Digital Commons Network^™

Seeding Effects Of Submicron Caal-No3 Ldh Particles On The Hydration And Properties Of Portland Cement And Sulfoaluminate Cement Pastes, Sukanta K. Mondal, Monday Uchenna Okoronkwo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Layered Double Hydroxide (LDH) Is Reported To Improve The Durability Of Concretes, Primarily Due To Its Ability To Exchange Anionic Species, Including Chloride, Which Is Implicated In Corrosion-Driven Durability Issues. However, There Is No Comprehensive Study Investigating The Effect Of LDH On The Properties Of Different Cement Systems At Both Early And Mature Ages. In This Study, The Early Age And Mature Age Properties Of Portland Cement (OPC) And Calcium Sulfoaluminate (CSA) Cement Pastes Seeded With Submicron-Sized Calcium Aluminum-NO3 LDH (CaAl-NO3 LDH) Were Investigated. The Effects Of The 1–5%mass Dosage Of LDH On The Hydration Of Both Cement Systems Were …

Assessing Hydrolysis Performance Of Ce(Oh)4@Pim-1 Composites Functionalized With Amidoxime, Aldoxime, And Carboxylate Groups Toward Dimethyl 4-Nitrophenylphosphonate, A Nerve Agent Simulant, Peter O. Aina, Sukanta K. Mondal, Ali A. Rownaghi, Fateme Rezaei

Chemical and Biochemical Engineering Faculty Research & Creative Works

In recent years, significant attention has been directed toward evaluating the reactivity of diverse polymers to gauge their catalytic activity against hazardous chemicals. Among these polymers, pim-1 has emerged as an exceptional candidate due to its noteworthy attributes including high surface area, excellent solubility, and the capability to fine-tune the nitrile functional groups along its polymeric backbone. In this study, we explored the impact of different functional groups, such as amidoxime (ax), aldoxime (ox), and carboxylate (cooh), on the degradation of dimethyl 4-nitrophenylphosphonate (dmnp) in comparison to pure pim-1 and their respective ce(oh)4-loaded polymer composites. Remarkably, the pim-1-ax analog exhibited …

2024-04-12 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

The meeting minutes of the Institutional Animal Care and Use Committee for April 12, 2024.

Emerging Therapies For Glioblastoma, Stella Aime Rios, Stephanie Oyervides, David Uribe, Angelica Maree Reyes, Victor Fanniel, Jonathan Vazquez, Megan Keniry

School of Integrative Biological & Chemical Sciences Faculty Publications

Simple Summary

Glioblastoma is the most common malignant brain cancer and is associated with poor prognosis, with an average survival after diagnosis of less than 18 months. Hundreds of clinical trials have been conducted, with more underway to make progress in treating glioblastoma. This review details conventional and emergent targeted therapies for glioblastoma.

Abstract

Glioblastoma is most commonly a primary brain tumor and the utmost malignant one, with a survival rate of approximately 12–18 months. Glioblastoma is highly heterogeneous, demonstrating that different types of cells from the same tumor can manifest distinct gene expression patterns and biological behaviors. Conventional therapies …

Immune Checkpoint Inhibitors: A Narrative Review On Pd-1/Pd-L1 Blockade Mechanism, Efficacy, And Safety Profile In Treating Malignancy, Ian Brandon

All Publications

Checkpoint inhibitors have been implicated in the treatment of several cancers due to their ability to exploit the immune system's regulatory pathways. This article serves to emphasize the importance of these immunotherapeutic agents and provide further insight into their mechanisms, efficacies, and safety profiles. The main agents in question include programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1). Several literature sources were found to assess the use of these inhibitors in cancers involving the lung, breast, and skin. Several peer-reviewed systematic reviews and the outcomes of clinical trials are combined within this article to support the …

A New Vicarious Technique For Radiometric And Spatial Calibration Of Drone-Based Multispectral And Hyperspectral Imaging Systems, David N. Conran

Theses

A new technology (convex mirrors) used for radiometric and spatial characterization of remote sensing imaging systems has demonstrated equal, but unique results when compared to Lambertian targets for vicarious calibration. Using convex mirrors to characterize the radiometric and spatial response of hyperspectral and multispectral imaging systems has yet to be thoroughly investigated for drone-based platforms. When imaged, a convex mirror produces a known radiant intensity source that can characterizes the radiometric and spatial performance of an imaging system. The simultaneous assessment supports a unique understanding of the hyperspectral and multispectral instrument’s response for vicarious characterization. Assessing a new technique for …

Multi-Resolution Diffusion For Privacy-Sensitive Recommender Systems, Derek Lilienthal, Paul Mello, Magdalini Eirinaki, Stas Tiomkin

Faculty Research, Scholarly, and Creative Activity

While recommender systems have become an integral component of the Web experience, their heavy reliance on user data raises privacy and security concerns. Substituting user data with synthetic data can address these concerns, but accurately replicating these real-world datasets has been a notoriously challenging problem. Recent advancements in generative AI have demonstrated the impressive capabilities of diffusion models in generating realistic data across various domains. In this work we introduce a Score-based Diffusion Recommendation Module (SDRM), which captures the intricate patterns of real-world datasets required for training highly accurate recommender systems. SDRM allows for the generation of synthetic data that …

Corrigendum: A Single-Institution Experience With 177lu Rpt Workflow Improvements And Qualifying The Spect/Ct Imaging For Dosimetry, Siju George, Ranjini Tolakanahalli, Santiago Aguirre, Vivek Mishra

All Publications

No abstract provided.

Miniature Battery-Free Epidural Cortical Stimulators, Joshua E Woods, Amanda L Singer, Fatima Alrashdan, Wendy Tan, Chunfeng Tan, Sunil A Sheth, Sameer A Sheth, Jacob T Robinson

Faculty, Staff and Student Publications

Miniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power …

Water, Sanitation, And Hygiene Infrastructure And Resources In Schools In Belize During The Covid-19 Pandemic, 2021-2023, Anh N Ly, Kelsey Mcdavid, Christina Craig, Dian Maheia, Yolanda Gongora, Alexandra Medley, Francis Morey, Russell Manzanero, Gerhaldine Morazan, Allison Lino, Vickie Romero, Rosalva Blanco, Kanako Ishida, Matthew Lozier, Kristy O Murray

Faculty, Staff and Students Publications

Access to water, sanitation, and hygiene (WASH) resources in schools is critical for disease prevention and control, especially during public health emergencies. In Belize, systematic, national data on WASH in schools are needed to inform public health decisions and interventions. From December 2021 to January 2022, a national survey was sent electronically to government and government-aided primary and secondary schools in Belize (N = 308) to gather information on WASH services. From the survey, 12 pilot schools were selected based on the highest self-reported need for WASH resources to participate in additional evaluation and intervention, which included environmental nudges, supplemental …

Fort Hays State University Tiger Weekly, April 12, 2024, University Relations

Tiger Weekly Newsletters

No abstract provided.

Structural Basis Of Dna Crossover Capture By Escherichia Coli Dna Gyrase, Marlène Vayssières, Nils Marechal, Long Yun, Brian Lopez Duran, Naveen Kumar Murugasamy, Jonathan M Fogg, Lynn Zechiedrich, Marc Nadal, Valérie Lamour

Faculty, Staff and Students Publications

DNA supercoiling must be precisely regulated by topoisomerases to prevent DNA entanglement. The interaction of type IIA DNA topoisomerases with two DNA molecules, enabling the transport of one duplex through the transient double-stranded break of the other, remains elusive owing to structures derived solely from single linear duplex DNAs lacking topological constraints. Using cryo–electron microscopy, we solved the structure of Escherichia coli DNA gyrase bound to a negatively supercoiled minicircle DNA. We show how DNA gyrase captures a DNA crossover, revealing both conserved molecular grooves that accommodate the DNA helices. Together with molecular tweezer experiments, the structure shows that the …

Akap12 Upregulation Associates With Pde8a To Accelerate Cardiac Dysfunction, Hanan Qasim, Mehrdad Rajaei, Ying Xu, Arfaxad Reyes-Alcaraz, Hala Y Abdelnasser, M David Stewart, Satadru K Lahiri, Xander H T Wehrens, Bradley K Mcconnell

Faculty, Staff and Students Publications

BACKGROUND: In heart failure, signaling downstream the β2-adrenergic receptor is critical. Sympathetic stimulation of β2-adrenergic receptor alters cAMP (cyclic adenosine 3',5'-monophosphate) and triggers PKA (protein kinase A)-dependent phosphorylation of proteins that regulate cardiac function. cAMP levels are regulated in part by PDEs (phosphodiesterases). Several AKAPs (A kinase anchoring proteins) regulate cardiac function and are proposed as targets for precise pharmacology. AKAP12 is expressed in the heart and has been reported to directly bind β2-adrenergic receptor, PKA, and PDE4D. However, its roles in cardiac function are unclear.

METHODS: cAMP accumulation in real time downstream of the β2-adrenergic receptor was detected for …

Influence Of Rna Circularity On Target Rna-Directed Microrna Degradation, Federico Fuchs Wightman, Jerónimo Lukin, Sebastián A Giusti, Michael Soutschek, Laureano Bragado, Berta Pozzi, María L Pierelli, Paula González, Juan P Fededa, Gerhard Schratt, Rina Fujiwara, Jeremy E Wilusz, Damián Refojo, Manuel De La Mata

Faculty, Staff and Students Publications

A subset of circular RNAs (circRNAs) and linear RNAs have been proposed to 'sponge' or block microRNA activity. Additionally, certain RNAs induce microRNA destruction through the process of Target RNA-Directed MicroRNA Degradation (TDMD), but whether both linear and circular transcripts are equivalent in driving TDMD is unknown. Here, we studied whether circular/linear topology of endogenous and artificial RNA targets affects TDMD. Consistent with previous knowledge that Cdr1as (ciRS-7) circular RNA protects miR-7 from Cyrano-mediated TDMD, we demonstrate that depletion of Cdr1as reduces miR-7 abundance. In contrast, overexpression of an artificial linear version of Cdr1as drives miR-7 degradation. Using plasmids that …

Storylines Of Family Medicine Xii: Family Medicine And The Healthcare System, William B Ventres, Leslie A Stone, Jeannette E South-Paul, Kendall M Campbell, Aerial R Petty, Hima Ekanadham, Kurt C Stange, Rebecca S Etz, William L Miller, Robert L Ferrer, Marianna Kong, Thomas Bodenheimer, Roger Strasser, Sharon C M Reece, Joshua Freeman, John M Westfall

Faculty, Staff and Students Publications

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and elsewhere around the world. In ‘XII: Family medicine and the future of the healthcare system’, authors address the following themes: ‘Leadership in family medicine’, ‘Becoming an academic family physician’, ‘Advocare—our call to act’, ‘The paradox of primary care and three simple rules’, ‘The quadruple aim—melding the patient and the health system’, ‘Fit-for-purpose medical workforce’, ‘Universal healthcare—coverage for all’, ‘The futures of family …

"In Our Community, We Normalize Pain": Discussions Around Menstruation And Uterine Fibroids With Black Women And Latinas, Minerva Orellana, Karen N Dsouza, Jane Q Yap, Abhirami Sriganeshan, M Elena Jones, Charis Johnson, Megan Allyse, Sateria Venable, Elizabeth A Stewart, Felicity Enders, Joyce E Balls-Berry

2020-Current year OA Pubs

BACKGROUND: Uterine fibroids are non-cancerous neoplasms that arise from the uterus affecting over 75% of women. However, there is a disparity with Black women having an increased prevalence of nearly 80%. Black women also experience increased symptom burden, including younger age at the time of diagnosis and increased number and volume of fibroids. Less is known about other ethnoracially diverse women such as Latinas and the potential cultural impacts on fibroid burden and treatment.

METHODS: Community engagement studios were conducted to facilitate discussions with stakeholders on their uterine fibroid and menstruation experience. We recruited Black women (n = 6) diagnosed …

2023-2024 Performance Forum - April 12, 2024, Angela Fiedler, Yu-Hsuan Feng, Li Yang Liu, Isabella Swalm, Sarah Conley, Jaewon Baek, Kari Jenks, Noah Suarez, Kyle Mechmet, Nataniel Farrar, Graydon Howard, Luis Pulido, Santiago Moreno, Andres Borja, Kenton Campbell, Mark Severeniuk, Lauren Washburn, Keegan Neely, Clair Ives, Dina Bikzhanova, William Penn

Performance Forum

No abstract provided.

Perceived Recovery States And Physical Fitness In Reserve Officers’ Training Corps Cadets, Lianne Emanuel, Jessie Hirsch, James Bodendorf, Amy Loin, Gregory Ioannides, Aliya Catanzarita, Tarek Harhash, Joseph Schnatter, Isaac Stein, Sean Kane, Julianne Rung, Katie Sell

International Journal of Exercise Science: Conference Proceedings

Reserve Officers’ Training Corps (ROTC) cadets are challenged mentally, emotionally, and physically with the physical fitness requirements (e.g., Army Combat Fitness Test or ACFT) required within their military science curriculum. Common physical fitness tests such as those for strength, power, and balance can provide insight into the recovery and readiness status of tactical athletes. PURPOSE: The purpose of this study was to explore the relationship between scores on the Short Recovery and Stress Scale (SRSS) and performance on a physical fitness test battery assessing balance, mobility, body composition, muscular strength, and power in collegiate ROTC cadets. METHODS: Seventeen ROTC cadets …

Knee Injuries In Nfl Linemen — Correlation With Bmi, Robert Farrell Md, Michael Lem Md, John Bianchi Do, Austin Irwin, Cole Siegenfeld

International Journal of Exercise Science: Conference Proceedings

Knee injuries are among the most common injuries suffered in the NFL which in turn can decrease a player's playing time in a given season and thus negatively impact future performance. Body Mass Index (BMI) may play a key role in knee injuries and possibly general lower-extremity injuries in high-level athletes. Understanding characteristics like BMI can help modify and identify players at risk for knee injuries. PURPOSE: By analyzing the incidence and sequelae of knee injuries in NFL linemen with their respective BMI, It may be helpful for the NFL to emphasize appropriate body habitus in these players. This ultimately …

Comparing The Effect Of N-95 Vs Surgical Mask Use On Resting Metabolic Data Change, Robert Steinberg, Alexander Rothstein, Amerigo Rossi, Alyssa Hillian, Joanne Difrancisco-Donoghue

International Journal of Exercise Science: Conference Proceedings

Face masks reduce the spread of viral respiratory particles, however, their impact on respiratory physiology requires further research. Previous studies reported reduced gas exchange when wearing a surgical mask, however, breath-by-breath data has not been analyzed. PURPOSE: To compare physiological changes when wearing an N95 mask and surgical mask at rest. Variables measured include oxygen consumption (VO2), carbon dioxide ventilation (VC02), respiratory exchange ratio (RER), heart rate (HR), respiratory rate (RR), minute ventilation (MV), and discomfort. METHODS: 42 subjects ages 18-55 (19 men; age 22.98±3.83) were recruited. Exclusion criteria was a history of metabolic disease/claustrophobia. Respiratory and metabolic data was …

Effects Of Electrical Exercise On Self-Reported Depression And Quality Of Life In Those With Spinal Cord Injury, Aj Barber, Eric Heidorn, John Mcdaniel, Cody S. Dulaney

International Journal of Exercise Science: Conference Proceedings

One of the most common psychological disorders that occur as a result of spinal cord injury (SCI) is depression along with reductions in quality of life. Moreover, depression is correlated with quality of life. It is increasingly apparent that exercise offers an accessible and non-pharmacological intervention to ease depressive symptoms and improve quality of life. Unfortunately, access to meaningful exercise options remains challenging to those with mobility impairments such as those seen with SCI. PURPOSE: The purpose of this study was to assess the chronic engagement of home-based electrical stimulation exercise (ESE) on self-reported depression and quality of life …

Effects Of Electrical Exercise And Affect On Self-Reported Anxiety In Those With Spinal Cord Injury, John Zimmerman, Eric Heidorn, John Mcdaniel, Cody S. Dulaney

International Journal of Exercise Science: Conference Proceedings

Those who have incurred a spinal cord injury (SCI) have severe and immediate changes to their lifestyle. Those with SCI have reported reduced levels of positive affect and no change in negative affect compared to controls. Also, those with SCI may have reduced opportunities for engaging in meaningful exercise either due to mobility or equipment access limitations. PURPOSE: The purpose of this study was to assess the chronic engagement of home-based electrical stimulation exercise (ESE) on self-reported anxiety and positive and negative affect. METHODS: 9 individuals with ASIA A or B SCI were recruited for this study. Participants …

Demonstrating The Effects Of Blood Flow Restriction During Online Strength Training In Older Adults, Daniela Presta

International Journal of Exercise Science: Conference Proceedings

Blood Flow Restriction (BFR) training entails limiting perfusion to specific body areas, allowing low-intensity exercise to simulate the effects of high-intensity workouts. Combining BFR and online exercise classes is a novel way of potentially improving both effectiveness and accessibility of training to an older population. It is essential to maintain strength as people age in order to avoid or manage physiological conditions like sarcopenia and osteoporosis. PURPOSE: To investigate if in five weeks of online low-intensity resistance training, improvements in strength will be greater among the older adults wearing BFR straps. METHODS: Men and women (mean age = …

Effects Of Acute Exercise And Socialization On Mood And Cognition, Justin E. English, Kristine Sabo, Jane Ekhtman, Emmanuel Egwuonwu, Andy Fernandez, Douglas J. Oberlin

International Journal of Exercise Science: Conference Proceedings

How do social interactions, exercise, or a combination of both affect a person’s mood and cognition? Research has shown benefits of aerobic exercise, for example, a recent study showed that group fitness classes decreased perceived stress among a group of medical students. However, it didn’t explain if that was because of the socialization that occurs in a group fitness setting or if it was because of the physical activity. PURPOSE: The purpose of this study was to compare how aerobic exercise and socialization contribute to acute improvements in mood and cognition. METHODS: Participants, recruited from CUNY campuses (n=19), …

Association Between Social Media Use, Muscle Dysmorphic Disorder And Psychological Health In Urban College Students, Andy Velasco-Arriola, Galila Werber-Zion

International Journal of Exercise Science: Conference Proceedings

The online fitness industry has expanded significantly in recent years. Since 2014, TikTok, Instagram and Snapchat have also grown tremendously, resulting in young adults spending hours scrolling on their smartphones looking at perceived ideal-body images. Muscle dysmorphia is a form of body disorder indicated by a pathological desire for increased muscle mass. Among American college students, the most prevalent diagnosed mental health problems are anxiety disorder and/or depression. PURPOSE: This pilot study evaluated the relationship between social media use, psychological health, and muscle dysmorphic disorder in ethnically diverse students attending an urban commuter college. METHODS: Forty-three students (mean age = …

Restoring Effective Sleep Time In Post Cardiac Surgery Patients: A Quality Improvement Project, Brooke Watts Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Restoring Effective Sleep Time in Post Cardiac Surgery Patients: A Quality Improvement Project

Brooke Watts, BSN, RN, DNP Student, Murray State University

Dr. Kristin Reid, DNP, APRN, ACNS-BC, DNP Program Director/Assistant Professor Murray State University

Aims: This quality improvement project was developed using DNP project guidelines provided through Murray State University and was designed to improve sleep in hospitalized cardiac surgery patients.

Processes: IRB approval was obtained from the healthcare institution and academic institution. This two-phase quality improvement project was designed to analyze the effects of a change in normalized hospital routines on self-reported sleep in post-cardiac surgery patients. …

Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara

Epsilon Sigma at-Large Research Conference

Trauma informed care nursing education is crucial. Trauma informed care is a method of providing health care which understands the likelihood of past and present traumatic events in patients and families. The experience of past or present trauma often led to chronic diseases, substance abuse disorder, fragmented health care, fears surrounding health care, chronic stress, and other negative health consequences. The purpose of this project is to increase licensed nurses’ awareness and ability to practice trauma informed care in clinical practice, as well as promote policy initiation within the health care facilities. Method planning integrated the Knowledge to Action Cycle. …

Will The Implementation Of Nurse Competency Days Improve Knowledge And Satisfaction In Nursing Staff Of A Community Health Center?, Christina Morton

Epsilon Sigma at-Large Research Conference

Background: Nursing competencies are important for quality of care, patient safety, and identifying gaps in knowledge and skills. Patient harm has been linked to a lack of competency and insufficient policy and procedures.

Purpose: The purpose of this quality improvement project was to achieve standardization of nursing competencies within nurse-led clinics.

Aims: The aims of this project were to validate select competency days and determine the satisfaction of the competency days by the participants. The second aim of this project was to develop an electronic tracking form. A third aim was to develop and present a policy and procedure …

The Effects Of Age, Employment, Marriage, And Education On Academic Motivation In Undergraduate Nursing Students, Jessica Hamm Msn Rn Phd Student

Epsilon Sigma at-Large Research Conference

The Effects of Age, Employment, Marriage, and Education on Academic Motivation in Undergraduate Nursing Students

Purpose: The amount of research on non-cognitive variables affecting motivation is limited in nursing students. By using Self-Determination Theory, faculty can determine what motivates students to learn which will allow the creation of a learning environment that promotes student achievement.

Aim: To determine the effect age, marriage status, employment, and education level have on academic motivation in nursing students in the third semester of a baccalaureate nursing program within the framework of Self-Determination Theory.

Method: A descriptive correlational design was used to identify the effect …

Comparisons Of Using Alcohol, Coping Strategies, Anxiety, And Depression Between Usa And Taiwanese College Students, Pi-Ming Yeh Associate Professor, Cheng-Huei Chiao Professor, Jennchang Liou Professor

Epsilon Sigma at-Large Research Conference

Purpose: In this study, we compared United States (US) and Taiwanese college students’ using alcohol, coping strategies, anxiety, and depression.

Research Questions:

1. What were the differences in demographic characteristics, using alcohol, coping strategies, anxiety, and depression between US and Taiwanese college students?

2. What were the relationships between US and Taiwanese college students’ using alcohol, coping strategies, anxiety, and depression?

3. How much of US and Taiwanese college students’ anxiety and depression were predicted by their use of alcohol, coping strategies?

Methods: Four hundred and one US and 180 Taiwanese college students were recruited in this study. This was …