Digital Commons Network^™

Bns Bldgs., Llc V. Thomas

All Decisions

In this nonpayment proceeding, the court grants respondent's motion for discovery with respect to the apartment's rent regulatory status. The court finds that respondent demonstrated ample need based on the DHCR rent history, which showed indicia of fraudulent deregulation.

Trends In Trauma: Increasing Rates Of Sexual And Domestic Violence Among Female Latin American Asylum Seekers, Alfonso Mercado, Andy U. Torres, Francisco Banda, Amanda Venta, Luz M. Garcini, Alejandro Luis Vázquez, Aldo Barrita, Oswaldo Moreno

Psychological Science Faculty Publications

The last 10 years of scientific research analyzing asylum-seekers’ mental health has established high rates of trauma exposure throughout the migratory trajectory. However, limited studies have identified gender-based violence among Central American asylum-seeking women. The purpose of this study was to identify the frequencies of gendered-base violence among asylum-seeking women from Central and South America at a humanitarian respite center (USA) and a tent encampment (Mexico) on both sides of the United States–Mexico Border using data from three independent studies in 2016, 2019, and 2023, respectively. Visual trend analysis identified a peak in domestic violence in 2019, a stable frequency …

Online Legislation: Developments And Trends In Data Privacy And Software Development, Garrett J. Splinter

Honors Program: Senior Projects (Public)

The increasingly relevant interaction between the law and data privacy, as well as compliance requirements enforced by the United States, is currently in a state of transition. Various states, such as California, Colorado, Connecticut, Nebraska, and many others, all have passed legislation with varied requirements and definitions that make for a challenging framework in which software developers operate, as the universal nature of the internet renders their compliance with current legislation a challenge. Enforcement also tends to be relatively relaxed in most modern examples, though it has escalated after 2020, and this trend may continue in the future, lending credence …

Analysis Of Dynamic Difficulty Scaling Ai In Video Games, Tyrese W. Walker

Honors Program: Senior Projects (Public)

Video games are a popular form of interactive media and, since their inception, have become one of the largest forms of media consumed. As such, they have evolved greatly from their humble beginnings into much more complex experiences, and adjusting the difficulty level to suit the needs of the player has become common practice. While there are simple ways to do so, the best games often feature a dynamic difficulty-scaling system that adapts to the player. Classics like Resident Evil and Left 4 Dead are excellent examples of innovative dynamic scaling design. By analyzing the strongest elements of these works, …

Practicing A Pedagogy Of Slow Resistance In The Writing Classroom, Kathleen Rose Dillon

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Especially during and following the ‘lockdown era’ of the COVID-19 pandemic, college writing instructors have sought ways to mitigate the harms of neoliberal and capitalist practices in the academy and writing classroom. Incorporating elements of Slow Pedagogy, Disability Studies, Anti-Capitalist Composition, and Participatory Action Research methodology, this dissertation argues for practicing a Pedagogy of Slow Resistance, centering co-creation and relationship-building, to resist neoliberal and capitalist values, and promote student belonging and well-being. This dissertation highlights a classroom study in which two undergraduate students in the TRIO program, which serves students who are first in their family to go to college, …

Brazilian Souls: Portraits Of Brazilian Nationalism In The Piano, Rafael Lima Lima De Paula

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This portfolio consists of the artifacts of the creative, artistic and research work realized during my doctoral studies. In its core, all recitals had Brazilian music, especially that of H. Villa-Lobos, as a unifying element, although personal taste and reasoning were also a driving force behind choosing repertoire and building a theme for each recital. The research work is connected to the repertoire performed, with Villa-Lobos' music and the Brazilian nationalist movement as common threads. “Respectful Majesty,” the research paper attached to Recital 1 analyzes elements present in Villa-Lobos Bachianas Brasileiras N.4 and brings the piece's neoclassical nature to the …

Digital Lean Transformation Through Mes–Scada Intergration: Reducing Transactional And Cognitive Waste In High-Volume Electronics Manufacturing, Kamal Alalul

Graduate Dissertations and Theses

This research addresses inefficiencies in Manufacturing Execution System (MES)-driven workflows, where excessive user interactions and fragmented access to work instructions introduce transactional and cognitive waste. To address these limitations, an integrated architecture was developed using Ignition as a SCADA-based operator interface connected to the MES through API-based communication. The system replaces direct MES interaction with a unified interface that embeds work instructions and automates transaction execution within the production workflow. The approach was implemented and evaluated through an industrial case study on a 15 station electronics manufacturing line. Results show a 51% reduction in total cycle time, decreasing from 2,996 …

Raman Spectroscopy With Machine-Learning Classification For The Prediction Of Stereotactic Radiotherapy Induced Treatment Toxicity In High-Risk Localised Prostate Cancer, Jade F. Monaghan, Daniel Cullen, Dinesh K.R. Medipally, Rahul Suresh, Kelly M. Redmond, Ciaran Fairmichael, Suneil Jain, Aidan D. Meade, Fiona M. Lyng

Research Outputs: 2025-Present

Radiotherapy can lead to late-onset toxicity, to varying extents between individuals due to differences in radiosensitivity. Predicting which patients are most at risk is key to augmenting the therapeutic window. However, the underlying biological mechanisms remain poorly understood, and current experimental methods often lack clinical applicability. This study employs Raman spectroscopy to analyse biochemical profiles in peripheral lymphocytes and plasma, aiming to monitor radiotherapeutic response and predict intrinsic radiosensitivity in high-risk localised prostate cancer patients treated with stereotactic radiotherapy. Partial-least squares discriminant analysis classification of Raman spectra at baseline (n = 20) from post-hormone therapy (n = 19), mid-treatment (pre-4 …

Pest Risk Modelling For Climate-Smart Vegetable Production In East Africa, Marc Marin Agbodjan, Komi Mensah Agboka, John Odindi, Elfatih Abdel-Rahman, Onisimo Mutanga, Frank Chidawanyika, Chrysantus Tanga, Daniel Munyao Mutyambai, Sevgan Subramanian, Bonoukpoè Mawuko Sokame

All Peer-Reviewed Publications

Agricultural productivity in East Africa is increasingly threatened by climate-sensitive insect pests. This study investigates the occurrence of key vegetable pests: Brevicoryne brassicae, Plutella xylostella, Maruca vitrata, and Liriomyza mik. A comparative species distribution modelling evaluated pest risk projections under climate change. Four variable selection strategies were tested: case 1 (correlation and variance inflation factor [VIF] filtering across all predictors), case 2 (correlation and VIF filtering of bioclimatic variables merged with other predictors), case 3 (filtering based on environmental values at species occurrence point to approximate realized niches), and case 4 (dimensionality reduction using principal component analysis). These strategies were …

Connecticut Residents Report Higher Social Media Use Than Neighbors, Most Say Social Media Negative For Society 5/5/2026, Unh Survey Center

All UNH Survey Center Polls

Social media users in Connecticut report using social media platforms just over 24 hours per week, higher than residents of Rhode Island, Massachusetts, and New Hampshire. More than half of social media users want to use it less, particularly those under 50, and a quarter feel addicted to social media. YouTube, Facebook, and Instagram are the most popular platforms among Connecticut residents, with YouTube used most frequently. Connecticut residents generally believe social media has a somewhat positive effect on creativity, but most feel it has a negative effect on productivity, mental health, and on society in general, and bipartisan majorities …

Learning Across Disciplines: A Team-Based Approach To Ce, Carissa Blumenshine, Heather Raeder

Nursing

No abstract provided.

Cracks In The Earth: Why Is East Africa Losing Its Soil?, Maarten Wynants, Aloyce Amasi, Will Blake, Pascal Boeckx, Andrew Brooks, Claire Kelly, Ivan Lizaga, Linus Munishi

School of Geography, Earth and Environmental Sciences

No abstract provided.

20260505: Women's Center, 1988-2025, Student Affairs

Guides to University Archives

These items include materials from the office of the Women's Center at Marshall University from 1988-2025. Items were received in 2026 and include Green Dot Training, Women of Color Celebration, Ms. Quotes, Women Connect and Women's History Month (2010-2011), Women's Center Events from 2011-2012, program attendance of programs from 2012-2014; Program Contracts; Run 4 RAINN event, Women of Marshall Award Nominations, and Parthenon Issues where the Women's Center was mentioned. This is not an exhaustive list. Please download the finding aid for a full list of contents.

Small Partial Deletion Of A Highly Gc-Rich Foxf1 Exon 1 In Two Deceased Siblings With Alveolar Capillary Dysplasia, Hiuling Chan Joiner, Shruti A Pande, Przemyslaw Szafranski, Partha Sen, Gail Deutsch, Pawel Stankiewicz

Faculty, Staff and Students Publications

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal lung developmental disorder caused by haploinsufficiency of FOXF1. While larger-sized coding and noncoding copy-number variant (CNV) deletions involving the FOXF1 locus are detected in approximately half of histopathologically-diagnosed ACDMPV patients, small CNVs remain diagnostically challenging. Here, we revisited an unsolved case of familial ACDMPV with two affected siblings. Whole genome sequencing (WGS) of 30-year-old archival lung autopsy tissue analyzed using AI powered platform revealed a 151 bp CNV deletion involving a highly GC-rich portion of exon 1 of FOXF1 that was not detected using Sanger sequencing and …

Timing Isn't Everything: Rethinking Mortality Risk In Type A Aortic Dissection Surgery, Anna H Xue, Joseph S Coselli

Faculty, Staff and Students Publications

No abstract provided.

Cd40 Specific Dna Aptamers As Vaccine Adjuvants, Adil Sabr Al-Ogaili, Tieshan Jiang, Christine Nguyen Vuong, Rohana Liyanage, Jackson Oliver Lay Jr, Thallapuranam Krishnaswamy Suresh Kumar, Luc Berghman, Young Min Kwon

Patents Granted

The present invention provides immunostimulatory nucleic acids that have an affinity to a specific target protein. The present invention also provides templates and methods for making and using the immunostimulatory nucleic acids. Further, methods for linking the immunostimulatory nucleic acids to antigens and using the resulting complexes to enhance an immune response are provided.

Transcriptome Predictors Of Second Breast Events In Ductal Carcinoma In Situ: A Case‒Control Study Including Black And White Women, Aditi Hazra, Emma Berdan, Thomas Walsh, Sarah Humble, Jen Tappenden, Katherine Deschryver, Deborah Veis, Kiran Vij, Shannan Ho Sui, Graham A Colditz

2020-Current year OA Pubs

BACKGROUND: Black women diagnosed with ductal carcinoma in situ (DCIS) experience disproportionately higher risk of second breast cancer events (SBEs), including both ipsilateral and contralateral recurrences, yet remain underrepresented in molecular biomarker studies compared to non-Hispanic White women.

METHODS: We performed RNA sequencing on 200 archival DCIS samples from the Resource of Archival Breast Tissue cohort, including 33% self-reported Black women. We correlated transcriptomic and clinical data to identify predictors of SBEs. Cases (n = 100) who developed SBEs between 1999 and 2019 were matched 1:1 to controls (n = 100) on age, race, and margin status, who remained event-free …

Apathy, Effort-Based Decisions And Brain Integrity In Alzheimer’S And Parkinson’S Diseases, Lee-Anne Morris, Hideo Suzuki, Seonjoo Lee, Zekai Jin, Bryan B Chen, Ana Marin, Edward D Huey, Yunglin Gazes, Sarah R Heilbronner, Campbell J Le Heron, Nora Vanegas-Arroyave

Faculty, Staff and Students Publications

Apathy, or loss of motivation, is a prominent syndrome accompanying both Alzheimer's and Parkinson's diseases, in addition to other disorders. One approach to understanding motivational loss is to examine the processes underlying goal-directed behaviour. Weighing up rewarding outcomes against the effort costs required to obtain them (effort-based decision-making) is a core computation when deciding to act for outcomes. Although a growing body of evidence points to disruption of this computation in people with apathy, which underlying decision parameters drive this disruption, their neural associations and whether these would generalize or differ across brain disorders have not been examined. People with …

Purine Metabolic Adaptation Protects The Endothelium From Disturbed Flow-Induced Dna Damage And Atherosclerosis, Qian Ma, Yongfeng Cai, Zhidan Zhang, Dingwei Zhao, Yuan Zhao, Peishan Xu, Tammy Lu, Wendy Zhang, Qiuhua Yang, Yaqi Zhou, Varadarajan Sudhahar, Tohru Fukai, Hanjoong Jo, Yiming Xu, Yuqing Huo

Faculty, Staff and Students Publications

Despite effective lipid-lowering therapies, atherosclerosis continues to be a leading cause of death, with considerable residual cardiovascular risk. Atherosclerotic lesions develop preferentially at arterial regions exposed to disturbed flow (d-flow), which induces genomic stress, endothelial injury, and barrier dysfunction. Hemodynamic forces are known to reprogram endothelial metabolism, but the role of de novo purine synthesis (DNPS), which supplies nucleotides for genome maintenance and whose terminal steps are catalyzed by the bifunctional enzyme ATIC, remains undefined in atherosclerosis. By integrating bulk and single-cell multiomics with in vitro flow systems and in vivo models, we show that d-flow upregulates DNPS and ATIC …

Low Inducer Concentrations At 10 °C Promotes Soluble Recombinant Expression Of Aedes Aegypti Mosquito Midgut Proteases In E. Coli, Daniel Fong, Neomi Millan, My Anh Le, Elizabeth Moreno-Galvez, Kevin Derisier, Abigail G. Ramirez, Kaelyn Pluta, Kimberly Houghton, Alberto A. Rascón

Faculty Research, Scholarly, and Creative Activity

Background: Soluble recombinant expression of Aedes aegypti mosquito midgut proteases in Escherichia coli prove to be difficult. These enzymes depend on disulfide bond formation for structural stability. Initial attempts in BL21(DE3) were unsuccessful due to a reducing cytoplasm. The use of T7 SHuffle cells (with a more oxidizing cytoplasm) led to soluble expression. However, other factors had to be altered (use of richer media and lower (< 25 °C) growth temperature). Not all mosquito proteases were equally soluble. Therefore, given the importance of IPTG in initiating transcription and translation, we set out to determine if low IPTG concentrations (< 0.1 mM) at 10 °C would increase soluble production of midgut proteases. Additionally, we investigated the effect of the small molecule osmolyte betaine on the soluble expression of midgut proteases. Results: For this study, the focus was on Aedes aegypti Late Trypsin (AaLT), Early Trypsin (AaET), Serine Protease I (AaSPI), Serine protease V (AaSPV), and Juvenile Hormone Associated 15 (JHA15). The colder bacterial growth, along with low IPTG, slows the rate of transcription/translation of T7 RNA polymerase. Lower expression of T7 RNA polymerase, along with slower transcription activity at 10 °C, prevents rapid simultaneous translation of midgut proteases thereby promoting soluble expression. In addition, we found that different growth periods also varied among the proteases. Soluble expression for AaLT and AaET was maximal at 52 h post-induction, 72 h for JHA15, and 168 h for AaSPI and AaSPV. Surprisingly, for AaET, temperature was the only important factor. The addition of betaine to the growths had a more pronounced effect at higher (> 0.05 mM) IPTG. Conclusions: Low IPTG at 10 °C slows the rate of transcription/translation of recombinantly expressed mosquito proteases in bacteria. By preventing rapid accumulation in the cell, prevents aggregation, and ultimately inclusion …

Nest Attendance In Two Finnish Waterfowl Species In Relation To Per- And Polyfluoroalkyl Substances And Thyroid Hormones, Farshad S. Vakili, Scott A. Shaffer, Veerle L.B. Jaspers, Silje Peterson, Elise Lunde Steensland, Pentti Runko, Bertille Mohring, Markus Öst, Kim Jaatinen, Bin Yan Hsu, Titiksha Peetumber, Nora M. Wilson, Christian Sonne, Stefan Björkman, Suvi Ruuskanen, Céline Arzel

Faculty Research, Scholarly, and Creative Activity

Contamination of aquatic environments with per- and polyfluoroalkyl substances (PFAS) may disrupt wildlife reproduction by altering hormonal-behavioural pathways. In birds, nest attendance is a key incubation behaviour, mediating embryonic development and hatchability. Yet, the potential associations between PFAS and nest attendance remains underinvestigated. In 2022 and 2023, we quantified plasma PFAS concentrations in breeding females from two Finnish waterfowl species: common goldeneyes (Bucephala clangula), an income breeding cavity nester, and common eiders (Somateria mollissima), a predominantly capital breeding ground nester. Egg-turning and egg temperature were recorded using data loggers inside artificial eggs. We related these nest attendance variables to PFAS …

Developing Play-Based Curriculum Implementation Guidelines As A Tool For Teachers’ Pedagogical Awareness: A Case Study At Tk Alam Jingga, Febi Robianti, Mufutau Oyedapo Raufu, Anis Ulfiyatin

Journal of Innovation and Teacher Professionalism

This study aims to analyze the structure, content, and integration of a play-based learning implementation guide as a pedagogical instrument to support reflective learning in early childhood education at TK Alam Jingga. A descriptive qualitative approach with document analysis was employed. The primary data source was the Play-Based Learning Implementation Guide, which integrates operational guidelines, technical procedures, instructional planning tools, and a monitoring and evaluation system. Data were collected through intensive and iterative document review and analyzed using qualitative content analysis. The findings indicate that the guide is systematically integrated and functions as a comprehensive pedagogical system rather than merely …

Early-Stage Rectal Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm Treated With Local Excision In A Frail Elderly Patient: A Multidisciplinary Management Dilemma, Christopher M. Ahmad, Rae-Anne Kastle, Talyn Smith, Harsha Kalagana, Kerry Williams-Wuch

Student Publications

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the rectum are rare tumors that typically demonstrate aggressive behavior, largely driven by high-grade neuroendocrine carcinoma components. Evidence guiding management is limited, particularly for early-stage lesions and for patients unable to tolerate standard oncologic surgery. We report the case of an elderly man with extensive comorbidities who was found to have a 1.3 cm rectal MiNEN following transanal endoscopic microsurgery (TEMS) performed for rectal bleeding. Histopathology revealed a moderately differentiated adenocarcinoma component and a well-differentiated grade 1 neuroendocrine tumor (NET) component, with submucosal invasion greater than 2 mm, negative margins, low tumor budding, small-vessel lymphovascular …

Reconstructing Plant Use And Food Practices: Microbotanical Evidence From Starch Grain Analysis In The Manteño Occupation At Río Blanco, Manabí, Ecuador, Jocelynne Alexandra Ayala Vera

Electronic Theses and Dissertations

The research examines plant resource management and food processing practices of the Manteño occupation of the Río Blanco, Manabí, Ecuador, through the analysis of starch grain residues recovered from archaeological artifacts. Twenty-six samples from four archeological sites (N4C4-044, N4C4-064, N4C4-068, N4C4-090) associated with domestic artifacts such as fragments of comales, vessels, and metates were analyzed, from which a total of 546 starch grains were identified, corresponding to several plant taxa including maize (Zea mays), beans (Phaseolus spp.), sweet potato (Ipomoea batatas), manioc (Manihot esculenta), chili pepper (Capsicum spp.), and squash (Cucurbita …

Patent Law Clinic Assists Innovator Addressing Water Insecurity, Shahrokh Falati

NYLS Community News

No abstract provided.

Ultrasound Neuromodulation Reveals Distinct Roles Of The Dorsal Anterior Cingulate Cortex And Anterior Insula In Learning, Nomiki Koutsoumpari, Johannes Algermissen, Siti Yaakub, Hanneke E. M. Den Ouden, Nadège Bault, Elsa Fouragnan

School of Psychology

Pavlovian biases reflect how evolutionarily hard-wired tendencies—automatic approach toward reward cues and withdrawal from threat cues—can interfere with flexible, goal-directed action. Such biases arise through three mechanisms: (a) anticipated rewards energize action while anticipated punishments suppress it (response bias), (b) agents learn differently from actions than from inactions (learning bias), and (c) reward/punishment cues themselves drive repetitive behavior, independent of outcomes (perseveration bias). The neural origin of these biases is unclear. Past evidence suggests dorsal anterior cingulate cortex (dACC) and anterior insula (aIns) as part of a “reset network” that rapidly responds to salient information and might contribute to these …

Mitochondrial Etf Insufficiency Drives Neoplastic Growth By Selectively Optimizing Cancer Bioenergetics, David Papadopoli, Sergej Djuranovic, Et Al.

2020-Current year OA Pubs

Mitochondrial electron transport flavoprotein (ETF) insufficiency causes metabolic diseases known as a multiple acyl-CoA dehydrogenase deficiency (MADD). In contrast to muscle, ETFDH is a non-essential gene in acute lymphoblastic leukemia NALM6 cells, and its expression is reduced across human cancers. In various human cancer cell lines and mouse models, ETF insufficiency caused by decreased ETFDH expression limits flexibility of OXPHOS fuel utilisation but paradoxically increases bioenergetics and accelerates neoplastic growth via activation of the mTORC1/BCL-6/4E-BP1 axis. Collectively, these findings reveal that while ETF insufficiency is rare and has detrimental effects in non-malignant tissues, it is common in neoplasia, where ETFDH …

Logistic Regression For Estimating Functional Effects With Spatial Transcriptomics, Michael Barkasi, Cody Nhan Pham, Demetrios Neophytou, Hysell V Oviedo

2020-Current year OA Pubs

Spatial transcriptomics (ST) unlocks potential for studying gene functions in processes that depend on orchestration of transcription across space. However, analysis tools for ST remain aimed at data exploration, with few resources for hypothesis testing. What's missing is a way to test whether a factor of interest affects functionally relevant parameters of a gene's spatial distribution. We present a tool to fill this gap, which we call a warped sigmoidal Poisson-process mixed-effects (WSP, pronounced "wisp") model. WSP models are the first ST tool allowing researchers to test critical questions without bespoke preprocessing pipelines for identifying key spatial parameters. By aligning …

Large-Scale Genetic Characterization Of Parkinson's Disease In The African And African Admixed Populations, Fulya Akçimen, Scott A Norris, Erin R Foster, Et Al.

2020-Current year OA Pubs

Elucidating the genetic contributions to Parkinson's disease aetiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization of potentially disease-causing, protein-altering and splicing mutations in 710 cases and 11 827 controls from genetically predicted African or African admixed ancestries. We explored copy number variants (CNVs) and runs of homozygosity in prioritized early onset and familial cases. Our study identified rare GBA1 coding variants to be the most frequent mutations among patients with Parkinson's disease, with a frequency of 4% in our case cohort. Of the 18 …

Contemplative Classrooms For Ecological Wisdom: Reimagining K-12 Education In Pakistan, China, And Beyond, Maha Shoaib, Jing Lin, Yueyue Wang

Journal of Contemplative and Holistic Education

This paper explores the transformative potential of contemplative environmental education in addressing the growing disconnection between humans and the natural world, particularly within K-12 education systems shaped by anthropocentric and capitalist paradigms. Modern schooling often frames nature as an object of study, rather than a sacred, living presence, contributing to ecological alienation amid intensifying environmental crises. We propose a radical shift toward contemplative, holistic education that draws on spiritual, Indigenous, and ecological knowledge systems. Grounded in Daoist philosophy, Islamic teachings on stewardship, Hindu ethics, and Indigenous worldviews, we reimagine education as a relational and sacred engagement with the Earth. We …