Digital Commons Network^™

Aurora Family Medicine Satellite Clinic At The Coa Goldin Center, Samantha Busch, Anne Getzin, Rachel Castillo, Kjersti Knox, Lorenzya Polnitz, Nicole Thompson

Aurora GME

No abstract provided.

Environmental Health And Community Engagement: An Introductory Curriculum For Pgy-1 Internal Medicine Residents, Amina Maamouri, Victoria Gillet, Deborah Simpson, Kate Buschmann, Kjersti Knox

Aurora GME

No abstract provided.

Challenges And Opportunities Of Developing An Efl Writing Course In Algeria: A Collaborative Auto-Ethnographic Study, Wafa Zekri, Kamal Belmihoub

Publications and Research

No abstract provided.

Analysis Of Post-Traumatic Stress Disorder Gene Expression Profiles In A Prospective, Community-Based Cohort, Jan Dahrendorff, Agaz Wani, Thomas Keller, Don Armstrong, Annie Qu, Derek E. Wildman, Maria Carmen Valero, Karestan C. Koenen, Allison E. Aiello, Monica Uddin

Human Biology Open Access Pre-Prints

Post-traumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, PTSD has been implicated in the development of a variety of chronic conditions including cardiovascular and metabolic diseases, suggesting that the biological alterations associated with the disorder can manifest themselves as chronic diseases in those suffering from PTSD. The biological underpinnings of the disorder are not well understood. Gene expression studies can illuminate the complex physiology of PTSD reflecting the embodiment of trauma, i.e., the process in which traumatic …

Double Reed Studio Recital, Arkansas State University Department Of Music

Performance Programs

No abstract provided.

"Journeys" Singing Statesmen Scarlet Voices Jonesboro Chorale, Arkansas State University Department Of Music

Performance Programs

No abstract provided.

Characterization Of Cellular Metabolism Regulation By The Transcription Factor Centromere Binding Factor 1 (Cbf1), Spencer Ellsworth

Theses and Dissertations

Centromere binding factor 1 (Cbf1) is a transcription factor that controls the transcription of many genes involved in cellular respiration and lipid biogenesis and, as such, has been associated with hypolipidemia in humans. It is a known substrate for PAS kinase, which phosphorylates Cbf1 and alters its activity. Our hypothesis is that this phosphorylation affects the genes it regulates and the DNA motifs it binds to, perhaps due to different transcription complexes being formed. In this study, we conduct a chromatin immunoprecipitation in Saccharomyces cerevisiae to determine what genes and DNA motifs Cbf1 binds to in its wild type versus …

Icu Made 4 U: Critical Care Education For Novice Nurses, Brooke Blair, Taylor Soltis, Jessica Schmidt, Jennifer Rice

2024 Henry Ford Jackson Hospital Research Symposium

Background: The novel Coronavirus 2019 (COVID-19) pandemic had a large impact on education in the healthcare setting. At Henry Ford Jackson Hospital (HFJH), due to staffing constraints and emergent clinical needs, nurses hired during the COVID-19 pandemic did not complete standard critical care orientation after March 2020. During yearly learning needs assessments, nurses identified opportunities for enhanced education regarding the management of critically ill patients. Staff Development Educators and Clinical Nurse Specialists (CNSs) within the acuity adaptable units identified a gap in knowledge regarding critical care concepts. At HFJH, acuity adaptable units house critical care patients on the Medical Universal …

Acute Endophthalmitis: A Case Report Highlighting The Importance Of Swift Diagnosis And Intervention, Abraham Kisule, Sakshi Bai, Ciji Robinson, Niroshan Ranjan, Akhil Rahman

2024 Henry Ford Jackson Hospital Research Symposium

Introduction: Endophthalmitis, a potentially devastating eye infection, can arise from various sources, including trauma, surgery, or intraocular injections. We present a case report of a patient with systemic signs of infection and bilateral eye erythema, whose condition rapidly deteriorated. Swift recognition of the symptoms and timely intervention by the medical team led to a conclusive diagnosis of endophthalmitis. The patient underwent anterior chamber (AC) washout and intravitreal injections, resulting in partial vision recovery. This case emphasizes the critical importance of early diagnosis and intervention to prevent irreversible vision loss and underscores the necessity of proactive management strategies.

Case Presentation: An …

Combating Workplace Violence: The Implementation Of A Behavioral Emergency Response Team, Jessica Schmidt

2024 Henry Ford Jackson Hospital Research Symposium

Background: Workplace violence, patient, and staff safety continue to be a top priority and concern for Henry Ford Jackson Health (HFJH). Evaluating the current process at HFJH, there was no formal process to support clinical staff members to maintain patient and staff safety during acute behavioral health crises on medical inpatient units prior to the activation of a “Security Assistance”, or security personnel response to situations involving an actual or potential physical threat to patients, staff, visitors, or property. Maintaining patient and staff safety, decreasing workplace violence, and mitigating sentinel events is critical. Significance: Violence against health care workers is …

Improving Sleep Quality And Patient Satisfaction By Reducing Nighttime Disturbances In Hospitalized Patients: A Dnp Project, Audrey Rutkowski

2024 Henry Ford Jackson Hospital Research Symposium

In 420-bed Midwest hospital, early 2023 HCAHPS results revealed that only 53% of patients always experienced a quiet nighttime environment. The state average where this hospital resides was 58%, while the national average was 62%.  Further break down revealed a single unit-based score of 16.67% in October 2023, ranking the unit in the 1st percentile nationwide, making this the primary unit of focus for this quality improvement project.

Introduction: Sleep is a primary, basic human need to achieve health and patient satisfaction and outcomes are affected by the quality of sleep in the hospital.

Background and Significance: Noise, light, routine …

Covid-19 Mrna Vaccine Linked To Dysgeusia And Hyposmia: A Case Report, Brian Shin, Anthony C. Tam

2024 Henry Ford Jackson Hospital Research Symposium

Abstract: Commonly reported adverse effects of vaccine administration include localized erythema, pain, lymphadenopathy, myalgias, fatigue, nausea, vomiting, fever, and in extreme cases, anaphylaxis. Myocarditis, pericarditis, and thrombosis have been reported as rare side-effects of COVID vaccine administration.3 Here, we present the case of a 74 year old male, who reported the onset of persistent dysgeusia and hyposmia shortly after receiving the Moderna COVID mRNA vaccine.

Hyponatremia As A Predictive Marker Of Mortality In Hospitalized Covid-19 Patients: A Healthcare System Analysis, Harjinder Singh, Candi C. Bachour, David Metcalf, Kavita Luthra, Vivek Kak

2024 Henry Ford Jackson Hospital Research Symposium

Background: There is documented evidence associating hyponatremia with mortality in hospitalized patients, including patients admitted with coronavirus disease-2019 (COVID-19) pneumonia [1] One of the proposed mechanisms of hyponatremia in COVID-19 is the syndrome of inappropriate antidiuretic hormone (SIADH) due to circulating cytokines such as IL-6 [2] These cytokines are proposed to be associated with lung inflammation and correlate with respiratory failure and in-hospital mortality [3] This study was undertaken to associate the severity of hyponatremia with in-hospital mortality in patients admitted with COVID-19 in multiple hospitals over a single health system network.

Objectives: To determine if hyponatremia is associated with …

Unusual Complication Of Pneumoperitoneum After Robotic Bronchoscopy On The MonarchTm Platform, Ashley Day, Mohan G. Kulkarni

2024 Henry Ford Jackson Hospital Research Symposium

Introduction: Bronchoscopy with associated mediastinal lymph node sampling and biopsy of pulmonary lesions is critical in the diagnosis of pulmonary disease, such as cancer or inflammatory conditions, as well as in oncologic staging. Biopsies via traditional flexible bronchoscopy have been limited to lesions easily accessible by the mainstem bronchi or larger segmental branches. Endobronchial ultrasound with fine needle aspiration (EBUS-FNA) of mediastinal lymph nodes or extraluminal lesions in central locations may also be performed. However, peripheral pulmonary lesions are often unable to be accessed easily or safely through flexible bronchoscopy. Computed Tomography (CT) guided transthoracic needle aspiration is an alternative …

The Colored Cap Project, Erin Andrews, Sylvester Paulasir

2024 Henry Ford Jackson Hospital Research Symposium

Trauma bays are a place in which the importance of teamwork and communication play an integral role in patient outcomes. Effective teamwork ensures that each team member plays their designated role with precision and contributes to the overall effort of stabilizing and treating trauma patients. Due to the large draw of resources to a small area (the trauma bay) the area can become crowded, and roles of each person become blurred or redundant. The aim of this project was to determine if personnel identification with colored caps improved communication and trauma bay crowd control.

The Generation Of Terahertz Light And Its Applications In The Study Of Vibrational Motion, Aldair Alejandro

Theses and Dissertations

Terahertz (THz) spectroscopy is a powerful tool that uses ultrashort pulses of light to study the properties of materials on picosecond time scales. THz light can be generated through a variety of methods. In our lab, we generate THz through the process of optical rectification in nonlinear optical (NLO) organic crystals. THz light can be used to study several phenomena in materials, such as spin precession, electron acceleration, vibrational and rotational motion. The work presented in this dissertation is divided into two parts: (1) the generation of THz light and (2) applications of THz light. The first portion of this …

Trauma-Informed Mindfulness-Based Stress Reduction To Increase Family Quality Of Life For Mothers Of Children With Autism: A Pilot Study, Carol May Vaughn

Theses and Dissertations

Mothers of children with autism have a higher rate of stress than mothers of neurotypical children and mothers of children with other disabilities. This impacts their family quality of life. This study aimed to show that by teaching mothers trauma-informed mindfulness-based stress reduction techniques they were able to switch their perspectives and feel that they had increased the relationships with their child with autism and increased the rating they give their family quality of life. The participants were recruited using word of mouth and through distribution of posters to autism communities following approval of the experiment through the institutional review …

Distinguishing Between Symptom Presence And Severity Using A Two-Part Sequential Model, Luiza Ferreira Pradera

Theses and Dissertations

Most symptom measures either implicitly or explicitly distinguish between symptom presence and symptom severity. For example, item 2 on the PHQ-9, a commonly used measure of depressive symptoms, asks respondents to rate how much they have been 'feeling down, depressed, or hopeless.' The response options are 0 (Not at all), 1 (Several Days), 2 (More than half the days), and 3 (Nearly every day). Answering 0 indicates that the symptom is not present, and any response greater than 0 suggests the symptom is present. Higher values indicate higher severity of the symptom. Although the response options distinguish between symptom presence …

Brafv600e-Mutant Metastatic Nsclc: Disease Overview And Treatment Landscape, David Planchard, Rachel E Sanborn, Marcelo V Negrao, Aria Vaishnavi, Egbert F Smit

Faculty, Staff and Student Publications

In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging treatment options, BRAF sequencing approaches, and unmet needs. The BRAFV600E mutation confers constitutive activity of the MAPK pathway, leading to enhanced growth, proliferation, and survival of tumor cells. Testing for BRAF mutations enables patients to be treated with therapies that directly target BRAFV600E and the MAPK pathway, but BRAF testing lags behind other oncogene testing in metastatic NSCLC. Additional therapies targeting BRAFV600E mutations provide options for patients with metastatic NSCLC. Emerging therapies and combinations under investigation could …

Detection And Characterization Of Copy Number Variation In Three Differentially-Selected Nellore Cattle Populations, Lorena F. Benfica, Luiz F. Brito, Ricardo D. Do Bem, Leticia F. De Oliveira, Henrique A. Mulim, Larissa G. Braga, Joslaine N.S.G. Cyrillo, Sarah F.M. Bonilha, Maria Eugenia Z. Mercadante

Purdue University Libraries Open Access Publishing Fund

Introduction: Nellore cattle (Bos taurus indicus) is the main beef cattle breed raised in Brazil. This breed is well adapted to tropical conditions and, more recently, has experienced intensive genetic selection for multiple performance traits. Over the past 43 years, an experimental breeding program has been developed in the Institute of Animal Science (IZ, Sertaozinho, SP, Brazil), which resulted in three differentially-selected lines known as Nellore Control (NeC), Nellore Selection (NeS), and Nellore Traditional (NeT). The primary goal of this selection experiment was to determine the response to selection for yearling weight (YW) and residual feed intake (RFI) on Nellore …

Optimal Aoi For Systems With Queueing Delay In Both Forward And Backward Directions, Chih-Chun Wang

Department of Electrical and Computer Engineering Technical Reports

Age-Of-Information (AoI) is a metric that focuses directly on the application-layer objectives, and a canonical AoI minimization problem is the update-through-queues models. Existing results in this direction fall into two categories: The open-loop setting for which the sender is oblivious of the packet departure time, versus the closed-loop setting for which the decision is based on instantaneous Acknowledgment (ACK). Neither setting perfectly reflects modern networked systems, which almost always rely on feedback that experiences some delay. Motivated by this observation, this work subjects the ACK traffic to a second queue so that the closed-loop decision is made based on delayed …

Cross-Sectional Study Of Personal Protective Equipment Use, Training And Biosafety Preparedness Among Healthcare Workers During The First Months Of The Sars-Cov-2 Pandemic In Brazil, Kerstin Muner, Julia Kilgour, Tatiana Ometta, Ana Perola Drulla Brandao, Andrea Pires Dos Santos, Ana Marcia Sa Guimaraes

Purdue University Libraries Open Access Publishing Fund

Objectives Brazil has high rates of COVID-19 and tuberculosis among healthcare workers (HCWs). Personal protective equipment (PPE) is essential for their protection. We aimed to evaluate PPE use, training, and preparedness among HCWs in the early months of the SARS-CoV-2 pandemic in Brazil.

Methods A cross-sectional study was performed using questionnaires available to HCWs through a website created to provide PPE guidelines. χ2 test and robust Poisson regression identified factors associated with HCWs treating COVID-19 patients (TCOVID-19), lack of training on PPE use and N95 respirator reuse. The speech content of open-ended questions was analysed.

Results We analysed 1410 questionnaires …

Relief In Gastrointestinal Symptoms With Medical Marijuana Over 1 Year, Matthew P. Wallingford, Erin L. Kelly, Allison Herens, Daniel Hanna, Emily Hajjar, Brooke Worster

Department of Family & Community Medicine Faculty Papers

INTRODUCTION: Subjective improvement in gastrointestinal (GI) symptoms was assessed among patients using medical marijuana (MMJ).

METHODS: Participants completed surveys at 0 days, 30 days, 6 months, and 12 months with questions about the severity of their GI symptoms on a scale from 1 (mild) to 3 (severe).

RESULTS: In each survey, participants reported a significant decrease in GI symptom severity when using MMJ versus when not using MMJ (p < 0.05). The most common self-reported side effects from using MMJ were increased appetite (12-21.4%), fatigue (6-16.7%), anxiety (4-11.9%), cough (4-11.9%), headache (6-7.9%), and dry mouth (4-7.1%).

CONCLUSION: In patients with chronic GI symptoms, MMJ may provide persistent symptom severity improvement. Limited product availability and mild to moderate side effects are factors to consider before trialing MMJ.

The Pml1-Wdr5 Axis Regulates H3k4me3 Marks And Promotes Stemness Of Estrogen Receptor-Positive Breast Cancer, Chun-Peng Pai, Han Wang, Darcie D. Seachrist, Neel Agarwal, Joshua A. Adams, Zhenghao Liu, Ruth A. Keri, Kaixiang Cao, William P. Schiemann, Hung-Ying Kao

Faculty Scholarship

The alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approved drug for ER+ breast cancer, in a mouse model. Moreover, PML1, rather than the well-known tumor suppressor isoform PML4, rescues the proliferation of PML …

Controlling The Broadband Enhanced Light Chirality With L-Shaped Dielectric Metamaterials, Ufuk Kilic, Matthew Hilfiker, Shawn Wimer, Alexander Ruder, Eva Schubert, Mathias Schubert, Christos Argyropoulos

Department of Electrical and Computer Engineering: Faculty Publications

The inherently weak chiroptical responses of natural materials limit their usage for controlling and enhancing chiral light-matter interactions. Recently, several nanostructures with subwavelength scale dimensions were demonstrated, mainly due to the advent of nanofabrication technologies, as a potential alternative to efficiently enhance chirality. However, the intrinsic lossy nature of metals and the inherent narrowband response of dielectric planar thin films or metasurface structures pose severe limitations toward the practical realization of broadband and tailorable chiral systems. Here, we tackle these problems by designing all-dielectric silicon-based L-shaped optical metamaterials based on tilted nanopillars that exhibit broadband and enhanced chiroptical response in …

10 Ways Unh Is Helping To Save The Earth, Robbin Ray, Keith Testa, Beth Potier, Rebecca Irelan, Scott Ripley

UNH Today Archive

No abstract provided.

Production Of Mrna Vaccine For Influenza, Christina Miller

Honors Theses

The objective of this project is to design a process to produce an mRNA influenza vaccine that serves as an alternative to conventional influenza vaccines, replacing current options with innovative mRNA technologies. Given that older populations are most likely to follow up on immunizations consistently, and the increasing average age worldwide, the market for this project appears to be expanding in the next 80 years. Additionally, experts predict more frequent mutations and outbreaks of viral disease from a variety of factors including globalization and global temperature trends. Rapid response to these viral outbreaks will continue to be as, or even …

Identifying Multilevel Predictors Of Behavioral Outcomes Like Park Use: A Comparison Of Conditional And Marginal Modeling Approaches, Marilyn E. Wende, S. Morgan Hughey, Alexander C. Mclain, Shirelle Hallum, J. Aaron Hipp, Jasper Schipperijn, Ellen W. Stowe, Andrew T. Kaczynski Ph.D.

Faculty Publications

This study compared marginal and conditional modeling approaches for identifying individual, park and neighborhood park use predictors. Data were derived from the ParkIndex study, which occurred in 128 block groups in Brooklyn (New York), Seattle (Washington), Raleigh (North Carolina), and Greenville (South Carolina). Survey respondents (n = 320) indicated parks within one half-mile of their block group used within the past month. Parks (n = 263) were audited using the Community Park Audit Tool. Measures were collected at the individual (park visitation, physical activity, sociodemographic characteristics), park (distance, quality, size), and block group (park count, population density, age structure, racial …

Recital: Convocation, April 16, 2024, Illinois State University School Of Music

School of Music Programs

Center for the Performing Arts
April 16, 2024
Tuesday Morning
11:00 a.m.

Playing It Sun Safe: A Quality Improvement Project, Sarah P. Tarr, Kathryn K. Dambrino, R. David Phillippi, Ashley Karpinos

DNP Projects

Background: Athletes who play outdoor sports have multiple risk factors for the development of skin cancer. Literature highlights the need for the use of evidence-based strategies to improve the knowledge and utilization of sun protection practices in this high-risk population. Methods: Playing it Sun Safe was a multifaceted skin cancer prevention initiative implemented in a population of collegiate soccer athletes in collaboration with a university athletic department and campus health clinic. Evidence-based interventions were designed through application of the Health Belief Model (HBM) and were implemented using the Institute for Healthcare Improvement (IHI) quality improvement framework. Purpose: The two-fold aim …