Digital Commons Network^™

Frailty Increases The Long-Term Risk For Fall And Fracture-Related Hospitalizations And All-Cause Mortality In Community-Dwelling Older Women, Elsa Dent, Jack Dalla Via, Trent Bozanich, Emiel O. Hoogendijk, Abadi K. Gebre, Cassandra Smith, Kun Zhu, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Frailty is associated with declines in physiological capacity across sensory, neurological, and musculoskeletal systems. An underlying assumption is that the frailer an individual, the more likely they are to experience falls and fractures. We examined whether grades of frailty can assess the long-term risk of hospitalized falls, fractures, and all-cause mortality in 1261 community-dwelling older women (mean age [SD] of 75.1 [2.7] yr) over 14.5 yr. Frailty was operationalized using a frailty index (FI) of cumulative deficits from 33 variables across multiple health domains (physical, mental, comorbidities) at baseline. The total score across these variables was summed and divided by …

Decline In Muscle Strength And Physical Function After Fracture In Men - The Prospective Strambo Study, Paweł Szulc, Joshua R. Lewis, Roland Chapurlat

Research outputs 2022 to 2026

Studies on muscle strength and physical function after fracture are focused on short follow-ups and adjacent anatomical region. We compared loss of muscle strength and physical function in men after fracture with normal ageing-related decline. In 823 men aged 60-87, measurements of grip strength and clinical tests (chair stands, balance) were performed every 4 years for 12 years. In 155 men with incident fracture, we compared the status after vs. before the fracture. In men without fracture (controls), we compared the status on the first follow-up (4 years) vs. baseline. In men with fracture, grip strength decreased more than in …

Adopting Information System Technologies In Construction Project Management, Hadi Haikal

Harrisburg University Dissertations and Theses

The construction sector has remained late in integrated information systems' adopting process to perform the system improving processes. Lack of adoption of technology has been a root cause of the early issues they faced, such as budgetary and scheduling overshoots, quality defects, safety occurrences, and generally poor communication and coordination among the stakeholders. This research looks into the benefits and challenges, the key success factors, and the implications of using an array of information systems, including building information modeling (BIM), artificial intelligence (AI), Internet of Things (IoT) sensing, and enterprise systems, to comprehensively address issues in project management in construction …

The Impact Of Using Standard Quality Measures Such As Iso 9001:2015 On Emerging Software Companies Created With Agile Methodologies., Elisa Orillac

Harrisburg University Dissertations and Theses

This qualitative research aimed to analyze the impact of applying quality measure standards, specifically ISO 9001:2015, in emerging software companies that have decided to manage their projects through Agile methodologies. While Agile methodologies are well known for their continuous delivery of software, the quality that results from these projects is not always guaranteed. This research aimed to evaluate what benefits in terms of cost, timely delivery of working software, and production have companies who already applied QMS had. Or, if applying the QMS had a negative result, why was this the case? The hypothesis for the research was that those …

Impact Of Emotional Intelligence On Client Satisfaction In Project Management, Mousami Berawala

Harrisburg University Dissertations and Theses

This study investigates the correlation between emotional intelligence (EI) and client satisfaction in project management. It is guided by the central research question: Is emotional intelligence linked to client satisfaction? To explore this, the research is structured around Practice of EI on Leadership and Junior level and impact on client satisfaction, the impact of varying work environments, including remote, hybrid, office-based, and site-based settings, on project outcomes post-pandemic; differences in EI practices across countries and the effect of diverse work cultures; the comparison of EI application across different fields, with a focus on work-life balance and industry-specific practices in banking, …

Tamara Lee Powell, Appellant V. Dean Deloy Powell, Appellee : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Third Judicial District Court, Salt Lake County, Honorable Mark Kouris, District Court No. 224906380

Dennis R. James, Counsel for Appellant

David M. Corbett, Counsel for Appellee

Regulation And Therapeutic Targeting Of Virus-Specific Resident Memory T Cells, Jordan Fredriksen Isaacs

Dartmouth College Ph.D Dissertations

CD8+ T cells are critical to the immune response to pathogens, as they kill infected cells and generate immunologic memory. Following infection, antigen-specific T cells expand approximately 10,000-fold and migrate to sites of inflammation in order to clear the pathogen. Once infection is resolved, a small pool of memory T cells persist in circulation and within tissues ready to respond rapidly upon re-exposure. Given the importance of CD8+ T cells, significant efforts have been made over the years to better understand how different memory T cell subsets are established, maintained, and regulated. The most recently identified subset, resident memory T …

Centralized Interactive Phenomics Resource: An Integrated Online Phenomics Knowledgebase For Health Data Users, Jacqueline Honerlaw, Yuk-Lam Ho, Francesca Fontin, Michael Murray, Ashley Galloway, David Heise, Keith Connatser, Laura Davies, Jeffrey Gosian, Monika Maripuri, John Russo, Rahul Sangar, Vidisha Tanukonda, Edward Zielinski, Maureen Dubreuil, Andrew J Zimolzak, Vidul A Panickan, Su-Chun Cheng, Stacey B Whitbourne, David R Gagnon, Tianxi Cai, Katherine P Liao, Rachel B Ramoni, J Michael Gaziano, Sumitra Muralidhar, Kelly Cho

Faculty, Staff and Students Publications

Objective: Development of clinical phenotypes from electronic health records (EHRs) can be resource intensive. Several phenotype libraries have been created to facilitate reuse of definitions. However, these platforms vary in target audience and utility. We describe the development of the Centralized Interactive Phenomics Resource (CIPHER) knowledgebase, a comprehensive public-facing phenotype library, which aims to facilitate clinical and health services research.

Materials and methods: The platform was designed to collect and catalog EHR-based computable phenotype algorithms from any healthcare system, scale metadata management, facilitate phenotype discovery, and allow for integration of tools and user workflows. Phenomics experts were engaged in the …

Coagulation Protease-Driven Cancer Immune Evasion: Potential Targets For Cancer Immunotherapy, Subhojit Paul, Tanmoy Mukherjee, Kaushik Das

School of Medicine Faculty Publications and Presentations

Blood coagulation and cancer are intrinsically connected, hypercoagulation-associated thrombotic complications are commonly observed in certain types of cancer, often leading to decreased survival in cancer patients. Apart from the common role in coagulation, coagulation proteases often trigger intracellular signaling in various cancers via the activation of a G protein-coupled receptor superfamily protease: protease-activated receptors (PARs). Although the role of PARs is well-established in the development and progression of certain types of cancer, their impact on cancer immune response is only just emerging. The present review highlights how coagulation protease-driven PAR signaling plays a key role in modulating innate and adaptive …

Chapter 1: Legal Divisions Of The Oceans And Airspace

International Law Studies

The Commander’s Handbook on the Law of Naval Operations is used in the United States and throughout the world as a restatement of U.S. doctrinal law positions on matters affecting the operations of the U.S. Navy, the U.S. Marine Corps, and the U.S. Coast Guard. Judge advocates and legal advisers have occasion to conduct deeper research to identify the context and source of the rules reflected in the Commander’s Handbook. Responding to this need, an Annotated Supplement to The Commander’s Handbook was produced in 1997 and published as volume 73 of International Law Studies. In the intervening decades, …

Chapter 3: Protection Of Persons And Property At Sea And Maritime Law Enforcement

International Law Studies

The Commander’s Handbook on the Law of Naval Operations is used in the United States and throughout the world as a restatement of U.S. doctrinal law positions on matters affecting the operations of the U.S. Navy, the U.S. Marine Corps, and the U.S. Coast Guard. Judge advocates and legal advisers have occasion to conduct deeper research to identify the context and source of the rules reflected in the Commander’s Handbook. Responding to this need, an Annotated Supplement to The Commander’s Handbook was produced in 1997 and published as volume 73 of International Law Studies. In the intervening decades, …

Chapter 4: Safeguarding U.S. National Interests In The Maritime Environment

International Law Studies

The Commander’s Handbook on the Law of Naval Operations is used in the United States and throughout the world as a restatement of U.S. doctrinal law positions on matters affecting the operations of the U.S. Navy, the U.S. Marine Corps, and the U.S. Coast Guard. Judge advocates and legal advisers have occasion to conduct deeper research to identify the context and source of the rules reflected in the Commander’s Handbook. Responding to this need, an Annotated Supplement to The Commander’s Handbook was produced in 1997 and published as volume 73 of International Law Studies. In the intervening decades, …

The Effects Of Class-Wide Function-Related Intervention Teams In A Self-Contained Elementary Classroom For Students With Emotional Or Behavioral Disorders, Peyton Ann Johnstone

Theses and Dissertations

Class-wide Function-related Intervention Teams (CW-FIT) is a classroom management intervention that incorporates positive behavior support (PBS) principles by teaching students specific classroom behavioral expectations during instructional time and providing students feedback on their behavior and use of social skills throughout the day. Students who are at risk for or are classified with Emotional or Behavioral Disorders (EBD) often struggle more both academically and socially than their peers. Because of the serious challenges that students with EBD face, it is important to find effective PBS interventions to help them be successful, both socially and academically. Researchers examined the effects of CW-FIT …

Ipsc-Based Modeling Of Preeclampsia Identifies Epigenetic Defects In Extravillous Trophoblast Differentiation, Robert Morey, Tony Bui, Virginia Chu Cheung, Chen Dong, Joseph E Zemke, Daniela Requena, Harneet Arora, Madeline G Jackson, Donald Pizzo, Thorold W Theunissen, Mariko Horii

2020-Current year OA Pubs

Preeclampsia (PE) is a hypertensive pregnancy disorder with increased risk of maternal and fetal morbidity and mortality. Abnormal extravillous trophoblast (EVT) development and function is considered to be the underlying cause of PE, but has not been previously modeled

Bioresorbable, Wireless, Passive Sensors For Continuous Ph Measurements And Early Detection Of Gastric Leakage, Shuo Li, Yameng Xu, Ying Yan, Jorge Zárate Rodriguez, Mitchell A Pet, Chet W Hammill, Matthew R Macewan, Wilson Z Ray, Et Al.

2020-Current year OA Pubs

Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time …

Sars-Cov-2 Omicron Ba.1 Variant Infection Of Human Colon Epithelial Cells, Avan Antia, David M Alvarado, Qiru Zeng, Luis A Casorla-Perez, Deanna L Davis, Naomi M Sonnek, Matthew A Ciorba, Siyuan Ding

2020-Current year OA Pubs

The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the ancestral strain. However, the infectivity of Omicron in the gastrointestinal tract is not fully defined, despite the fact that 70% of COVID-19 patients experience digestive disease symptoms. Here, using primary human colonoids, we found that, regardless of individual variability, Omicron infects colon cells similarly or less effectively than the ancestral strain or the Delta variant. The variant induced limited type III interferon expression and showed …

Sleep And Circadian Biomarkers Of Postoperative Delirium (Sleep-Pod): Protocol For A Prospective And Observational Cohort Study, Elizabeth Sugg, Elizabeth Gleeson, Sarah N Baker, Peng Li, Chenlu Gao, Ariel Mueller, Hao Deng, Shiqian Shen, Esteban Franco-Garcia, Richa Saxena, Erik S Musiek, Oluwaseun Akeju, Zhongcong Xie, Kun Hu, Lei Gao

2020-Current year OA Pubs

INTRODUCTION: Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. This protocol presents a single-site, prospective observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association could be moderated or mediated by Alzheimer's disease (AD) pathology and genetic risk for AD.

METHODS AND ANALYSIS: Study staff members will screen for eligible patients (age ≥70) seeking joint replacement or spinal surgery at Massachusetts General Hospital (MGH). At the inclusion visit, patients will be asked a …

Knowledge Translation Task Force For Core Measures Clinical Practice Guideline: A Short Report On The Process And Utilization, Marghuretta D Bland, Jennifer L Moore, Elizabeth Anderl, Megan Eikenberry, Arlene Mccarthy, Geneviève N Olivier, Tracy Rice, Amelia Siles, Hallie Zeleznik, Wendy Romney

2020-Current year OA Pubs

BACKGROUND: As part of the 2018 Clinical Practice Guideline (CPG): A Core Set of Outcome Measures for Adults with Neurologic Conditions Undergoing Rehabilitation, a Knowledge Translation (KT) Task Force was convened. The purpose of this short report was to (1) demonstrate the potential impact of a CPG KT Task Force through a practical example of efforts to implement a CPG into neurologic physical therapy practice and (2) describe the process to convene a KT Task Force and develop products (KT Toolkit) to facilitate implementation of the CPG.

METHODS: To describe the process used by the KT Task Force to develop …

User-Driven Data Privacy Protection In An Iot Environment, Nivetha B, Frank Michaud, Rahul Kata, Pranetha Priya R, Ganesh Paramasivan

Defensive Publications Series

Techniques are presented herein that enhance user data privacy in an Internet of things (IoT) environment. Aspects of the techniques introduce a third actor into such an environment – apart from a user and an IoT device – whose sole purpose is to empower a user to protect their own data. Such a data Custodian or Sanitizer may collect inputs from a user through a software as a service (SaaS) solution and then leverage the capabilities of the extended Berkeley Packet Filter (eBPF) to apply those inputs to an IoT device.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.