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Assessing The Impact Of Septic Cardiomyopathy On The Right Ventricle: A Serial Echocardiogram Study, Shivika Agrawal Apr 2024

Assessing The Impact Of Septic Cardiomyopathy On The Right Ventricle: A Serial Echocardiogram Study, Shivika Agrawal

University of Montana Conference on Undergraduate Research (UMCUR)

Purpose:

Sepsis frequently manifests as distributive shock and affects several organs, including the heart, which may progress to septic cardiomyopathy (SCM). SCM typically reduces the ejection fraction and causes dilation of the left heart; however, a full understanding of SCM on the right heart is incomplete. Through echocardiography, further qualitative and quantitative alterations in the heart can be identified and guide our clinical management. We aim to identify such alterations in the right ventricle (RV) in patients with SCM through evaluation of serial echocardiography reports.

Methods:

A retrospective cohort study (IRB 20-008691) was conducted on 13,969 sepsis patients hospitalized at …


Identifying Cross-Linguistic Language Deficits In Bilinguals With Aphasia Through Picture Identification Task, Mia Cara Parkes, Violet Rosenquist, Ashlynn Everett Apr 2024

Identifying Cross-Linguistic Language Deficits In Bilinguals With Aphasia Through Picture Identification Task, Mia Cara Parkes, Violet Rosenquist, Ashlynn Everett

University of Montana Conference on Undergraduate Research (UMCUR)

Aphasia, which is the loss of language commonly caused by stroke, can have several implications on grammar production. Significant research has been conducted on ways in which grammar is affected by aphasia, however, little is known about what these deficits look like for bilinguals with aphasia (BWA). This study examines the similarity of grammar deficits between languages by having Spanish-English BWA participate in a picture identification task. This research aims to explore whether deficits in one language influence performance on the other, as well as identify any patterns of cross-linguistic (i.e., the relation between two languages) influence on grammar processing. …


Measurement Of Atmospheric 2,5-Dimethylfuran Using Proton Transfer Reaction-Mass Spectrometry, Mercedes Tucker Apr 2024

Measurement Of Atmospheric 2,5-Dimethylfuran Using Proton Transfer Reaction-Mass Spectrometry, Mercedes Tucker

University of Montana Conference on Undergraduate Research (UMCUR)

2,5-Dimethylfuran (DMF) is a proposed biofuel with low solubility in water and high miscibility with gasoline and diesel oil. DMF can be synthesized from cellulose found in dry plant matter, such as agricultural residues, energy crops, forestry residues, and yard trimmings. Furthermore, it is also found in tobacco smoke, roasted coffee aroma, and biomass burning smoke through combustion processes. When compared to leading industry renewable biofuels like ethanol it has a higher energy density, lower volatility, and a higher-octane level. Many studies have been conducted on DMF’s performance as a biofuel, when added to or compared to current leading fuels …


Case Studies Of Outdoor Education, Casey L. Simons Apr 2024

Case Studies Of Outdoor Education, Casey L. Simons

University of Montana Conference on Undergraduate Research (UMCUR)

Abstract

This study analyzed the benefits and drawbacks of outdoor education on elementary-aged children. The educational environment a child experiences is critical to their experience for their entire academic careers. Outdoor education has been in existence since the 1940s. Six schools and institutions that provide outdoor education within their curriculum were selected to be a part of this study. Outdoor education school administrators were interviewed and asked a series of questions regarding the implementation of outdoor education within their institution. The interviews detailed how outdoor education impacted students and their future education experiences within the education they received at that …


Overview: High-Quality Atmospheric Readings And Telemetry (Hart) Station, Joseph Hart Knudsen Apr 2024

Overview: High-Quality Atmospheric Readings And Telemetry (Hart) Station, Joseph Hart Knudsen

University of Montana Conference on Undergraduate Research (UMCUR)

The High-quality Atmospheric Readings and Telemetry (HART) Station is a modular, solar-powered array of tripod-mounted meteorological and particulate matter (PM) instruments. It also includes a data-logger and a laptop which consolidates collected data and uploads it to a remote storage cache in Google Drive. There are three main purposes for the HART station:

  1. Provide quality PM data to assist in filling in the PM data gap in Montana.

  2. Increase awareness and education of the public, primarily the middle and high-school demographics, of the importance of meteorological and air quality studies and the potential health-risks of PM exposure.

  3. Contribute to the …


Artificial Intelligence: The Road More Traveled. Writing And Conducting Research With Ai, Laura Zucca-Scott, Samuel Stinson Apr 2024

Artificial Intelligence: The Road More Traveled. Writing And Conducting Research With Ai, Laura Zucca-Scott, Samuel Stinson

Georgia International Conference on Information Literacy

This project illustrates and discusses actionable examples of how collaborative, supportive virtual or in-person environments can foster democratic learning models in the age of Artificial Intelligence.

The workshop models, whether in person or virtual, provide dialogical opportunities for growth. Critically examining information and developing writing skills become crucial in supporting scholarly growth and intellectual exploration while providing access to academic pursuits to otherwise marginalized individuals and groups.

The experiences we share are situated in a specific context and are interconnected with the perspectives, backgrounds, and expectations of the scholars involved. However, as the writing workshops continue to evolve due to …


The Specific Jurisdiction Of The Major And Minor Criminal Courts In Accordance With The Federal Criminal Procedure Law, Khaled Nedaila Al Nuaimi Apr 2024

The Specific Jurisdiction Of The Major And Minor Criminal Courts In Accordance With The Federal Criminal Procedure Law, Khaled Nedaila Al Nuaimi

Thesis/ Dissertation Defenses

This study deals with the rules of specific jurisdiction for the major and minor criminal courts in accordance with the Federal Code of Criminal Procedure, where specific jurisdiction is one of the most important jurisdictions stipulated by the federal legislator, by allocating specific courts to specific types of crimes, after the general rule was that the court of misdemeanors and violations was competent to try those accused of committing A misdemeanor, or a violation, the Criminal Court has jurisdiction over felonies. In light of this, the federal legislator in the United Arab Emirates has singled out a new system with …


The Dragon In The Room: The Perils And Possibilities Of Ai-Generated, Openly-Licensable Rpg Program Content, Nathaniel Lee Bareford Apr 2024

The Dragon In The Room: The Perils And Possibilities Of Ai-Generated, Openly-Licensable Rpg Program Content, Nathaniel Lee Bareford

Georgia International Conference on Information Literacy

Role playing games (RPGs) like Dungeons and Dragons are becoming increasingly popular and more in-demand by patrons of both academic and public libraries. Research has demonstrated that role playing games are valuable tools for reinforcing discipline-specific knowledge, developing career-ready soft skills, and cultivating information literacy practices. However, librarians are taxed for time and the investment required to produce practically usable, openly licensed RPG content is substantial. Additional access barriers such as material costs and licensing restrictions often prevent librarians from being able to sustain roleplaying game programming. If AI can produce usable, open RPG resources based firmly on open licenses …


Evaluating The Effect Of Skipping Ticagrelor Doses And Need For Bolus Doses Upon Treatment Resumption Through Population Pk/Pd Simulation, Hiroyoshi Matsui, Le Thien Truc Pham, Eyob D. Adane Apr 2024

Evaluating The Effect Of Skipping Ticagrelor Doses And Need For Bolus Doses Upon Treatment Resumption Through Population Pk/Pd Simulation, Hiroyoshi Matsui, Le Thien Truc Pham, Eyob D. Adane

ONU Student Research Colloquium

Ticagrelor (Brilinta (R)) is the first reversibly binding oral P2Y12 receptor antagonist. It is used, mostly in combination with aspirin, in patients with acute coronary syndromes to reduce thrombosis. The manufacturer of ticagrelor recommends discontinuing it at least 5 days before any surgery when possible. While the effect of dose interruptions on the risk of thrombosis is not directly studied, it is important to understand the impact of skipping doses on ticagrelor's PK/PD profile for clinical-decision making. The objectives of the current study were to simulate the impact of therapy interruption on the PK/PD of ticagrelor and examine the need …


Differential Behavioral Responses In Male And Female Mice Lacking Either Rgs2 Or Rgs4 Proteins After Acute Administration Of Antidepressants And Anxiolytics, Hiroyoshi Matsui, Sarah Seeley, Manoranjan S. D'Souza Apr 2024

Differential Behavioral Responses In Male And Female Mice Lacking Either Rgs2 Or Rgs4 Proteins After Acute Administration Of Antidepressants And Anxiolytics, Hiroyoshi Matsui, Sarah Seeley, Manoranjan S. D'Souza

ONU Student Research Colloquium

The overall objective of the study was to assess the acute behavioral effects of currently used antidepressants and anxiolytics in male and female mice lacking regulator of G protein-signaling (RGS) proteins 2 and 4 and their wild-type counterparts. RGS 2 and 4 proteins negatively modulate signaling pathways of G protein-coupled receptors (GPCRs), which play an important role in mediating the effects of monoamine neurotransmitters such as dopamine, norepinephrine, and serotonin. These neurotransmitters in turn play an important role in the action of antidepressant and anxiolytic medications. The study was undertaken because no studies till date have systematically assessed the behavioral …


Body Mass Index Of Male And Female Athletes At Onu From 2000-2023, Sydney Kilgore, Hunter King, Scott Swanson Apr 2024

Body Mass Index Of Male And Female Athletes At Onu From 2000-2023, Sydney Kilgore, Hunter King, Scott Swanson

ONU Student Research Colloquium

Title: Body Mass Index of Male and Female Athletes at ONU from 2000-2023

Introduction/Background:

Body Mass Index (BMI) is a quick and simple measurement examining the ratio of body mass to height. Many athletes are larger than their non-athlete counterparts due to increased muscle mass and may have elevated BMI’s. The NCAA’s Division III has the largest number of athletes (>200,000 participants) and comprises nearly 40% of all the athletes in the three NCAA athletic Divisions. Despite the number of athletes participating in Division III athletics, little is known about their overall physical characteristics and BMI.

Purpose:

Determine …


Pharmacokinetic/Pharmacodynamic Modeling And Simulation Of Various Bolus And Infusion Doses Of Cangrelor, Le Thien Truc Pham, Eyob Adane Apr 2024

Pharmacokinetic/Pharmacodynamic Modeling And Simulation Of Various Bolus And Infusion Doses Of Cangrelor, Le Thien Truc Pham, Eyob Adane

ONU Student Research Colloquium

Background: Cangrelor (Kengreal(R) is a non-thienopyridine parenteral antiplatelet drug approved as an adjunct for the reduction of periprocedural myocardial infarction and stent thrombosis risk in patients undergoing percutaneous coronary intervention (PCI). It is also used off-label for bridging in patients who are off their antiplatelet agents prior to surgery. Cangrelor blocks the binding of adenosine diphosphate (ADP) by reversibly binding to P2Y12 receptors on platelet surfaces. In comparison to other P2Y12 antagonists, cangrelor has a rapidly reversible platelet inhibition effect with a short half-life of approximately 3-5 minutes. Data on simultaneous PK/PD modeling of cangrelor are, however, lacking. The aims …


Effects Of Kappa Opioid Receptor Manipulation On Methamphetamine-Induced Behavioral Sensitization In Adolescent Male And Female Rats, Hiroyoshi Matsui Mr, Sarah Seeley, Manoranjan S. D'Souza Apr 2024

Effects Of Kappa Opioid Receptor Manipulation On Methamphetamine-Induced Behavioral Sensitization In Adolescent Male And Female Rats, Hiroyoshi Matsui Mr, Sarah Seeley, Manoranjan S. D'Souza

ONU Student Research Colloquium

Methamphetamine abuse amongst adolescents has been on the rise in the United States. In this study, we assessed the effects of manipulation of KORs on methamphetamine-induced behavioral sensitization in adolescent male and female rats. Methamphetamine-induced behavioral sensitization is an animal model to study methamphetamine addiction. Behavioral sensitization usually occurs in animals who have been treated with methamphetamine followed by a period of withdrawal. It is hypothesized that brain circuits are altered during the period of withdrawal after methamphetamine exposure resulting in sensitized (increased) responses to methamphetamine at the end of the withdrawal period. The experiment was conducted over 28 days. …


2023 Tcpea Outstanding Dissertation Of The Year Research Summary, Maegan Collins, Kaye Shelton Dissertation Chair Apr 2024

2023 Tcpea Outstanding Dissertation Of The Year Research Summary, Maegan Collins, Kaye Shelton Dissertation Chair

School Leadership Review

This phenomenological study explored perceived first-generation college student retention at a Texas four-year higher education institution post-vertical transfer. The participants in this study consisted of 12 full-time and part- time students who identified as first-generation college students and had vertically transferred from a two-year higher education institution. In addition, participants transferred between 35 and 120 academic credit hours from a two-year higher education institution and had been enrolled for at least one academic semester at their four-year higher education institution. On-campus and virtual semi-structured interviews were conducted and analyzed, which resulted in major themes. This study revealed academic and social …


Comprehensive Evaluation Of The Quest Experience-Based Class: A 7-Year Program Review, Louis Stevens, Carly Byrne Apr 2024

Comprehensive Evaluation Of The Quest Experience-Based Class: A 7-Year Program Review, Louis Stevens, Carly Byrne

University of Montana Conference on Undergraduate Research (UMCUR)

QUEST (Questions for Undergraduates Exploring Social Topics) represents a dynamic collaboration between the University of Montana's esteemed Davidson Honors College (DHC) and a valued community partner. Originating in 2017 from the visionary initiative of two dedicated DHC students, this innovative program was conceived to foster interdisciplinary exploration with real-world impact.

In the heart of Missoula, QUEST empowers student teams to embark on a transformative journey of research, design, and advocacy, tackling pressing, cross-disciplinary challenges facing our community. Guided by the rigors of two semesters of intensive study (HONR 495), participants delve deep into their chosen topics, forging comprehensive solutions that …


Identifying Environmental Drivers Of Shell Shape Variation In The Freshwater Gastropod Campeloma Decisum, Lauren Western, David Zanatta Apr 2024

Identifying Environmental Drivers Of Shell Shape Variation In The Freshwater Gastropod Campeloma Decisum, Lauren Western, David Zanatta

University of Montana Conference on Undergraduate Research (UMCUR)

Freshwater gastropods are important indicators of ecosystem health. Many native gastropod species are considered highly imperiled while other non-indigenous species are considered damaging invaders. Campeloma decisum, Pointed Campeloma, is a common freshwater gastropod from family Viviparidae found in varied habitats across the eastern United States and southeastern Canada. Our study sought to increase the knowledge on C. decisumusing geometric morphometric analyses to test which environmental factors may be driving shell shape variation. C. decisum (n = 458) and environmental data were collected from 22 sites in 6 lakes in central and northern Michigan. Specimens were photographed with apertures …


The End Of Roe: An Examination Of The Dobbs Decision’S Effect On Abortion Access In Montana And Nation-Wide, Molly Ruth/Bratton Heenan Apr 2024

The End Of Roe: An Examination Of The Dobbs Decision’S Effect On Abortion Access In Montana And Nation-Wide, Molly Ruth/Bratton Heenan

University of Montana Conference on Undergraduate Research (UMCUR)

The landscape of reproductive rights has shifted dramatically following the Supreme Court’s Dobbs decision. My research is looking to analyze the implications of the Dobbs decision and the broader context of abortion rights in this our country, and in Montana. I will be examining the landscape of reproductive rights in Montana, its unique state constitutional protection of privacy, and the political shifts undergone which have taken us to current legislative “born-alive proposals. I will be looking at changes in the state’s partisan makeup, and further radicalization of both parties, creating deeper divisions on the issue of abortion. Additionally, I want …


Cybersecurity Continuous Learning Towards Fulfilling National Cybersecurity Strategic Plan Mandates, Saleh Hamad Aldaajeh Apr 2024

Cybersecurity Continuous Learning Towards Fulfilling National Cybersecurity Strategic Plan Mandates, Saleh Hamad Aldaajeh

Thesis/ Dissertation Defenses

This dissertation delves into enhancing cybersecurity education by aligning academic curricula with national cybersecurity strategic plan (NCSP) objectives, emphasizing the crucial role of Higher Education Institutions (HEIs) in developing a skilled cybersecurity workforce. Analyzing ten NCSPs, it identifies strategic themes and gaps between national goals and HEI offerings. The study reviews NCSP guidelines, international cybersecurity indices, and literature, including the NICE-NIST framework, to develop a framework that bridges the educational gap, improving learning outcomes and arming students with vital skills, knowledge, and competencies. Furthermore, it introduces a platform for continuous cybersecurity learning, employing micro-credentials, blockchain technology, and AI-driven systems. Based …


The Effect Of Using Social Media Platforms In The Public Service Sector On Customer Satisfaction: The Case Of Al Ain City Municipality, Salma Matar Almansouri Apr 2024

The Effect Of Using Social Media Platforms In The Public Service Sector On Customer Satisfaction: The Case Of Al Ain City Municipality, Salma Matar Almansouri

Thesis/ Dissertation Defenses

Information and Communication Technology has transformed how individuals and organizations interact with each other and the way they function, produce, and consume. As more than 59 percent of the world’s population is on social media, the social channels have become an integral part of an organization’s service delivery plan. Government’s too started service provision and relationship building with their customers through social media, as part of their e-Governance strategy. To understand the role of technology as an enabler to Enact Electronic Government Success (EEGS), the present study focuses on the effectiveness of social media use by local government, viz., the …


The "Indian" Alexander: Reworking Nationalism, Myth, And Sikandar, John Sexton Apr 2024

The "Indian" Alexander: Reworking Nationalism, Myth, And Sikandar, John Sexton

Madison Historical Review

This article seeks to expand scholarly inquiry regarding the Alexander Romance into twentieth century India and away the Near East of Antiquity and the Europe of the Middle Ages where it is usually confined. In particular this article will discuss the Alexander Romance’s impact upon and connection with the modern invention of the cinema. Besides the usual cinematic culprit of analysis, Oliver Stone's Alexander (2004), there is another less-discussed cinematic work regarding Alexander the Great. That being Sohrab Modi's Hindustani historical epic Sikandar (1941) from British colonial India. Regarding the Macedonian conqueror and his reputation among Indian scholars such as …


Considering The “Special Considerations”: The Treatment Of Female Inmates In The People’S Republic Of China Since 1994, Niklas Berry Apr 2024

Considering The “Special Considerations”: The Treatment Of Female Inmates In The People’S Republic Of China Since 1994, Niklas Berry

Madison Historical Review

The purpose of this paper is to historicize contemporary gendered legal practices in the People’s Republic of China and to demonstrate that, despite rhetoric to the contrary, paternalistic assumptions rooted in Confucianism still inform the treatment of female prisoners today. Though China underwent massive political and economic shifts after the formation of the People’s Republic of China in 1949 and the death of Mao Zedong in 1976, certain longstanding societal principles were preserved in modern China, including long-held paternalistic stereotypes about the physical and mental fragility of women. These precepts undergirded the PRC’s reforms of its judicial and criminal systems …


Toros, Moros, And Empire: The Sixteenth-Century Spanish Bullfight, David A. Gonzalez Apr 2024

Toros, Moros, And Empire: The Sixteenth-Century Spanish Bullfight, David A. Gonzalez

Madison Historical Review

Toros, Moros, and Empire: The Sixteenth-Century Spanish Bullfight

By David A. González-2023

Relying on the methodological tools provided by New Historicism and Critical Race Theory, this paper evaluates the primary texts of Franciscan minor Francisco de Alcocer’s Tratado del Juego (1559) and the Spanish aristocrat Luis Zapata de Chaves’ Carlo Famoso (1566) and Varia Historia: Miscelania (c. 1595) to assess the extent of non-Europeans’ role and impact on the development of the early modern bullfight. These texts highlight the conflicting views over the bullfight’s European legitimacy. As such, they shed light on the larger debates between church and aristocracy over …


Fighting For The Franchise: African American Disfranchisement In Charlottesville, Virginia, Thomas R. Seabrook Apr 2024

Fighting For The Franchise: African American Disfranchisement In Charlottesville, Virginia, Thomas R. Seabrook

Madison Historical Review

Around the turn of the twentieth century, white Southerners crossed the political aisle to disfranchise African American voters through a series of legislation at the state level. Though African Americans resisted these efforts to strip them of their citizenship rights, many historians believe that African Americans had been practically shut out of politics by 1900. Disfranchisement did not mean that African Americans stopped asserting their constitutional rights, however, as historians who trace African American organization and resistance have shown. In this article, I examine the response of African Americans in Charlottesville, Virginia, to disfranchisement and I consider the effect disfranchisement …


Is Humanitarian Aid Neutral? The American Ambulance Field Service And The American Red Cross, Laura Neis Apr 2024

Is Humanitarian Aid Neutral? The American Ambulance Field Service And The American Red Cross, Laura Neis

Madison Historical Review

The United States did not outwardly join WWI until April of 1917. However, in the nearly three years in which the U.S. was neutral, they provided medical support to the suffering. This act has been dismissed as humanitarian charity work, and therefore not breaking with neutrality agreements, but it was actually a hotly contested act of foreign policy, and different propaganda campaigns were used to change the minds of American citizens.

Two different groups of medical volunteers show how humanitarian aid shapes perspectives on war. The American Ambulance Field Service drove ambulances for the French army on the front line, …


The Necessary Bargain: How Texas Education Utilized President Johnson’S Elementary And Secondary Education Act, 1965-1970, Kade L. Kahanek Apr 2024

The Necessary Bargain: How Texas Education Utilized President Johnson’S Elementary And Secondary Education Act, 1965-1970, Kade L. Kahanek

Madison Historical Review

President Lyndon Johnson announced his “War on Poverty” campaign at the State of the Union Address in January 1964. Johnson’s address acknowledged that United States citizens suffered from poverty in many regions and enclosed a plan to relieve poverty in America. President Johnson’s administration administered “Great Society” programs under education, healthcare, and the job corps to help ease the burdening symptoms of poverty. It has been long debated whether Johnson’s policies to improve America’s society have succeeded, but many fail to recognize that his education plan was the centerpiece and perhaps not an instant cure to poverty; instead, something concrete …


Republican Manhood And The Disabled Revolutionary War Veteran In The Early American Republic, 1789 – 1797, Virgil Clark Apr 2024

Republican Manhood And The Disabled Revolutionary War Veteran In The Early American Republic, 1789 – 1797, Virgil Clark

Madison Historical Review

In the aftermath of the American Revolutionary War, several Disabled Continental Army soldiers scattered across the burgeoning Republic were driven by desperation to write letters, pleading with General George Washington for his support. The soldiers’ decision to draft these letters stemmed from their profound frustration and disillusionment with the post-Revolution American state. The soldiers' discontent resulted from the sense of neglect they experienced after the state rejected their petitions for a Disabled Veteran’s pension. As time passed and rent went unpaid, medical bills piled up, and the threat of vagrancy loomed over these men like a malevolent specter. Unable to …


Letter From The Editor, Kevin Johnson Apr 2024

Letter From The Editor, Kevin Johnson

Madison Historical Review

No abstract provided.


Mhr Volume 21 Full Issue Apr 2024

Mhr Volume 21 Full Issue

Madison Historical Review

No abstract provided.


Scorpions Of The Horn Of Africa (Arachnida: Scorpiones) Part Xxxi. Two New Genera From Somaliland: Sanaag Gen. N. And Sahil Gen. N. (Buthidae), František Kovařík Apr 2024

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones) Part Xxxi. Two New Genera From Somaliland: Sanaag Gen. N. And Sahil Gen. N. (Buthidae), František Kovařík

Euscorpius

Two new monotypic buthid genera are described: Sanaag gen. n. and Sahil gen. n. from Somaliland, both belonging to the ‘Buthus’ group. Sanaag gen. n. (type species Gint maidensis Kovařík et al., 2018) differs from Gint Kovařík et al., 2013 in the structure of its hemispermatophore, which has a large, tall, subtriangular hook-like basal lobe, and in the shape of its telson which is rather bulbous. Sahil gen. n. (type species Sahil elmii sp. n.) differs from all morphologically similar small-sized genera of the Horn of Africa in having the ventral aspect of cheliceral fixed finger with two denticles, …


Pharmaceutical Composition Comprising Rimegepant, Ravi Kumar Nithiyanandam; Dr. Mahesh N. Padamwar; Dr. Sabyasachi Swain; Msn Laboratories Private Limited, R&D Center, Hyderabad & India Apr 2024

Pharmaceutical Composition Comprising Rimegepant, Ravi Kumar Nithiyanandam; Dr. Mahesh N. Padamwar; Dr. Sabyasachi Swain; Msn Laboratories Private Limited, R&D Center, Hyderabad & India

Defensive Publications Series

The present invention relates to pharmaceutical composition comprising rimegepant or a pharmaceutically acceptable salts thereof and process for preparation which is simple, economic, cost-effective, and industrially amenable to scale up. Further, the said invention is used for the acute treatment of migraine with or without aura in adults and preventive treatment of episodic migraine in adults