Digital Commons Network^™

2024-05-01 Remedying Recent Issues For The Seattle Public Library, Riley Zalbert

The Spectator Online

No abstract provided.

2024-05-01 Undergraduate Research Awards Fund Academic Inquiry, Leila Bunker, Chloe Platt

The Spectator Online

No abstract provided.

Tofacitinib For The Treatment Of Refractory Immune Checkpoint Inhibitor-Associated Immune Nephritis

Faculty, Staff and Student Publications

Immune checkpoint inhibitor (ICI)-associated immune nephritis or acute interstitial nephritis (AIN) is one of the rare but known complication of ICI therapy. Guidelines recommend treatment of ICI-associated AIN with steroids, then TNF-alpha inhibitor infliximab. However, some cases are refractory to these therapies, potentially due to insufficient cytokine blockade. This is the first case where a 65-year-old female with metastatic lung adenocarcinoma, requiring high maintenance doses of steroids for immune nephritis was treated with tofacitinib, an oral Janus kinase (JAK) inhibitor. Tofacitinib enabled successful steroid tapering and might be a therapy option for refractory immune nephritis.

Abnormality Of Early White Matter Development In Tuberous Sclerosis Complex And Autism Spectrum Disorder: Longitudinal Analysis Of Diffusion Tensor Imaging Measures, Jamie K Capal, Hope Northrup, Joyce Y Wu, Simon K Warfield, Mustafa Sahin, Bo Zhang, Tacern Study Group

Faculty, Staff and Student Publications

Background:

Abnormalities in white matter development may influence development of autism spectrum disorder in tuberous sclerosis complex (TSC). Our goals for this study were as follows: (1) use data from a longitudinal neuroimaging study of tuberous sclerosis complex (TACERN) to develop optimized linear mixed effects models for analyzing longitudinal, repeated diffusion tensor imaging metrics (fractional anisotropy, mean diffusivity) pertaining to select white matter tracts, in relation to positive Autism Diagnostic Observation Schedule–Second Edition classification at 36 months, and (2) perform an exploratory analysis using optimized models applied to all white matter tracts from these data.

Methods:

Eligible participants (3-12 months) …

Cross-Cohort Replicable Resting-State Functional Connectivity In Predicting Symptoms And Cognition Of Schizophrenia, Jessica A Turner, Shile Qi, Vince D Calhoun

Faculty, Staff and Student Publications

Schizophrenia (SZ) is a debilitating mental illness characterized by adolescence or early adulthood onset of psychosis, positive and negative symptoms, as well as cognitive impairments. Despite a plethora of studies leveraging functional connectivity (FC) from functional magnetic resonance imaging (fMRI) to predict symptoms and cognitive impairments of SZ, the findings have exhibited great heterogeneity. We aimed to identify congruous and replicable connectivity patterns capable of predicting positive and negative symptoms as well as cognitive impairments in SZ. Predictable functional connections (FCs) were identified by employing an individualized prediction model, whose replicability was further evaluated across three independent cohorts (BSNIP, SZ …

Pulmonary Endobronchial Hamartoma Presenting With Post-Obstructive Pneumonia, Ramesh Kesavan

Faculty, Staff and Student Publications

Pulmonary hamartomas (PH) are rare but are the most common benign tumors found in the lungs. They are slow-growing and are usually found incidentally on chest imaging during the sixth decade of life. Approximately 10% of pulmonary hamartomas are endobronchial. Rarely, pulmonary hamartomas can cause a spectrum of pulmonary symptoms depending on their size and location. We present a case of endobronchial hamartoma causing airway obstruction and recurrent post-obstructive pneumonia.

Coronary Pathophysiology Underlying The Obesity Paradox

Faculty, Staff and Student Publications

No abstract provided.

Systemic Symptoms In Huntington's Disease: A Comprehensive Review

Faculty, Staff and Student Publications

Background: Although Huntington's disease (HD) is usually thought of as a triad of motor, cognitive, and psychiatric symptoms, there is growing appreciation of HD as a systemic illness affecting the entire body.

Objectives: This review aims to draw attention to these systemic non-motor symptoms in HD.

Methods: We identified relevant studies published in English by searching MEDLINE (from 1966 to September 2023), using the following subject headings: Huntington disease, autonomic, systemic, cardiovascular, respiratory, gastrointestinal, urinary, sexual and cutaneous, and additional specific symptoms.

Results: Data from 123 articles were critically reviewed with focus on systemic features associated with HD, such as …

Simultaneous Hemorrhage And Venous Thrombosis In A Patient With Systemic Lupus Erythematosus

Faculty, Staff and Student Publications

No abstract provided.

Treatments Perceived To Be Helpful For Neuropathic Pain After Traumatic Spinal Cord Injury: A Multicenter Cross-Sectional Survey Study, Abigail Welch

Faculty, Staff and Student Publications

DESIGN: Cross-sectional survey.

OBJECTIVE: To evaluate the perceived helpfulness of pharmacological and non-pharmacological interventions and their combinations for neuropathic pain (NeuP) and subcategories of NeuP after spinal cord injury (SCI).

SETTING: Six Spinal Cord Injury Model System Centers.

METHODS: Three hundred ninety one individuals at least one year post traumatic SCI were enrolled. A telephone survey was conducted to determine the pharmacologic and non-pharmacologic treatments used in the last 12 months for each participant's three worst pains, whether these treatments were "helpful", and if currently used, each treatments' effectiveness.

RESULTS: Two hundred twenty participants (56%) reported 354 distinct NeuPs. Pharmacological …

Light Scattering By Vitreous Of Humans With Vision Degrading Myodesopsia From Floaters, J Sebag

Faculty, Staff and Student Publications

PURPOSE: Vision-degrading myodesopsia (VDM) from vitreous floaters significantly degrades vision and impacts visual quality of life (VQOL), but the relationship to light scattering is poorly understood. This study compared in vitro measures of light scatter and transmission in surgically excised human vitreous to preoperative indexes of vitreous structure, visual function, and VQOL.

METHODS: Pure vitreous collected during vitrectomy from 8 patients with VDM had wide-angle straylight measurements and dark-field imaging, performed within 36 hours of vitrectomy. Preoperative VQOL assessment with VFQ-25, contrast sensitivity (CS) measurements with Freiburg acuity contrast testing, and quantitative ultrasonography were compared to light scattering and transmission …

A Case Of Osseous Metaplasia In A Juvenile Rectal Polyp

Faculty, Staff and Student Publications

Rectal mucosal prolapse is uncommon in children. While most patients present with rectal bleeding and constipation, the occurrence of osseous metaplasia within the prolapsed mucosa is extremely rare. Overlapping clinical, gross, and histological features between rectal mucosal prolapse polyps and malignancy pose a challenge for diagnoses. We describe a case of a 16-year-old male who had a rectal mucosal prolapsed polyp with osseous metaplasia. He initially presented due to periumbilical pain with a sore throat and fever. Incidentally, during the workup of his periumbilical pain, he was found to have a soft tissue mass in his rectum on a CT …

Association Of Maternal Body Mass Index And Maternal Morbidity And Mortality, Ronald J Wapner, Mona Prasad, Alan T N Tita, George R Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa

Faculty, Staff and Student Publications

Objective: This study aimed to assess the association of maternal body mass index (BMI) with a composite of severe maternal outcomes.

Study design: Secondary analysis of a cohort of deliveries on randomly selected days at 25 hospitals from 2008 to 2011. Data on comorbid conditions, intrapartum events, and postpartum course were collected. The reference group (REF, BMI: 18.5-29.9kg/m2), obese (OB; BMI: 30-39.9kg/m2), morbidly obese (MO; BMI: 40-49.9kg/m2), and super morbidly obese (SMO; BMI ≥ 50kg/m2) women were compared. The composite of severe maternal outcomes was defined as death, intensive care unit (ICU) admission, ventilator use, deep venous thrombosis/pulmonary embolus (DVT/PE), …

Toward A Politics Of Care: Southeast Asian Refugee Organizing, Kinship, Care, And Reunion

Faculty, Staff and Student Publications

From a critical refugee studies orientation, our article redefines care within the context of myriad forms of state violence impacting Southeast Asian post-war refugee communities. Research reveals how harm is compounded at every step of Southeast Asian refugee journeys: war, forced displacement, resettlement, family separation, inherited health conditions, and generational trauma. How do we reckon with refugee trauma without conceding to it as an unchangeable fact of our lives? What knowledge might we gain by attending to the everyday work of survival in refugee communities? To answer these questions, the authors conceptualize care through (a) abolitionist organizing, (b) queer kinship …

Practice Facilitation And Peer Coaching For Uncontrolled Hypertension Among Black Individuals: A Randomized Clinical Trial, Joshua Richman, Muna Anabtawi, Lynn Andreae, Elizabeth Baquero, Joanna Bryan, Debra Sanders-Clark, Ethel Johnson, Erica Richman, Orysya Soroka, Jimmy Tillman, Andrea L Cherrington

Faculty, Staff and Student Publications

IMPORTANCE: Rural Black participants need effective intervention to achieve better blood pressure (BP) control.

OBJECTIVE: Among Black rural adults with persistently uncontrolled hypertension attending primary care clinics, to determine whether peer coaching (PC), practice facilitation (PF), or both (PCPF) are superior to enhanced usual care (EUC) in improving BP control.

DESIGN, SETTING, AND PARTICIPANTS: A cluster randomized clinical trial was conducted in 69 rural primary care practices across Alabama and North Carolina between September 23, 2016, and September 26, 2019. The participating practices were randomized to 4 groups: PC plus EUC, PF plus EUC, PCPF plus EUC, and EUC alone. …

Endovascular Thrombectomy Versus Intravenous Thrombolysis Of Posterior Cerebral Artery Occlusion Stroke, Patrik Michel, Pekka Virtanen, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Anh Nguyen, Joji B Kuramatsu, David Haupenthal, Martin Köhrmann, Cornelius Deuschl, Jordi Kühne Escolà, Jelle Demeestere, Robin Lemmens, Lieselotte Vandewalle, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P O Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstoc, Tobias Engelhorn, Anne Berberich, Piers Klein, Diogo C Haussen, Mahmoud H Mohammaden, Hend Abdelhamid, Isabel Fragata, Bruno Cunha, Michele Romoli, Wei Hu, Jianlon Song, Johanna T Fifi, Stavros Matsoukas, Sunil A Sheth, Sergio A Salazar-Marioni, João Pedro Marto, João Nuno Ramos, Milena Miszczuk, Christoph Riegler, Sven Poli, Khouloud Poli, Ashutosh P Jadhav, Shashvat Desai, Volker Maus, Maximilian Kaeder, Adnan H Siddiqui, Andre Monteiro, Tatu Kokkonen, Francesco Diana, Hesham E Masoud, Neil Suryadareva, Maxim Mokin, Shail Thanki, Pauli Ylikotila, Kemal Alpay, James E Siegler, Italo Linfante, Guilherme Dabus, Dileep Yavaghal, Vasu Saini, Christian H Nolte, Eberhart Siebert, Markus A Möhlenbruch, Peter A Ringleb, Raul G Nogueira, Uta Hanning, Lukas Meyer, Urs Fischer, Daniel Strbian

Faculty, Staff and Student Publications

Background and purpose: Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) with or without intravenous thrombolysis (IVT) to patients treated with IVT alone.

Methods: From the multicenter retrospective Posterior cerebraL ArTery Occlusion (PLATO) registry, we included patients with isolated PCAo treated with reperfusion therapy within 24 hours of onset between January 2015 and August 2022. The primary outcome was the distribution of the modified Rankin Scale (mRS) at 3 months. Other outcomes comprised 3-month excellent (mRS …

Social Support In An Internet Weight Loss Community

Faculty, Staff and Student Publications

Many low- and middle-income countries have introduced public works programs (PWPs) to fight poverty. This paper provides the first evidence that children from families who benefit from PWPs show increased foundational cognitive skills. The results, based on unique tablet-based data collected as part of a long-standing longitudinal survey, show positive associations between participation in the Productive Safety Net Programme (PSNP) in Ethiopia during childhood with long-term memory and implicit learning, and suggestive evidence for working memory. These associations appear to be strongest for children whose households were still PSNP participants in the year of data collection. Evidence suggests that the …

Voiding Phase Dysfunction In Multiple Sclerosis: Contemporary Review Of Terminology, Diagnosis, Management, And Future Directions

Faculty, Staff and Student Publications

Lower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are presently accessible for managing LUTS in MS, there is a need for further investigation into emerging treatments such as percutaneous tibial nerve, and noninvasive brain stimulation.

Bacteria Synergized With Pd-1 Blockade Enhance Positive Feedback Loop Of Cancer Cells-M1 Macrophages-T Cells In Glioma, Jiajie Zhang, Xinyi Yan, Qi Zhang, Di Wu, Zhong Chen

Faculty, Staff and Student Publications

Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy. This is accomplished not by enhancing the delivery of PD-1 blockade to enhance the effect of immunotherapy, but by …

The Association Between Uncertainty, Reproductive Distress, And Avoidance In Assigned Female At Birth Adolescent And Young Adult (Aya-F) Cancer Survivors, Devon Ann Pons

Doctoral Dissertations

Family building and fertility is a complex component of survivorship for assigned female at birth Adolescent and Young Adult’s (AYA-F’s), often accompanied by a mix of cognitive uncertainty, emotional uncertainty, reproductive distress, and avoidance. These psychological components present in survivorship for AYA-F’s can impact coping, identity development, and individualized care plans throughout survivorship. This novel examination of data from a cross sectional study shed light on the associations between reproductive distress, uncertainty, and avoidance and how they are experienced differently by various subgroups within the sample.

Results demonstrate that reproductive distress fully mediated the association between emotional uncertainty and avoidance, …

The Effects Of Online Mind Mapping On The Cognitive Outcomes Of Students And Their Perceptions In The Collaborative Prewriting Stage, Yen Thanh Hai Duong

Doctoral Dissertations

In language acquisition, writing is the most challenging skill that English learners must master. Students often struggle at the beginning of their writing process with idea generation. Due to students’ low academic achievement and their struggles, online mind mapping is suggested as a useful tool to support language students’ brainstorms and idea organization during the writing process. The purpose of this mixed-method study was to investigate how online mind mapping can help students collaboratively brainstorm and organize their ideas during the prewriting process. This study focused on the effects of online mind-mapping intervention on student academic writing performance and perceptions …

The Effectiveness Of Mind Maps As An Instructional Approach For Developing Critical-Thinking Skills And Dispositions: A Meta-Analysis, Carmen De Jesus

Doctoral Dissertations

Mind mapping is the most flexible visual learning and active instructional approach. It has many applications, such as brainstorming, taking notes, memorizing, and conceptualizing complex topics using associations between images and keywords, colors, and visuospatial characteristics. Students can elaborate mind maps individually and collaboratively, digitally or nondigitally. Teachers can also elaborate mind maps for studying purposes. This meta-analysis aims to investigate the effectiveness of mind mapping as an instructional approach for developing critical-thinking skills and dispositions. With 22 studies (20 of which are international) and 1,535 participants, all employing a quasi- experimental study design, this meta-analysis is a comprehensive exploration. …

Exploring The Development Of Intercultural Competence Within Efl Teachers In Thailand, Chelsea Cullen-Tran

Doctoral Dissertations

English has become a significant element in Asian countries for many reasons. A few of these reasons derive from colonialism to wanting English for international exchanges. To start understanding the complexity of English and its specific role in Asia, one must analyze English’s functionality and significance. English in Thailand has and continues to play an important role. The acquisition of English has evolved from a way to resist colonialism to now being a mandatory class, starting as early as primary school, in an attempt to keep up the international demand and use of English. This shift has prompted Thailand to …

Examining Community-Based Esol Teachers’ And Tutors’ Conceptualization Of Culturally Responsive Teaching, Lynne S. Von Glahn

Doctoral Dissertations

Community-based organizations offer English Speakers of Other Languages (ESOL) support to community members due to a severe shortage of trained and certified Teaching English Speakers of Other Languages (TESOL) teachers (Sutcher et al., 2019). Many of these organizations rely on volunteers to teach and tutor students enrolled in the programs they offer. Volunteers play an invaluable role in providing ESOL support and instruction, but many lack the necessary preparation and training (Henrichsen, 2010). Untrained and unprepared volunteers can ultimately result in cultural mismatches and ineffective instruction, adversely affecting learners (Durham & Kim, 2019). Training in culturally responsive teaching strategies can …

Exploring The Experiences Of Chinese Heritage Language Learners In California Public High Schools: A Mixed Methods Study, Min Chuan Jasmine Wang

Doctoral Dissertations

The purpose of this study was to comprehend the motivations and learning experiences of Chinese Heritage Language Learners (CHLLs) who study in Chinese programs in California public high schools where Chinese American students are under-studied and their voices are not heard. The study used Gardner’s Socio-educational Model, Fishman’s Reversing Language Shift (RLS), and Asian Critical Theory (AsianCrit) as the theoretical frameworks for the investigation. The methodology of this study applied the mixed-methods sequential explanatory design, starting with an online survey data collection and following up with interviews with CHLLs and language teachers. The researcher then conducted classroom observations to support …

For The Love Of Black Children: Towards Black Liberatory Educational Subversion, Tamra Gertrude Jenkins

Doctoral Dissertations

American K-12 schooling is one cog in a system of structural racism, with antiblackness as a foundational pillar (Brown University, 2015; Dumas, 2014; Dumas & ross, 2016). Within the structurally racist institution of education, Black students are most likely to experience criminalization, adultification, invisiblization, ostracization, and tokenization in school settings (Brown University, 2015; Bryan, 2020; Epstein, Black, & Gonzalez, 2017). For Black students in suburban schools, especially, the antiblack messaging can be more consistent and direct, having deleterious effects on their development (Chapman, 2017; Ferguson, 2002). Centering my work inside a suburban school district via a Black women-founded-and-run non-profit, this …

Emergence: Social Movements, Law Enforcement, And Defending The Sanctity Of Life, Diana Elizabeth Aroche

Doctoral Dissertations

This study examines the aftermath of national social movements advocating for police reforms and accountability, with San Francisco emerging as a pivotal city at the forefront of criminal justice and policing transformations. Rebuilding community trust and implementing substantive police reforms aimed at preserving lives has proven to be a formidable challenge. The convergence of interests among all stakeholders, driven by a shared commitment to dismantling institutional racism and implementing reforms that fostered trust with communities of color and law enforcement, played a pivotal role.

A significant aspect of this reform process has been the development of social movement convergence, where …

The Aspirations Of The Youth Of South Sudan Towards Tertiary Technical Education, Peace, Development And Civic Engagements, Sunil Orathel

Doctoral Dissertations

South Sudan, the youngest nation in the world, gained independence on July 9, 2011, following many long years of civil war and untold human suffering. After a decade of independence and millions spent from international assistance, neither stability nor development have been secured in the country. Although primary education is improving, tertiary education, particularly tertiary technical education, is considered a neglected sector. This descriptive mixed-method study documents and analyzes 1,461 surveys and 60 interviews, capturing the aspirations of the secondary school youth and stakeholders across the nation of South Sudan towards tertiary technical education, peace, development and civic engagements. Historical …

From Novitiate To Classroom: A Case Study Of Catholic Teaching Sisters, Melissa Broome Ursin

Doctoral Dissertations

This study was conducted to understand the formation of the Sisters of the Presentation of the Blessed Virgin Mary, San Francisco and how their communal practices supported and sustained their vocation to educate in Catholic schools. As the number of women religious in the United States decline, their work of Catholic education is being continued by lay teachers who may not have experienced the robust formation of religious in teaching orders. This qualitative case study used archives and oral histories to uncover how Sisters were formed and sustained as Catholic educators through Sacred texts, practices of prayer, and communal life. …

Mothering In Higher Education - Creating Inclusive Spaces For Mother-Scholar Faculty At Jesuit Universities, Michele Carlene Darchuck

Doctoral Dissertations

The percentage of female faculty members who have achieved tenure is disproportionately represented against their male peers. Even more so, female faculty members who are also mothers, or mother-scholars, represent less than half of tenured female faculty. Current research posits that a lack of female faculty in higher education translates to a lack of female students in the classroom, as well as lack of female students who see themselves in higher education positions. Mother-scholars face additional stressors as compared to their male, and/or non-parent peers that leads to an increased likelihood of mother-scholars not pursuing tenure. While there is significant …