Digital Commons Network^™

Intestinal Cell Diversity And Treatment Responses In A Parasitic Nematode At Single Cell Resolution, Rahul Tyagi, Bruce A Rosa, Amanda Swain, Maxim N Artyomov, Douglas P Jasmer, Makedonka Mitreva

2020-Current year OA Pubs

BACKGROUND: Parasitic nematodes, significant pathogens for humans, animals, and plants, depend on diverse organ systems for intra-host survival. Understanding the cellular diversity and molecular variations underlying these functions holds promise for developing novel therapeutics, with specific emphasis on the neuromuscular system's functional diversity. The nematode intestine, crucial for anthelmintic therapies, exhibits diverse cellular phenotypes, and unraveling this diversity at the single-cell level is essential for advancing knowledge in anthelmintic research across various organ systems.

RESULTS: Here, using novel single-cell transcriptomics datasets, we delineate cellular diversity within the intestine of adult female Ascaris suum, a parasitic nematode species that infects animals …

S24rs Sgb No. 8 (Icc Lounge Renovations), Andre Korea

Student Senate Enrolled Legislation

No abstract provided.

Remote Sensing Of Residential Landscape Irrigation In Weber County, Utah, Annelise Marie Capener

Theses and Dissertations

Irrigation of residential properties in urban settings is typified by small and irregular areas, many untrained water users, limited end-use metering, and differing groundcover in contrast to agricultural settings. This makes analyzing irrigation patterns to promote efficient water use challenging. Analysis of Irrigation by Remote Sensing (AIRS) combines multispectral aerial imagery, evapotranspiration data, and ground-truthed measurements to overcome these challenges. We demonstrate the application of AIRS on eight neighborhoods in West Haven, Utah, using 0.6 m National Agriculture Imagery Program (NAIP) and 0.07 m drone imagery, reference evapotranspiration (ET), and water meter data from Weber Basin Water Conservancy District (WBWCD). …

April 2024 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

The Clinical Implications Of Kras Mutations And Variant Allele Frequencies In Pancreatic Ductal Adenocarcinoma, Faria Nusrat, Akshay Khanna, Aditi Jain, Wei Jiang, Harish Lavu, Charles Yeo, Wilbur Bowne, Avinoam Nevler

Department of Surgery Faculty Papers

The KRAS proto-oncogene is a major driver of pancreatic tumorigenesis and is nearly ubiquitously mutated in pancreatic ductal adenocarcinoma (PDAC). KRAS point mutations are detected in over 90% of PDAC cases, and these mutations have been shown to be associated with worse therapy response and overall survival. Pathogenic KRAS mutations are mostly limited to codons 12, 13 and 61, with G12D, G12V, G12R, Q61H, and G13D accounting for approximately 95% of the mutant cases. Emerging data have shown the importance of specific mutant subtypes, as well as KRAS variant allele frequency on clinical prognosis. Furthermore, novel technologies and therapies are …

The Scarlet - Volume Cii, No. 10 (April 24, 2024), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The April 24, 2024 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

First Day Declaration - Mcnamara

Catholic Dioceses in Bankruptcy

No abstract provided.

Cash Management Motion

Catholic Dioceses in Bankruptcy

No abstract provided.

First-In-Human Phase I Study Of Tinengotinib (Tt-00420), A Multiple Kinase Inhibitor, As A Single Agent In Patients With Advanced Solid Tumors, Sarina A Piha-Paul, Binghe Xu, Ecaterina E Dumbrava, Siqing Fu, Daniel D Karp, Funda Meric-Bernstam, David S Hong, Jordi A Rodon, Apostolia M Tsimberidou, Kanwal Raghav, Jaffer A Ajani, Anthony P Conley, Frank Mott, Ying Fan, Jean Fan, Peng Peng, Hui Wang, Shumao Ni, Caixia Sun, Xiaoyan Qiang, Wendy J Levin, Brenda Ngo, Qinhua Cindy Ru, Frank Wu, Milind M Javle

Faculty, Staff and Student Publications

PURPOSE: This first-in-human phase I dose-escalation study evaluated the safety, pharmacokinetics, and efficacy of tinengotinib (TT-00420), a multi-kinase inhibitor targeting fibroblast growth factor receptors 1-3 (FGFRs 1-3), Janus kinase 1/2, vascular endothelial growth factor receptors, and Aurora A/B, in patients with advanced solid tumors.

PATIENTS AND METHODS: Patients received tinengotinib orally daily in 28-day cycles. Dose escalation was guided by Bayesian modeling using escalation with overdose control. The primary objective was to assess dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), and dose recommended for dose expansion (DRDE). Secondary objectives included pharmacokinetics and efficacy.

RESULTS: Forty-eight patients were enrolled (dose escalation, …

Syphilis Complicating Pregnancy And Congenital Syphilis. Reply, Irene A Stafford, Kimberly A Workowski, Laura H Bachmann

Faculty, Staff and Student Publications

The authors reply: The Jarisch–Herxheimer reaction is an underreported and often-over-looked sequela of antimicrobial therapy in persons with spirochetal disease and is caused by the release of treponemal constituents.1 Sandoval’s description of the clinical manifestations of this reaction is an important reminder for clinicians to recognize the reaction and avoid the pitfalls of incorrectly diagnosing it as an allergic reaction to penicillin; it also highlights a critical aspect of care for persons with syphilis, including neonates with congenital syphilis.

The Hallmarks Of Precancer, Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, Robert J Coffey, Martha J Shrubsole, Keith S Chan, William M Grady, Srinivasan Yegnasubramanian, Costas A Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau

Faculty, Staff and Student Publications

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

2024-04-04 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from April 4, 2024.

T-Cell Dysfunctions In Myelodysplastic Syndromes, Juan Jose Rodriguez-Sevilla, Simona Colla

Faculty, Staff and Student Publications

Escape from immune surveillance is a hallmark of cancer. Immune deregulation caused by intrinsic and extrinsic cellular factors, such as altered T-cell functions, leads to immune exhaustion, loss of immune surveillance, and clonal proliferation of tumoral cells. The T-cell immune system contributes to the pathogenesis, maintenance, and progression of myelodysplastic syndrome (MDS). Here, we comprehensively reviewed our current biological knowledge of the T-cell compartment in MDS and recent advances in the development of immunotherapeutic strategies, such as immune checkpoint inhibitors and T-cell- and antibody-based adoptive therapies that hold promise to improve the outcome of patients with MDS.

Understanding How Volunteer Companionship Impacts Those During The End Of Life: A Realist Evaluation, John Downey, Susan Cooper, Lynn Bassett, Alejandra Dubeibe Fong, Margaret Doherty, Jon Cornwall

School of Nursing and Midwifery

Volunteers are a popular unpaid support role in end of life care yet how accompaniment influences the dying is underdeveloped. This study examined how companionship works, for whom, in what circumstances and why. Initial realist ideas were developed through participant observation (14 months), document analysis, and realist interviews with companionship trainers (n = 6). Theory testing involved volunteer interviews (n = 7), accounts from the dying, proxy accounts for the dying, and written reflections from companionship training. Companionship helps people live well until they die, prepare for death, and experience a good death. Four areas of volunteering explain these outcomes …

Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine

LSU Doctoral Dissertations

Cancer is a disease characterized by a wide array of dysregulated cellular function, activity, and growth. At times, specific dysregulations associated with cancer can be exploited as avenues of potential treatment. The sodium handling mechanisms and their associated proteins in cancer have received closer attention recently closely as such a potential mechanism to exploit for treating advanced cancer. Some novel treatments aim to inhibit the expression or activity of these sodium handling proteins in an attempt to prevent the cancer from advancing or becoming more aggressive; however, such approaches have had limited success. Targeted osmotic lysis (TOL) is a new …

Analytic Wavefront Sets Of Spherical Distributions On The De Sitter Space, Iswarya Sitiraju

LSU Doctoral Dissertations

In this work, we determine the wavefront set of certain eigendistributions of the Laplace-Beltrami operator on the de Sitter space. Let G′ = O_1,n(R) be the Lorentz group, and let H′ = O_1,n−1(R) ⊂ G′ be its subset. The de Sitter space dSⁿ is a one-sheeted hyperboloid in R^1,n isomorphic to G′/H′. A spherical distribution is an H′-invariant eigendistribution of the Laplace-Beltrami operator on dSⁿ. The space of spherical distributions with eigenvalue λ, denoted by D_λ^H'(dSⁿ), has dimension 2. We construct a basis for the space of …

Digital Leadership Within Large South Korean Firms, Jin Woong Yoo, Saeyeon Roh, Smita Tripathi, Hyunmi Jang

Plymouth Business School

Drawing upon Person-Environment fit (PE fit) theory, this paper attempts to explore the determinants of digital leadership and its interactions between personal and environmental dimensions, including organizational, interpersonal and external dimensions, in South Korea. As Remote Work (RW) and Digital Transformation (DT) have been discussed since the start of the COVID-19 pandemic, this research focuses upon the concept of digital leadership, which can effectively cope with both RW and DT. To help Human Resource (HR) practitioners support digital leadership, this paper employs the fuzzy-Decision Making Trial and Evaluation Laboratory (f-DEMATEL) method. Through the convenience sampling method, we collected data sets …

April 4, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Women Of Three Mile Island Recount Their Untold Truths, Jennifer Bancamper

NYLS Community News

No abstract provided.

Scher V. 698 D Realty Llc

All Decisions

In a holdover-breach of lease case, the court ruled in favor of the landlord, dismissing the tenant's claim for a declaration that the apartment is rent stabilized, acknowledging the proper means of calculating rent overcharge per recent Court of Appeals decisions. The court declared the lawful stabilized rent and granted the landlord's motion for summary judgment on various claims, while denying the tenant's cross-motion for summary judgment.

Thurman V. Sullivan Props. L.P.

All Decisions

The Appellate Division affirmed the denial of the landlord's motion to dismiss the market-rate tenant's claims that the apartment was illegally deregulated after the last rent-controlled tenant vacated in 2005. Although lease documents showed the rent exceeded the deregulation threshold, they did not utterly refute allegations of wrongful deregulation. While a fair market rent appeal is time-barred after 4 years of vacancy, this plenary action challenging the apartment's deregulated status is not subject to that limitation and may examine rental history beyond 4 years. A tenant can challenge an apartment's deregulated status at any time during tenancy.

In The Matter Of 57 Elmhurst, Llc

All Decisions

The DHCR affirmed the Rent Administrator's order granting a permanent rent reduction of $50 per month due to the landlord's modification of the lobby area, which reduced the available space and constituted a decrease in required services. This case highlights that tenants are entitled to a rent reduction for the loss of required services and that the DHCR has the authority to determine the appropriate amount of reduction on a case-by-case basis.

Vista Checkpoint Inhibition By Ph-Selective Antibody Sns-101 With Optimized Safety And Pharmacokinetic Profiles Enhances Pd-1 Response, Thomas Thisted, Yoshiko Takeuchi, Robert D Schreiber, Et Al.

2020-Current year OA Pubs

VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges. Structural and biochemical analyses confirmed the pH-selectivity and unique epitope targeted by SNS-101. These properties confer favorable pharmacokinetic and safety profiles on SNS-101. In syngeneic tumor models utilizing human VISTA knock-in mice, SNS-101 shows in vivo efficacy when combined with a PD-1 inhibitor, modulates cytokine and chemokine signaling, and alters the …

Induction Of Viral Mimicry Upon Loss Of Dhx9 And Adar1 In Breast Cancer Cells, Kyle A Cottrell, Sua Ryu, Jackson R Pierce, Luisangely Soto Torres, Holly E Bohlin, Angela M Schab, Jason D Weber

2020-Current year OA Pubs

UNLABELLED: Detection of viral double-stranded RNA (dsRNA) is an important component of innate immunity. However, many endogenous RNAs containing double-stranded regions can be misrecognized and activate innate immunity. The IFN-inducible ADAR1-p150 suppresses dsRNA sensing, an essential function for adenosine deaminase acting on RNA 1 (ADAR1) in many cancers, including breast. Although ADAR1-p150 has been well established in this role, the functions of the constitutively expressed ADAR1-p110 isoform are less understood. We used proximity labeling to identify putative ADAR1-p110-interacting proteins in breast cancer cell lines. Of the proteins identified, the RNA helicase DHX9 was of particular interest. Knockdown of DHX9 in …

Type 1 Vwd Classification Revisited: Novel Insights From Combined Analysis Of The Lovic And Win Studies, Ferdows Atiq, Jorge Di Paola, Et Al.

2020-Current year OA Pubs

There is significant ongoing debate regarding type 1 von Willebrand disease (VWD) defintion. Previous guidelines recommended patients with von Willebrand factor (VWF) levels < 30 IU/dL be diagnosed type 1 VWD, whereas patients with significant bleeding and VWF levels from 30 to 50 IU/dL be diagnosed with low VWF. To elucidate the relationship between type 1 VWD and low VWF in the context of age-induced increases in VWF levels, we combined data sets from 2 national cohort studies: 162 patients with low VWF from the Low VWF in Ireland Cohort (LoVIC) and 403 patients with type 1 VWD from the Willebrand in The Netherlands (WiN) studies. In 47% of type 1 VWD participants, VWF levels remained < 30 IU/dL despite increasing age. Conversely, VWF levels increased to the low VWF range (30-50 IU/dL) in 30% and normalized (>50 IU/dL) in 23% of type 1 VWD cases. Crucially, absolute VWF antigen (VWF:Ag) levels and increase of VWF:Ag per year overlapped between low VWF and normalized type 1 VWD participants. Moreover, multiple regression analysis demonstrated that VWF:Ag levels in low VWF and normalized type 1 VWD patients would not have been different had they been diagnosed at the same age (β = 0.00; 95% confidence interval, -0.03 to 0.04). Consistently, no difference was found in the …

First Day Declaration - Greene

Catholic Dioceses in Bankruptcy

No abstract provided.

The Columbus Promise: Year One Evaluation Report, Michelle Miller-Adams, Kevin Hollenbeck, Bridget Timmeney, Kyle Huisman

Reports

No abstract provided.

First-Time Market Steer, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

The target audience for this fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H steer. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

First-Time Market Hog, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

This fact sheet is for 4-H youth who are thinking about or have recently purchased their first 4-H hog. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

Study Of Hybrid Nanofluid Flow In A Stationary Cone-Disk System With Temperature-Dependent Fluid Properties, A. S. John, Mahanthesh Basavarajappa, G. Lorenzini

School of Mathematical & Statistical Sciences Faculty Publications

Cone-disk systems find frequent use such as conical diffusers, medical devices, various rheometric, and viscosimetry applications. In this study, we investigate the three-dimensional flow of a water-based Ag-MgO hybrid nanofluid in a static cone-disk system while considering temperature-dependent fluid properties. How the variable fluid properties affect the dynamics and heat transfer features is studied by Reynolds’s linearized model for variable viscosity and Chiam’s model for variable thermal conductivity. The single-phase nanofluid model is utilized to describe convective heat transfer in hybrid nanofluids, incorporating the experimental data. This model is developed as a coupled system of convective-diffusion equations, encompassing the conservation …