Digital Commons Network^™

Capn2 Correlates With Insulin Resistance States In Pcos As Evidenced By Multi-Dataset Analysis, Xi Luo, Yunhua Dong, Haishan Zheng, Xiaoting Zhou, Lujuan Rong, Xiaoping Liu, Yun Bai, Yunxiu Li, Ze Wu

Faculty, Staff and Student Publications

OBJECTIVE: IR emerges as a feature in the pathophysiology of PCOS, precipitating ovulatory anomalies and endometrial dysfunctions that contribute to the infertility challenges characteristic of this condition. Despite its clinical significance, a consensus on the precise mechanisms by which IR exacerbates PCOS is still lacking. This study aims to harness bioinformatics tools to unearth key IR-associated genes in PCOS patients, providing a platform for future therapeutic research and potential intervention strategies.

METHODS: We retrieved 4 datasets detailing PCOS from the GEO, and sourced IRGs from the MSigDB. We applied WGCNA to identify gene modules linked to insulin resistance, utilizing IR …

Application Of High-Deflection Strain Gauges To Characterize Spinal-Motion Phenotypes Among Patients With Clbp, Spencer Alan Baker

Theses and Dissertations

Chronic low back pain (CLBP) is a nonspecific and persistent ailment that entails many physiological, psychological, social, and economic consequences for individuals and societies. Although there is a plethora of treatments available to treat CLBP, each treatment has varying efficacy for different patients, and it is currently unknown how to best link patients to their ideal treatment. However, it is known that biopsychosocial influences associated with CLBP affect the way that we move. It has been hypothesized that identifying phenotypes of spinal motion could facilitate an objective and repeatable method of determining the optimal treatment for each patient. The objective …

The Role Of The Patient Liaison Nurse In The Ambulatory Care Context Of A Middle Eastern Teaching Hospital: A Practice Model, Mustafa Morris E. Bodrick

Dissertations

The commencement of the role of patient liaison nurse (PLN) in the ambulatory care context of a Middle Eastern teaching hospital was an organizational response to patient care concerns during the site absence of physicians and the healthcare team. The PLN consequently evolved as a functional role of the registered nurse (RN) in ambulatory care nursing. The core research question asked was: how can a model be developed to describe the PLN role? The related topics for research included (i) the lived experiences of nurses in the functional role of the RN as PLN, (ii) what the nursing management team …

Black Law Students Association (Blsa) | 28th Annual Alumni Awards Dinner, New York Law School

Student Organizations

April 12, 2024

The Next Thirty Years: Developments In Mandamus Jurisprudence In The Last Thirty Years And Why The General Rule That Mandamus Is Unavailable To Review The Denial Of Summary Judgment Is Inconsistent With Modern Mandamus Jurisprudence Under The In Re Prudential Balancing Test, Timothy Delabar

St. Mary's Law Journal

No abstract provided.

Shots Fired, Shots Refused: Scientific, Ethical & Legal Challenges Surrounding The U.S. Military's Covid-19 Vaccine Mandate, Shawn Mckelvy, L. William Uhl, Armand Balboni

St. Mary's Law Journal

The COVID-19 pandemic provided uncertain and challenging circumstances under which to lead a nation and the military that protects it. Those in charge and in command faced unique challenges—scientific, ethical, and legal—at our various levels of government to both keep people safe while keeping government and society functioning. While there were many successes to celebrate, there are also many criticisms for how this “whole-of-government approach” may have degraded some of our most cherished liberties along the way. The authors focus on the U.S. military’s vaccine mandate and propose military leaders may have failed to fully consider the evolving science, weigh …

Corrigendum: A Single-Institution Experience With 177lu Rpt Workflow Improvements And Qualifying The Spect/Ct Imaging For Dosimetry, Siju George, Ranjini Tolakanahalli, Santiago Aguirre, Vivek Mishra

All Publications

No abstract provided.

2024-04-12 Minutes Of The Executive Committee Of The Academic Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Photophobia Is Associated With Lower Sleep Quality In Individuals With Migraine: Results From The American Registry For Migraine Research (Armr), Nina Sharp, Mark J Burish, Kathleen B Digre, Jessica Ailani, Mahya Fani, Sophia Lamp, Todd J Schwedt

Faculty, Staff and Student Publications

BACKGROUND: Patients with migraine often have poor sleep quality between and during migraine attacks. Furthermore, extensive research has identified photophobia as the most common and most bothersome symptom in individuals with migraine, second only to headache. Seeking the comfort of darkness is a common strategy for managing pain during an attack and preventing its recurrence between episodes. Given the well-established effects of daily light exposure on circadian activity rhythms and sleep quality, this study aimed to investigate the relationship between photophobia symptoms and sleep quality in a cohort of patients with migraine.

METHODS: A cross-sectional observational study was conducted using …

Serum Neuroactive Metabolites Of The Tryptophan Pathway In Patients With Acute Phase Of Affective Disorders, Yanli Li, Leilei Wang, Junchao Huang, Ping Zhang, Yanfang Zhou, Jinghui Tong, Wenjin Chen, Mengzhuang Gou, Baopeng Tian, Wei Li, Xingguang Luo, Li Tian, L Elliot Hong, Chiang-Shan R Li, Yunlong Tan

Faculty, Staff and Student Publications

BACKGROUND: Many studies showed disrupted tryptophan metabolism in patients with affective disorders. The aims of this study were to explore the differences in the metabolites of tryptophan pathway (TP) and the relationships between TP metabolites and clinical symptoms, therapeutic effect in patients with bipolar disorder with acute manic episode (BD-M), depressive episode (BD-D) and major depressive disorder (MDD).

METHODS: Patients with BD-M (n=52) and BD-D (n=39), MDD (n=48) and healthy controls (HCs, n=49) were enrolled. The serum neuroactive metabolites levels of the TP were measured by liquid chromatography-tandem mass spectrometry. Hamilton Depression Scale-17 item (HAMD-17) and Young Mania Rating Scale …

Phase 1b Study Of Intraperitoneal Ipilimumab And Nivolumab In Patients With Recurrent Gynecologic Malignancies With Peritoneal Carcinomatosis, Anne Knisely, Emily Hinchcliff, Bryan Fellman, Ann Mosley, Kathryn Lito, Sara Hull, Shannon N Westin, Anil K Sood, Kathleen M Schmeler, Jolyn S Taylor, Steven Y Huang, Rahul A Sheth, Karen H Lu, Amir A Jazaeri

Faculty, Staff and Student Publications

Background: Intravenous immune checkpoint blockade (ICB) has shown poor response rates in recurrent gynecologic malignancies. Intraperitoneal (i.p.) ICB may result in enhanced T cell activation and anti-tumor immunity.

Methods: In this phase 1b study, registered at Clinical.

Trials: gov (NCT03508570), initial cohorts received i.p. nivolumab monotherapy, and subsequent cohorts received combination i.p. nivolumab every 2 weeks and i.p. ipilimumab every 6 weeks, guided by a Bayesian design. The primary objective was determination of the recommended phase 2 dose (RP2D) of the combination. Secondary outcomes included toxicity, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).

Findings: …

Combined Deletion Of Men1, Atrx And Pten Triggers Development Of High-Grade Pancreatic Neuroendocrine Tumors In Mice, Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M Flores, Simone Hausmann, Pawel K Mazur

Faculty, Staff and Student Publications

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of tumors that exhibit an unpredictable and broad spectrum of clinical presentations and biological aggressiveness. Surgical resection is still the only curative therapeutic option for localized PanNET, but the majority of patients are diagnosed at an advanced and metastatic stage with limited therapeutic options. Key factors limiting the development of new therapeutics are the extensive heterogeneity of PanNETs and the lack of appropriate clinically relevant models. In that context, genomic sequencing of human PanNETs revealed recurrent mutations and structural alterations in several tumor suppressors. Here, we demonstrated that combined loss of MEN1, …

Mass Incarceration, Violent Crimes, And Lengthy Sentences: Using The Race-Class Narrative As A Messaging Framework For Shortening Prison Sentences, Eric Petterson

St. Mary's Law Journal

No abstract provided.

Restore Texas Land: A Proposal To Utilize Emission Reduction Credits To Fund The Railroad Commission Of Texas' Well Plugging Initiative, George Coates Roberts

St. Mary's Law Journal

No abstract provided.

456, Llc V. Wagstaff

All Decisions

In a holdover non-primary residence proceeding for a rent-controlled apartment, the landlord failed to prove by a preponderance of the evidence that the tenant did not primarily reside in the subject premises, as required by the NYC Rent and Rehabilitation Law. The court emphasized the importance of a substantial, ongoing physical nexus with the controlled premises for actual living purposes in defining "primary residence." The decision affirms the dismissal of the landlord's petition following a nonjury trial.

2023-2024 Performance Forum - April 12, 2024, Angela Fiedler, Yu-Hsuan Feng, Li Yang Liu, Isabella Swalm, Sarah Conley, Jaewon Baek, Kari Jenks, Noah Suarez, Kyle Mechmet, Nataniel Farrar, Graydon Howard, Luis Pulido, Santiago Moreno, Andres Borja, Kenton Campbell, Mark Severeniuk, Lauren Washburn, Keegan Neely, Clair Ives, Dina Bikzhanova, William Penn

Performance Forum

No abstract provided.

Exploring Entrepreneurial Intention And Subjective Beliefs: A Comparative Analysis Of General Education Schools And Commercial Schools, Julia Riess, Bettina Fuhrmann, Gerhard Geissler

International Journal for Business Education

This study examines the entrepreneurial intentions of Austrian secondary school students, specifically comparing students from commercial schools with those from general education schools. We analyzed 2,329 data sets and found that subjective beliefs, primarily behavioral and control beliefs, significantly influence entrepreneurial intentions. In addition, demographic factors such as gender, language, acquaintance with entrepreneurs, and school type play a significant role in explaining the variance in entrepreneurial intentions.

Our detailed analysis shows that students from commercial schools have stronger entrepreneurial intentions and subjective beliefs. Particularly notable are the differences in behavioral beliefs, where students from commercial schools find all aspects of …

2024-04-12 Compensation Guidelines, Morehead State University. Staff Congress.

Staff Congress Records

A message from the University's administration on new compensation guidelines submitted to the Staff Congress on April 12, 2024.

Ensemble-Based Mutational Profiling And Network Analysis Of The Sars-Cov-2 Spike Omicron Xbb Lineages For Interactions With The Ace2 Receptor And Antibodies: Cooperation Of Binding Hotspots In Mediating Epistatic Couplings Underlies Binding Mechanism And Immune Escape, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we performed a computational study of binding mechanisms for the SARS-CoV-2 spike Omicron XBB lineages with the host cell receptor ACE2 and a panel of diverse class one antibodies. The central objective of this investigation was to examine the molecular factors underlying epistatic couplings among convergent evolution hotspots that enable optimal balancing of ACE2 binding and antibody evasion for Omicron variants BA.1, BA2, BA.3, BA.4/BA.5, BQ.1.1, XBB.1, XBB.1.5, and XBB.1.5 + L455F/F456L. By combining evolutionary analysis, molecular dynamics simulations, and ensemble-based mutational scanning of spike protein residues in complexes with ACE2, we identified structural stability and binding …

2024-04-12 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

The meeting minutes of the Institutional Animal Care and Use Committee for April 12, 2024.

Understanding The Mechanism Behind Hfip's Effect On Diastereomeric Separation Of Oligonucleotides, Ian Neidigh

Honors Theses

The goal of this research was to determine the mechanism behind 1,1,1,3,3,3-hexafluoroisopropanol's (HFIP0 ability to suppress the separation of oligonucleotide diastereomers. This was accomplished by selecting different molecules that were like HFIP but differed in specific ways such as polarity, number and type of halogen(s), alcohol group location, carbon chain length, hydrophobicity, and chao/kosmotropicity. These molecules replaced HFIP in an IPRP chromatography method to determine if splitting of the diastereomers was observed and then they would becompared to HFIP's effect. Viscosity tests were to run to acquire quantitative data to determine chao/kosmotropicity. No decisive trend among a single factor was …

My Journey In Researching Depression Among Black People: Experiences Of A Researcher In A Sensitive Study, Brightness L. Kgatla

The Qualitative Report

The interest in qualitative research on mental health within Black communities is rapidly growing. However, there are still debates on the conceptualization of depression among the Black community. This paper focuses on the researcher’s experiences as a young Black South African experiencing depression, and their reflections on interpretivist qualitative research focused on the realities of Black South African youth experiencing depression. The paper highlights the importance of reflexivity in a qualitative study and how the topics researched by a Black South African experiencing depression which is still considered a taboo within some parts of the Black community. If a researcher …

Student Academic Policies Committee Minutes Of The Academic Senate 2024-04-12, University Of Dayton. Student Academic Policies Committee

All Committee Minutes

No abstract provided.

The Borderline Between Beneficial And Dishonest Ai: A Technical Report, Seth Richards, Katherine Shell, Seth Wright

Student Works

Artificial Intelligence (AI) has been used since 1950 but it was largely overlooked by the public until 2022. Current discussions about AI center around academic integrity. This report seeks to understand if AI can be handled, used, or accepted in Lipscomb’s academic environment as a beneficial aid to writing and research, without actively doing these tasks for an individual. Generative AI is a neural network, which enables it to receive input, gather information from a database of existing content, and create new content [2]. Due to the nature of generative AI, its beneficial contributions to academia are extremely limited.

Individualized Learning As An Ai Tool: A Technical Report, Petsimnan Blessing Dayit, Kasen Holt, Nuala Roper

Student Works

The purpose of the report’s research is to test and analyze whether Artificial Intelligence (AI) platforms can be used as beneficial tools for individualized learning at Lipscomb University without violating the Academic Integrity Policy. The methods section evaluates AI on the scopes of accuracy, analytical thinking, and adaptability. The results demonstrated how each platform responded to the prompts within the lines of the scope. The answers they gave were accurate, detailed, and contained various adaptations to make explanations clearer for the user. The team concluded that AI can be used at Lipscomb as a beneficial tool for students in their …

The Challenges Of Conducting Qualitative Research In Quantitative Culture: Saudi Arabia As A Case Study, ِAbdulrahman Awdah Albeladi

The Qualitative Report

In the Kingdom of Saudi Arabia (KSA), qualitative research methods are infrequently employed, as researchers in the region are more accustomed to quantitative approaches, with a certain hesitancy to embrace qualitative methodology. This research endeavor focuses on exploring the impediments faced by individuals engaged in qualitative research within the Saudi context. To do so, I conducted semi-structured interviews with eight doctoral students and employed a qualitative case study design for this paper. Utilizing the MAXQDA software, I also applied thematic analysis to the data gathered from the interviews. The primary findings highlight three significant themes: (a) challenges related to organizational …

Predicting Women Students' Major: Stem Vs Non-Stem, Patricia Berchiolli

Faculty and Staff Publications & Presentations

No abstract provided.

Sga 55 Senate 2024-04-12 Agenda, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Comparison Of Injuries Sustained On Grass And Artificial Turf By Usl1 Men’S Soccer Team. Part 1: Match Related Injuries, Michael Osterholt, Jason Meredith, Jenenne A. Geske

Posters and Presentations: Family Medicine

No abstract provided.