypothesis is that by enhancing work, time and mental health conditions, there may be a reduction in the number of novelties, with an enhancement of academic's role as producers of truth.

The Contradiction Between Use-Value And Exchange-Value: Ecology, Imperialism, And The Telos Of Production, Larry Alan Busk, Elizabeth Portella

Emancipations: A Journal of Critical Social Analysis

This article elaborates and defends a critique of capitalism which, despite its appearance in various bodies of work, has not been named or systematically differentiated. The critique locates a contradiction between production for use-value and production for exchange-value, or a contradiction in what we call “the telos of production.” While maintaining that it has some basis in Marx’s work, we defend this model as preferable to the critique of capitalism based strictly on the exploitation of labor (which we call the “exploitation-exclusive critique”). We attempt to show this by applying the two approaches to the empirical realities of the ecological …

The Symbolic Capital Of The Neoliberal University, Chad Lavin

Emancipations: A Journal of Critical Social Analysis

The paper examines the concerns about the enduring value of liberal education in the broader context of a shift from a liberal to a neoliberal society. While so much literature on “the neoliberal university” tends to characterize neoliberalism as a hostile force invading the sacred space of the university, the knowledge comprising neoliberalism is in large part the product of research coming out of universities. Using the concept of symbolic capital to explore the role of university researchers in developing and consecrating neoliberal ideas, the paper argues that even in this era of heightened skepticism toward experts and expertise, university …

What Comes After The Critique Of The Corporate University? Toward A Syndicalist University, Clyde W. Barrow

Emancipations: A Journal of Critical Social Analysis

For the past three decades, university faculty have produced a cascade of contemporary protest literature that routinely criticizes the knowledge factory, academic capitalism, managed professionals, college for sale, the university in ruins, the corporate corruption of higher education, and University, Inc. University faculty are regularly warned about the fall of the faculty, the last professors, and the last intellectuals. This article reviews the historical development of the corporate and neoliberal university, but it takes the next step of asking what is to be done after the critique of the corporate university. It calls on faculty to engage in a variety …

Walk, Don't Run For Employee Wellness, Francesca Citro, Danielle Cassidy, Maura Bednarcik

Academic Festival

There are a multitude of factors that have an impact on individuals’ physical activity. Specifically, implementing walking initiatives has proven to be beneficial when it comes to workplace wellness and can contribute to the increased physical activity level among employees in the workplace. The implementation of wearables and walking treadmills are one of many ways to initiate the increase of physical activity among employees.

Machine Learning Model For Os Detection, Victor Ginart Belmonte, Ravjeet Chahal

Academic Festival

This poster shows the development of a deep learning model for OS detection. We begin by explaining the objectives and applications of the model. Then we show the methods used to create it, along with its results. Finally, we discuss the results, problems and future improvements.

How Mini Grants Impact Student Learning, Jenna D'Angelo, Karen Hansen

Academic Festival

As recipients of the Robert Noyce Teacher Scholarship, we have been lucky enough to get the opportunity to provide our clinical classrooms and school, both located at the Discovery Interdistrict Magnet School, with materials and/ or resources that foster growth in STEM education. Before our acceptance into the Noyce Program, neither of us were aware of what a mini grant was, how to apply for one, nor how it can be beneficial to the school's community. This learning was possible through our application and acceptance of mini grants that we developed and presented during the end of the Fall 2023 …

How Income Affects Depression In Adults Aged 25-65, Stephanie Capito, Jillian F. Spindel, Claudia Uva

Academic Festival

In this paper, we explore socioeconomic status and how it is related to depression rates. This is an important topic to study because economic status determines an individual's standing in life. Furthermore, as the transfer from childhood to adulthood occurs, finding a stable job that will support the individual becomes extremely important and without it moving into adulthood becomes much more difficult. This is an issue that impacts millions of Americans as 37.2 million people live in poverty (Bureau, U.C, 2021). The number of people living in poverty increased by 11.4 percent from 2015 to 2020. Adults living in poverty …

The Effect Of Stigma Against Mental Illness On The Disparities Of The Psychiatric Healthcare System, Avery Vandyke

Academic Festival

Mental illness affects a significant portion of the population, yet stigma surrounding it persists, leading to disparities in psychiatric healthcare. This paper discusses the impact of stigma on mental health treatment, drawing insights from scholarly literature, clinical experiences, and societal observations. It addresses the stereotypes and misconceptions that contribute to the reluctance of individuals to seek treatment and examines the influence of media representations and cultural attitudes surrounding psychiatric healthcare. Moreover, the paper explores the implications of stigma on the quality of care provided by healthcare professionals, particularly focusing on the attitudes of nurses in psychiatric settings. Drawing from firsthand …

Can Markerless Motion Capture Software Consistently And Reliably Auto Detect Important Pitch Event Markers For Baseball Players?, Jenna Engels, Sarah Mandelkow, Jacqueline Lage

Academic Festival

Markerless motion capture systems offer promising data for analyzing athletic performance with high precision; however, the camera systems utilized as part of the Pioneer Performance Center have not been tested with higher speed motions. Theia 3D software, mainly used for gait analyses previously, was utilized to examine the effectiveness of the SONY RX 0II camera system and consistency of identifying key event markers during fast moving motions, such as pitching.

A specialized pipeline was developed to auto detect the frames corresponding to 4 different important event markers: maximum hip flexion, foot touchdown, late cocking, and ball release. The automated data …

Relationship Between Kinematics And Velocity Using 3d Markerless Motion Capture In High School Baseball Pitchers, Kylie Mcnamara, Lindsay Houlihan, Jenna Springer

Academic Festival

Baseball pitching relies on biomechanics and kinetics, where the pitcher's body works to produce power and pitch accuracy. Analyzing movement sequences, from wind-up to ball release, highlights the significance of joint angles and force in relation to the velocity and location of the pitch. Mastering these principles not only improves the pitcher's overall performance, but also helps prevent injuries. The effect of knee flexion at ball release and stride length on velocity were tested and analyzed in high school baseball pitchers. Our research is comparable to other studies when looking at values of knee flexion angle and stride length as …

Neuroprotection Through Positioning Neonates In The Critical Care Setting, Kaleigh Schofield

Academic Festival

On the neonatal intensive care unit at Greenwich, new positioners, known as the dandelions, allow for nurses to reposition patients in an easier manner. Most nurses had expressed that they were used to using rolled blankets or towels as a way to position in the past; therefore, the nurses expressed some confusion on the importance of these new positioners and how they can provide better support for neurological development. It is important to educate the unit nurses on the importance of positioning with the dandelion in order to support the infants neurologically as well as physically.

Evidence-Based (Ebp) Quality Improvement (Qi) Falls Presentation, Isabella Guarente

Academic Festival

No abstract provided.

The Deep-Sea And The Complex Ethical Conundrum Of Mining The Seafloor, Aaron Martino

Academic Festival

No abstract provided.

Investigation Of The Role Of Deregulated Mir-654 And Mir-4454 In Melanoma Pathogenesis And Progress, Julianna Doucette, Jaclyn Doucette, Farah Mahmood

Academic Festival

Investigation of the role of deregulated miR-654 and miR-4454 in melanoma pathogenesis and progress.

Farah Mahmood, Jaclyn Doucette, Julianna Doucette, Sankhiros Babapoor, PhD.

The incidence of melanoma has continually increased mortality rates over the past decade in the United States. In 2013, it was estimated that 76,690 individuals (both male and female) were diagnosed with new cases of cutaneous melanoma, and out of those cases, 9,480 resulted in death. MicroRNA(miRNA)s are endogenous, 22 nucleotide non-coding small RNAs, which can regulate gene expression in animals and plants by complementary base-pairing to the mRNAs of target genes- which specifies mRNA cleavage or …

Prevalence Of False Step Starting Preference In Track & Field Middle Distance Runners, Kayla Perez

Academic Festival

Middle distance track & field runners start from a non-parallel, staggered foot stance utilizing either a forward- or false-step technique. Previous studies have investigated these starting techniques with most investigations determining that the false step is both preferred and faster, however, it is currently unknown which technique is commonly performed within the 800-meter race.

Purpose: Determine starting type prevalence rates (forward, false step) in high school (HS), collegiate (C), and senior (S) runners competing in the 800-meter race distance. Additionally, to classify variants of false step within this same population.

Methods: This cross-sectional, observational study evaluated publicly available YouTube videos …

The Prevention Of Pressure Injuries In Pediatric Patients Through The Implementation Of A Uniform Turning Schedule., Ailie Daley

Academic Festival

This project involves the implementation of a uniform turning schedule, in the form of a clock denoting which position (right lying, left lying, supine) a patient should be in at certain times, with the goal to decrease the incidence of pressure injuries on a pediatric medical-surgical unit.

Breaking The Stigma And Raising Awareness: The Grisly Effects Developmental Trauma Has On Early Adulthood And How To Put A Stop To This Monstrosity, Grace Fleishman

Academic Festival

I lived a great childhood, and I mean really great. I had a seemingly stable home life and the world was full of colors and endless possibilities. Then suddenly, on my twentieth birthday, I found myself locked in a psych ward not wanting to be alive. Imagine growing up in a world full of colors. Everything is bright and happy and you live in a house full of love, safety, and security. Then, once you hit early adulthood, the world goes gray.

Sometimes, you cannot always describe why you feel a certain way or why things are the way that …