Digital Commons Network^™

The Effectiveness Of Using Near-Peer Role Models And Mentoring: A Phenomenological Reflection On Stem For Success, Bruce G. Bukiet, Cristo Leon, James Lipuma

STEM for Success Resources

The proper study of communication from existing models opens the doors to scientific research that allows exploring language and coding as an integral part of effective communication to generate new models that include Trans-Disciplinary Collaboration. The authors analyze the communication factors to describe the application of Trans-Disciplinary Communication. This paper aims to define communication processes and their relationship with language, considering their impact on trans-disciplinary collaboration and innovation. After conducting a systematic literature review, the article explored the concepts of communication, functions, language, and Trans-Disciplinary Communication. This led to its application in the convergence research approach presented in the Collaborative …

Nardilysin-Regulated Scission Mechanism Activates Polo-Like Kinase 3 To Suppress The Development Of Pancreatic Cancer, Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, explaining the often-reduced Plk3 expression in human PDAC. Importantly, a 41-kDa Plk3 (p41Plk3) that contains the entire kinase domain at the N-terminus (1-353 aa) is activated by scission of the precursor p72Plk3 at Arg354 by metalloendopeptidase nardilysin (NRDC), and the resulting p32Plk3 C-terminal Polo-box domain (PBD) is removed by proteasome degradation, preventing the inhibition of p41Plk3 by PBD. We find …

Genomes Of Bacteroides Ovatus, B Cellulosilyticus, B Uniformis, Phocaeicola Vulgatus, And P Dorei Isolated From Gut Cavernous Fistulous Tract Micropathologies In Crohn’S Disease, Vaidhvi Singh, Gail West, Claudio Fiocchi, Fabio Cominelli, Caryn E Good, Michael R Jacobs, Alexander Rodriguez-Palacios

Faculty, Staff and Student Publications

Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six CavFT bacterial isolates representing the Bacteroidota genera Bacteroides and Phocaeicola. Plasmids were identified in Bacteroides cellulosilyticus and Phocaeicola vulgatus.

April 11, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

2024 Conference Program, Georgia Southern University

South East Coastal Conference on Languages & Literatures (SECCLL)

2024 Conference Program

The World Health Organization Was Born As A Normative Agency: Seventy-Five Years Of Global Health Law Under Who Governance, Lawrence O. Gostin, Benjamin Mason Meier, Safura Abdool Karim, Judith Bueno De Mesquita, Gian Luca Burci, Danwood Chirwa, Alexandra Finch, Eric A. Friedman, Roojin Habibi, Sam F. Halabi, Tsung-Ling Lee, Brigit Toebes, Pedro Villarreal

Georgetown Law Faculty Publications and Other Works

The World Health Organization (WHO) was born as a normative agency and has looked to global health law to structure collective action to realize global health with justice. Framed by its constitutional authority to act as the directing and coordinating authority on international health, WHO has long been seen as the central actor in the development and implementation of global health law. However, WHO has faced challenges in advancing law to prevent disease and promote health over the past 75 years, with global health law constrained by new health actors, shifting normative frameworks, and soft law diplomacy. These challenges were …

2024-04-11 Faculty Welfare & Concerns Committee Meeting Minutes, Morehead State University. Faculty Senate., Faculty Welfare & Concerns Committee.

Faculty Senate Records

Meeting minutes from the Faculty Welfare & Concerns Committee for April 11, 2024.

Supporting An Infrastructure For Experienced Nurses: A Fellowship Foundation, Melissa Oberle

Nursing

A Nursing Professional Development (NPD) Specialist identified 90% of first-year turnover occurred with experienced nurses in the acute care setting, which accrues a cost of $60,000 per nurse. Experienced nurses departed within the first year of hire due to the work environment and personal reasons. This high-risk population had minimal targeted training, specifically nurses with greater than six months of experience. A survey of newly hired experienced nurses revealed interest in a program to support their transition. An experienced nurse fellowship program was created to promote a healthy work environment, professional growth, and retention by allowing organizational assimilation. The program …

Quaker Campus, April 11, 2024 (Vol. 22, Issue 13), Whittier College

Quaker Campus

No abstract provided.

Kenyon Collegian - April 11, 2024

The Kenyon Collegian

No abstract provided.

Bacterial And Viral Co-Infections In Aquaculture Under Climate Warming: Co-Evolutionary Implications, Diagnosis, And Treatment, S Vega-Heredia, I Giffard-Mena, M Reverter

School of Biological and Marine Sciences

Climate change and the associated environmental temperature fluctuations are contributing to increases in the frequency and severity of disease outbreaks in both wild and farmed aquatic species. This has a significant impact on biodiversity and also puts global food production systems, such as aquaculture, at risk. Most infections are the result of complex interactions be - tween multiple pathogens, and understanding these interactions and their co-evolutionary mechanisms is crucial for developing effective diagnosis and control strategies. In this review, we discuss current knowledge on bacteria-bacteria, virus-virus, and bacterial and viral co-infections in aquaculture as well as their co-evolution in the …

Trial Of Early Minimally Invasive Removal Of Intracerebral Hemorrhage, Gustavo Pradilla, Salah G Keyrouz, Et Al.

2020-Current year OA Pubs

BACKGROUND: Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcomes than medical management is not known.

METHODS: In this multicenter, randomized trial involving patients with an acute intracerebral hemorrhage, we assessed surgical removal of the hematoma as compared with medical management. Patients who had a lobar or anterior basal ganglia hemorrhage with a hematoma volume of 30 to 80 ml were assigned, in a 1:1 ratio, within 24 hours after the time that they were last known to be well, to minimally invasive surgical …

Lead Compound Development Of Src-3 Inhibitors With Improved Pharmacokinetic Properties And Anticancer Efficacy, Dong Lu, Jianwei Chen, Li Qin, Imani Bijou, Ping Yi, Feng Li, Xianzhou Song, Kevin R Mackenzie, Xin Yu, Bin Yang, Sandipan Roy Chowdhury, James D Korp, Bert W O'Malley, David M Lonard, Jin Wang

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is a critical mediator of many intracellular signaling pathways that are crucial for cancer proliferation and metastasis. In this study, we performed structure-activity relationship (SAR) exploration and drug-like optimization of the hit compound SI-2, guided by in vitro/in vivo metabolism studies and cytotoxicity assays. Our efforts led to the discovery of two lead compounds, SI-10 and SI-12. Both compounds exhibit potent cytotoxicity against a panel of human cancer cell lines and demonstrate acceptable pharmacokinetic properties. A biotinylated estrogen response element (ERE) pull-down assay demonstrated that SI-12 could disrupt the recruitment of SRC-3 and p300 in …

Organizing The Dissemination And Implementation Field: Who Are We, What Are We Doing, And How Should We Do It?, Gretchen J R Buchanan, Lindsey M Filiatreau, Julia E Moore

2020-Current year OA Pubs

Two decades into its tenure as a field, dissemination and implementation (D&I) scientists have begun a process of self-reflection, illuminating a missed opportunity to bridge the gap between research and practice-one of the field's foundational objectives. In this paper, we, the authors, assert the research-to-practice gap has persisted, in part due to an inadequate characterization of roles, functions, and processes within D&I. We aim to address this issue, and the rising tension between D&I researchers and practitioners, by proposing a community-centered path forward that is grounded in equity.We identify key players within the field and characterize their unique roles using …

Impact Of Self-Reported Loss Of Balance And Gait Disturbance On Outcomes Following Adult Spinal Deformity Surgery, Bassel G Diebo, Munish C Gupta, Et Al.

2020-Current year OA Pubs

No abstract provided.

Mastigoneme Structure Reveals Insights Into The O-Linked Glycosylation Code Of Native Hydroxyproline-Rich Helices, Jin Dai, Meisheng Ma, Qingwei Niu, Robyn J Eisert, Xiangli Wang, Poulomi Das, Karl F Lechtreck, Susan K Dutcher, Rui Zhang, Alan Brown

2020-Current year OA Pubs

Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicroscopy (cryo-EM) to determine the structure of the hydroxyproline-rich mastigoneme, an extracellular filament isolated from the cilia of the alga Chlamydomonas reinhardtii. The structure demonstrates that mastigonemes are formed from two HRGPs (a filament of MST1 wrapped around a single copy of MST3) that both have hyperglycosylated poly(hydroxyproline) helices. Within the helices, O-linked glycosylation of the hydroxyproline residues and O-galactosylation of interspersed serine residues create a …

Macromolecular Condensation Organizes Nucleolar Sub-Phases To Set Up A Ph Gradient, Matthew R King, Kiersten M Ruff, Andrew Z Lin, Avnika Pant, Mina Farag, Jared M Lalmansingh, Tingting Wu, Martin J Fossat, Wei Ouyang, Matthew D Lew, Emma Lundberg, Michael D Vahey, Rohit V Pappu

2020-Current year OA Pubs

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nucleolar proteins. We show that the localization preferences of nucleolar proteins are determined by their IDRs and the types of RNA or DNA binding domains they encompass. In vitro reconstitutions and studies in cells showed how condensation, which combines binding and complex coacervation of nucleolar components, contributes to nucleolar organization. D/E tracts of nucleolar proteins contribute to lowering the pH of co-condensates formed with nucleolar RNAs in vitro. In cells, this …

Promoting The Use For Sugammadex In Robotic- Assisted Surgeries:, Amr Ali

Scholars Week

No abstract provided.

Prevalence And Severity Of Adhd Among Children With Second-Hand Smoke Exposure – A Us Population-Based Study, Saral R. Desai, Edward Lin

Tower Health Research Day

No abstract provided.

Predictors Of Treatment Admissions For Hallucinogen Use In The United States, Saral R. Desai, Hayden Sando, Edward Lin

Tower Health Research Day

No abstract provided.

Typhlitis In A Neutropenic Patient, Alice He Bs, Wern Lynn Ng Md, Lay She Ng Md, Si Yuan Khor Md, Chandi Garg Md

Tower Health Research Day

No abstract provided.

Wisdom & Creativity In Interior Design, Joshua Shockley

Seminar in Textiles and Clothing

Joshua Shockley graduated in 2001 from the University of Rhode Island with a B.S. in Textile Science and later obtained a Certificate of Interior Decorator at the Rhode Island School of Design (RISD). With this background, Shockley has built a successful solo business specializing in high-end residential and boutique design projects across New England. His approach emphasizes client communication, contract clarity, and textile performance, especially in healthcare settings. He exercises freedom by refraining from utilizing modern marketing strategy as he relies on word of mouth and a legacy client program to grow his clientele. His journey exemplifies the balance of …

Correlation Of Am Lpbf Processing Parameters To Grain Morphology Of Ss316l, Patrick Merighe

Student Research Symposium

Laser Powder Bed Fusion (LPBF) is a 3D printing technology that uses a recoater to spread powdered metal across a substrate. A laser then selectively fuses layers of this metal powder, intricately shaping three-dimensional objects. This process repeats, with each new layer of powder being spread across the previous layer to form a solid part.

Optimizing Nonprofit Impact: A Comprehensive Approach To Donor Data Management, Gracie Shippen

Student Research Symposium

The Malouf Foundation, addresses the critical issue of sexual violence, abuse, assault, exploitation, and human trafficking with an innovative donor data management program. This new program optimizes support for survivors while educating the public, increasing donations, and igniting community engagement.

• Maximizes resources for survivors, showing the impact of philanthropy on social issues.
• Boosts donations and awareness of sexual violence and trafficking.
• Drives increased support for survivors.

Navigating Uncertainty In Tax Strategy Due To The Tax Cuts And Jobs Act (Tcja) Sunset, Tate Smith

Student Research Symposium

Everyone files taxes and wants to pay as little as possible, but tax planning becomes complicated when new laws could come into effect. This research was designed to find the best tax planning strategy for the upcoming 2025 Tax Cuts and Jobs Act Sunset.

Development Of Systems For Processing & Managing Donations For The W.A.B. Warming Center, Landon Corbett

Student Research Symposium

The purpose of this project was to identify the specific needs of the William A. Burnard (WAB) Warming Center related to processing and managing donations and inventory and then propose a needs-based, evidenced-informed solution.

Predictable Movement Behaviors Of Feral Horses Make Them Vulnerable To Cougar Predation, Katelyn Davies

Student Research Symposium

Background

• Horses are water -dependent species whereas deer can get much of their water from forage
• Horses are typically diurnal, deer are crepuscular, and cougars show crepuscular and nocturnal behavior

Simulating Ice Nuclei Under Atmospheric Electric Fields, Joseph Cooney

Student Research Symposium

Orographic clouds generally form over mountains when valleys are sunny. The unstable atmosphere can trigger clouds over the mountains, which can be convective. When this happens, the cloud particles (water droplets and ice particles) become charged, ultimately creating ice crystals. In this study, we want to evaluate the impact of electricity on the formation of ice crystals and used a simulation to do so.

Do Modern Queer Musicians Conceal Their Identity?, Cristina Chirvasa

Student Research Symposium

Musicians such as Elton John, Jennifer Knapp, and George Michael have told stories of concealed identity, unfair treatment, and internal turmoil due to the tension between authenticity and marketability. A lot has changed since then: musicians are even more accessible with the invention of the internet, and in cases like Taylor Swift or Harry Styles, function as a brand of their own.

Testing Resilience Of Microalgae Biofilms When Exposed To Hydrothermal Liquefaction Aqueous Phase, Davis Haag

Student Research Symposium

Hydrothermal liquefaction (HTL) is a process that transforms wet biomass into a mixture of aqueous phase (AP), biochar solids, biocrude oil, and biogas.

The HTL process is not economically viable on a large scale partially because the HTL-AP is a toxic waste product with no current use.

The HTL-AQ contains high amounts of nitrogen (N) and phosphorus (P), but also environmental toxins such as phenolic compounds. The N and P could potentially be used to grow algae if it can survive the toxins.

Rotating algal biofilm reactors (RABRs) provide a method to grow algae biomass as a biofilm on plastic …