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Inhibition Of Pro-Inflammatory Lipid Mediators By Yersinia Pestis., Amanda Brady May 2024

Inhibition Of Pro-Inflammatory Lipid Mediators By Yersinia Pestis., Amanda Brady

Electronic Theses and Dissertations

Yersinia pestis causes the human disease known as plague. A key manifestation of plague is a delayed inflammatory response. Because this delay in inflammation is required for virulence, I was interested in defining the molecular mechanisms used by Y. pestis to evade immune recognition. Eicosanoids are produced early during infection and necessary to initiate a rapid inflammatory response. Despite the importance of these lipids in mediating inflammation, the role of eicosanoids during plague has not been previously investigated. Using an intranasal mouse model infection, I determined the kinetics of eicosanoid synthesis during pneumonic plague. I further demonstrated that LTB4 …

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Porphyromonas Gingivalis Inactivates Anti-Viral Immunity At The Oral And Respiratory Epithelium., Carlos J. Rodriguez Hernandez May 2024

Porphyromonas Gingivalis Inactivates Anti-Viral Immunity At The Oral And Respiratory Epithelium., Carlos J. Rodriguez Hernandez

Electronic Theses and Dissertations

The host microbiome plays an important role in fine-tuning host immune responses in a manner that ultimately impacts outcomes in viral infection. Symbiotic relationships between commensal bacteria and host epithelial and immune cells prime interferon (IFN) signaling, modulating the nature and intensity of the immune response to viral infections at mucosal barrier surfaces. In this doctoral thesis, I explore how dysbiotic shifts in the oral microbial communities modulate antiviral responses at the oral and oro-respiratory mucosal barriers. I identified that in response to a viral challenge, gingival epithelial cells (GECs) preferentially induced type III IFNs (IFN-λ), a newly described family …

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Using A Planetarium To Support Pre-Service Elementary Teachers' Development Of Ngss-Aligned Science Teaching., Breanna Graven May 2024

Using A Planetarium To Support Pre-Service Elementary Teachers' Development Of Ngss-Aligned Science Teaching., Breanna Graven

Electronic Theses and Dissertations

This dissertation is a case study of five elementary pre-service teachers within a science methods course who attended a planetarium-enriched experience. The experience was designed and taught by an instructor with both experience and education in astronomy and with K-12 students. The focus of the planetarium experience was to teach the science content these PSTs will have to teach to their future elementary students and teach how to teach science in an NGSS-aligned way, by incorporating the Science and Engineering Practices and Crosscutting Concepts. This is a qualitative case study that relied on interviews, open-response surveys, and video prompt responses …

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Children's Beliefs About Search Engines., Lauren N. Girouard-Hallam May 2024

Children's Beliefs About Search Engines., Lauren N. Girouard-Hallam

Electronic Theses and Dissertations

Children rely on information from other sources to think and learn about the world around them. As the world around them digitizes, their options for where to seek new information have expanded to include technological sources like Google Search. This dissertation examines what factors impact children’s trust in search engines, particularly Google. In the first set of studies, 4- to 8-year old children were asked whether technological informants and a teacher could answer stable and changing questions, and which informant would have the better answer. With age, children endorsed the Google search engine at higher rates and the teacher at …

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Using Dynamic Schemas For Query Optimization Over Json Data., Tomas Felipe Llano-Rios May 2024

Using Dynamic Schemas For Query Optimization Over Json Data., Tomas Felipe Llano-Rios

Electronic Theses and Dissertations

Query optimization in document stores has traditionally relied on rule-based approaches, but recent research advocates for a shift towards cost-based optimization. However, this transition is hindered by the fragmented nature of existing approaches, stemming from the early development stage of cost-based query optimization for document databases. A key challenge lies in the absence of a standardized query language and semantics, exacerbated by the diverse and schema-less nature of JSON document collections. To tackle these challenges, the literature has proposed dynamic schemas, primarily utilized at parsing time. However, these schemas lack a formal foundation that describes meaningful semantics for query optimization. …

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Educating For Diversity Through A Global Citizenship Education Framework: A Phenomenological Investigation Of Practice., Andrew Alexander Terry May 2024

Educating For Diversity Through A Global Citizenship Education Framework: A Phenomenological Investigation Of Practice., Andrew Alexander Terry

Electronic Theses and Dissertations

With 7.8 billion people in the world, there is a vast array of races, cultures, and languages creating an incredibly diverse globe. Along with the diverse population, we have a world that is also incredibly interconnected. As businesses begin crisscrossing the globe due to global corporations, and advancements in technology we find it more important than ever before to understand all people groups across the globe. So, what does this mean for education in the United States as we become more interconnected with countries all over? Our students need to be better prepared with global competencies that will allow them …

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Control Of Muscle Activation In The Lower Limbs During Leg Cycling After A Motor Complete Spinal Cord Injury., Jae Fish May 2024

Control Of Muscle Activation In The Lower Limbs During Leg Cycling After A Motor Complete Spinal Cord Injury., Jae Fish

Electronic Theses and Dissertations

Spinal cord injury (SCI) affects the central nervous system (CNS) causing muscle paralysis and autonomic dysfunctions throughout the body. Muscle activation after SCI is essential to facilitate functional recovery and may be produced via remaining input from supraspinal centers, the central pattern generators (CPG), or muscle stretch reflex responses. In this study, assisted leg cycling is evaluated as a tool to identify the neural structure control of muscle activation after motor complete SCI. Eight individuals with a complete or sensory incomplete SCI between C2 and T5 participated in the study. Participants completed leg cycling trials with and without supraspinal intention …

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Origin Stories., Danielle Deeley May 2024

Origin Stories., Danielle Deeley

Electronic Theses and Dissertations

This thesis is an investigation into the Peruvian pre-Columbian collection at the Speed Art Museum in Louisville, Kentucky. The Speed Art Museum acquired this collection in 1934 and it has largely remained unresearched for nearly a century after acquisition into the museum’s collection. This investigation is not an attempt to make broad characterizations of pre-Columbian ceramics. Nor is its goal to fill in all the gaps of the collection’s history. Instead, this thesis follows the evidence the collection presents: the physical attributes of the ceramics, the donor’s history, U.S. history, and information from the collection file provided by the Speed …

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The Impact Of Cognitive Coaching On Educator Identity And Teamwork Through Classroom Observation As Perceived By Teachers And Administrators., Carrie Elizabeth Wade May 2024

The Impact Of Cognitive Coaching On Educator Identity And Teamwork Through Classroom Observation As Perceived By Teachers And Administrators., Carrie Elizabeth Wade

Electronic Theses and Dissertations

Classroom observations are meant to help teachers improve their instructional practice and improve learning outcomes for students. But for many educators, traditional, in-person classroom observations can not only be difficult to arrange but difficult to truly gain valuable feedback from when teachers can’t see what was happening in the moment (Drago-Severson & Blum-Stefano, 2017). Teaching and leading in an environment characterized by a constant state of change is more likely to cause stress and negative feelings when the employees care deeply about the outcome (Wisse & Sleebos, 2016). Cognitive Coaching methods, applied to classroom observations, aim to reduce focus on …

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The Utilization Of Grassroots Organizing By Black Women Pioneers To Achieve Reproductive Justice., Madison Ruth Ellsworth May 2024

The Utilization Of Grassroots Organizing By Black Women Pioneers To Achieve Reproductive Justice., Madison Ruth Ellsworth

Electronic Theses and Dissertations

Since enslavement in the United States Black women have cultivated different ways to fight for their Reproductive Justice. After emancipation Black women have continued to utilize the practices learned from our ancestors to obtain Reproductive Justice. Despite the women’s movement becoming mainstream in the 1960s many Black women continued to grassroots organize to adequately address the issues that were unique to them. The efforts of various Black women organizers tend to go unacknowledged because the mainstream women’s movement attracts the attention of most. In my research I focused on Byllye Avery, Loretta Ross, and Toni Bond to explore and showcase …

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A Design Science And Implementation Framework For Studying Interruptions And Its Application In A Dental Clinic., Carsten Ziegler May 2024

A Design Science And Implementation Framework For Studying Interruptions And Its Application In A Dental Clinic., Carsten Ziegler

Electronic Theses and Dissertations

Interruptions during dental treatment are frequent, and often have detrimental effects on quality of care, patient safety and processing times, and have an impact on provider satisfaction and performance. Interruptions can significantly increase the cognitive load on dental providers, making it hard for them to concentrate on complex procedures. Frequent interruptions also disrupt the workflow in general, leading to delays in treatment, which can reduce the overall throughput of a clinic. Unfortunately, there is no comprehensive approach to collectively (i) analyze interruptions in dental healthcare, (ii) design an intervention, and (iii) implement and sustain it. This research proposes a comprehensive …

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Modifiers Of The Effects Of Different Dimensions Of Social Support On Cardiac Rehabilitation Adherence., Melissa Amraotkar May 2024

Modifiers Of The Effects Of Different Dimensions Of Social Support On Cardiac Rehabilitation Adherence., Melissa Amraotkar

Electronic Theses and Dissertations

Introduction: Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Cardiac Rehabilitation (CR) is a Class I, level A indication for treatment and prevention further complications of CVD. The attendance rate for CR in the U.S. is very low, especially among female patients. Dimensions of social support, sex of the support provider, and the quality of primary intimate relationship are associated with health-promoting behavior and may influence CR adherence in patients. Purpose: The purpose of this study was to examine the relationship between dimensions of social support and CR adherence, and whether these relationships were moderated by factors such …

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Electrokinetic Particle Trapping Performance Of Conductive Nanofiber Mats In Microfluidic Wells., Jacob Hunter West May 2024

Electrokinetic Particle Trapping Performance Of Conductive Nanofiber Mats In Microfluidic Wells., Jacob Hunter West

Electronic Theses and Dissertations

The frequency dependence of electrokinetic particle trapping using large-area (>mm2) conductive carbon nanofiber (CNF) mat electrodes is investigated. The fibers provide nanoscale geometric features for the generation of high electric field gradients, which is necessary for particle trapping via dielectrophoresis (DEP). A device was fabricated with an array of microfluidic wells for repeated experiments; each well included a CNF mat electrode opposing an aluminum electrode. Fluorescent microspheres (1 µm) were trapped at various electric field frequencies between 30 kHz – 1 MHz. Digital images of each well were analyzed to quantify particle trapping. DEP trapping by the …

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Class Of 1884: Black Education In Louisville And The Inaugural Graduating Class Of Central Colored High School., Jordan Tierre Jackson-Collins May 2024

Class Of 1884: Black Education In Louisville And The Inaugural Graduating Class Of Central Colored High School., Jordan Tierre Jackson-Collins

Electronic Theses and Dissertations

This thesis offers both a historical analysis of the emergence of the black public school system in Louisville, Kentucky and a probe into the academic posture of 19th century black education in the state. It addresses how the early black school in Kentucky worked to shape students’ self-image and worldview by focusing on Louisville’s Central Colored High School, the first public high school for blacks in Kentucky, and more closely, its 1884 yearbook––a collection of student-essays in which each of the seven inaugural graduates wrote lengthy reports concerning their individual outlook on education, American society, and the Negro’s responsibilities …

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Fly Ash Based Geopolymer: Water, Curing Temperature And, Cao Content Effects On Microstructure And Compressive Strength., Lujain Salem May 2024

Fly Ash Based Geopolymer: Water, Curing Temperature And, Cao Content Effects On Microstructure And Compressive Strength., Lujain Salem

Electronic Theses and Dissertations

Geopolymer, an emerging alternative to Portland cement-based concrete, relies on alumina and silica-rich precursors like fly ash for its formation. Geopolymerization is a chemical process that creates a three-dimensional polymer network by reacting with an alkaline activator. While fly ash's calcium oxide (CaO) content is crucial in its classification, it behaves differently in geopolymerization, where it competes with hydration. Therefore, a better understanding of the impact of CaO content in fly ash on geopolymerization is needed to effectively utilize fly ash. This study investigates the effects of CaO content, water, and curing temperature on geopolymerization. Using fly ash from a …

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Social Undermining Among Police Officers In The United States., Weston B. Anderson May 2024

Social Undermining Among Police Officers In The United States., Weston B. Anderson

Electronic Theses and Dissertations

Policing is a large and critical part of the American criminal justice system. Although a focal study group for research, little is known of how social undermining impacts police officers and organizations. Social undermining can cause a variety of negative consequences, including lower job satisfaction, reduction in work-related outcomes, and mental and physical health problems (Duffy et al., 2002; Hershcovis & Barling, 2010; Sabeen & Arshad, 2019). To date, no study has examined social undermining in police officers within the United States. This qualitative research examined social undermining among police officers. Using a blend of inductive and deductive thematic analysis, …

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“I’M Going To Have To Be Far More Prepared": A Critical Discourse Analysis Of Teacher Candidate Discussion And Projected Teaching Of Literature., Taylor Rose-Dougherty May 2024

“I’M Going To Have To Be Far More Prepared": A Critical Discourse Analysis Of Teacher Candidate Discussion And Projected Teaching Of Literature., Taylor Rose-Dougherty

Electronic Theses and Dissertations

This qualitative dissertation study contributes to conversations around the practical knowledge gap–professional behaviors or practices which are underdeveloped in available research–between critically oriented literacy teacher preparation programs and praxis in early career classrooms. Critical literacy, or engaging with major texts, discourses, and ways of communicating in a culture or context, attempts to locate and disrupt power imbalances and encourage justice-oriented activism. While teacher candidates (TCs) often practice critical literacy in their training programs, they often struggle to facilitate critical literacy instruction in their own classrooms. Using Thematic Analysis (TA) for data reduction and Critical Discourse Analysis (CDA) for data analysis, …

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W.E. B. Du Bois And Audre Lorde's Pan-African Development: Remedies For The Problem Of Othering., J.E. Young May 2024

W.E. B. Du Bois And Audre Lorde's Pan-African Development: Remedies For The Problem Of Othering., J.E. Young

Electronic Theses and Dissertations

W.E.B. Du Bois and Audre Lorde’s Pan-African Development: Remedies for the Problem of Othering is an Afrocentric reading of Black U.S intellectual traditions of self-definition from the late 19th to early 21st century. I argue that W.E.B. Du Bois and Audre Lorde adhered to two major Afrocentric principles: balance and justice. At the root of these principles is the understanding that binaries constructed as oppositions create unjust hierarchies. My theoretical approach is attuned to the distinct ways that Du Bois and Lorde communicated the importance of self-definition and Africana spirituality in relationship to other Black intellectual thought. Placing them in …

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Attention Guided Data Augmentation For Improving The Classification Performance Of Vision Transformers., Nada Baili May 2024

Attention Guided Data Augmentation For Improving The Classification Performance Of Vision Transformers., Nada Baili

Electronic Theses and Dissertations

For over a decade, Deep Neural Networks (DNNs) have been rapidly progressing and achieving great success, forming a robust foundation of state of the art machine learning algorithms that impacted various domains. The advances in data acquisition and processing have undeniably played a major role in these breakthroughs. Data is a crucial component in building successful DNNs, as it enables machine learning models to optimize complex architectures, necessary to perform certain difficult tasks. However, acquiring large-scale data sets is not enough to learn robust models with generalizable features. Instead, an ideal training set should be diverse enough and contain enough …

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Transforming Into A Politically Engaged Actor Through Gem Of The Ocean., Tajleed Steven Hardy May 2024

Transforming Into A Politically Engaged Actor Through Gem Of The Ocean., Tajleed Steven Hardy

Electronic Theses and Dissertations

This thesis explores my transformation into a politically engaged theatre artist through my performance as Citizen Barlow in the University of Louisville's Department of Theatre Arts’ 2024 production of August Wilson's Gem of the Ocean. My thesis defines the characteristics of a politically engaged theatre artist and proposes specific ways actors can prepare to perform in any production of any play. My transformation into a politically engaged theatre artist resulted from a combination of the skills I gathered as an undergraduate student at Norfolk State University and the new analytical and acting techniques I learned as an MFA in …

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Are The Good Times Really Over For Good? American Political Nostalgia's Relationship With Rurality, Authoritarianism, And Victimhood., Chancellor R. Peterson May 2024

Are The Good Times Really Over For Good? American Political Nostalgia's Relationship With Rurality, Authoritarianism, And Victimhood., Chancellor R. Peterson

Electronic Theses and Dissertations

There are many discussions about why rural and urban Americans exhibit different attitudes about politics, partisan loyalties, and ideologies. Some of these differences can be explained by psychological processes and traits. People act differently and influence (or are influenced by) political processes differently based on their perceptions of and emotions regarding the past, present, and future states of the world. The same is true with rural and urban Americans. This research will investigate the effects of one potent emotion on political attitudes: nostalgia. Prior research has indicated that political nostalgia can be harnessed as a strong political tool. This thesis …

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Investigation Of Avaren-Fc's Therapeutic Potential Against Ovarian Cancer., Katarina Lee Mayer May 2024

Investigation Of Avaren-Fc's Therapeutic Potential Against Ovarian Cancer., Katarina Lee Mayer

Electronic Theses and Dissertations

This thesis describes the investigation of Avaren-Fc (AvFc), a novel lectin-based therapeutic fusion protein consisting of the recombinant Avaren lectin and the Fc region of human IgG1, against ovarian cancer. AvFc possesses selectivity toward tumor associated N-linked high-mannose-type glycans. The present study demonstrates AvFc’s in vitro activity against OVCA cell lines via antibody-dependent cell-mediated cytotoxicity and its ability to extend the survival of mice challenged with murine ID8 OVCA cells after repeated systemic administration. Furthermore, AvFc treatment in this model was found to increase the presence of peritoneal leukocytes, suggesting a shift toward an improved antitumor immune response. Another key …

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The Impersonation Artist: A Novel With Critical Afterword: Displacement And Dissent In Fiction And Art., Flora K. Schildknecht May 2024

The Impersonation Artist: A Novel With Critical Afterword: Displacement And Dissent In Fiction And Art., Flora K. Schildknecht

Electronic Theses and Dissertations

This dissertation consists of a creative project, The Impersonation Artist: A Novel, and a critical afterword, “Displacement and Dissent in Fiction and Art.” On a narrative level, The Impersonation Artist engages the question of how, and if, participatory art can reveal and intervene in oppressive conditions. The novel employs a stylistic methodology in which the use of multiple narrators and narrative fragmentation formally gestures toward the complex dilemma of how artists might intervene in contemporary problems in the face of conflicting ideologies and ever increasing precarity. The novel follows three characters: an environmental activist; a young man veering towards …

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Pre-Columbian Soil Management, Settlement, And Land Use In Amazonia: Insights Using Micro-Regional Predictive Modelling In Gurupá, Brazil., Lauren Zacks May 2024

Pre-Columbian Soil Management, Settlement, And Land Use In Amazonia: Insights Using Micro-Regional Predictive Modelling In Gurupá, Brazil., Lauren Zacks

Electronic Theses and Dissertations

The results of a micro-regional predictive model of terra preta sites in the municipality of Gurupá are presented here. A Maximum Entropy approach was selected and modified to fit a presence-background model, rather than a presence-absence model typical of binary classifications. 13 known terra preta sites were used as input samples for the relative suitability model, with explanatory variables in the respective categories of topography, hydrology, soil type and vegetation index. A 30m spatial resolution DEM served as the basis for the former two categories, while additional TauDEM analysis was performed for the hydrology category. A Sentinel-2A mosaicked quarterly composite …

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Preserving Archaeology In The Digital Age: Evaluating Strategies For Effective Curation And Database Management., Cenetria Leshun Crockett May 2024

Preserving Archaeology In The Digital Age: Evaluating Strategies For Effective Curation And Database Management., Cenetria Leshun Crockett

Electronic Theses and Dissertations

The “curation crisis” is a dark cloud that consistently looms over the archaeological discipline, affecting the ways we plan, execute, and curate research projects. It is especially prominent within curation facilities and institutions that have the duty to preserve archaeological collections. The development of digital curation presents an avenue through which curators and collection managers can combat the crisis. Digital curation grants collection managers the ability to manage and ensure archaeological collection accessibility. Digital collection databases, particularly, have grown to become a significant component of collection management as it permits collections to be easily preserved, managed, saved, and accessible at …

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Do American Bison Practice Democracy? Group Consensus Decision Making Drives Bison Herd Movements And Cohesion., Matthew Sapien May 2024

Do American Bison Practice Democracy? Group Consensus Decision Making Drives Bison Herd Movements And Cohesion., Matthew Sapien

Electronic Theses and Dissertations

The American bison is an iconic mammal that lives in large social herds and is considered a threatened species. Little is known about how bison make decisions as a group, whether through despotic individuals or group consensus. In this dissertation, I researched the mechanisms bison use to make herd movement decisions in 3 herds in the United States. In chapter one I examined the number of bison that participated in voting events for herd movement decisions and whether the final movement decision matched the direction with the most votes. Bison herd movements did match the direction with the most adult …

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Context Dependent Training Data Selection For Automatic Target Detection., Tylman Michael May 2024

Context Dependent Training Data Selection For Automatic Target Detection., Tylman Michael

Electronic Theses and Dissertations

An Automatic Target Detection (ATD) algorithm is capable of identifying the location of targets of interest captured by Infra-Red imagery in vastly different contexts. ATD is often a precursor in a 2-stage methodology in order to ascertain the location and nature of a target in both military and civilian applications. In order to train an ATD algorithm, a large amount of data from varied sources is required. One drawback of this requirement is that some sources of data may harm the performance of the method in different contexts. This thesis explores utilizing an unsupervised method to identify a subset of …

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Mental Health Counseling For Individuals With Intellectual Disabilities: A Phenomenological Study Of Client Perspectives., Kathleen Nagle Barnett May 2024

Mental Health Counseling For Individuals With Intellectual Disabilities: A Phenomenological Study Of Client Perspectives., Kathleen Nagle Barnett

Electronic Theses and Dissertations

Mental illness is three to four times as prevalent among individuals with intellectual disabilities compared to those without intellectual disabilities (Munir, 2016). There is a body of research supporting the efficacy of mental health counseling to decrease symptoms and behaviors in individuals with intellectual disabilities, but scarce research exists which describes the experiences of these individuals. This interpretive phenomenological analysis was designed to gather information about how individuals with mild intellectual disabilities experience the four common components of psychotherapy that contribute to change (from Lambert, 1992; Thomas, 2006) – client and extra therapeutic factors, relationships factors, expectancy, and model / …

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Examination Of Solutrean Lithic Technology At The Vale Boi Site, Southwestern Portugal., Jordan Durham May 2024

Examination Of Solutrean Lithic Technology At The Vale Boi Site, Southwestern Portugal., Jordan Durham

Electronic Theses and Dissertations

During the Last Glacial Maximum (27 – 19 ka), much of northern Europe became uninhabitable as icesheets expanded causing populations to withdraw into refugia around south-central Europe. Southwestern Iberia served as an ecological refuge for hunter-gatherer populations due to favorable climate and resource availability. Solutrean (25 -19 ka) techno-complex represented shifts in human adaptations and new social configurations in Iberia. Lithic analysis of 1380 artifacts from Solutrean, Layer 3 Terrace, at the Vale Boi site (southwestern Portugal) permitted insights into hunter-gatherer cultural adaptations reflected in technological behavior. Major conclusions are: (a) Solutrean techno-complex at Vale Boi utilized expedient tool production …

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Teacher Identity Matters: The Influence Of Identity On Student/Teacher Relationships And Special Education Student Performance., Jamil Anderson May 2024

Teacher Identity Matters: The Influence Of Identity On Student/Teacher Relationships And Special Education Student Performance., Jamil Anderson

Electronic Theses and Dissertations

I have had the opportunity of many years of experience in public education as a teacher who provides services for students who in Special Education. I have classes where there is a small group setting for content instruction, as well as the role of a “co-teacher” alongside general educators. From my work, I find that there are differences of expectations of success and rigor in the inclusive setting from the general education teacher, often resulting in deficits in their academic achievement when compared to their peers who do not receive services. As I developed my topic for this study, it …

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