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Orchestra, April 15th, Arkansas State University Department Of Music Apr 2024

Orchestra, April 15th, Arkansas State University Department Of Music

Performance Programs

No abstract provided.


Research On Cross-Domain Unmanned Swarm Cooperative Anti-Submarine Search Method, Ning Wang, Xiaolong Liang, Jiaqiang Zhang, Yueqi Hou, Aiwu Yang Apr 2024

Research On Cross-Domain Unmanned Swarm Cooperative Anti-Submarine Search Method, Ning Wang, Xiaolong Liang, Jiaqiang Zhang, Yueqi Hou, Aiwu Yang

Journal of System Simulation

Abstract: For the maritime ASW search, a cross-domain unmanned swarm cooperative search method is proposed in which USVs are used as the communication relay of UAVs. The digital grid map is used to characterize the mission area and the kinematic model of cross-domain platform is constructed. The cooperative method of cross-domain unmanned systems is proposed, and the distributed information fusion mechanism of unmanned systems is designed. The search objective function for heterogeneous platforms is designed to guide the unmanned systems to make real-time decisions in search task. The simulation results show that the proposed method can be effective to the …


Simulation Verification And Decision-Making Key Technologies Of Unmanned Swarm Game Confrontation: A Survey, Xiaolong Liang, Aiwu Yang, Jiaqiang Zhang, Yueqi Hou, Ning Wang, Xiao Huang, Junbin Gong Apr 2024

Simulation Verification And Decision-Making Key Technologies Of Unmanned Swarm Game Confrontation: A Survey, Xiaolong Liang, Aiwu Yang, Jiaqiang Zhang, Yueqi Hou, Ning Wang, Xiao Huang, Junbin Gong

Journal of System Simulation

Abstract: Unmanned swarm game confrontation is a new combat mode and plays a crucial role in intelligent warfare. Its core is the autonomous generation of a series of game confrontation decision sequences to "empower" the swarm. The progress of system simulation verification for the unmanned swarm game confrontation is analyzed. The key technologies of the autonomous decision-making are discussed from three aspects, technology based on expert systems and game theory, technology based on swarm intelligence and optimization theory, and technology based on neural networks and reinforcement learning. The key technology research conducted by the author's team on the autonomous decisionmaking …


Research On Integration Of Virtual-Real Hybrid Simulation Experiment Environment For Unmanned Swarm, Huijie Yang, Taoshun Xiao, Chen Wu, Lingfeng Guo Apr 2024

Research On Integration Of Virtual-Real Hybrid Simulation Experiment Environment For Unmanned Swarm, Huijie Yang, Taoshun Xiao, Chen Wu, Lingfeng Guo

Journal of System Simulation

Abstract: Constructing the experiment environment and researching the core technology, key equipment and operation theory is the key step for the development of unmanned swarm. Based on the requirement of hybrid simulation environment for unmanned swarm, the elements of the experiment environment are analyzed, and the architecture is proposed, which is composed of common infrastructure, general experiment services, special experiment tools, security and support tool. The key experiment environment integration technology is studied from the aspects of experiment network, model data and experiment application. The feasibility of the method to construct the virtual-real hybrid simulation environment is verified by an …


Mixed-Variable Particle Swarm Optimization Algorithm Based On Competitive Coevolution, Hu Zhang, Heng Zhang, Zilu Huang, Zhe Wang, Qingpo Fu, Jin Peng, Feng Wang Apr 2024

Mixed-Variable Particle Swarm Optimization Algorithm Based On Competitive Coevolution, Hu Zhang, Heng Zhang, Zilu Huang, Zhe Wang, Qingpo Fu, Jin Peng, Feng Wang

Journal of System Simulation

Abstract: For the current algorithm, it is difficult to obtain the available solution due to the irregularity of problem decision space caused by the numerous mixed variable optimization problems during real industrial applications. The coevolution strategy is introduced and a mixed variable particle swarm optimization algorithm(CCPSO) based on competitive coevolution is proposed. The search direction adjustment mechanism based on tolerance is designed to judge the evolution state of particles, adaptively adjust the search direction of particles, avoid falling into local optimum, and balance the convergence and diversity of the population. The learning object generation mechanism is adopted for each particle …


Handling Constrained Multi-Objective Optimization Problems Based On Relationship Between Pareto Fronts, Yubo Wang, Chengyu Hu, Wenyin Gong Apr 2024

Handling Constrained Multi-Objective Optimization Problems Based On Relationship Between Pareto Fronts, Yubo Wang, Chengyu Hu, Wenyin Gong

Journal of System Simulation

Abstract: To address the challenges of balancing the constraint satisfaction and objective function optimization, and dealing with the complex feasible regions in constrained multi-objective optimization problems(CMOPs), a classification-based search approach is proposed based on different Pareto front relationships. A dual-population dual-phase framework is proposed in which an auxiliary population Pa and a main population Pm are evolved and the evolution process is divided into a learning phase and a search phase. During the learning phase, Pa explores unconstrained Pareto front (UPF) and Pm explores constrained Pareto front(CPF), through which the relationship between UPF and CPF is determined. After completing the …


Element Grouping Faceted Fully Connected Network Based On Ris, Shunhu Hou, Shengliang Fang, Qingyao Zeng, Mengtao Wang Apr 2024

Element Grouping Faceted Fully Connected Network Based On Ris, Shunhu Hou, Shengliang Fang, Qingyao Zeng, Mengtao Wang

Journal of System Simulation

Abstract: In view of the over-fitting problem that caused by multiple parameters and high memory usage of the full connection layer of neural network in training, a RIS-based element grouping areal fully connected neural network (RGFCNN) is proposed for the first time based on the structural characteristics of reconfigurable intelligence surface (RIS). Based on the structural characteristics of RIS, the network is optimized on traditional FCNN. A novel transmission surface attention mechanism is designed for the effective feature extraction of data. Compared with the traditional FCNNs, the proposed network does not arrange the data in one-dimensional manner. Instead, a element …


In Support Of Industry-Conscious Disclosure Standards For Pharmaceutical And Biotechnology Patents, Mark T. Roundtree Apr 2024

In Support Of Industry-Conscious Disclosure Standards For Pharmaceutical And Biotechnology Patents, Mark T. Roundtree

Texas A&M Law Review

One of the fundamental requirements for a patent application is a disclosure of the invention via an accurate written description with sufficient detail to enable the recreation of the invention. The U.S. patent system has historically reviewed patent applications from various industries with a uniform set of requirements and standards. However, the biotechnology and pharmaceutical industries operate on notably extended product development timelines and face unique administrative pressures related to their products when compared with other industries. In response to these pressures, biotechnology and pharmaceutical companies have traditionally applied for patent protections through liberal use of genus claims and other …


Can You Smell A Lawsuit Cooking? Possible Risks With The Rock’S Trademarks, Cameron Brody Apr 2024

Can You Smell A Lawsuit Cooking? Possible Risks With The Rock’S Trademarks, Cameron Brody

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

Dwayne Johnson is one of the most recognizable and successful working actors on the planet. For an entire generation, he is synonymous with smash-hit franchises such as Baywatch, Tooth Fairy, and Jungle Cruise. In fact, between 2019 and 2021, he was the highest-paid actor in Hollywood and raked in $270,000,000 in 2022 alone. Further, he is a co-founder of Teremana Tequila, which holds an estimated value of $3.5 billion, putting him on track alongside George Clooney and Ryan Reynolds as success stories in the celebrity alcohol market. His most recent endeavor, however, may put him on track towards a series …


Shades Of Green: Navigating The Legality Of Environmental Marketing, David Zack Apr 2024

Shades Of Green: Navigating The Legality Of Environmental Marketing, David Zack

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

A majority of Americans are concerned about climate change.1 This fear seems to be a driver of consumer spending decisions. According to a study by PDI Technologies, 68% of Americans are willing to spend more on environmentally sustainable products than their competitors that are not sustainable.2 This number has steadily grown over the past two years.3 This figure is even greater for key marketing demographics. 77% of Gen Z, 72% of millennials, and 76% of parents would be willing to do so. Because of this, companies have increasingly sought to position and market themselves as green companies.

This post was …


Cas Connections- 2024 Spring Term - April, Dean's Office College Of Arts And Science Apr 2024

Cas Connections- 2024 Spring Term - April, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.


General Non-Destructive Evaluation For Friction Stir Welding, Johnathon Bryce Hunt Apr 2024

General Non-Destructive Evaluation For Friction Stir Welding, Johnathon Bryce Hunt

Theses and Dissertations

Friction stir welding (FSW) is an advantageous solid state joining method for many different engineering designs. It was invented in 1991 by TWI and since that time a tremendous amount of research has been executed to understand and implement FSW in a myriad of materials in numerous industries such as aerospace, ship building, train, automotive, energy, agriculture and others. Most industries have strict weld inspection processes to validate a weld before it is put into service. One of the main weld characteristics that is measured is the size of any subsurface volumetric voids. The current standard to test friction stir …


Application Of The Immobilized Low-Activity Waste Glass Corrosion Model To The Static Dissolution Of 24 Statistically-Designed Alkali-Borosilicate Waste Glasses, Sebastien N. Kerisit, James J. Neeway, Charmayne E. Lonergan, Benjamin Parruzot, Jarrod V. Crum, Richard C. Daniel, Gary L. Smith, R. Matthew Asmussen Apr 2024

Application Of The Immobilized Low-Activity Waste Glass Corrosion Model To The Static Dissolution Of 24 Statistically-Designed Alkali-Borosilicate Waste Glasses, Sebastien N. Kerisit, James J. Neeway, Charmayne E. Lonergan, Benjamin Parruzot, Jarrod V. Crum, Richard C. Daniel, Gary L. Smith, R. Matthew Asmussen

Materials Science and Engineering Faculty Research & Creative Works

Glass corrosion models that capture the complex mechanisms of the glass-water reaction enable the prediction of nuclear waste glass durability in disposal scenarios. Parameterization of such models is challenging because of the need to capture changes in corrosion behavior with time, reaction conditions, and glass composition. Here, we describe and employ the ILAW (immobilized low-activity waste) glass corrosion model (IGCM) in geochemical simulations of static dissolution tests, at two temperatures (40 °C and 90 °C), for a matrix of 24 enhanced low-activity waste (eLAW) glasses statistically designed to cover a processable composition space defined by 8 major glass components (Al …


The Study On Mechanical Model Considering Optimal Self-Adaption In The Bottleneck Area, Longcheng Yang, Huajun Wang, Jun Hu, Hongyu Pan, Juan Wei, Lei You, Hao Zhang, Junxi Wang Apr 2024

The Study On Mechanical Model Considering Optimal Self-Adaption In The Bottleneck Area, Longcheng Yang, Huajun Wang, Jun Hu, Hongyu Pan, Juan Wei, Lei You, Hao Zhang, Junxi Wang

Faculty, Staff and Student Publications

It aims to solve the problem that the evacuation state of pedestrians depicted by the traditional social force model in a crowded multiexit scenario has a relatively large difference with the actual state, especially the 'optimal path' considered by the self-driving force is the problem of shortest path, and the multiexit evacuation mode depicted by the 'herd behavior' is the local optimum problem. Through in-depth analysis of actual evacuation data of pedestrians and causes of problem, a new crowd evacuation optimization model is established in order to effectively improve the simulation accuracy of crowd evacuation in a multi-exit environment. The …


Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker Apr 2024

Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker

Faculty, Staff and Student Publications

PURPOSE: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need.

EXPERIMENTAL DESIGN: Tissue and longitudinal blood specimens from phase III trial S1400I in patients with metastatic squamous non-small cell carcinoma (SqNSCLC) treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink.

RESULTS: Higher immune scores from immune gene expression profiling or immune cell infiltration by mIF were associated with response to ICIs and improved survival, except regulatory T cells, which were associated with worse …


Safety Profile And Adverse Event Management For Futibatinib, An Irreversible Fgfr1-4 Inhibitor: Pooled Safety Analysis Of 469 Patients, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Masashi Shimura, Bailey Anderson, Nanae Hangai, Volker Wacheck, Lipika Goyal Apr 2024

Safety Profile And Adverse Event Management For Futibatinib, An Irreversible Fgfr1-4 Inhibitor: Pooled Safety Analysis Of 469 Patients, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Masashi Shimura, Bailey Anderson, Nanae Hangai, Volker Wacheck, Lipika Goyal

Faculty, Staff and Student Publications

PURPOSE: Futibatinib, a covalently-binding inhibitor of fibroblast growth factor receptor (FGFR)1-4 gained approval for the treatment of refractory, advanced intrahepatic cholangiocarcinoma (iCCA) harboring an FGFR2 fusion/other rearrangement. An integrated analysis was performed to evaluate safety and provide guidance on the management of futibatinib-associated adverse events (AEs) in patients with unresectable/metastatic tumors, including iCCA.

PATIENTS AND METHODS: Data from three global phase I or II studies of futibatinib (NCT02052778; JapicCTI-142552) were pooled. AEs were graded per NCI CTCAE v4.03, where applicable. Safety was analyzed for patients receiving any futibatinib starting dose (overall population) and in those receiving the approved starting dose …


Applying The Consumer Decision-Making Model To An On-Campus Coffee Shop, Madalynne Chapman Apr 2024

Applying The Consumer Decision-Making Model To An On-Campus Coffee Shop, Madalynne Chapman

Honors Projects

The purpose of this research was to use the consumer decision-making model as a framework to assess if there are factors that may prompt (or not prompt) an individual to make a purchase at Forhan’s Café, a small coffee shop located inside of the Maurer Center at Bowling Green State University. To answer this, both a personal interview with a BGSU Dining staff member and an online survey of campus consumers were conducted. The personal interview was conducted to understand their current marketing strategies for the café and to guide the survey design. The online survey consisted of 24 questions …


Clarice Lispector: From Brazil To The World, Earl Fitz Apr 2024

Clarice Lispector: From Brazil To The World, Earl Fitz

Purdue Studies in Romance Literatures

Clarice Lispector: From Brazil to the World explains why the Brazilian master was so transformative of modern Brazilian literature and why she has become such a celebrity in the world literature arena. This book also shows why Lispector is not one writer, as many think, but many writers. By offering close readings of her novels, stories, and nonfiction pieces, Earl E. Fitz shows the diverse sides of her literary world. Chapters cover Lispector’s devotion to language and its connection to identity; her political engagement; and her humor, eroticism, and struggle with the concept of God. The last chapter seeks to …


Personality Traits And Depressive Symptoms Among Chinese Older People: A Network Approach, Jia Lee, Jihong Zhang Apr 2024

Personality Traits And Depressive Symptoms Among Chinese Older People: A Network Approach, Jia Lee, Jihong Zhang

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Background

The present study aims to investigate the network structure of depressive symptoms, the interrelationships between individual personality traits and depressive symptoms, and gender differencesamong Chinese older people aged 60 and above.

Method

We performed network analyses with a regularized Graphical GaussianModel and a case-dropping bootstrap approach. A sample of 4876 older Chinese people aged 60+ was included in the analyses. We investigated the central symptoms in the depression network and the bridge nodes that connect personality facets and depressive symptoms. Gender differences were investigated by testing the global strength, network invariance, and edge weights.

Results

Sadness …


Finite Rigid Sets In Sphere Complexes, Edgar A. Bering, Christopher J. Leininger Apr 2024

Finite Rigid Sets In Sphere Complexes, Edgar A. Bering, Christopher J. Leininger

Faculty Research, Scholarly, and Creative Activity

A subcomplex X≤C of a simplicial complex is strongly rigid if every locally injective, simplicial map X→C is the restriction of a unique automorphism of C. Aramayona and the second author proved that the curve complex of an orientable surface can be exhausted by finite strongly rigid sets. The Hatcher sphere complex is an analog of the curve complex for isotopy classes of essential spheres in a connect sum of n copies of S1×S2. We show that there is an exhaustion of the sphere complex by finite strongly rigid sets for all n≥3 and that when n=2 the sphere complex …


Influence Of Eco-Friendly Agar-Derivatives On The Electrochemical Performance Of Carbon Felts Electrodes Of Vanadium Redox Flow Battery, Abdulmonem Fetyan, Ayoob Alhammadi, Zineb Matouk, Anugrah Andisetiawan, Ahmed Bahaa Apr 2024

Influence Of Eco-Friendly Agar-Derivatives On The Electrochemical Performance Of Carbon Felts Electrodes Of Vanadium Redox Flow Battery, Abdulmonem Fetyan, Ayoob Alhammadi, Zineb Matouk, Anugrah Andisetiawan, Ahmed Bahaa

All Works

In this study, bio-derived natural agar powder was used as an electrocatalyst for application as an electrode in all‑vanadium redox flow batteries. Different concentrations of agar solution were tested, and cyclic voltammetry studies confirmed that agar loaded felts have good catalytic activity toward both redox couples V4+/V5+ at the positive and V2+/V3+ at the negative side. Energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy demonstrated the presence of higher amount of oxygen-functional groups on the surface of the fibers. Contact angle measurements demonstrated an enormous increase in hydrophilicity of the felts treated with agar. Long-term charge/discharge profiles revealed 6 % …


Modelling The Building-Related Photovoltaic Power Production Potential In The Light Of The Eu's Solar Rooftop Initiative, Gergely Molnár, Luisa F. Cabeza, Souran Chatterjee, Diana Ürge-Vorsatz Apr 2024

Modelling The Building-Related Photovoltaic Power Production Potential In The Light Of The Eu's Solar Rooftop Initiative, Gergely Molnár, Luisa F. Cabeza, Souran Chatterjee, Diana Ürge-Vorsatz

School of Geography, Earth and Environmental Sciences

Decarbonizing the building sector is key to meet the EU climate goals by 2050. Although the recent policies recognized the importance of on-site solar energy production in the energy transition, there are only a few modelling studies analyzing how much the gap between the technically possible and policy-driven power generation of rooftop photovoltaic (PV) panels can be reduced. This study, therefore, uses geospatial techniques and the high-resolution Building Integrated Solar Energy (BISE) supply model to estimate the main spatial and temporal characteristics of the rooftop PV energy production potential. To support decision-making, important implications of the Solar Rooftop Initiative action …


China Maritime Report No. 37: Re-Engaging With The World: China's Military Diplomacy In 2023, Jie Gao, Kenneth W. Allen Apr 2024

China Maritime Report No. 37: Re-Engaging With The World: China's Military Diplomacy In 2023, Jie Gao, Kenneth W. Allen

CMSI China Maritime Reports

China’s military diplomacy plays a crucial role in advancing the nation's foreign policy objectives and safeguarding its strategic interests. This report highlights a diverse array of activities within military diplomacy, including senior-level meetings, joint military exercises, naval port calls, UN peacekeeping operations, and academic exchanges. Our findings reveal a significant—but incomplete—recovery in China's military diplomacy activities in 2023, following a period of reduced contacts with foreign militaries during the COVID-19 pandemic. Southeast Asia and Russia remain primary partners for China, with emerging strategic importance also seen in Africa, Oceania, and the Middle East. Overall, China's military diplomacy underscores its efforts …


The Role Internships Play In Political Science Education, Madaline Lankford Apr 2024

The Role Internships Play In Political Science Education, Madaline Lankford

Honors Theses

This project will explore the critical role internships play in undergraduate education, with a particular focus on political science, by examining the history and impact of Western Michigan University’s Capital Internship Program. The study aims to shed light on the diverse experiences of past participants and conduct comprehensive research into the significance of internships in shaping the academic and professional trajectories of countless students. By delving into the stories and reflections of former interns, this research will provide testimonials that underscore the value of experiential learning. These personal accounts will highlight how internships bridge the gap between theoretical knowledge acquired …


State Of Utah, Plaintiff/ Appellee V. Cory Jason Thomas, Defendant/ Appellant : Brief Of Appellant, Utah Court Of Appeals Apr 2024

State Of Utah, Plaintiff/ Appellee V. Cory Jason Thomas, Defendant/ Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Second Judicial District Court, Weber County, Honorable Judge Hyde, District Court No. 211900875

Christopher F. Allred, Benjamin Gabbert, Counsel for Appellee

Hannah Leavitt-Howell, Jessica Hyde Holzer, Counsel for Appellant


Trisha Dawn Small, Appellee/Petitioner And, Nathan Dale Small., Appellant/Respondent: Brief Of Appellee, Utah Court Of Appeals Apr 2024

Trisha Dawn Small, Appellee/Petitioner And, Nathan Dale Small., Appellant/Respondent: Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

INTERLOCUTORY APPEAL FROM THE FIRST DISTRICT COURT. BOX ELDER COUNTY, STATE OF UTAН THE HONORABLE SPENCER WALSIH, PRESIDING

Jeremy G. Jones, Attorney for Respondent/Appellant

Michael E. Christiansen, Attorney for Petitioner/Appellee


Excellence Summit 2024, Office Of Research And Sponsored Projects Operations Apr 2024

Excellence Summit 2024, Office Of Research And Sponsored Projects Operations

Excellence Summit (Research Week) Archived Proceedings

In it's 17th year, the University of the Incarnate Word, welcome all to read and review the proceedings of the annual research week. The 2024 Excellence Summit highlighted academic excellence across all schools featuring topics from nutrition studies to soil amendments, artificial intelligence, medical case studies, and music composition studies. The rich mixture of humanities, health sciences, physical sciences, education, and business can be found in this booklet. We thank all that contributed to these works and hope the community enjoys learning from today's and tomorrow's leaders in research, inquiry, and scholarship.


Mcl-1 Mediates Intrinsic Resistance To Raf Inhibitors In Mutant Braf Papillary Thyroid Carcinoma, Maria Cavallo, Jacob Yo, Kayla Gallant, Camille Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa Sanders, Andrew Aplin, Edmund Pribitkin, Edward Hartsough Apr 2024

Mcl-1 Mediates Intrinsic Resistance To Raf Inhibitors In Mutant Braf Papillary Thyroid Carcinoma, Maria Cavallo, Jacob Yo, Kayla Gallant, Camille Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa Sanders, Andrew Aplin, Edmund Pribitkin, Edward Hartsough

Kimmel Cancer Center Faculty Papers

Papillary thyroid carcinoma (PTC) is the most frequent form of thyroid cancer. PTC commonly presents with mutations of the serine/threonine kinase BRAF (BRAFV600E), which drive ERK1/2 pathway activation to support growth and suppress apoptosis. PTC patients often undergo surgical resection; however, since the average age of PTC patients is under 50, adverse effects associated with prolonged maintenance therapy following total thyroidectomy are a concern. The development of mutant-selective BRAF inhibitors (BRAFi), like vemurafenib, has been efficacious in patients with metastatic melanoma, but the response rate is low for mutant BRAF PTC patients. Here, we assay the therapeutic response …


On Learning Your Gender: A Comprehensive View, Audra M. Hazelwood Apr 2024

On Learning Your Gender: A Comprehensive View, Audra M. Hazelwood

Theses

This essay provides a metaphysical and epistemological account of gender. The metaphysics involves a ‘non-reductionist view of gender’, which is to say that gender cannot be reduced to a single factor. On this view gender begins with one’s innate gender inclinations (in the vein of Julia Serano). These inclinations pick out a specific range of gender possibilities from the gender spectrum that apply to a person. At the same time we live in communities and cultures with certain gender norms. This is where epistemology comes into play since our gender inclinations are filtered through gender norms and some people are …


Friction Stir Welding Of Tube-To-Tubesheet And Spot Joints For Virgin And Recycled Thermoplastic Materials., Syed Haris Iftikhar Apr 2024

Friction Stir Welding Of Tube-To-Tubesheet And Spot Joints For Virgin And Recycled Thermoplastic Materials., Syed Haris Iftikhar

Thesis/ Dissertation Defenses

Thermoplastic materials are becoming popular, due to their chemically inert and anti-fouling properties, for use in industrial heat exchanger applications involving heating/cooling of highly reactive fluids like acids. A novel nonconventional joining framework, based on the friction stir welding (FSW) technique, is developed to create high-quality thermoplastic tube-to-tubesheet joints (TTJs). The proposed technique has applications in the thermoplastic shell-andtube heat exchanger and piping industries (as flange-to-pipe joints). The primary objective is to study the feasibility of the FSW technique for developing thermoplastic TTJs, followed by optimization of the process parameters and detailed material characterizations. This work used workpieces (tube, tubesheet) …