Digital Commons Network^™

Spatiospectral Lobes And Radiation Modeling Of Partially Coherent Supersonic Jet Noise, Tyce Wayne Olaveson

Theses and Dissertations

Noise fields generated by high-performance military jets are known to contain acoustic structures that differ from their simulated and lab-scale counterparts. These differences may limit current noise control efforts, which are designed and tested at scale before being considered for full-scale aircraft. One such noise structure is the presence of spatiospectral lobes, which appear as multiple spectral peaks at single microphone locations and multiple radiation lobes in field reconstructions. This dissertation uses data collected from the T-7A jet noise measurement to characterize the spatial behavior of the spatiospectral lobes as well as their first time-domain description. A multiple wavepacket decomposition …

Practice With Purpose Policy Project: The Pediatric Ng/Og Tube Safety Hierarchy, Caitlin Roush, Christine Hajovsky, Delaney Dewolf, Elizabeth Hernandez, Giselle Daclan, Jay Barber, Kris Noel, Kristen Dickey, Lynde Craig, Madeline Herrera, Margaret Willenburg, Mckenzie Pedigo, Melynda Olguin, Myesha Vines, Rhianna Brard, Teresa Wynee

Practice With Purpose

No abstract provided.

Ebp-Rc Practive With Purpose: Blood Specimen Collection, Katelyn Clark, Sarah Ritchie, Hinal Gandhi, Brady Franklin, Hailey Holt, Melanie Hubbard, Joshua Mckay, Zan Jayroe, Beena Oommen, Dhanu Bhandari, Erin Bullock, Gabriella Wiemann, Janelle Heygster, Juli Nascimento, Olga De Leon, Sharley Magaan, Tara Gunther, Thi Phan

Practice With Purpose

No abstract provided.

Ebp-Rc Practice With Purpose: Blood Specimen Collection From Piv, Katelyn Clark, Sarah Ritchie, Hinal Gandhi, Brady Franklin, Hailey Holt, Melanie Hubbard, Joshua Mckay, Zan Jayroe, Beena Oommen, Dhanu Bhandari, Erin Bullock, Gabriella Wiemann, Janelle Heygster, Juli Nascimento, Olga De Leon, Sharley Magaan, Tara Gunther, Thi Phan

Practice With Purpose

No abstract provided.

Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Nick Steele, Ahmed Hussain, C. Lexi Baird, Courtney C. Haswell, Delin Sun, Leonel Rangel-Jimenez, Chadi G. Abdallah, Michael Angstadt, Geoffrey May, Hannah Berg, Jennifer U. Blackford, Josh M. Cisler, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Wissam El-Hage, Amit Etkin, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Ryan J. Herringa, Anna R. Hudson, Neda Jahanshad, Tanja Jovanovic, Anthony King, Saskia B.J. Koch, Ruth Lanius, Amit Lazarov, Gen Li

Psychiatry Faculty Publications

Background: Previous investigations of whole thalamus and thalamic nuclei volumes in posttrauma psychopathology have been sparse and limited in scope and have yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic nuclei were obtained from structural brain magnetic resonance imaging scans from 2058 participants across 20 worldwide sites in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Posttraumatic Stress Disorder (PTSD) working group. Methods: Thalamic volumes were compared in trauma-exposed participants with PTSD (n = 238), major depressive disorder (MDD) (n = 184), and comorbid PTSD+MDD (n = 618) and in trauma-exposed control participants (n …

Daily Rainfall Forecasting Over West Bengal With Spatio-Temporal Graph Networks, Risheek Ghosh

Master’s Dissertations

Daily rainfall is hard to forecast where most days are dry, a few days are very wet, and almost all of the rain arrives in one season. This dissertation studies day-ahead rainfall forecasting over West Bengal, India, using models that learn from both the temporal and the spatial layout of measuring stations. We first build up a forecasting model in stages, from simple models that look at one station’s past to a graph-based model that links nearby stations, and we identify the strongest deterministic forecaster among them. We then ask whether the choice of input data changes the story, by …

Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian

Markey Cancer Center Faculty Publications

Cognitive impairment (CI) is prevalent among heart failure (HF) patients. Although the brain injury in HF is multifactorial, oxidative stress and neuroinflammation are common pathological features of neurological disorders and are increasingly recognized as key mechanisms underlying CI. Extracellular vesicles (EVs) are well-established mediators of biological signaling in myocardial function and are widely recognized for transporting a variety of microRNAs. However, whether myocardial injury alters the miRNA profiles of brain EVs, potentially contributing to cognitive impairment (CI) by disrupting brain homeostasis, remains poorly understood. Using a rodent myocardial infarction (MI) model, we isolated brain EVs and characterized their miRNA profiling …

Cardioprotective Effects Of 1,3 Butanediol In Masld Via Reversal Of Cardiac Lipid Accumulation And Suppression Of Cardiac Fibrosis, Olufunto O. Badmus, Landon D. Parrow, Karis E. Mcgowen, La Brenda Bell, Jennifer R. Greer, Marcela De Carvalho Cruz, Terry D. Hinds, David E. Stec

Markey Cancer Center Faculty Publications

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly associated with the development of cardiovascular disease (CVD); however, the mechanisms responsible are currently unknown. We have developed a model of MASLD due to the loss of hepatocyte peroxisome proliferator-activated receptor α (PPARα^HEPKO). We found that plasma beta-hydroxybutyrate (BHOB) levels were significantly reduced in PPARα^HEPKO mice and aimed to investigate the therapeutic potential of restoring BHOB levels in the development of CVD in these mice. Thirty-week-old PPARα^HEPKO and control PPARα^FL/FL mice were randomized to receive 1,3 butanediol (1,3-BDO), a precursor of BHOB, in drinking water for 6 …

Antioxidant Therapy Reverses Hepatotoxicity Induced By Microcystin-Lr In A Cellular Model Of Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Apurva Lad, Jason Kindle, Prajwal Hegde, Gabriel G. Kleer, Andrew L. Kleinhenz, Johnna A. Birbeck, Judy Westrick, Nicholas J. Peraino, Terry D. Hinds, Neeraja Purandare, Andrew M. Fribley, Steven T. Haller, David J. Kennedy

Markey Cancer Center Faculty Publications

Microcystin-LR (MC-LR) is a potent hepatotoxin that has been shown to cause liver damage even at doses lower than the established Low Observable Adverse Effect Level (LOAEL) of 200 μg/kg in animal models. We have previously observed that low-dose exposure to MC-LR in animals with diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and subsequent treatment with antioxidants like N-acetylcysteine (NAC) and the Na⁺/K⁺ ATPase-Src kinase inhibitor pNaKtide significantly alleviated hepatic infiltration of immune cells, downregulated markers of inflammation and hepatotoxicity, increased the breakdown of the toxin molecule, and restored phase I and II drug metabolism pathways, including …

Chemical Structure Representation Standardization Is Needed To Generalize Metabolite-Pathway Involvement Prediction Across Kegg, Reactome, And Metacyc Knowledgebases, Erik D. Huckvale, Hunter N.B. Moseley

Markey Cancer Center Faculty Publications

Background/Objectives: Due to the utility of knowing the pathway involvement of metabolites detected in biological experiments, knowledgebases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome, and MetaCyc have annotated compound entries to specific pathways defined by the knowledgebase. However, these compound-pathway annotations are largely incomplete and are costly to obtain experimentally or curate from published scientific literature. This metabolite-pathway annotation incompleteness problem is amenable to machine learning (ML)-based solutions. But to date, no machine learning model has been trained on all three knowledgebases to maximize its performance and robustness. This may be due to inconsistencies in chemical …

GαQ Is A Heterotrimeric G-Protein Subunit That Directs The Selectivity Of Pparγ-Induced Gene Pathways Toward Energy-Related Processes Rather Than Adiposity, Evelyn A. Bates, Zachary A. Kipp, Wang Hsin Lee, Genesee J. Martinez, Sally N. Pauss, Philipp E. Scherer, Terry D. Hinds

Markey Cancer Center Faculty Publications

Background/Objectives: Signaling mediators of PPARγ influence pathways involved in adipogenesis, lipid storage, inflammation, energy-related processes, and glucose utilization. Recent research indicates that PPARγ coregulators, recruited or released during ligand binding, govern specific gene pathways. It was recently discovered that Gα_q, a heterotrimeric G protein subunit, also signals to PPARγ and may significantly affect adipogenesis and glucose sensitivity. Methods: To explore Gα_q’s role in adipocytes, we generated CRISPR-mediated Gα_q (Gnaq) knockout (Gnaq KO) and scramble control cells from 3T3-L1 preadipocytes. Results: The absence of Gα_q resulted in increased lipid accumulation and elevated serine 273 (but …

In Situ Molecular Organization And Heterogeneity Of The Legionella Dot/Icm T4ss, Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen

Markey Cancer Center Faculty Publications

The Dot/Icm type IV secretion system (T4SS) is essential for Legionella pneumophila infection, but its in situ architecture and mechanism remain incompletely understood. Using cryo-electron tomography, we performed subtomogram averaging and 3D classification to resolve structural heterogeneity within the complex. We identified multiple assembly states of the inner membrane complex, including a fully assembled form with a hexamer-of-dimers DotO ATPase and symmetry mismatches between subcomplexes. A composite in situ model revealed a central channel above the inner membrane, likely used for substrate secretion. Imaging of infected macrophages showed T4SSs tethered to host vacuoles and extracellular vesicle release, suggesting additional effector …

Understanding The Role Of Age And U.S. Acculturation Factors On The Relationship Between Allostatic Load And Cancer Mortality Risk In Hispanic Americans, Jessica Amezcua, Valeria Miranda, Melissa Lopez-Pentecost, Jessica Y. Islam, Marlo M. Vernon, Kathleen O’Connor, Justin Xavier Moore

Markey Cancer Center Faculty Publications

Purpose: Despite growing recognition of stress-related health inequities, the role of nativity and acculturation in shaping the relationship between chronic stress and cancer outcomes among Hispanic populations remains poorly understood. The purpose of this study was to examine whether nativity factors (United States (US) citizenship status and length of time residing in the US modify the association between allostatic load (AL), a measure of chronic physiologic stress, and cancer mortality among Hispanic adults. Methods: We performed a prospective cohort analysis using data from the National Health and Nutrition Examination Survey (NHANES) 1999 – 2010, linked to National Death Index with …

How Much And How Fast Do Investors Respond To Equity Premium Changes? Evidence From Wealth Taxation, Andreas Fagereng, Luigi Guiso, Marius Ring

Cowles Foundation Discussion Papers

Using administrative panel data on Norwegian investors’ portfolios, we document strong but slow portfolio allocation responses to a persistent wealth-tax-induced shock to the equity premium. Short-run responses resemble the modest sensitivity documented using surveys. The longer-run responses are much larger and can be rationalized by moderate risk aversion. We document that equity premium shocks affect stock market entry but not exits, suggesting that entry costs dominate participation costs. Our finding of slow responses supports the asset-pricing literature that uses adjustment frictions to explain important asset-pricing puzzles, and has implications for optimal capital taxation when tax rates differ across assets.

Enhancing Postsecondary Outcomes For Students With Emotional And Behavioral Disorders: A Design-Based Mixed Methods Approach To Transition Planning, Kate M. Schrum

Dissertations

Students with emotional and behavioral disorders (EBD) experienced significantly lower postsecondary outcomes when compared to same-aged peers. These outcomes included lower graduation rates, higher unemployment rates, and difficulty establishing independent living arrangements (Wagner & Newman, 2015). Following a human-centered, design-based approach, the scholar-practitioner found a lack of consistent and meaningful transition support specifically designed for students with EBD. Working with a stakeholder team of educational professionals directly involved in supporting transition for students with EBD at an alternative special education program, the scholar-practitioner developed a "Transition Toolkit". The toolkit contained scaffolded grade-level checklists (for grades 6–12) with self-advocacy and goal-setting …

Compliance And Systems Data Management Report: Monthly Waiver Participation Trends, June 2026, Tennessee. Department Of Disability And Aging

Compliance & System Data/Reports

This monthly report provides data on various aspects of the department's activities and programs.

Can Generative Ai Make Farming Decisions? Current Status And Future Pathways: A Case Study In Row Crop Production With Chatgpt, Nipuna Chamara, Yufeng Ge, Joe Luck, Yu Pan, Saleh Taghvaeian, Cory Walters, Christopher Proctor, Daran Rudnick, Daren Redfearn

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The agricultural decision-making process is experience-based, knowledge-dependent, time-sensitive, complex, and driven by historical data. Planting, fertilization, irrigation, and chemigation are key categories in farm decision-making, and currently there is no one-shot decision-support tool that covers all these activities. Generative Artificial Intelligence (AI) models are more advanced than traditional machine learning and deep learning models. These models have been trained on vast amounts of data from the internet, allowing them to accept unstructured data in various forms and generate human-like text, solutions to problems, and scenario predictions. Given this capability, we became interested in exploring the potential of generative AI in …

Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Elizabeth Vaughan, Xiaoying Yu, Amber Amspoker, Aanand Naik, Ashok Balasubramanyam, Craig Johnston, Christi Ballantyne, Salim S. Virani, Shelton Brown, Kristina Mena

Population Health, East Africa

Importance  Community health workers (CHWs) improve chronic disease management in underserved populations, but scalable integration strategies are limited.

Objective  To evaluate whether a multidimensional intervention incorporating telementored CHWs and a structured participant-CHW-clinician feedback loop can improve diabetes outcomes.

Design, Setting, and Participants  This 12-month randomized clinical trial was conducted at 3 institutionally and geographically diverse community clinics in Texas between September 1, 2023, and April 30, 2025, and included low-income, uninsured White Hispanic adults with type 2 diabetes identified through clinic databases. Data were analyzed between May 1 and July 31, 2025.

Intervention  Individuals were randomized 1:1 to the intervention …

Mathematical Models Of Multisensory Detection And Decision-Making, Rebecca M. Brady

Doctoral

The brain seamlessly integrates signals from multiple sensory modalities to interpret the world efficiently. By using information from various senses, the brain can enhance its ability to detect and respond to stimuli more quickly and accurately. However, combining sensory cues from multiple modalities is only sometimes beneficial as it may lead to illusions and reduced behavioural performance. Behavioural and electrophysiological experiments have revealed that detection and decision-making strategies for multisensory cues evolve throughout human development and ageing. Additionally, studies have demonstrated that maladaptive multisensory processing is a key indicator of a proclivity to falls in older adults and individuals with …

News Media Coverage Of Measure Ula: How The Story Of La’S Big Project To Address Homelessness And Affordable Housing Got Sidetracked By The Story Of Big Real Estate, Christopher R. Martin

Faculty Publications

“Measure ULA,” named after United to House LA, was approved by voters in Los Angeles in 2022 to create a dedicated, long-term funding source for solutions to homelessness in LA, including funding the construction of affordable homes and preventing homelessness by helping tenants stay in their homes. The funding would come from a new tax on the most expensive real estate transactions in L.A. (i.e., mansion tax), and would affect fewer than 4% of all property transactions. At the end of three years of local news coverage about Measure ULA from the Los Angeles Times and LAist, the news audience …

Newly Diagnosed Solid Tumors (Diagnostic Management), Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Hunger, Hardship, And Distress In Late Life: A Moderated Mediation Analysis Of Wealth, Food Insecurity, And Psychological Distress Among Older Kenyans, James Muruthi, Gabrielle Maloney, Beatrice Oppong, Joy Ogingo, Diana Orawo, Risper Kirui

Psychological Science Faculty Publications

No abstract provided.

Free Flap Eras, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Mastoiditis, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Ndls Communicator: Week Of 06.01.26, Notre Dame Law School

NDLS Communicator

The Latest News

• Notre Dame Law School’s Religious Liberty Clinic Advises Catholic Dioceses on Best Practices for Organizational Governance

Student News

• The Notre Dame Exoneration Justice Clinic (EJC) hosted a welcome picnic yesterday for this year’s cohort of students joining the EJC’s summer internship program
• Perla Khattar, J.S.D. candidate

Alumni News

• Thomas Curtin, ‘68 J.D.
• Batul Ather, ’24 J.D. 

Faculty Briefs

• Paolo Carozza
• Paolo Carozza & Msgr. John Paul Kimes
• Paul Miller
• Carter Snead
• Derek Muller
• Lloyd Mayer
• Daniel Slate
• Devan Patel, 20' J.D.
• Dan Kelly, former colleague

Around the Watercooler

• Happy Birthday to celebrants in May
• ND Well-Being Reminders …

The Effects Of Adverse Childhood Experiences On Female College Students' Social Emotional Development: Is Flourishing Possible?, Kaylee Kirkwood

University Honors Theses

Adverse childhood experiences are events of trauma and abuse that occur prior to age eighteen. High rates of sexual violence against girls and female undergraduate students inspired this study to explore how trauma may impact development and overall college experience. This thesis employed a small exploratory pilot study to investigate childhood trauma and social-emotional development among a small sample of female college students (ages 18-25; n = 41). Participants recruited through the Prolific Database completed an online Qualtrics survey consisting of screeners, demographic questions, measures of trauma history and emotional functioning, and optional open-ended experience-based questions. Measures were guided by …

A Twilight World Of Unspeakable Horror: Lesbian Camp And The Vampire Lovers (1970), Mirielle Lemay

University Honors Theses

From the late 1960s through the early 1970s, a wave of lesbian vampire themed exploitation films proliferated through UK, US, and Western European cinemas. In critical literature on this subgenre, camp reading is often dismissed, unacknowledged, or understood as circumscribed by authorial intent and/or intended audience. With this alternating lack of attention to and dismissal of camp, the interpretive agency of the queer spectator is constrained, their spectatorship implicitly subordinated to that of the "conventional" horror audience—the voyeuristic-sadistic male spectator. Through a reading of The Vampire Lovers, a 1970 British production from Hammer Studios, I seek to explore how …

Disability Experiences Of University Students: An Interview Study, Cece Austin

University Honors Theses

This thesis explores the experiences of college/university students with disabilities within the educational system. Using a qualitative research design, semi-structured interviews were conducted with students who identify as disabled or having disabilities in order to explore impacts of disability on their lives, with a focus on experiences navigating academic environments and accessing accommodations. Findings revealed two recurring themes: 1) the importance of both registered accommodations and accessibility efforts from faculty, and 2) difficulties with accommodations, internalized ableism, and disclosure. This research contributes to broader discussions on disability, inclusion, and educational equity by highlighting the lived experiences of students with disabilities …

Holding Pattern: The Making Of An Ep, On Intuition, And Form Becoming The Content, Oscar Larson Phillips

University Honors Theses

This craft essay traces the making of "Holding Pattern," a three-song EP representing the culmination of five years of development in composition, production, lyric writing, and sound engineering. Each song addresses its own distinct emotional territory: the tension between confidence and self-doubt, resistance to creative conformity, and the experience of emotional dissociation. Together they form a single arc: reaching out, holding your ground, and surviving it. This essay moves through each song, examining how production decisions, lyrical construction, and the recording process each served the content of the work. Working intuitively across composition, sampling, collaboration, and recording, what only became …

Applications Of Prior And Novel Computational Tools In Mental Health Treatment, And Their Potential To Uncover The Explanatory Gap, Ambika Vyas

University Honors Theses

The explanatory gap is a widely discussed concept in scientific and philosophical literature. In neuroscience, the solution to the explanatory gap is highly sought out, but the general consensus is that it is unsolvable. Numerous articles discuss the explanatory gap alongside computational tools and how these tools could aid neuroscientists in uncovering the mental health explanatory gap. However, significant developments in machine learning have been made since 2020, coinciding with the rise in Large Language Models (LLMs). This thesis is a literature review on computational methods, tools, and devices developed and utilized by researchers to improve how mental health disorders …