Digital Commons Network^™

Strategies For Addressing The Lack Of Skilled Workers In The Gig Economy, Joseph Charles Blanchard

Walden Dissertations and Doctoral Studies

No abstract provided.

Early Introduction Of Stem: A Qualitative Study, Michael Toussaint Crosby

Walden Dissertations and Doctoral Studies

No abstract provided.

Role Of Pregnancy Intention And Substance Use In Postpartum Depression Among Black Women, Asaye Birhanu Mekonnen

Walden Dissertations and Doctoral Studies

No abstract provided.

Soundscape - A Guided Approach To Post-Tonal Horn Repertoire, Selena B. Boyda

LSU Doctoral Dissertations

More modern post-tonal works are being composed and it is imperative that horn players interpret the music as accurately as possible. Analyzing the music is a way one can interpret the music accurately. The purpose of this research is to develop a guided approach for interpretation of post-tonal horn repertoire using analytical techniques. Selected works analyzed and used are Olivier Messiaen’s “Appel Interstellaire,” Stanley Friedman’s Topanga Variations, and Jenni Brandon’s Dawn. Analytical techniques used include set theory, limited modes of transposition, contour relations, motivic patterns, modal analysis, and motifs.

Students To Present Research From Variety Of Disciplines At John Wesley Powell Conference On April 13, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Primary Anastomosis With Diverting Loop Ileostomy Vs. Hartmann's Procedure For Acute Diverticulitis: What Happens After Discharge? Results Of A Nationwide Analysis, Arturo J. Rios Diaz, Lisa A. Bevilacqua, Theodore E. Habarth-Morales, Alicja Zalewski, David Metcalfe, Caitlyn Costanzo, Charles J. Yeo, Francesco Palazzo

Department of Surgery Faculty Papers

BACKGROUND: Current guidelines recommend resection with primary anastomosis with diverting loop ileostomy over Hartmann's procedure if deemed safe for acute diverticulitis. The primary objective of the current study was to compare the utilization of these strategies and describe nationwide ostomy closure patterns and readmission outcomes within 1 year of discharge.

METHODS: This was a retrospective, population-based, cohort study of United States Hospitals reporting to the Nationwide Readmissions Database from January 2011 to December 2019. There were 35,774 patients identified undergoing non-elective primary anastomosis with diverting loop ileostomy or Hartmann's procedure for acute diverticulitis. Rates of ostomy closure, unplanned readmissions, and …

Discovery Of A Small-Molecule Inhibitor That Traps Polθ On Dna And Synergizes With Parp Inhibitors, William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John Krais, Yifan Wang, Umeshkumar Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang Chen, Richard Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Polθi) class with 4-6 nM IC₅₀ that selectively kills HR-deficient cells and acts synergistically with PARP inhibitors (PARPi) in multiple genetic backgrounds. X-ray crystallography and biochemistry reveal that Polθi selectively inhibits Polθ polymerase (Polθ-pol) in the closed conformation on B-form DNA/DNA via an induced fit mechanism. In contrast, Polθi fails to inhibit Polθ-pol catalytic activity on A-form DNA/RNA in which the enzyme binds in …

Multi-Faceted Approach To Educating Physicians About The Impacts Of Climate Change On Their Patients’ Health, Deborah Simpson, Anne Getzin, Kjersti Knox, Kari A. Schmidt Oliver, Victoria Gillet, Karen Hanus, Amina Maamouri, Nicole Heilman, Rita Mitchell, Yolanda Manson, Kristin Ouweneel, Kathryn Agard

Aurora GME

No abstract provided.

Population Health Pop-Spotting, Stephenie Quirke, Morgan Erickson, Catherine Degrandville, Glenda Sundberg, Christina Dukehart, Will Lehmann

Aurora GME

No abstract provided.

Stop-Ama: A Quality Improvement Project To Reduce Ama Discharges Through Early Recognition And Intervention, Sean Fabry, David Hamel

Aurora GME

No abstract provided.

Vot+Er: Voter Registration To Address Structural & Social Determinants Of Health, Terry Frederick, Tricia La Fratta, Deborah Simpson, Victoria Gillet, Lawrence Moore, Kjersti Knox, Esmeralda Santana, Oyinkansola Okubanjo, Nicole Salvo, Jacob Bidwell, Kristin Ouweneel

Aurora GME

No abstract provided.

A Macrophage-Cell Model Of Hiv Latency Reveals The Unusual Importance Of The Bromodomain Axis, Javan K Kisaka, Daniel Rauch, Malachi Griffith, George B Kyei

2020-Current year OA Pubs

BACKGROUND: Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood. To understand the fundamental mechanisms of viral latency in macrophages, there is an urgent need to develop latency models amenable to genetic manipulations and screening for appropriate latency-reversing agents (LRAs). Given that differentiated THP-1 cells resemble monocyte-derived macrophages in HIV replication mechanisms, we set out to establish a macrophage cell model for HIV latency using THP-1 cells.

METHODS: We created single-cell clones of THP-1 cells infected with a single …

Subcellular Pathways Through Vglut3-Expressing Mouse Amacrine Cells Provide Locally Tuned Object-Motion-Selective Signals In The Retina, Karl Friedrichsen, Jen-Chun Hsiang, Chin-I Lin, Liam Mccoy, Katia Valkova, Daniel Kerschensteiner, Josh L Morgan

2020-Current year OA Pubs

VGluT3-expressing mouse retinal amacrine cells (VG3s) respond to small-object motion and connect to multiple types of bipolar cells (inputs) and retinal ganglion cells (RGCs, outputs). Because these input and output connections are intermixed on the same dendrites, making sense of VG3 circuitry requires comparing the distribution of synapses across their arbors to the subcellular flow of signals. Here, we combine subcellular calcium imaging and electron microscopic connectomic reconstruction to analyze how VG3s integrate and transmit visual information. VG3s receive inputs from all nearby bipolar cell types but exhibit a strong preference for the fast type 3a bipolar cells. By comparing …

Mamás Metidas: Empowering Latinx Spanish-Dominant Parents In Independent Schools Through Culturally Responsive School Leadership, Silvia Salazar Rivera

LMU Theses and Dissertations

Latinx families, particularly those whose primary language is Spanish, are significantly underrepresented in independent schools nationwide and experience barriers to engaging in their children’s education. Recognizing the crucial role of parent engagement in student academic success and socioemotional well-being, this research aimed to understand the unique challenges faced by Spanish-dominant parents in navigating the independent school contexts. Grounded in Khalifa et al.’s (2016) culturally responsive school leadership framework, the study intended to identify effective practices and strategies that facilitate Spanish-dominant parent engagement. The narrative data, collected through both a group plática and individual interviews, offered valuable insights into the experiences …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The Relationship Between Immune-Related Adverse Events During Ipilimumab Monotherapy And Survival Outcomes Among Melanoma Patients: A Systematic Review, Jason Sheng, Manav Nayeni, Monali Malvankar

Student Publications

Background: Ipilimumab disinhibits immune system activity which results in the elimination of malignant cells. An unintended consequence of ipilimumab therapy is off-target immune-related adverse events (irAEs). It has therefore been proposed that the incidence of irAEs is a manifestation of treatment effectiveness. The objective of this systematic review is to examine the relationship between irAEs and survivability among melanoma patients administered ipilimumab monotherapy.

Methods: A comprehensive search was conducted across several databases which yielded a total of 2381 studies. Clinical trials and prospective studies administering ipilimumab monotherapy to melanoma patients were included. Furthermore, there was no restriction placed on publication …

2023-2024 Performance Forum - April 5, 2024, Juan Ignacio Díaz, Anna Dunford, Jeremiah Grace, Steven Halpner, Caroline Drantal, Eliza Willett, Jeremy Jefferson, Anttuan Rios Pelaez, Jasmin Abdunazarova, Esther Platt, Victoria Bramble, Samuel Dionisio, Niloufar Mirzanabi Khani, Adriana Fernandez, Angela Fiedler, Lauren Swartz, Jon Cruz

Performance Forum

No abstract provided.

Application Of Deep Learning On Mammographies To Discriminate Between Low And High-Risk Dcis For Patient Participation In Active Surveillance Trials, Sena Alaeikhanehshir, Madelon M Voets, Frederieke H Van Duijnhoven, Esther H Lips, Emma J Groen, Marja C J Van Oirsouw, Shelley E Hwang, Joseph Y Lo, Jelle Wesseling, Ritse M Mann, Jonas Teuwen

Faculty, Staff and Student Publications

BACKGROUND: Ductal Carcinoma In Situ (DCIS) can progress to invasive breast cancer, but most DCIS lesions never will. Therefore, four clinical trials (COMET, LORIS, LORETTA, AND LORD) test whether active surveillance for women with low-risk Ductal carcinoma In Situ is safe (E. S. Hwang et al., BMJ Open, 9: e026797, 2019, A. Francis et al., Eur J Cancer. 51: 2296-2303, 2015, Chizuko Kanbayashi et al. The international collaboration of active surveillance trials for low-risk DCIS (LORIS, LORD, COMET, LORETTA), L. E. Elshof et al., Eur J Cancer, 51, 1497-510, 2015). Low-risk is defined as grade I or II DCIS. Because …

Impact Of Living Donor Liver Transplantation On The Improvement Of Hepatocellular Carcinoma Treatment, Yucel Yankol, Oswaldo Aguirre, Luis A Fernandez

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, with increasing incidence. There are different treatment options, but only 30%-40% of HCC cases are diagnosed at an early stage for curative treatment. With the implementation of Milan Criteria for liver transplantation (LT) in HCC cases and its use for organ allocation with successful outcomes, LT has become an optimal treatment. Seeking new criteria for LT and developing updated algorithms for HCC treatment has become a hot topic nowadays. With the experience in living donor liver transplantation (LDLT), especially in Asian countries, LDLT was established and adopted with …

The Saga Of E Faecium, Rishika Prasad, Robert R Jenq

Faculty, Staff and Student Publications

An enzyme that remodels the cell wall of Enterococcus faecium helps these gut bacteria to divide and generate peptide fragments that enhance the immune response against cancer.

Race And Racism Through The Lens Of Black Men: Exploring The Talk And Lessons Black Fathers Teach Their Children About Race And Racism In America., Conial C. Caldwell Jr

LSU Doctoral Dissertations

The history of racism and racial violence is embedded in the fabric of America and has driven Black people to develop strategies to navigate society that racism has produced. “The Talk” is a racial socialization practice and cultural phenomenon that has existed within Black families for centuries and remains a necessity due to the ongoing acts of racism and violence of Black Americans. Prior research has found that parents rear their children based on their own lived experiences, which many Black Americans have experienced or have been exposed to racism and racial violence. Yet, there are few empirical studies that …

A Study Of Selected Vocal Works By Shande Ding: The Mysterious Sound Of Flute And Poems On Western Yunnan, Chuyan Luo

LSU Doctoral Dissertations

This study aims to delve into and interpret “The Mysterious Sound of Flute” and “Poems on Western Yunnan” from a singer’s perspective while also providing guidance and recommendations for other performers. The research encompasses the history of Chinese art songs, a biography of Shande Ding, and an introduction to his compositional style. A comprehensive examination of each song includes background information, song analysis, translation, a Chinese lyric diction guide, and performance suggestions.

Art songs constitute a significant genre in music composition, and Chinese art songs have yielded numerous outstanding composers and captivating works over the years. Among these composers, Shande …

Spatial Behavior Of Hospital Visits By Hand, Foot, And Mouth Disease Patients In Nanchang, China, Zeliu Zheng

LSU Doctoral Dissertations

Hand foot mouth disease (HFMD) is one of the widespread transmissible diseases that target preschool children, especially in urban regions in East Asia. Understanding the travel patterns of the HFMD patients helps us understand how the spatial behaviors of patients vary across space and what are the underlying forces. It is essential for understanding the healthcare market and planning for resource allocation. Foremost, health behavior and outcome change significantly across geographic regions of various urbanicities (i.e., degrees of urbanization) due to the uneven distribution of healthcare resource. In addition, health studies in the U.S. often use hospital service areas (HSAs) …

Flaxman, Judy, Laura Oldfather

Bronx Jewish History Project

Summarizer: Sophia Maier

Judy Flaxman’s family came to the Lower East Side from Eastern Europe in the early 1900s. As they grew more affluent, they moved to the Bronx, where Flaxman was born in 1948. She lived on Walton Avenue near Tremont Avenue, which she describes as very Jewish with some Catholics. She attended PS 28, Wade Junior High School, and Bronx Science. She played many outdoor games with friends from her community and did after school activities at the YM/WHA, through which she attended a day camp during the summers.

Flaxman’s mother was a secretary and her father, after …

Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham

LSU Master's Theses

In 2022, ~288,000 American women were diagnosed with metastatic breast cancer which was the leading cause of patient mortality with ~43,000 American women succumbing to the disease. Women can be diagnosed with four different molecular subtypes of breast cancer: luminal A, luminal B, human epithelial growth receptor type 2 enriched (HER2+), and triple-negative breast cancer (TNBC). TNBC accounts for ~12% of all breast cancers, yet it has the worst outcomes. TNBC is highly invasive, with ~46% of TNBC patients developing metastatic disease. A further understanding of metastatic TNBC is needed to provide a greater understanding of how to treat this …

Design And Test Of Wpum Topography Monitor For Iqos, Rawah Azeez

Theses

With the emergence of diverse tobacco product forms, such as electronic cigarettes and heat-not-burn, the global user base has surged to an estimated 1.3 billion. In the United States, 28.3 million adults and 3.08 million middle and high school adolescents engage in tobacco product use. However, our understanding of the usage behaviors of these various products is lacking. Puff topography, which measures the inhalation patterns of tobacco products, provides a wealth of information, including puff flow rate, duration, volume, and more. This information is crucial in understanding the health effects of tobacco products and the influence of usage behavior on …

Supercook: Design Interactive Culinary Experiences With Ai Technology, Yize Peng

Theses

The project 'SuperCook' is a groundbreaking design project that explores the integration of AI with culinary apps. It aims to revolutionize the kitchen experience by connecting users to new and accessible culinary adventures through personalized recipe recommendations, real-time cooking guidance, and interactive meal planning. By leveraging AI technology, 'SuperCook' not only enhances user convenience and efficiency but also fosters a deeper engagement with cooking and promotes healthier eating habits. This thesis delves into the design process, user testing, and iterative improvements that culminated in a user-centered, intuitive, and visually appealing UI/UX solution for modern cooking enthusiasts. In designing 'SuperCook,' attention …

Senior Recital: Peyton Gray, Trombone; Lu Witzig, Piano; April 5, 2024, Peyton Gray, Lu Witzig

School of Music Programs

Kemp Recital Hall
April 5, 2024
Friday Evening
9:00 p.m.

Junior Recital: Jennifer Budlong-Brewer, Saxophone; Lu Witzig, Piano; Lauren Cancio, Trumpet; April 5, 2024, Jennifer Budlong-Brewer, Lu Witzig, Lauren Cancio

School of Music Programs

Kemp Recital Hall
April 5, 2024
Friday Evening
6:00 p.m.

Swiss Cheese Heart: A Tale Of Multiple Valve Perforations, Hussam Al Hennawi, Shayan I. Khan, Aamna Khan, Usama Sadiq, Sung-Hae Cho

Abington Jefferson Health Papers

Gerbode defect, an anomalous connection between the left ventricle and right atrium, is often congenital but can be acquired or iatrogenically formed. We present an exceedingly rare case of this defect associated with multiple valve perforation in an otherwise healthy patient with bicuspid aortic valve and endocarditis.