Digital Commons Network^™

Terrestrial Exchange Of Atmospheric Metals: Insights From Fallout Radionuclides, Joshua D. Landis

Dartmouth College Ph.D Dissertations

Forests mediate the exchange of gases and particulate matter (PM2.5 and PM10) between terrestrial ecosystems and the atmosphere over 30% of global land area. Because forest foliage efficiently absorbs PM with persistent pollutants including metals Pb and Hg, as well as CO₂ and gaseous elemental mercury (GEM), this exchange profoundly influences the composition of the atmosphere as well as terrestrial biogeochemical cycles. The processes by which PM is absorbed remain enigmatic, however, due to the complexity of micrometeorological physics and submicron physical scale of the interaction. Here, measurements of fallout radionuclides (FRNs) beryllium-7 and lead-210, which are quintessential tracers …

Critical Assessment Of Variant Prioritization Methods For Rare Disease Diagnosis Within The Rare Genomes Project, Grace E Vannoy, Stephanie Ditroia, Vijay S Ganesh, Emily Groopman, Emily O'Heir, Brian Mangilog, Ikeoluwa Osei-Owusu, Lynn S Pais, Jillian Serrano, Moriel Singer-Berk, Ben Weisburd, Michael W Wilson, Christina Austin-Tse, Marwa Abdelhakim, Azza Althagafi, Giulia Babbi, Riccardo Bellazzi, Samuele Bovo, Maria Giulia Carta, Rita Casadio, Pieter-Jan Coenen, Federica De Paoli, Matteo Floris, Manavalan Gajapathy, Robert Hoehndorf, Julius O B Jacobsen, Thomas Joseph, Akash Kamandula, Panagiotis Katsonis, Cyrielle Kint, Olivier Lichtarge, Ivan Limongelli, Yulan Lu, Paolo Magni, Tarun Karthik Kumar Mamidi, Pier Luigi Martelli, Marta Mulargia, Giovanna Nicora, Keith Nykamp, Vikas Pejaver, Yisu Peng, Thi Hong Cam Pham, Maurizio S Podda, Aditya Rao, Ettore Rizzo, Vangala G Saipradeep, Castrense Savojardo, Peter Schols, Yang Shen, Naveen Sivadasan, Damian Smedley, Dorian Soru, Rajgopal Srinivasan, Yuanfei Sun, Uma Sunderam, Wuwei Tan, Naina Tiwari, Xiao Wang, Yaqiong Wang, Amanda Williams, Elizabeth A Worthey, Rujie Yin, Yuning You, Daniel Zeiberg, Susanna Zucca, Constantina Bakolitsa, Steven E Brenner, Stephanie M Fullerton, Predrag Radivojac, Heidi L Rehm, Anne O'Donnell-Luria

Faculty, Staff and Students Publications

BACKGROUND: A major obstacle faced by families with rare diseases is obtaining a genetic diagnosis. The average "diagnostic odyssey" lasts over five years and causal variants are identified in under 50%, even when capturing variants genome-wide. To aid in the interpretation and prioritization of the vast number of variants detected, computational methods are proliferating. Knowing which tools are most effective remains unclear. To evaluate the performance of computational methods, and to encourage innovation in method development, we designed a Critical Assessment of Genome Interpretation (CAGI) community challenge to place variant prioritization models head-to-head in a real-life clinical diagnostic setting.

METHODS: …

Cytokine Activity Estimation And Receptor Abundance Approximation With Multimodal Scrna-Seq/Cite-Seq Data., Azka Javaid

Dartmouth College Ph.D Dissertations

Single-cell RNA-sequencing (scRNA-seq) data enables individual cell resolution quantification of messenger RNA. While revolutionary for revealing key cell type and cell phenotype-specific heterogeneity, scRNA-seq data has important statistical challenges. First, scRNA-seq data is usually more sparse and second, it is more variable than bulk transcriptomics data. Given these challenges, more intuitive and interpretive statistical and computational methods are needed to develop appropriate solutions. Here, we detail the development of three techniques to perform receptor abundance estimation and cytokine activity estimation for scRNA-seq data. While SPECK (Surface Protein abundance Estimation using CKmeans-based clustered thresholding) and STREAK (gene Set Testing-based Receptor abundance …

Ectoparasites Of The Critically Endangered Green Sawfish Pristis Zijsron And Sympatric Elasmobranchs In Western Australia, Jack Ingelbrecht, Karissa O. Lear, Storm B. Martin, Alan J. Lymbery, Bradley M. Norman, Geoffrey A. Boxshall, David L. Morgan

Harold W. Manter Laboratory of Parasitology: Library Materials

This study reports the metazoan ectoparasite fauna of juvenile Critically Endangered green sawfish, Pristis zijsron, and sympatric elasmobranchs in Western Australia. Five parasite taxa were found on 76 screened P. zijsron: Caligus furcisetifer (Copepoda: Caligidae), Dermopristis pterophila (Monogenea: Microbothriidae), Branchellion plicobranchus and Stibarobdella macrothela (Hirudinea: Piscicolidae), and praniza larvae of an unidentified gnathiid isopod. Only C. furcisetifer and D. pterophila were common, exhibiting discrepant site-specificity, with C. furcisetifer occurring mostly on the head and rostrum, and D. pterophila around the pectoral and pelvic fins. Intensity of infection for C. furcisetifer and D. pterophila increased with host total length and …

Modernizing The Power Of The Purse Statutes, Eloise Pasachoff

Georgetown Law Faculty Publications and Other Works

Two foundational statutes limit the executive branch’s important and necessary work in executing the budget against the backdrop of congressional control: the Antideficiency Act, dating back to the post-Civil War era, and the Impoundment Control Act, which emerged from the Nixon years. This Article, originally written as an invited contribution to The George Washington Law Review’s annual issue on administrative law, calls these the Power of the Purse statutes. While these statutes have been generally successful in responding to the problems that first prompted them, this Article illustrates gaps in the statutes that have become apparent in an era of …

Implementing And Marketing Diversity, Equity And Inclusion Practices And Resources: Creating The E‐Buzz!, Essraa Nawar, Kristin Laughtin-Dunker

Library Presentations, Posters, and Audiovisual Materials

Leatherby Libraries Librarians are committed to supporting and promoting diversity, equity, and inclusion for students, faculty, researchers, and staff. We demonstrate this commitment holistically through the provision of all resources and services in support of teaching, learning, and research. Our goal is to reduce obstacles to accessing diverse research resources, services, learning, and engagement through educational outreach in order to raise awareness of diversity related issues.

In 2020, Library administration selected a Diversity and Outreach librarian that was charged with creating a comprehensive Diversity, Equity and Inclusion (DEI) and Outreach plan. As a result, a number of practices and initiatives …

Assessing Brain Processing Deficits Using Neuropsychological And Vision-Specific Tests For Concussion, Brent A. Harper, Rahul Soangra

Physical Therapy Faculty Articles and Research

Introduction: Since verbal memory and visual processing transpire within analogous cerebral regions, this study assessed (i) if a visual function can predict verbal memory performance. It also hypothesized whether neurocognitive (e.g., ImPACT) tests focusing on the Visual Memory and Cognitive Efficacy Index will predict Verbal Memory scores and (ii) if vision metrics and age can identify individuals with a history of concussion. Finally, it also hypothesized that King–Devick and near point of convergence scores alongside age considerations will identify candidates with a prior reported history of concussion. Materials and methods: This observational cohort assessed 25 collegiate ice hockey players prior …

Prólogo - Para Un Hispanismo Sin Fronteras (Los Editores, Pp. 6-9), Jorge A. Hernández Jr., Alessio Piras

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

Número Completo

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

Diáspora, Diversidad Y Política Lingüística: El Spanglish Como Ícono De La Vibrante Identidad Puertorriqueña (Piero Visconte Y Mariana Escalona, Pp. 46-67), Piero Visconte, Mariana Escalona

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

“I think in spanish, i write in english” [sic] es un extracto de “graduation speech”, escrito por Tato Laviera en su colección de poemas “La carreta made a U-turn” (Laviera 1979), el cual refleja la vibrante identidad de la diáspora puertorriqueña en los Estados Unidos, capaz de mantener conectados dos lugares con herencias muy diferentes. Este estudio analiza la situación de Puerto Rico, colonia española por más de 400 años y, a partir de 1898, convertida en posesión de los Estados Unidos a raíz de la Guerra Hispanoamericana. Con su invasión, los Estados Unidos prometieron “libertad, prosperidad y ventajas” a …

Reseñas (Pp. 105 -116), Alessio Piras, Laura Cruz, Laura Torre, Natalie Rovello

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

“So, Like… Tú Sabes”: An Approach To Bilingual Discourse Markers In Puerto Rican Spanish Oral Interaction (Piero Visconte, Pp. 21-45), Piero Visconte

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

This paper examines discourse markers (DMs) (i.e., pues, entonces, you know, so, I mean, etc.) and their linguistic variations in contexts of English-Spanish interaction in Puerto Rico. This linguistic category represents an aspect of discourse analysis that has captivated great interest in recent years, since its “main function is to connect utterances to each other and to the larger context” (Crible and Blackwell 2020: 24). As shown in several sociolinguistic research articles conducted in the Puerto Rican diaspora of New York City in the last twenty years (Torres 1997, 2002; Lipski 2005), the profound and protracted contact between Spanish and …

Electron-Phonon Interaction Mediated Gigantic Enhancement Of Thermoelectric Power Factor Induced By Topological Phase Transition., Zhi Li, Koushik Pal, Huiju Lee, Chris Wolverton, Yi Xia

Mechanical and Materials Engineering Faculty Publications and Presentations

We propose an effective strategy to significantly enhance the thermoelectric power factor (PF) of a series of 2D semimetals and semiconductors by driving them toward a topological phase transition (TPT). Employing first-principles calculations with an explicit consideration of electron-phonon interactions, we analyze the electronic transport properties of germanene across the TPT by applying hydrogenation and biaxial strain. We reveal that the nontrivial semimetal phase, hydrogenated germanene with 8% biaxial strain, achieves a considerable 4-fold PF enhancement, attributed to the highly asymmetric electronic structure and semimetallic nature of the nontrivial phase. We extend the strategy to another two representative 2D materials …

Ndls Communicator: Week Of 04.29.24, Notre Dame Law School

NDLS Communicator

The Latest News

• Notre Dame Law School and University of Cape Town establish historic partnership
• Fitzgerald Institute's Church Properties Initiative and Notre Dame Law School Host Affordable Housing Discussion with Rev. Patrick Reidy, C.S.C.
• Notre Dame Law School celebrates outstanding third-year students at Champions for Justice Reception
• Patrick Corrigan's new article, "'ES' Versus 'G' in Corporate Governance: You Can’t Have It All," was featured in the Harvard Law School Forum on Corporate Governance.
• Emily Bremer wrote a blog post for Notice & Comment on "FTC rulemaking and the attorney general's committee on administrative procedure."
• Sam Bray's research and writings about …

Exploradores De Idiomas: High School Led Spanish Lessons, Lauren Sebring

Honors Projects

To better understand how to educate U.S. students to be global citizens, this applied research project will investigate how cities can begin to incorporate small language programs into their communities in order to create more opportunities for students to become bilingual and develop global competence.

Nestedbd: Bayesian Inference Of Phylogenetic Trees From Single-Cell Copy Number Profiles Under A Birth-Death Model, Yushu Liu, Mohammadamin Edrisi, Zhi Yan, Huw A Ogilvie, Luay Nakhleh

Faculty, Staff and Student Publications

Copy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via “bulk sequencing,” the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inference of evolutionary trees (topologies and branch lengths with relative mutation rates) from single-cell data. We evaluated NestedBD’s performance using …

Interaction Of High-Fat Diet And Brain Trauma Alters Adipose Tissue Macrophages And Brain Microglia Associated With Exacerbated Cognitive Dysfunction, Oleg Makarevich

Faculty, Staff and Student Publications

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects between high-fat diet-induced obesity (DIO) and TBI. Adult male mice were fed a high-fat diet (HFD) for 12 weeks prior to experimental TBI and continuing after injury. High-throughput transcriptomic analysis using Nanostring panels of the total visceral adipose tissue (VAT) and cellular components in the brain, followed by unsupervised clustering, principal component analysis, and IPA pathway analysis were used to determine shifts in gene expression patterns and molecular pathway activity. Cellular …

Interaction Of High-Fat Diet And Brain Trauma Alters Adipose Tissue Macrophages And Brain Microglia Associated With Exacerbated Cognitive Dysfunction, Rebecca J Henry, James P Barrett, Maria Vaida, Niaz Z Khan, Oleg Makarevich, Alan I Faden

Faculty, Staff and Student Publications

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects between high-fat diet-induced obesity (DIO) and TBI. Adult male mice were fed a high-fat diet (HFD) for 12 weeks prior to experimental TBI and continuing after injury. High-throughput transcriptomic analysis using Nanostring panels of the total visceral adipose tissue (VAT) and cellular components in the brain, followed by unsupervised clustering, principal component analysis, and IPA pathway analysis were used to determine shifts in gene expression patterns and molecular pathway activity. Cellular …

A Matter Of Time: How Musical Training Affects Time Perception

Faculty, Staff and Student Publications

Musical training has been linked to changes in early attentional and perceptual processing. Thus, such an altered attentional and perceptual processing has enabled musicians to judge the duration differently than non-musicians. Although these claims seem intriguing, there are many questions that are not addressed yet, for example, how would the performance of musically-trained differ from that of untrained on visual and auditory temporal judgments? Is there any advantage to musically-trained person in temporal processing? To understand these questions, we thus conducted a series of Auditory and Visual Temporal Bisection Tasks on 32 musically-trained and 32 musically-untrained participants. We hypothesized that …

Notes On North American Butterflies, 1, Harry Pavulaan

The Taxonomic Report of the International Lepidoptera Survey

New natural history elements and distribution records of several North American butterflies are reported. Taxonomy is often driven by geographical analyses. Cartography, coupled with internet-based imagery, opens up a promising wealth of information, allowing avocational researchers a tool by which inconvenient visits to institutional collections are no longer necessary for resolving some basic questions. While diversity and distribution of butterflies in North America are commonly believed to be fully known, the findings presented here show that much is yet to be learned of our butterfly fauna.

Contractile Vacuoles: A Rapidly Expanding (And Occasionally Diminishing?) Understanding, Kiran J. More, Harpreet Kaur, Alastair G.B. Simpson, Frederick W. Spiegel, Joel B. Dacks

Biological Sciences Faculty Publications and Presentations

Osmoregulation is the homeostatic mechanism essential for the survival of organisms in hypoosmotic and hyperosmotic conditions. In freshwater or soil dwelling protists this is frequently achieved through the action of an osmoregulatory organelle, the contractile vacuole. This endomembrane organelle responds to the osmotic challenges and compensates by collecting and expelling the excess water to maintain the cellular osmolarity. As compared with other endomembrane organelles, this organelle is underappreciated and under-studied. Here we review the reported presence or absence of contractile vacuoles across eukaryotic diversity, as well as the observed variability in the structure, function, and molecular machinery of …

Therapeutic Efficacy Of Generic Artemether-Lumefantrine In The Treatment Of Uncomplicated Malaria In Ghana: Assessing Anti-Malarial Efficacy Amidst Pharmacogenetic Variations, Nicholas Ekow Thomford, Tracy Kellermann, Robert Peter Biney, Charné Dixon, Samuel Badu Nyarko, Richmond Owusu Ateko, Martins Ekor, George B Kyei

2020-Current year OA Pubs

BACKGROUND: Despite efforts made to reduce morbidity and mortality associated with malaria, especially in sub-Saharan Africa, malaria continues to be a public health concern that requires innovative efforts to reach the WHO-set zero malaria agenda. Among the innovations is the use of artemisinin-based combination therapy (ACT) that is effective against Plasmodium falciparum. Generic artemether-lumefantrine (AL) is used to treat uncomplicated malaria after appropriate diagnosis. AL is metabolized by the cytochrome P450 family of enzymes, such as CYP2B6, CYP3A4 and CYP3A5, which can be under pharmacogenetic influence. Pharmacogenetics affecting AL metabolism, significantly influence the overall anti-malarial activity leading to variable therapeutic …

An Interview With Santiago Vaquera-Vásquez, An Unrepentant Border Crosser (Jorge A. Hernández Jr. Y Alonso Arana, Pp. 11-15), Jorge A. Hernández Jr., Alonso Arana

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

Having a conversation with Santiago Vaquera-Vásquez, professor and Chair of the Department of Spanish and Portuguese at the University of New Mexico, is like sitting down at your family table and sharing a deep conversation about the best tacos in town, experiences about crossing the U.S.-Mexico border, traveling across the globe, and everything in between. This interview was born out of our long-time relationship as students of his and out of personal and shared connections, reflections, and conversations regarding the U.S.-Mexico borderlands, la frontera, and northern Mexico. In this interview, he talks about his upbringing, influences within his creative and …

The Second Rebellion Of Satan: The Beautiful Raw Power Of The She-Other. An Interview With Violet Castro (Mario Morera, Pp. 16-19), Mario Morera

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

The idea of this interview was, in fact, born from the participation of Violet Castro in the anthology Inferno (The Infernal Clock, 2020.) Such text presents a series of short stories representing each of the nine circles of hell in Dante’s Divine Comedy. Her short story At the bottom of my lake of blood, inspired by circle number six, suggests to accompany its reading with the 1990’s song Seasons in the abyss, by the californian trash metal band Slayer. A particular daring trait in this short story is the fact that Satan is portrayed as woman. This interview took place …

La Alternancia De Códigos En El Habla De Los Beisbolistas Hispano- Hablantes: Un Análisis Lingüístico (Sarah Walker, Pp. 68-81), Sarah Walker

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

El fenómeno de la alternancia de códigos resulta del contacto entre lenguas y, de esta manera, se puede afectar a millones de personas y llevar una variedad casi infinita. Según Myers-Scotton (2017), la alternancia de códigos es la producción de discursos que contienen morfemas de múltiples variedades o lenguas. Puede tomar la forma interoracional o intraoracional, y sigue su propio conjunto de reglas (Myers-Scotton, 2017). El presente trabajo intenta explorar y describir el fenómeno de la alternancia de códigos en relación con el deporte del béisbol desde una perspectiva semántica, sintáctica y sociolingüística. Dado que la literatura ya incluye información …

Cuentos (Pp. 82-89), Carmen Julia Holguín Chaparro, Fredy Mendieta, Carmella Scorcia Pacheco

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

Poemas (Pp. 90-104), Ángela Escobar Clarimonda, Julián Jiménez Arellano, Juan Carlos Ureña

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

Créditos (Pp. 117-121)

Intersecciones Hispánicas: Revista de Cultura, Literatura y Lingüística

No abstract provided.

Hydrological Model Of The Diyala River Watershed In Iraq Using Soil Water Assessment Tool, Ahmed Sagban Khudier, Ahmed Naseh Ahmed Hamdan

Al-Bahir

The motivation of the present study is to study and address the limitations imposed on hydrological models and the spatial and temporal distribution of streamflow in the Watershed Diyala River (WDR) from January 1996 to April 2023, which has an area of 25652 km2, which is considered an important source of water for central and southern Iraq, to enable decision-makers to make a future management plan for streamflow. To achieve this motivation, the SWAT model was used and fed by input data such as a Digital elevation model with a 30 m resolution, a soil map, the land use and …

Surface Treatments' Effects On The Capacitor's Dielectric Performance Under Electro-Thermal Stresses, Haider. M. Umran, Feipeng Wang

Karbala International Journal of Modern Science

Biaxial-oriented polypropylene (BOPP) films are characterized by unfavorable aging behavior because of their poor susceptibility to high temperatures, humidity, and high electric fields. This makes them unqualified to withstand harsh operating conditions, such as in capacitor applications. This study investigates the impact of annealing BOPP samples at 100 °C for five hours after fluorination at different times (15, 30, and 60 minutes) on their electrical and mechanical performance under electro-thermal stresses. Scanning electron microscope (SEM) images confirm that there is an increase in surface roughness and the formation of a dense layer of fluorine-containing groups monotonically with fluorination time. So, …