Digital Commons Network^™

Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elderly, and those with weakened immune systems, the accurate classification of COVID-19 poses challenges, especially with highly dimensional image data. Past studies have faced limitations due to simplistic algorithms and small, biased datasets, yielding inaccurate results. In response, our study introduces a novel classification model that integrates advanced texture feature extraction methods, including GLCM, GLDM, and wavelet transform, within a deep learning framework. This innovative approach enables the effective …

Understanding The ‘Dancing Nurses Of Tiktok’, Jacqueline Christianson, Sarah Marie Calonder, Jessica Leiberg, Virginia F. Riggs

College of Nursing Faculty Research and Publications

Judgment by nursing leaders is the wrong response.

Synthetic Interbody Devices And Traditional Bone Graft Are Associated With A Similar Rate Of Surgical Complications After 1-2 Level Anterior Cervical Discectomy And Fusions, Geet Shukla, Abhijith V. Matur, Xu Tao, Syed Khalid, Rebecca Garner, Justin Gibson, Daryn Cass, Andrew Wu, Seth Street, Julia Garcia-Vargas, Jay P. Mehta, Kelly Childress, Henry Ofori Duah, Benjamin Motley, Joseph Cheng, Owoicho Adogwa

College of Nursing Faculty Research and Publications

Study Design:  Retrospective cohort. Objective:  To compare the rates of all-cause surgical complications of synthetic interbody devices versus allograft or autograft in patients undergoing 1-2 levels anterior cervical discectomy and fusion (ACDF) procedures. Summary of Background Data:  Cervical degenerative disorders affect up to 60% of older adults in the United States. Both traditional allograft or autograft and synthetic interbody devices (polyetheretherketone or titanium) are used for decompression and arthrodesis, with increasing utilization of the latter. However, the differences in their postsurgical complication profiles are not well-characterized. Patients and Methods:  Patients who underwent 1-2 level ACDFs for cervical radiculopathy or myelopathy …

The Ideal Family In The Prophetic Sunnah : The Household Of The Prophet (Peace Upon Him), Dr. Atef Abdelhamid Ahmed

Faculty Peer-Reviewed Papers | بحوث هيئة التدريس المحكمة

No abstract provided.

The Risks Of Electronic Rumors On The National Security Of State :The Use Of Electronic Robots (Bots) In Spreading Rumors And Fake News, Dr. Emadeldin Mohamed Kammel

Faculty Peer-Reviewed Papers | بحوث هيئة التدريس المحكمة

No abstract provided.

Modulation Of Host Immunity By Sensory Neurons, Telma Saraiva-Santos, Tiago H Zaninelli, Felipe A Pinho-Ribeiro

2020-Current year OA Pubs

Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary …

Cooking With Liquefied Petroleum Gas Or Biomass And Fetal Growth Outcomes: A Multi-Country Randomised Controlled Trial, William Checkley, Victor G Dávila-Román, Lisa De Las Fuentes, Et Al.

2020-Current year OA Pubs

BACKGROUND: Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth.

METHODS: The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18-34 years (9-19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, continuous fuel delivery, and behavioural messaging or to continue usual cooking with biomass for 18 months. …

Inflammatory Myofibroblastic Tumor In A Patient With X-Linked Hypophosphatemia: A Case Of Occam's Razor Or Hickam's Dictum?, Farhan Chowdry, Kelsey M Miller, Ersan Altun, Sara E Wobker, Gary S Gottesman, Hikmat Al-Ahmadie, Tracy L Rose, Eric M Wallen, Matthew I Milowsky

2020-Current year OA Pubs

We present the case of a patient with X-Linked Hypophosphatemia (XLH) and an inflammatory myofibroblastic tumor (IMT) of the bladder which prompted further investigation into the possible relationship between XLH and IMT i.e. a case of Occam's Razor or Hickam's Dictum?

Explainable Ai-Based Deep-Shap For Mapping The Multivariate Relationships Between Regional Neuroimaging Biomarkers And Cognition, Puskar Bhattarai, Deepa Singh Thakuri, Yuzheng Nie, Ganesh B Chand

2020-Current year OA Pubs

BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal aging and linked to the alterations of brain volume quantified by magnetic resonance imaging (MRI) and amyloid-beta (Aβ) quantified by positron emission tomography (PET). Yet, the complex relationships between these regional imaging measures and cognition in MCI/AD remain unclear. Explainable artificial intelligence (AI) may uncover such relationships.

METHOD: We integrate the AI-based deep learning neural network and Shapley additive explanations (SHAP) approaches and introduce the Deep-SHAP method to investigate the multivariate relationships between regional imaging measures and cognition. After validating this approach on simulated data, we …

Ethical Concerns For Remote Computer Perception In Cardiology: New Stages For Digital Health Technologies, Artificial Intelligence, And Machine Learning, Kristin Kostick-Quenet, Jerry Estep, Jennifer S Blumenthal-Barby

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Rejection, Creation, And Abolitionist Futures: Sustaining Ecosystems Of Care Under Neoliberal Violence 1980-Present, Maya Phelps

Senior Honors Papers / Undergraduate Theses

The enforcement of the child welfare system through policies, funding practices, and ideologies is a national investment in the nuclear family as a critical social institution to the United States (US); this investment communicates to the broader population that conforming to this heteropatriarchal, white supremacist conception of family provides protection from state intervention to those who conform. My project interrogates child welfare’s enforcement of normative families, and the resistance from Black family formations and kinship based on their social position and its relation to power. Focusing on the period between 1980 and the present, I examine the ways Black family …

Disruption Of Polyunsaturated Fatty Acid Biosynthesis Drives Sting-Dependent Acute Myeloid Leukemia Cell Maturation And Death, Joice Kanefsky, Mary Basse, Judith Sokei, Orsola Di Martino, Liana Valin, Jeffrey A Magee, Francesca Ferraro, Stephen M Sykes, Et Al.

2020-Current year OA Pubs

The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that fatty acid desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to healthy controls and that elevated FADS1 expression correlates with worse overall AML patient survival. Functionally, shRNA-mediated inhibition of FADS1 reduced AML cell growth in vitro and significantly delayed leukemia onset in an AML mouse model. AML cell lines depleted of FADS1 arrested in the G1/S-phase of the cell cycle, acquired characteristics of myeloid maturation and subsequently …

Epidemiology Of Dsm-5 Psychiatric Disorders In Kenyan Youth With Low And High Psychosis Risk, Rebekka H Sæle, David M Ndetei, Victoria N Mutiso, Daniel Mamah

2020-Current year OA Pubs

INTRODUCTION: There are few psychiatric epidemiology studies among Kenyan youth and fewer among those at high psychosis risk (HR).

METHODS: This study assessed the epidemiology of DSM-5 psychiatric disorders in HR and low-risk (LR) individuals to inform research and mental health services. 567 participants (aged 15-25) in HR (n = 246) and LR (n = 260) groups based on Washington Early Recognition Center Affectivity and Psychosis (WERCAP) Screen scores. Diagnostic Interview Schedule, version 5 (DIS-5) assessed DSM-5 psychiatric disorder prevalence. Diagnostic comorbidity and demographic relationships were investigated.

RESULTS: A higher prevalence was observed for all DSM-5 disorders in the HR …

A Prospective Phase I/Ii Clinical Trial Of High-Dose Proton Therapy For Chordomas And Chondrosarcomas, Sana S Dastgheyb, Alexandra D Dreyfuss, Michael J Lariviere, Jahan J Mohiuddin, Brian C Baumann, Jacob Shabason, Robert A Lustig, Jay F Dorsey, Alexander Lin, Sean M Grady, Bert W O'Malley, John Y K Lee, Jason G Newman, James M Schuster, Michelle Alonso-Basanta

2020-Current year OA Pubs

PURPOSE: The purpose of this study was to evaluate the feasibility and safety of dose-escalated proton beam therapy for treating chordomas and chondrosarcomas of the skull base and spine. Methods: A prospective cohort of 54 patients (42 with chordomas and 12 with chondrosarcomas) was enrolled between 2010 and 2018. The primary endpoints were feasibility and < 20% rate of acute grade ≥3 toxicity, and secondary endpoints included cancer-specific outcomes and toxicities. Patients were followed with magnetic resonance imaging or computed tomography at 3-month intervals. Proton beam therapy was delivered with doses up to 79.2 Gy using protons only, combination protons/intensity modulated radiation therapy (IMRT), or IMRT only.

RESULTS: Feasibility endpoints were met, with only 2 out of 54 patient radiation therapy plans failing to meet dosimetric constraints with protons, and 4 out of 54 experiencing a delay or treatment break >5 days, none for toxicities related to treatment. There were no grade …

Innovation In Targeted Violence And Terrorism Prevention: Phase Ii Summary Report, Joel Elson, Erin M. Kearns

Reports, Projects, and Research

This report provides summary findings for data collection efforts in Phase II of the entitled FY21 TVTP grant. In Phase II, the primary aims were to 1) use insights from Phase I to create a chatbot aimed to improve and increase tips reporting and 2) validate the chatbot's efficacy. Importantly, major technological advancement - namely generative chatbots like ChatGPT - occurred between the time this project was proposed in 2021 and data were conducted for this report in 2023. To be responsive to these developments and changing needs associated with them, we developed and tested multiple chatbot systems beyond what …

Innovation In Targeted Violence And Terrorism Prevention: Final Closeout Report, Joel Elson, Erin M. Kearns

Reports, Projects, and Research

Effective terrorism and targeted violence (TTY) prevention and intervention relies upon members of the public to report concerning behavior they observe. Yet, there are multiple points during the process of identifying and sharing information about potential TTY threats where breakdowns can occur, hindering intervention efforts resulting in deadly consequences. This project's overarching aim was to improve the tips reporting process to minimize breakdowns in actions required to intervene and prevent TTY. Specifically, with this lVTP innovation grant, we developed and tested evidence-informed chatbot technologies to improve TTY tips reporting. In the IMP, we listed three project goals with objectives and …

Threat And Risk Assessment Measurement: A State Of The Science Review, Samuel Hunter, Katherine Parsons, Kelsey Ciagala, Sydney L. Reichin, Matt Allen, Erin M. Kearns, Austin C. Doctor, Joel Elson

Reports, Projects, and Research

Threat and risk assessment are the processes of identifying, assessing, and managing threats of targeted violence prompted by warning behaviors. Threat assessment differs from the traditional operations of law enforcement as it may provide predictive information rather than investigating threats after a violent offense has been committed. Threat and risk assessment examines the escalation of behavior over time and corroborates information from multiple sources to reach a level of concern. Initially developed as a way to prevent assassinations, the tools and approaches around threat assessment have emerged as a violence prevention measure in many settings, including workplaces, schools, universities, and …

Validation Of A Stenotrophomonas Maltophilia Bloodstream Infection Prediction Score In The Hematologic Malignancy Population, Emily L Gill, Christian M Gill, Colleen Mcevoy

2020-Current year OA Pubs

Stenotrophomonas maltophilia (SM) bloodstream infections (BSIs) contribute to significant mortality in hematologic malignancy (HM) and hematopoietic stem cell transplantation (HSCT) patients. A risk score to predict SM BSI could reduce time to appropriate antimicrobial therapy (TTAT) and improve patient outcomes. A single center cohort study of hospitalized adults with HM/HSCT was conducted. Patients had ≥ 1 blood culture with a Gram-negative (GN) organism. A StenoSCORE was calculated for each patient. The StenoSCORE2 was developed using risk factors for SM BSI identified via logistic regression. Receiver operating characteristic (ROC) curves were plotted. Sensitivity and specificity for the StenoSCORE and StenoSCORE2 were …

Red Flag Signs And Symptoms For Patients With Early-Onset Colorectal Cancer: A Systematic Review And Meta-Analysis, Joshua Demb, Cassandra D L Fritz, Yin Cao, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than age 50 years, is increasing, and so-called red flag signs and symptoms among these individuals are often missed, leading to diagnostic delays. Improved recognition of presenting signs and symptoms associated with EOCRC could facilitate more timely diagnosis and impact clinical outcomes.

OBJECTIVE: To report the frequency of presenting red flag signs and symptoms among individuals with EOCRC, to examine their association with EOCRC risk, and to measure variation in time to diagnosis from sign or symptom presentation.

DATA SOURCES: PubMed/MEDLINE, Embase, CINAHL, and Web of Science were searched …

Genetic Complexities Of Cerebral Small Vessel Disease, Blood Pressure, And Dementia, Muralidharan Sargurupremraj, Chia-Ling Phuah, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain.

OBJECTIVE: To investigate the causal association between white matter hyperintensity (WMH) burden, clinical stroke, blood pressure (BP), and dementia risk, while accounting for potential epidemiologic biases.

DESIGN, SETTING, AND PARTICIPANTS: This study first examined the association of genetically determined WMH burden, stroke, and BP levels with Alzheimer disease (AD) in a 2-sample mendelian randomization (2SMR) framework. Second, using population-based studies (1979-2018) with prospective dementia surveillance, the genetic association of WMH, stroke, and BP with incident all-cause dementia was …

Integrating Medical Librarians Into Infectious Disease Rounding Teams: Survey Results From A Pilot Implementation Study, Mia T Vogel, Lauren H Yaeger, Jason P Burnham

2020-Current year OA Pubs

Medical librarians participating as infectious disease rounding team members add value by facilitating knowledge acquisition and dissemination and by improving clinical decision making. This pilot study implementing medical librarians on infectious disease rounding teams was a well-received and beneficial intervention to study participants.

High Rates Of Missed Hiv Testing Among Oral Prep Users In The United States From 2018-2021: A National Assessment On Compliance With Hiv Testing Recommendations Of The Cdc Prep Guidelines, Jason Baron, Tamar Tchelidze, Benjamin Labrot, Joseph Yao, Kenneth H Mayer, Daniel Kuritzkes, Nicole Robinson, Rupa R Patel

2020-Current year OA Pubs

BACKGROUND: The US Centers for Disease Control and Prevention recommends HIV testing every 3 months in oral PrEP users. We performed a national assessment of HIV testing compliance among oral PrEP users.

METHODS: We analyzed 408 910 PrEP prescriptions issued to 39 809 PrEP users using a national insurance claims database that contained commercial and Medicaid claims. We identified PrEP use based on pharmacy claims and outpatient diagnostic coding. We evaluated the percentage of PrEP prescription refills without HIV testing (identified by CPT codes) within the prior 3, 6, and 12 months using time to event methods. We performed subgroup …

Decade-Long Trends In Incidence Of Slipped Capital Femoral Epiphysis In The United States: A Nationwide Database Analysis Of Over 33 Million Patients, Aaron Singh, Travis Kotzur, Beltran Torres-Izquierdo, David Momtaz, Rishi Gonuguntla, Amir Human Hoveidaei, Ali Seifi, María Galán-Olleros, Pooya Hosseinzadeh

2020-Current year OA Pubs

PURPOSE: Slipped capital femoral epiphysis (SCFE) is a prevalent pediatric hip disorder linked to severe complications, with childhood obesity as a crucial risk factor. Despite the rising obesity rates, contemporary data on SCFE's epidemiology remain scarce in the United States. This study examined SCFE incidence trends and demographic risk factors in the United States over a decade.

METHODS: A decade-long (2011 to 2020) retrospective cohort study was undertaken using the Healthcare Cost and Utilization Project National Inpatient Sample. Patients aged younger than 18 years were identified and further analyzed if diagnosed with SCFE through ICD-9 or ICD-10 codes. Key metrics …

Outcomes Of Limited Stage Primary Bone Diffuse Large B-Cell Lymphoma In The Rituximab Era: A Multicenter, Retrospective Study, Alexandra Rezazadeh, Nancy L. Bartlett, Et Al.

2020-Current year OA Pubs

Primary bone diffuse large B-cell lymphoma is a rare variant of extranodal non-Hodgkin lymphoma historically treated with induction chemotherapy followed by consolidative radiation therapy (RT). It remains unknown whether RT confers additional benefit following rituximab-based chemoimmunotherapy (CIT) induction in patients with limited stage disease. We conducted a multicenter, retrospective analysis of patients treated between 2005 and 2019 using rituximab-based CIT regimens with or without consolidative RT to discern whether consolidative RT adds benefit in patients with stage I-II disease that could be encompassed in one radiation field. A total of 112 patients were included: 78 received CIT and radiation (RT …

From Chest Trauma To Coronary Artery Dissection, Hakob Harutyunyan, Nnamdi Chukwuka, Arafat Ali Farooqui, Vahagn Tamazyan, Ashot Batikyan, Aleksan Khachatryan, Elliot Borgen, Joshua Kerstein

2020-Current year OA Pubs

Despite being rare, traumatic coronary artery dissection after blunt chest trauma can lead to life-threatening consequences that can be fatal. This case report focuses on a 51-year-old woman who suffered chest trauma at home and was later found to have right coronary artery dissection. This manuscript aims to elucidate the risk factors, diagnostic challenges, and management strategies associated with traumatic coronary artery dissection. This case report emphasizes the evaluation of risk factors, the significance of early detection with appropriate imaging modalities while maintaining high clinical suspicion, and the critical necessity of optimizing patient outcomes in such circumstances.

Plecanatide Improves Abdominal Bloating And Bowel Symptoms Of Irritable Bowel Syndrome With Constipation, Darren M Brenner, Amol Sharma, Satish S C Rao, Adam P Laitman, Zeev Heimanson, Christopher Allen, Gregory S Sayuk

2020-Current year OA Pubs

BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C).

AIM: To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity.

METHODS: Pooled phase 3 data (2 randomized, controlled IBS-C trials) from adults treated with plecanatide 3 mg or placebo for 12 weeks were analyzed. Patients were stratified post-hoc by baseline bloating severity (11-point scale: mild [≤ 5] and moderate-to-severe [> 5]). Assessments included change from baseline in bloating, abdominal pain, and complete spontaneous bowel movement (CSBM) frequency. Abdominal pain and bloating composite responders were defined as patients with ≥ 30% improvement from baseline in …

Tabernanthalog And Ibogainalog Inhibit The Α7 And Α9Α10 Nicotinic Acetylcholine Receptors Via Different Mechanisms And With Higher Potency Than The Gabaa Receptor And Cav2.2 Channel, Han-Shen Tae, Marcelo O Ortells, Arsalan Yousuf, Sophia Q Xu, Gustav Akk, David J Adams, Hugo R Arias

2020-Current year OA Pubs

In this study, we have investigated the pharmacological activity and structural interaction of two novel psychoplastogens, tabernanthalog (TBG) and ibogainalog (IBG) at heterologously-expressed rat (r) and human (h) nicotinic acetylcholine receptors (nAChRs), the rα1β2γ2L γ-aminobutyric acid type A receptor (GABA

Coenzyme Q4 Is A Functional Substitute For Coenzyme Q10 And Can Be Targeted To The Mitochondria, Laura H Steenberge, Sean Rogers, Andrew Y Sung, Jing Fan, David J Pagliarini

2020-Current year OA Pubs

Coenzyme Q10 (CoQ

Is Crystalloid Co-Loading Necessary To Prevent Spinal Hypotension During Elective Cesarean Delivery? A Randomized Double-Blind Trial, B S Buddeberg, E Seeberger, C Bläsi, G Dutilh, L A Steiner, O Bandschapp, A Palanisamy, T Girard

2020-Current year OA Pubs

BACKGROUND: Hypotension is common during spinal anesthesia for cesarean delivery. Preventive strategies include fluid loading and phenylephrine. We hypothesized that if prophylactic phenylephrine infusion is used, omission of fluid loading would be non-inferior to fluid co-loading in maintaining cardiac output. We assumed that if there was a difference, the increase in cardiac output would be greater in the no-loading than in the co-loading group.

METHODS: Term pregnant women scheduled for elective cesarean delivery were randomized to receive 1 L crystalloid co-loading or maintenance fluids only. Phenylephrine was titrated to maintain blood pressure. Changes in cardiac output following spinal anesthesia were …

Genetic Dissection Of Diverse Seed Coat Patterns In Cowpea Through A Comprehensive Gwas Approach, Haizheng Xiong, Yilin Chen, Waltram Ravelombola, Beiquan Mou, Xiaolun Sun, Qingyang Zhang, Yiting Xiao, Yang Tian, Qun Luo, Ibtisam Alatawi, Kenani Edward Chiwina, Hanan Mohammedsaeed Alkabkabi, Ainong Shi

Poultry Science Faculty Publications and Presentations

This study investigates the genetic determinants of seed coat color and pattern variations in cowpea (Vigna unguiculata), employing a genome-wide association approach. Analyzing a mapping panel of 296 cowpea varieties with 110,000 single nucleotide polymorphisms (SNPs), we focused on eight unique coat patterns: (1) Red and (2) Cream seed; (3) White and (4) Brown/Tan seed coat; (5) Pink, (6) Black, (7) Browneye and (8) Red/Brown Holstein. Across six GWAS models (GLM, SRM, MLM, MLMM, FarmCPU from GAPIT3, and TASSEL5), 13 significant SNP markers were identified and led to the discovery of 23 candidate genes. Among these, four specific …