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2024-04-11 Faculty Welfare & Concerns Committee Meeting Minutes, Morehead State University. Faculty Senate., Faculty Welfare & Concerns Committee.

Faculty Senate Records

Meeting minutes from the Faculty Welfare & Concerns Committee for April 11, 2024.

Supporting An Infrastructure For Experienced Nurses: A Fellowship Foundation, Melissa Oberle

Nursing

A Nursing Professional Development (NPD) Specialist identified 90% of first-year turnover occurred with experienced nurses in the acute care setting, which accrues a cost of $60,000 per nurse. Experienced nurses departed within the first year of hire due to the work environment and personal reasons. This high-risk population had minimal targeted training, specifically nurses with greater than six months of experience. A survey of newly hired experienced nurses revealed interest in a program to support their transition. An experienced nurse fellowship program was created to promote a healthy work environment, professional growth, and retention by allowing organizational assimilation. The program …

Enhancement Of Applied Rice Breeding Programs: Exploring Factors Impacting Genomic Selection Accuracy And Discovery Of A Novel Gene For Grain Shape, Maria G. Montiel

LSU Doctoral Dissertations

Plant breeding is a crucial tool in addressing global challenges such as climate change, population growth, and the need for more resilient crops. Rice serves as a staple food for a significant portion of the global population and has served as a model crop for genetic and genomic studies. Genomic selection (GS) has become valuable tool in plant breeding, allowing breeders to predict breeding lines’ performance based on their genotypes. The training (TS) set is a central component of genomic selection and the optimization of the training set is crucial for efficient implementation of genomic selection. The first two objectives …

Research On 3d Printing Resin Exposure Properties And Its Application On Centrifugal Microfluidic Platform Based On Fluorescence Detection, Zheng Qiao

LSU Doctoral Dissertations

This dissertation encapsulates significant advancements in the field of SLA 3D printing and centrifugal microfluidics. Central to the research is the development of a novel mathematical model for predicting trapped resin thickness in SLA 3D printing, a groundbreaking contribution that addresses a critical aspect of printing intricate structures. This model, the first to establish a mathematical relationship for resin thickness, is rooted in a comprehensive study of the resin curing process. The research leverages the concept of 'critical dosage' for resin curing, leading to a more refined and theoretically grounded approach for calculating curing thickness. Experimentation further validates the model, …

Targeted Deletion Of Nr2f2 And Vcam1 In Theca Cells Impacts Ovarian Follicular Development: Insights Into Polycystic Ovary Syndrome?†, Nicholes R Candelaria, Joanne S Richards

Faculty, Staff and Students Publications

Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) as a selective androgen target gene in specific NR2F2/SF1 (+/+) theca cells. By deleting NR2F2 and VCAM1 selectively in CYP17A1 theca cells in mice, we documented that NR2F2 and VCAM1 impact distinct and sometimes opposing theca cell functions that alter ovarian follicular development in vivo: including major changes in ovarian morphology, steroidogenesis, gene expression profiles, immunolocalization images (NR5A1, CYP11A1, NOTCH1, CYP17A1, INSL3, VCAM1, NR2F2) as well as …

Patterns, Drivers, And Implications Of Postfire Delayed Tree Mortality In Temperate Conifer Forests Of The Western United States, Sebastian Busby, Cody Evers, Andrés Holz

Geography Faculty Publications and Presentations

Conifer forest resilience may be threatened by increasing wildfire activity and compound disturbances in western North America. Fire refugia enhance forest resilience, yet may decline over time due to delayed mortality—a process that remains poorly understood at landscape and regional scales. To address this uncertainty, we used high-resolution satellite imagery (5-m pixel) to map and quantify delayed mortality of conifer tree cover between 1 and 5 years postfire, across 30 large wildfires that burned within three montane ecoregions in the western United States. We used statistical models to explore the influence of burn severity, topography, soils, and climate moisture deficit …

Lead Compound Development Of Src-3 Inhibitors With Improved Pharmacokinetic Properties And Anticancer Efficacy, Dong Lu, Jianwei Chen, Li Qin, Imani Bijou, Ping Yi, Feng Li, Xianzhou Song, Kevin R Mackenzie, Xin Yu, Bin Yang, Sandipan Roy Chowdhury, James D Korp, Bert W O'Malley, David M Lonard, Jin Wang

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is a critical mediator of many intracellular signaling pathways that are crucial for cancer proliferation and metastasis. In this study, we performed structure-activity relationship (SAR) exploration and drug-like optimization of the hit compound SI-2, guided by in vitro/in vivo metabolism studies and cytotoxicity assays. Our efforts led to the discovery of two lead compounds, SI-10 and SI-12. Both compounds exhibit potent cytotoxicity against a panel of human cancer cell lines and demonstrate acceptable pharmacokinetic properties. A biotinylated estrogen response element (ERE) pull-down assay demonstrated that SI-12 could disrupt the recruitment of SRC-3 and p300 in …

Upstarts T3: An Asynchronous And Cohort-Based Entrepreneurship Train-The-Trainer Program, Surin Kim, Maria Rosario T. De Guzman, Kieu-Anh Do, Irene Padasas, Claire Nicholas, Olivia Kennedy, Anna Erdmann, Andy Larson

Journal of Extension

UpStarts is a reverse-mentoring youth program designed to foster an entrepreneurial mindset among participants and a sense of connection between youth and adults. Effective facilitators are critical to the success of the program. This paper describes an asynchronous, cohort-based virtual train-the-trainer (T3) program for potential UpStarts facilitators that was developed to navigate the challenges posed by the COVID pandemic. Participants of the initial UpStarts T3 program reported positive feedback for the training and a high sense of efficacy in implementing UpStarts in their communities. The current T3 model is emerging as a promising means of preparing facilitators to implement UpStarts …

Latinx Science Students’ Sense Of Belonging In Rural Wisconsin, Patrick Robinson, Cynthia Baeza, Luis Gonzalez-Quizhpe, Abigail Robinson, Diego Román, Katherine Ward

Journal of Extension

This study explores the sense of belonging of rural middle and high school Latinx science students in Wisconsin. Between 2000 and 2015, the Latinx population was the fastest growing ethnic group in Wisconsin and increased by 95%. Yet, little is known about the experiences of these students in rural schools or their engagement in science learning. Our research contributes to addressing this knowledge gap and provides insights into Latinx student experiences relative to the science classroom and community. Our findings indicate that a primary determinant of Latinx science students’ positive sense of belonging is a positive relationship with their teachers.

Evaluation Of The Michigan Water School: Water Education Program For Local Leaders, Heather A. Triezenberg, Jennifer Hunnell, Erick Elgin, Bindu Bhakta, Mary Bohling

Journal of Extension

Local leaders are essential for helping Michigan achieve its 30-year water strategy goals. The Michigan Water School is an Extension nonformal educational program to address the knowledge gap of local leaders. We evaluated programs conducted from 2017-2019. Results revealed program outcomes in knowledge, attitudes, perceptions of criticalness to work, and stewardship and behavioral intentions aligned to water quality, water quantity, and field experience units. Growth areas for program improvement include water policy, economics, planning, and finance as well as expanding the focus of the program for transformational leadership and to broaden recruitment efforts.

An Instrument To Evaluate 4-H Cloverbud Stem Programming, Alisha M. Hardman, Donna J. Peterson, Mariah S. Morgan, H. Elizabeth Solace

Journal of Extension

Evaluation data is needed to demonstrate the impact of 4-H science, technology, engineering, and mathematics (STEM) programming on children and youth. However, collecting evaluation data from cloverbuds (ages 5-7) is particularly challenging given their developmental age. We adapted an observational Cloverbud evaluation tool to measure basic life skills, essential elements of positive youth development experiences, and, unique to this tool, STEM specific experiences. We developed the STEM items using educational science standards allowing Extension to document STEM in addition to youth development outcomes. Doing so, may increase the adoption of 4-H STEM programming by teachers in the school setting.

Tools For Capturing Outcomes In Virtual Educational Programs, Leyla Marandi, Eleanor Haworth, Vikram Koundinya, Katherine Webb-Martinez, Kit Alviz

Journal of Extension

During the COVID-19 pandemic, organizations increased virtual programming and adoption of online technologies. This article outlines the [University redacted] assessment of tools for gathering data on participant learning outcomes from virtual educational programs. After assessing colleagues’ experiences and searching for new web applications, a central repository was created. [University redacted] team will use this information to assist extension professionals in collecting program planning and evaluation data. We believe that these tools can help other extension programs nationally and globally with similar efforts, as more virtual programming is likely to increase in the future.

Trial Of Early Minimally Invasive Removal Of Intracerebral Hemorrhage, Gustavo Pradilla, Salah G Keyrouz, Et Al.

2020-Current year OA Pubs

BACKGROUND: Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcomes than medical management is not known.

METHODS: In this multicenter, randomized trial involving patients with an acute intracerebral hemorrhage, we assessed surgical removal of the hematoma as compared with medical management. Patients who had a lobar or anterior basal ganglia hemorrhage with a hematoma volume of 30 to 80 ml were assigned, in a 1:1 ratio, within 24 hours after the time that they were last known to be well, to minimally invasive surgical …

Use Of Barium For Diagnosis Of Colonic Perforation Leads To Challenging Barium Peritonitis, Ariana Naaseh, Jorge G Zarate Rodriguez, Matthew J Mchale, Grace M Niziolek, Thoi H Ngo, John P Kirby, Lindsay M Kranker

2020-Current year OA Pubs

No abstract provided.

Impact Of Self-Reported Loss Of Balance And Gait Disturbance On Outcomes Following Adult Spinal Deformity Surgery, Bassel G Diebo, Munish C Gupta, Et Al.

2020-Current year OA Pubs

No abstract provided.

Multisensory Flicker Modulates Widespread Brain Networks And Reduces Interictal Epileptiform Discharges, Lou T Blanpain, Eric R Cole, Emily Chen, James K Park, Michael Y Walelign, Robert E Gross, Brian T Cabaniss, Jon T Willie, Annabelle C Singer

2020-Current year OA Pubs

Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect …

Organizing The Dissemination And Implementation Field: Who Are We, What Are We Doing, And How Should We Do It?, Gretchen J R Buchanan, Lindsey M Filiatreau, Julia E Moore

2020-Current year OA Pubs

Two decades into its tenure as a field, dissemination and implementation (D&I) scientists have begun a process of self-reflection, illuminating a missed opportunity to bridge the gap between research and practice-one of the field's foundational objectives. In this paper, we, the authors, assert the research-to-practice gap has persisted, in part due to an inadequate characterization of roles, functions, and processes within D&I. We aim to address this issue, and the rising tension between D&I researchers and practitioners, by proposing a community-centered path forward that is grounded in equity.We identify key players within the field and characterize their unique roles using …

Mastigoneme Structure Reveals Insights Into The O-Linked Glycosylation Code Of Native Hydroxyproline-Rich Helices, Jin Dai, Meisheng Ma, Qingwei Niu, Robyn J Eisert, Xiangli Wang, Poulomi Das, Karl F Lechtreck, Susan K Dutcher, Rui Zhang, Alan Brown

2020-Current year OA Pubs

Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicroscopy (cryo-EM) to determine the structure of the hydroxyproline-rich mastigoneme, an extracellular filament isolated from the cilia of the alga Chlamydomonas reinhardtii. The structure demonstrates that mastigonemes are formed from two HRGPs (a filament of MST1 wrapped around a single copy of MST3) that both have hyperglycosylated poly(hydroxyproline) helices. Within the helices, O-linked glycosylation of the hydroxyproline residues and O-galactosylation of interspersed serine residues create a …

Macromolecular Condensation Organizes Nucleolar Sub-Phases To Set Up A Ph Gradient, Matthew R King, Kiersten M Ruff, Andrew Z Lin, Avnika Pant, Mina Farag, Jared M Lalmansingh, Tingting Wu, Martin J Fossat, Wei Ouyang, Matthew D Lew, Emma Lundberg, Michael D Vahey, Rohit V Pappu

2020-Current year OA Pubs

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nucleolar proteins. We show that the localization preferences of nucleolar proteins are determined by their IDRs and the types of RNA or DNA binding domains they encompass. In vitro reconstitutions and studies in cells showed how condensation, which combines binding and complex coacervation of nucleolar components, contributes to nucleolar organization. D/E tracts of nucleolar proteins contribute to lowering the pH of co-condensates formed with nucleolar RNAs in vitro. In cells, this …

Chemotherapy Activates Inflammasomes To Cause Inflammation-Associated Bone Loss, Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu-Amer, Gabriel Mbalaviele

2020-Current year OA Pubs

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including the skeleton, but the underlying mechanisms have yet to be elucidated. Using tumor-free mouse models, which are commonly used to assess direct off-target effects of anti-neoplastic therapies, we found that doxorubicin caused massive bone loss in wild-type mice, a phenotype associated with increased number of osteoclasts, leukopenia, elevated serum levels of danger-associated molecular patterns (DAMPs; e.g. cell-free DNA and ATP) and cytokines (e.g. IL-1β and IL-18). Accordingly, …

Promoting The Use For Sugammadex In Robotic- Assisted Surgeries:, Amr Ali

Scholars Week

No abstract provided.

Prevalence And Severity Of Adhd Among Children With Second-Hand Smoke Exposure – A Us Population-Based Study, Saral R. Desai, Edward Lin

Tower Health Research Day

No abstract provided.

Predictors Of Treatment Admissions For Hallucinogen Use In The United States, Saral R. Desai, Hayden Sando, Edward Lin

Tower Health Research Day

No abstract provided.

Typhlitis In A Neutropenic Patient, Alice He Bs, Wern Lynn Ng Md, Lay She Ng Md, Si Yuan Khor Md, Chandi Garg Md

Tower Health Research Day

No abstract provided.

Wisdom & Creativity In Interior Design, Joshua Shockley

Seminar in Textiles and Clothing

Joshua Shockley graduated in 2001 from the University of Rhode Island with a B.S. in Textile Science and later obtained a Certificate of Interior Decorator at the Rhode Island School of Design (RISD). With this background, Shockley has built a successful solo business specializing in high-end residential and boutique design projects across New England. His approach emphasizes client communication, contract clarity, and textile performance, especially in healthcare settings. He exercises freedom by refraining from utilizing modern marketing strategy as he relies on word of mouth and a legacy client program to grow his clientele. His journey exemplifies the balance of …

Correlation Of Am Lpbf Processing Parameters To Grain Morphology Of Ss316l, Patrick Merighe

Student Research Symposium

Laser Powder Bed Fusion (LPBF) is a 3D printing technology that uses a recoater to spread powdered metal across a substrate. A laser then selectively fuses layers of this metal powder, intricately shaping three-dimensional objects. This process repeats, with each new layer of powder being spread across the previous layer to form a solid part.

Optimizing Nonprofit Impact: A Comprehensive Approach To Donor Data Management, Gracie Shippen

Student Research Symposium

The Malouf Foundation, addresses the critical issue of sexual violence, abuse, assault, exploitation, and human trafficking with an innovative donor data management program. This new program optimizes support for survivors while educating the public, increasing donations, and igniting community engagement.

• Maximizes resources for survivors, showing the impact of philanthropy on social issues.
• Boosts donations and awareness of sexual violence and trafficking.
• Drives increased support for survivors.

Navigating Uncertainty In Tax Strategy Due To The Tax Cuts And Jobs Act (Tcja) Sunset, Tate Smith

Student Research Symposium

Everyone files taxes and wants to pay as little as possible, but tax planning becomes complicated when new laws could come into effect. This research was designed to find the best tax planning strategy for the upcoming 2025 Tax Cuts and Jobs Act Sunset.

Development Of Systems For Processing & Managing Donations For The W.A.B. Warming Center, Landon Corbett

Student Research Symposium

The purpose of this project was to identify the specific needs of the William A. Burnard (WAB) Warming Center related to processing and managing donations and inventory and then propose a needs-based, evidenced-informed solution.

Predictable Movement Behaviors Of Feral Horses Make Them Vulnerable To Cougar Predation, Katelyn Davies

Student Research Symposium

Background

• Horses are water -dependent species whereas deer can get much of their water from forage
• Horses are typically diurnal, deer are crepuscular, and cougars show crepuscular and nocturnal behavior