Digital Commons Network^™

Shared Genomic Segments Analysis Identifies Mhc Class I And Class Iii Molecules As Genetic Risk Factors For Juvenile Idiopathic Arthritis, Cecile N. Avery, Nicole D. Russell, Cody J. Steely, Aimee O. Hersh, John F. Bohnsack, Sampath Prahalad, Lynn B. Jorde

Markey Cancer Center Faculty Publications

Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease encompassing several clinically defined subtypes of varying severity. The etiology of JIA remains largely unknown, but genome-wide association studies (GWASs) have identified up to 22 genes associated with JIA susceptibility, including a well-established association with HLA-DRB1. Continued investigation of heritable risk factors has been hindered by disease heterogeneity and low disease prevalence. In this study, we utilized shared genomic segments (SGS) analysis on whole-genome sequencing of 40 cases from 12 multi-generational pedigrees significantly enriched for JIA. Subsets of cases are connected by a common ancestor in large extended pedigrees, increasing the …

Review Of Methodological Decisions In Life Cycle Assessment (Lca) Of Biorefinery Systems Across Feedstock Categories, James Gaffey, Maurice N. Collins, David Styles

Publications

The application of life cycle assessment (LCA) to biorefineries is a necessary step to estimate their environmental sustainability. This review explores contemporary LCA biorefinery studies, across different feedstock categories, to understand approaches in dealing with key methodological decisions which arise, including system boundaries, consequential or attributional approach, allocation, inventory data, land use changes, product end-of-life (EOL), biogenic carbon storage, impact assessment and use of uncertainty analysis. From an initial collection of 81 studies, 59 were included within the final analysis, comprising 22 studies which involved dedicated feedstocks, 34 which involved residue feedstocks (including by-products and wastes), and a further 3 …

Identifying A Group Of Factors Predicting Cognitive Impairment Among Older Adults, Longgang Zhao, Yuan Wang, Eric Mishio Bawa, Zichun Meng, Jingkai Wei, Sarah Newman-Norlund, Tushar Trivedi, Hatice Hasturk, Roger Newman-Norlund, Julius Fridriksson Ph.D., Anwar T. Nerchant

Faculty Publications

Background

Cognitive impairment has multiple risk factors spanning several domains, but few studies have evaluated risk factor clusters. We aimed to identify naturally occurring clusters of risk factors of poor cognition among middle-aged and older adults and evaluate associations between measures of cognition and these risk factor clusters.

Methods

We used data from the National Health and Nutrition Examination Survey (NHANES) III (training dataset, n = 4074) and the NHANES 2011–2014 (validation dataset, n = 2510). Risk factors were selected based on the literature. We used both traditional logistic models and support vector machine methods to construct a composite score …

Factors Affecting Honey Bee (Apis Mellifera L.) Health As Perceived By South Georgia Commercial Beekeepers, Kimberly Post

Journal of Extension

Honey bees (Apis mellifera L.) are critical to the pollination of many crops. Bee-oriented organizations survey beekeepers annually to gather information about colony loss and contributing factors. Unfortunately, these surveys provide insufficient data from sideliner and commercial beekeepers in Georgia. Through a survey to better understand South Georgia beekeepers’ perceptions of honey bee health, this project engaged a previously underrepresented group of sideliner and commercial beekeepers.

Baccalaureate Nurses' Experiences And Understanding Of Adults Living With Sickle Cell Disease, Shelia A. Reid

Dissertations

Background: Sickle cell disease (SCD) is a chronic, genetic blood disorder with most treatment interventions geared toward the acute phase of the disease, which often leads to fragmented care. In Canada, the teaching of SCD occurs without a genetic competency, resulting in miscommunication, misunderstanding, and inadequate nursing care.

Purpose: This investigator examined baccalaureate nurses' experiences and understanding of working with adults living with SCD.

Methods: A semi-structured interview guide was used to explore baccalaureate nurses' experiences and understanding of working with young adults living with SCD.

Results: Lindseth and Norbergs' (2004) interpretation of Ricoeur's hermeneutic interpretative phenomenological approach was used …

2024 Conference Program, Georgia Southern University

South East Coastal Conference on Languages & Literatures (SECCLL)

2024 Conference Program

Intrinsic Vs. Extrinsic Religiosity: Implications For The Parasympathetic Nervous System, Sydnee Bond, Hannah Hornberger, Parker Mckasson, Patrick Steffen Phd

FHSS Mentored Research Conference

Background

Intrinsic religiosity is a deeply rooted connection to one's faith. Individuals with high intrinsic religiosity find purpose and meaning through their spiritual connections. Extrinsic religiosity is primarily driven by social or other superficial factors. Intrinsic religiosity has demonstrated associations with lower self-reported stress, however, associations between intrinsic/extrinsic religiosity and baseline heart rate variability (HRV), a proxy measure of the parasympathetic nervous system, have not been studied. We hypothesize that higher self-reported stress will be associated with a lower baseline HRV, higher intrinsic religiosity will be correlated with higher baseline HRV, and intrinsic religiosity will serve as a buffer, such …

Charting The Cellular Biogeography In Colitis Reveals Fibroblast Trajectories And Coordinated Spatial Remodeling, Paolo Cadinu, Kisha N Sivanathan, Aditya Misra, Rosalind J Xu, Davide Mangani, Evan Yang, Joseph M Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J Quintana, Ana C Anderson, Vijay K Kuchroo, Jeffrey R Moffitt, Roni Nowarski

Faculty, Staff and Student Publications

Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used multiplexed error-robust fluorescence in situ hybridization (MERFISH) to profile the expression of 940 genes in 1.35 million cells imaged across the onset and recovery from a mouse colitis model. We identified diverse cell populations, charted their spatial organization, and revealed their polarization …

2024 April 11 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Risk Factors For Failure Of Same-Day Discharge Total Knee Arthroplasty, Kevin X. Farley, Robert S. Dean, Eli Auch, Mark Karadsheh, Drew Moore

Conference Presentation Abstracts

OBJECTIVE: Cemented total knee arthroplasty (TKA) is the gold standard treatment for osteoarthritis, but uncemented TKA offers benefits like improved osseointegration and reduced complications from cement debris. This study aimed to investigate (1) if there has been a rise in uncemented TKA and (2) if there are differences in early complications between cemented and uncemented TKA. METHODS: We retrospectively reviewed data from the Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) database of primary TKA patients from 2017 to 2021 at a single health system (six hospitals). Uncemented TKA (uncemented fixation for femur and tibia) patients were analyzed for demographics and …

National Incidence And Economic Burden Of Revision Shoulder Arthroplasty In The United States: Projections Through 2030, Kevin X. Farley, Robert S. Dean, Eric R. Wagner, Michael B. Gottschalk, J Michael Wiater

Conference Presentation Abstracts

PURPOSE: This study sought to use an all-payor inpatient claims database to investigate the incidence and national cumulative costs of revision shoulder arthroplasty in the United States, including those being performed for PJI. In addition, we also aimed to project the incidence and national economic impact of revision shoulder arthroplasty in the US through 2030. METHODS: The National Inpatient Sample (NIS) was used to estimate the annual number of revision shoulder arthroplasties performed between 2008 and 2019 using ICD procedure codes. Cumulative national costs were estimated. Septic revision shoulder arthroplasties were identified (i.e., cases being done for a prosthetic joint …

Sex Differences In Adult Incarceration After Pediatric Traumatic Brain Injury, Anurag Modak, Kyle E. Zappi, Alexander J. Catoya, Mehdi S. Lemdani, Gretchen M. Koller, Laurel Seltzer, Ryan E. Radwanski, Susan C. Pannullo

Student Publications

Pediatric traumatic brain injury (pTBI) is a major risk factor associated with adulthood incarceration. Most research into the link between pTBI and adulthood incarceration has focused on incarcerated males, who comprise the vast majority of incarcerated adults, particularly in industrialized nations. In this review, we sought to identify sex-related differences in the incidence and pathophysiology of pTBI and subsequent risk of adulthood incarceration. A scoping review was undertaken using PubMed, Scopus, Ovid, and the Cochrane Library. Articles analyzing sex-related differences in pTBI and adult incarceration rates, studies conducted on an incarcerated population, and cohort studies, cross-sectional studies, clinical trials, systematic …

Inservice Professional Development For Educators In A Democracy: Moving From Theory To Practice, Rachel Lynn Wadham

Theses and Dissertations

This dissertation presents research that addresses the question of how professional development influences inservice teachers' professional identity. In three journal articles, specific inquiries address research questions drawn from this broader conversation. In article one, we answered the question of what unifying characteristics democratic educators exhibit in their pedagogies and methods. By conducting an integrative literature review, we find that those who indicate that they are democratic educators used four major pedagogical categories including inquiry methods, artistic methods, oral methods, and student-centered methods. In the second article, we addressed the question of how professional development influences teachers' professional civic identities. In …

The Effectiveness Of Using Near-Peer Role Models And Mentoring: A Phenomenological Reflection On Stem For Success, Bruce G. Bukiet, Cristo Leon, James Lipuma

STEM for Success Resources

The proper study of communication from existing models opens the doors to scientific research that allows exploring language and coding as an integral part of effective communication to generate new models that include Trans-Disciplinary Collaboration. The authors analyze the communication factors to describe the application of Trans-Disciplinary Communication. This paper aims to define communication processes and their relationship with language, considering their impact on trans-disciplinary collaboration and innovation. After conducting a systematic literature review, the article explored the concepts of communication, functions, language, and Trans-Disciplinary Communication. This led to its application in the convergence research approach presented in the Collaborative …

Genomes Of Bacteroides Ovatus, B Cellulosilyticus, B Uniformis, Phocaeicola Vulgatus, And P Dorei Isolated From Gut Cavernous Fistulous Tract Micropathologies In Crohn’S Disease, Vaidhvi Singh, Gail West, Claudio Fiocchi, Fabio Cominelli, Caryn E Good, Michael R Jacobs, Alexander Rodriguez-Palacios

Faculty, Staff and Student Publications

Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six CavFT bacterial isolates representing the Bacteroidota genera Bacteroides and Phocaeicola. Plasmids were identified in Bacteroides cellulosilyticus and Phocaeicola vulgatus.

Quaker Campus, April 11, 2024 (Vol. 22, Issue 13), Whittier College

Quaker Campus

No abstract provided.

Strength And Stiffness Optimization Of Coated Structures With Lattice Infill, Ali Tamijani, Zhichao Wang

Publications

A machine-implemented method for establishing optimized parameters defining a model of a coated structure with a lattice infill can include receiving constraints for the model of the coated structure. The machine-implemented method can also include initializing a lattice infill defined by respective lattice cells according to the constraints for the model of the coated structure. The machine-implemented method can also include optimizingthe lattice infill and a shape of the coated structure by iteratively modifyingthe lattice infill and the shape of the coated structure and evaluating a strength-based criterion. The machine-implemented method can also include generating, usingthe optimized lattice infill and …

Platonic Intelligence And The United States Constitution, Elizabeth M. Iglesias

USF Tampa Graduate Theses and Dissertations

This dissertation demonstrates the Platonic logic that informs the order of value and design elements of the U.S. Constitution as defended in the Federalist Papers. The dissertation has four movements that reveal the Platonic logic of the U.S. Constitution. The first takes up the repudiation of tyranny in defense of a way of being called ordered liberty in both Plato and the Federalist. The second takes up the commitment to the supremacy of intelligence over power, an order of value that is distinctly Platonic and permeates the design logic of the U.S. Constitution. Intelligence in this context is understood as …

Seminoles, Soldiers, And Settlers: Identity And Power On The Florida Frontier, Jean Louise Lammie

USF Tampa Graduate Theses and Dissertations

This project uses an historical archaeological approach to analyze the processes of cultural negotiation between disparate social groups living in a remote borderland in the early to mid-nineteenth centuries. Florida, first colonized by the Spanish in the 1500s was passed to the United States in 1821 as part of the young nation’s nascent Manifest Destiny. The Seminoles experienced multiple colonial conflicts, dealt with new diseases, and selected aspects of European culture to incorporate into their daily practices of lifeways.

Archaeological studies of culture change tend to focus on the product of colonial interactions rather than the processes of change that …

‘Joining The Dots: Linking Prenatal Drug Exposure To Childhood And Adolescence’ – Research Protocol Of A Population Cohort Study, Kate Lawler, Mithilesh Dronavalli, Andrew Page, Evelyn Lee, Hannah Uebel, Barbara Bajuk, Lucinda Burns, Michelle Dickson, Charles Green, Lauren Dicair, John Eastwood, Ju Lee Oei

Faculty, Staff and Student Publications

INTRODUCTION: Prenatal drug exposure (PDE) is one of the most important causes of child harm, but comprehensive information about the long-term outcomes of the families is difficult to ascertain. The

METHODS AND ANALYSIS: Information from routinely collected administrative databases was linked for all births registered in New South Wales (NSW), Australia between 1 July 2001 and 31 December 2020 (n=1 834 550). Outcomes for seven mutually exclusive groups of children with varying prenatal exposure to maternal substances of addiction, including smoking, alcohol, prescription/illicit drugs and neonatal abstinence syndrome will be assessed. Key exposure measures include maternal drug use type, maternal …

‘Joining The Dots: Linking Prenatal Drug Exposure To Childhood And Adolescence’ – Research Protocol Of A Population Cohort Study, Kate Lawler, Mithilesh Dronavalli, Andrew Page, Evelyn Lee, Hannah Uebel, Barbara Bajuk, Lucinda Burns, Michelle Dickson, Charles Green, Lauren Dicair, John Eastwood, Ju Lee Oei

Faculty, Staff and Student Publications

INTRODUCTION: Prenatal drug exposure (PDE) is one of the most important causes of child harm, but comprehensive information about the long-term outcomes of the families is difficult to ascertain. The

METHODS AND ANALYSIS: Information from routinely collected administrative databases was linked for all births registered in New South Wales (NSW), Australia between 1 July 2001 and 31 December 2020 (n=1 834 550). Outcomes for seven mutually exclusive groups of children with varying prenatal exposure to maternal substances of addiction, including smoking, alcohol, prescription/illicit drugs and neonatal abstinence syndrome will be assessed. Key exposure measures include maternal drug use type, maternal …

Recital: Oboe Studio, April 11, 2024, Illinois State University School Of Music

School of Music Programs

Kemp Recital Hall
April 11, 2024
Thursday Evening
7:30 p.m.

Nardilysin-Regulated Scission Mechanism Activates Polo-Like Kinase 3 To Suppress The Development Of Pancreatic Cancer, Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, explaining the often-reduced Plk3 expression in human PDAC. Importantly, a 41-kDa Plk3 (p41Plk3) that contains the entire kinase domain at the N-terminus (1-353 aa) is activated by scission of the precursor p72Plk3 at Arg354 by metalloendopeptidase nardilysin (NRDC), and the resulting p32Plk3 C-terminal Polo-box domain (PBD) is removed by proteasome degradation, preventing the inhibition of p41Plk3 by PBD. We find …

April 11, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Trial Of Early Minimally Invasive Removal Of Intracerebral Hemorrhage, Gustavo Pradilla, Salah G Keyrouz, Et Al.

2020-Current year OA Pubs

BACKGROUND: Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcomes than medical management is not known.

METHODS: In this multicenter, randomized trial involving patients with an acute intracerebral hemorrhage, we assessed surgical removal of the hematoma as compared with medical management. Patients who had a lobar or anterior basal ganglia hemorrhage with a hematoma volume of 30 to 80 ml were assigned, in a 1:1 ratio, within 24 hours after the time that they were last known to be well, to minimally invasive surgical …

Chemotherapy Activates Inflammasomes To Cause Inflammation-Associated Bone Loss, Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu-Amer, Gabriel Mbalaviele

2020-Current year OA Pubs

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including the skeleton, but the underlying mechanisms have yet to be elucidated. Using tumor-free mouse models, which are commonly used to assess direct off-target effects of anti-neoplastic therapies, we found that doxorubicin caused massive bone loss in wild-type mice, a phenotype associated with increased number of osteoclasts, leukopenia, elevated serum levels of danger-associated molecular patterns (DAMPs; e.g. cell-free DNA and ATP) and cytokines (e.g. IL-1β and IL-18). Accordingly, …

Impact Of Self-Reported Loss Of Balance And Gait Disturbance On Outcomes Following Adult Spinal Deformity Surgery, Bassel G Diebo, Munish C Gupta, Et Al.

2020-Current year OA Pubs

No abstract provided.

Use Of Barium For Diagnosis Of Colonic Perforation Leads To Challenging Barium Peritonitis, Ariana Naaseh, Jorge G Zarate Rodriguez, Matthew J Mchale, Grace M Niziolek, Thoi H Ngo, John P Kirby, Lindsay M Kranker

2020-Current year OA Pubs

No abstract provided.

Multisensory Flicker Modulates Widespread Brain Networks And Reduces Interictal Epileptiform Discharges, Lou T Blanpain, Eric R Cole, Emily Chen, James K Park, Michael Y Walelign, Robert E Gross, Brian T Cabaniss, Jon T Willie, Annabelle C Singer

2020-Current year OA Pubs

Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect …

The World Health Organization Was Born As A Normative Agency: Seventy-Five Years Of Global Health Law Under Who Governance, Lawrence O. Gostin, Benjamin Mason Meier, Safura Abdool Karim, Judith Bueno De Mesquita, Gian Luca Burci, Danwood Chirwa, Alexandra Finch, Eric A. Friedman, Roojin Habibi, Sam F. Halabi, Tsung-Ling Lee, Brigit Toebes, Pedro Villarreal

Georgetown Law Faculty Publications and Other Works

The World Health Organization (WHO) was born as a normative agency and has looked to global health law to structure collective action to realize global health with justice. Framed by its constitutional authority to act as the directing and coordinating authority on international health, WHO has long been seen as the central actor in the development and implementation of global health law. However, WHO has faced challenges in advancing law to prevent disease and promote health over the past 75 years, with global health law constrained by new health actors, shifting normative frameworks, and soft law diplomacy. These challenges were …