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Treatment At An Academic Medical Center Eliminates Survival Disparities For Appalachian Kentuckians With Pancreatic Ductal Adenocarcinoma, Emily Cassim, Hannah Mcdonald, Megan Harper, Quan Chen, Miranda Lin, Reema Patel, Michael Cavnar, Prakash Pandalai, Bin Huang, Pamela C. Hull, Joseph Kim, Erin Burke Apr 2024

Treatment At An Academic Medical Center Eliminates Survival Disparities For Appalachian Kentuckians With Pancreatic Ductal Adenocarcinoma, Emily Cassim, Hannah Mcdonald, Megan Harper, Quan Chen, Miranda Lin, Reema Patel, Michael Cavnar, Prakash Pandalai, Bin Huang, Pamela C. Hull, Joseph Kim, Erin Burke

Journal of Appalachian Health

Introduction: Rates of cancer mortality in Appalachian Kentucky is among the highest in the nation. It is unknown whether geographic location of treatment for pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers worldwide, influences survival in Appalachian Kentuckians.

Purpose: This study compares outcomes among Appalachian Kentuckians with PDAC who received treatment at an academic medical center (AMC) or community facility (CF).

Methods: Using the Kentucky Cancer Registry, patients diagnosed with PDAC between 2003 and 2018 were identified. Patients were categorized according to treatment location (AMC v. CF) and county of residence (Appalachian v. non-Appalachian). Kaplan-Meier curves were constructed to …


Conscientious Objection: Understanding When And Why Primary Care Physicians Object To Providing Health Care To Transgender And Gender-Diverse Patients In An Appalachian Medical Center, Mili S. Patel, Kelley A. Jones, Laura Davisson, Elizabeth Miller, Nicole Kahn, Pamela J. Murray, Kacie M. Kidd Apr 2024

Conscientious Objection: Understanding When And Why Primary Care Physicians Object To Providing Health Care To Transgender And Gender-Diverse Patients In An Appalachian Medical Center, Mili S. Patel, Kelley A. Jones, Laura Davisson, Elizabeth Miller, Nicole Kahn, Pamela J. Murray, Kacie M. Kidd

Journal of Appalachian Health

Introduction: Transgender and gender-diverse (TGD) individuals face barriers to accessing primary and gender-affirming care, especially in rural regions where a national shortage of medical providers with skills in caring for TGD people is further magnified. This care may also be impacted by individual providers’ strongly held personal or faith beliefs and associated conscientious objection to care.

Purpose: This study assesses the prevalence of conscientious objection to providing care and gender-affirming hormone (GAH) therapy to TGD individuals among physicians in an Appalachian academic medical center.

Methods: An anonymous, online, cross-sectional survey of physicians was distributed to resident and faculty physicians in …


Check With The Intended Audience First! Content Validation As A Method For Inclusive Research For Primary Care Engagement In Rural Appalachia, Sydeena E. Isaacs, Jennifer Schroeder Tyson, Ashley Parks, Danielle Adams Apr 2024

Check With The Intended Audience First! Content Validation As A Method For Inclusive Research For Primary Care Engagement In Rural Appalachia, Sydeena E. Isaacs, Jennifer Schroeder Tyson, Ashley Parks, Danielle Adams

Journal of Appalachian Health

Introduction: To date, referral practices based on social determinants of health (SDOH) among primary care providers (PCPs) and clinic staff in rural regions, including Appalachian North Carolina (NC), are not well understood.

Purpose: This study aims to develop and content validate a primary care engagement (PCE) survey to assess (1) engagement and burnout; (2) referral practices; and (3) self-efficacy and confidence in making referrals based on SDOH among PCPs and clinic staff in Appalachian NC.

Methods: Using the Social-Ecological Model as a theoretical framework, researchers developed a 37-item PCE survey. Content validation was completed by a panel of experts recruited …


Best Practices To Increase Stakeholder Engagement In Agile Project Management For Urban Real Estate Affordable Housing Projects, Tran Pham Apr 2024

Best Practices To Increase Stakeholder Engagement In Agile Project Management For Urban Real Estate Affordable Housing Projects, Tran Pham

Harrisburg University Dissertations and Theses

This study article presented a quantitative examination of stakeholder participation in urban real estate affordable housing projects, specifically focusing on implementing agile project management approaches. The study identified areas requiring further understanding of stakeholder engagement strategies and has filled these gaps by utilizing current empirical research. Quantitative research methodology gathered data via anonymous surveys distributed to individual initiatives. The results underscored the effectiveness of agile techniques in enhancing stakeholder involvement, providing valuable perspectives for project managers, developers, and policymakers. The research significantly contributed to the current body of knowledge by providing empirical evidence to support stakeholder engagement techniques, addressing a …


Volume 122, Number 5 - Tuesday, April 30th, 2024, Saint Mary's College Of California Apr 2024

Volume 122, Number 5 - Tuesday, April 30th, 2024, Saint Mary's College Of California

The Collegian

No abstract provided.


Implementation Of A Standardized Process To Increase Referrals To The Tobacco Quitline In An Underserved General Oncology Cancer Survivorship Clinic, Kristyn-Mae Rosales Apr 2024

Implementation Of A Standardized Process To Increase Referrals To The Tobacco Quitline In An Underserved General Oncology Cancer Survivorship Clinic, Kristyn-Mae Rosales

Doctor of Nursing Practice Final Project Abstract

PURPOSE The purpose of this scholarly project was to implement a standardized process to increase referral rates to the tobacco quitline among cancer survivors in an outpatient center. The intent was to promote the usage of tobacco cessation resources for this vulnerable population.

BACKGROUND “Cigarette smoking remains the leading cause of preventable disease, disability, and death in the United States” (CDC, 2023). This project was implemented in an ambulatory clinic among the Harris County population, Houston, Texas. The aim of this project was to increase the number of quitline referrals by 20% in six months.

METHODOLOGY Interventions were implemented to …


Effectiveness Of A Positive Psychotherapy Tool In Reducing Burnout And Increasing Morale Of Night Shift Mental Health Workers On An Acute Pediatric Psychiatric Floor, Esther Gatonye Apr 2024

Effectiveness Of A Positive Psychotherapy Tool In Reducing Burnout And Increasing Morale Of Night Shift Mental Health Workers On An Acute Pediatric Psychiatric Floor, Esther Gatonye

Doctor of Nursing Practice Final Project Abstract

Purpose: This scholarly project's purpose was to enhance the well-being of mental healthcare workers on the night shift in an acute pediatric mental health unit by implementing the Three Good Things (3GT) positive psychotherapy tool. The project intended to address the issue of high burnout rates among healthcare workers and improve employee well-being and patient care.

Background: The project was implemented in a 16-bed Mental Health Unit within a pediatric hospital located in the Austin Metroplex.

Methodology: The project employed a non-randomized pre-, mid, and post-design and utilized surveys to evaluate burnout, well-being, and coping skills. Burnout was measured using …


The Prospector, April 30, 2024, Utep Student Publications Apr 2024

The Prospector, April 30, 2024, Utep Student Publications

The Prospector

No abstract provided.


Putting A Slam On Alcohol Violators Through Dram- How The State Of Ohio Can Improve The Day-To-Day Safety Of Its Residents Through Dram Laws, Steven Iwanek Apr 2024

Putting A Slam On Alcohol Violators Through Dram- How The State Of Ohio Can Improve The Day-To-Day Safety Of Its Residents Through Dram Laws, Steven Iwanek

Honors Projects

In the realm of legal frameworks governing the service and consumption of alcohol, Dram Shop Liability Laws play a pivotal role in holding establishments accountable for the consequences of alcohol-related incidents. These laws, known as dram laws, vary across states, delineating the responsibilities of alcohol servers and establishments in preventing the overconsumption of alcohol and the resultant harm. This examination delves into a comprehensive background of dram laws, particularly focusing on their historical evolution, their present implications, and the imperative need for refinement.

As societal dynamics and patterns of alcohol consumption evolve, so too must the legislative mechanisms designed to …


Factors Predicting Work Ability Among Community Healthcare Providers In Yangon, Myanmar, Phyu Nyein Wai, Naw Clara Apr 2024

Factors Predicting Work Ability Among Community Healthcare Providers In Yangon, Myanmar, Phyu Nyein Wai, Naw Clara

Makara Journal of Health Research

Background: In healthcare organizations, a high level of work ability is necessary for workers to perform their tasks under different working conditions. This study aimed to describe the quality of work life, work environment, and work ability and examine predictors of the work ability of community healthcare providers.

Methods: A cross-sectional descriptive study was conducted from May 2020 to July 2020. The study enrolled 284 registered nurses and midwives from 38 public health departments in Yangon, Myanmar. Data were collected using the work-related quality of life scale (WRQoL) 2, work environment impact scale (WEIS-SR), and work ability index …


The Evolving Crime Of Sex Trafficking, Madison Krause Apr 2024

The Evolving Crime Of Sex Trafficking, Madison Krause

Senior Honors Theses

Human trafficking is a global crime that occurs in all countries regardless of status or rank. It victimizes both genders and all age groups. The two most common types of human trafficking are for the purposes of forced labor and commercialized sexual exploitation. The demand for commercialized sexual exploitation has increased throughout the United States. Technology and social media have enhanced and made the ability to commit sex trafficking easier and more efficient. The ties between pornography and sexual exploitation have also had an impact on sex trafficking recruiting and grooming.


Perception Of Lean Adoption Among Emergency Department Personnel In Public Hospitals In Selangor, Malaysia, Azizul Rahman Mohamad Jamil, Mohd Rizal Abdul Manaf, Sharifa Ezat Wan Puteh, Kiran Ganesh Balakrishnan Apr 2024

Perception Of Lean Adoption Among Emergency Department Personnel In Public Hospitals In Selangor, Malaysia, Azizul Rahman Mohamad Jamil, Mohd Rizal Abdul Manaf, Sharifa Ezat Wan Puteh, Kiran Ganesh Balakrishnan

Makara Journal of Health Research

Background: This research aims to assess the perceptions of the staff working in emergency departments in Selangor, Malaysia, regarding the adoption of lean management and identify the factors that affect their perceptions.

Methods: A cross-sectional study using the Lean in Healthcare Questionnaire was conducted with 251 respondents, which consisted of doctors, nurses and medical assistants employed in three selected hospitals.

Results: One-way analysis of variance (ANOVA) showed a significant difference in every domain score in accordance with the occupation category. For the domain process, a significant negative correlation was found between age and domain score (r = …


Healthcare Provider Engagement And Its Effects On Patient Rereferral: Insights From Indonesia, Felicia Setiawan Apr 2024

Healthcare Provider Engagement And Its Effects On Patient Rereferral: Insights From Indonesia, Felicia Setiawan

Makara Journal of Health Research

Background: In the highly competitive landscape of healthcare, nurturing strong relationships between referring healthcare providers and healthcare facilities is essential for maintaining patient loyalty. This study explores the factors influencing referring health care provider engagement and its subsequent impact on the willingness to rerefer to healthcare facilities.

Methods: A cross-sectional quantitative survey was conducted with 181 healthcare providers who regularly refer patients to a private hospital in Jakarta. Data were collected through an online structured questionnaire consisting of 29 questions. The following dimensions were covered: specialist characteristics, practice characteristics, healthcare provider–specialist interaction, patient–specialist interaction, returning referral, training opportunity, …


Barriers And Facilitators Of Pharmacists’ Roles During The Pandemic In Malaysia, Thanushiri Palani Velu, Farida Islahudin, Wei Wen Chong Apr 2024

Barriers And Facilitators Of Pharmacists’ Roles During The Pandemic In Malaysia, Thanushiri Palani Velu, Farida Islahudin, Wei Wen Chong

Makara Journal of Health Research

Background: The coronavirus disease 2019 (COVID-19) left a devastating impact on healthcare systems worldwide. The crisis initially emerged as a supply disruption issue but eventually evolved into a myriad of additional challenges, which were attributed mainly to the extensive scale of the pandemic. This study aimed to explore the barriers to the role of hospital pharmacists and related facilitators encountered during the COVID-19 pandemic.

Methods: Pharmacists in Malaysia participated in a cross-sectional online questionnaire-based survey. The participants were recruited using convenient sampling. Cronbach alpha of the questionnaire was analyzed.

Results: The study successfully enrolled 367 pharmacists. The …


Most Common Symptoms Of Prediabetic And Insulin Resistance In Adults In Saudi Arabia, Hassan Mazzhar Bukhari, Fatoon Mohammed Albuqami, Alanoud Mohammed Asiri, Ghadeer Othman Yatim, Jomana Abdullah Alshareef, Ruba Saeed Alzahrani Apr 2024

Most Common Symptoms Of Prediabetic And Insulin Resistance In Adults In Saudi Arabia, Hassan Mazzhar Bukhari, Fatoon Mohammed Albuqami, Alanoud Mohammed Asiri, Ghadeer Othman Yatim, Jomana Abdullah Alshareef, Ruba Saeed Alzahrani

Makara Journal of Health Research

Background: The prediabetic stage exhibits common symptoms; hence, the risk of developing diabetes can be reduced by identifying these symptoms in the most affected population. This study aimed to examine the prevalence of the main symptoms of insulin resistance in healthy adults aged 18 years and above.

Methods: A cross-sectional study was conducted on 1,514 Saudi adults using an online questionnaire collected from 13th November 2020 to 23rd March 2021. Data on personal, lifestyle, and common symptoms were gathered, and the main symptoms were presented as frequencies with percentages. Association with insulin resistance was evaluated using the Chi-square …


Assessment Of Sociodemographic Status, Self-Awareness, And Risk Factors Affecting Patients With Prediabetes In Bangladesh: Cross-Sectional Study, Farhana Sultana, Muhammed Mohibul Islam, Aparajita Das, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md Kayes Mahmud, Md. Saqline Mostaq, Saadullah Saadullah, Md. Saddam Hossain, Saikat Fakir, Mohammad Nurul Amin Apr 2024

Assessment Of Sociodemographic Status, Self-Awareness, And Risk Factors Affecting Patients With Prediabetes In Bangladesh: Cross-Sectional Study, Farhana Sultana, Muhammed Mohibul Islam, Aparajita Das, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md Kayes Mahmud, Md. Saqline Mostaq, Saadullah Saadullah, Md. Saddam Hossain, Saikat Fakir, Mohammad Nurul Amin

Makara Journal of Health Research

Background: Poor glycemic control and high diabetes and prediabetes incidence are influenced by socioeconomic disparity. Raising awareness and ensuring that people with prediabetes are receiving medication, maintaining their glycemic control, and getting the proper care they need despite their socioeconomic situation are crucial in the fight against diabetes. This study aims to assess the sociodemographic status, self-awareness, and risk factors associated with prediabetes in Bangladesh.

Methods: A cross-sectional survey was carried out among 500 participants aged >18 years to evaluate and summarize their demographic data, socioeconomic status, and responses to various questionnaires about their conditions related to prediabetes …


Determinant Of Unintended Pregnancy In Indonesia, Pika Novriani Lubis, Ratna Djuwita, Asri C. Adisasmita, Sudarto Ronoatmodjo, Maria Gayatri Apr 2024

Determinant Of Unintended Pregnancy In Indonesia, Pika Novriani Lubis, Ratna Djuwita, Asri C. Adisasmita, Sudarto Ronoatmodjo, Maria Gayatri

Makara Journal of Health Research

Background: Unintended pregnancy is a global health problem. The number of unintended pregnancies globally is still high, accounting for 1 in 4 pregnancies. In Indonesia, it occupies 15% of total pregnancies. However, studies discussing the determinants of unintended pregnancies in Indonesia were conducted on a small scale.

Methods: This cross-sectional research utilized the data of 15,316 respondents of the 2017 Indonesia Demographic and Health Survey.

Results: The prevalence of unintended pregnancies in women with live births in the last 3–5 years was approximately 16%. The highest risk of unintended pregnancies was recorded for those with the youngest …


Disaster Response Self-Efficacy Of Students In The Nursing Department: A Cross-Sectional Study, Dilek Yılmaz, Gonca Buran Apr 2024

Disaster Response Self-Efficacy Of Students In The Nursing Department: A Cross-Sectional Study, Dilek Yılmaz, Gonca Buran

Makara Journal of Health Research

Background: Nurses take on important roles in disasters. In this regard, the disaster response self-efficacy of nursing students must be evaluated. The study aimed to determine the self-efficacy of nursing students in disaster response.

Methods: In this descriptive cross-sectional study, the study sample consisted of 207 nursing students who were in their third or fourth year attending the nursing department of a state university in the Marmara region of Türkiye between October and December 2023. Data were collected using a student description form and the disaster response self-efficacy scale.

Results: The mean age of the study participants …


Investigating Nursing Students’ Levels Of Knowledge About Alzheimer’S Disease, Dilek Doruk Kondakci, Aliye Mandiracioğlu Apr 2024

Investigating Nursing Students’ Levels Of Knowledge About Alzheimer’S Disease, Dilek Doruk Kondakci, Aliye Mandiracioğlu

Makara Journal of Health Research

Background: Given that Alzheimer’s disease (AD) has become a major public health problem, this study aimed to investigate the AD knowledge level of nursing students who are health professional candidates.

Methods: The population of this cross-sectional study consisted of 346 nursing students taking up a 4-year program. They were asked to fill out a sociodemographic information form and answer questions from the Alzheimer’s Disease Knowledge Scale (ADKS).

Results: Among the participants, 67.6% were female and 98.8% were single. The mean age of the students was 20.55 ± 2.05 years. Their general knowledge about AD was low, with …


Experimental Analysis Study Wave Drift Force Of Moored Floating Production Units (Fpu), Arifin Rifliansah, Wibowo Harso Nugroho Apr 2024

Experimental Analysis Study Wave Drift Force Of Moored Floating Production Units (Fpu), Arifin Rifliansah, Wibowo Harso Nugroho

Makara Journal of Technology

Drift forces caused by sea waves and currents are an important aspect that needs to be studied in planning moored floating structures, especially Floating Production Units (FPU) type ships which are operated for oil and gas exploration. This study describes the drift forces on the FPU which is subjected to environmental loads in the form of waves. The slow-drift movement that occurs in a moored FPU, and experiencing irregular waves is a very important problem. The complexity of determining drift forces analytically and numerically requires the use of hydrodynamics model test. In the model test on a certain model scale …


Hybrid Method Neighbor Node Discovery In Wireless Sensor Networks: A Framework, Sagar Mekala, Shahu Chatrapati Kaila, Jyothi Rani Matang Apr 2024

Hybrid Method Neighbor Node Discovery In Wireless Sensor Networks: A Framework, Sagar Mekala, Shahu Chatrapati Kaila, Jyothi Rani Matang

Makara Journal of Technology

Wireless devices are now being adapted for diverse purposes, such as healthcare, agriculture, transportation, and tactical operations, which present challenges in network formation owing to high device mobility. Current methods rely on discovery techniques for forming wireless sensor networks (WSNs); however, the existing research has been criticized for its high time complexity and redundant neighbor discovery process. In this study, we provide a hybrid strategy to effectively handle the difficulties of locating neighboring nodes in WSNs. Our method combines several strategies to produce precise and effective neighbor detection. Herein, shared memory–based discovery, a beacon technique, and range and distance overlap …


Can Listeners Differentiate Varieties Using Prosodic Information? Lect Identification In A Persona-Matching Task, Nicole Holliday, Rachel Steindel Burdin, Paul Reed Apr 2024

Can Listeners Differentiate Varieties Using Prosodic Information? Lect Identification In A Persona-Matching Task, Nicole Holliday, Rachel Steindel Burdin, Paul Reed

Faculty Publications

Sociolinguists and lay people have long been interested in the mechanisms by which dialect and speaker identification occur. The current study aims to test whether realizational differences found in production studies are salient factors in identification of different lects, as well as to examine differences between groups in identification. In this study, listeners were instructed to match clips containing H* and L+H* pitch accents with specific personae who represented speakers of five lects of interest (African American English, Jewish English, Appalachian English, Southern English, and Midwestern English). Listeners from different groups (Appalachian, African American, Jewish, and those who were not …


Direct Precipitation Of Siderite In Ferruginous Environments, A Grengs, G Ledesma, Y Xiong, S Katsev, S W. Poulton, E D. Swanner, C Wittkop Apr 2024

Direct Precipitation Of Siderite In Ferruginous Environments, A Grengs, G Ledesma, Y Xiong, S Katsev, S W. Poulton, E D. Swanner, C Wittkop

Faculty Publications

Siderite (FeCO 3 ) is often assumed to precipitate from dissimilatory reduction of Fe-(oxyhydr)oxides, but geochemical and mineralogical analyses from ferruginous (anoxic, Fe-rich) Canyon Lake, USA, suggest Fe-carbonate represents a direct early precipitate unrelated to substantial oxide burial.X-ray absorption near edge structure (XANES) spectroscopy of sediment trap materials and an anoxic sediment core indicated a mixture of Fe(II) and Fe(III) in water column particulates and ferruginous surface sediments, while all Mn phases were reduced.About 60 cm below the sediment-water interface, Fe-Mn carbonates were detected by X-ray diffraction and XANES, while Fe extended X-ray absorption fine structure (EXAFS) spectra were best …


Social, Ethical, Environmental, Economic And Technological Aspects Of Rabbit Meat Production - A Critical Review, Shahida Anusha Siddiqui, Danung Nur Adli, Widya Satya Nugraha, Bara Yudhistira, Filipp V. Lavrentev, Sergey Shityakov, Xi Feng, Andrey Nagdalian, Salam A. Ibrahim Apr 2024

Social, Ethical, Environmental, Economic And Technological Aspects Of Rabbit Meat Production - A Critical Review, Shahida Anusha Siddiqui, Danung Nur Adli, Widya Satya Nugraha, Bara Yudhistira, Filipp V. Lavrentev, Sergey Shityakov, Xi Feng, Andrey Nagdalian, Salam A. Ibrahim

Faculty Research, Scholarly, and Creative Activity

Rabbit (RM) has become a valuable source of nutrients since the 1970s, helping to transform the European food industry into the largest RM producer in the world. However, the RM industry is experiencing a critical period of ethical imbalance. This trend, described as feed conversion ratio, impacts the environmental and financial performance of RM farms, which could lead to an increase production of industrial waste. In addition, the loss of corporate ethical responsibility and sustainable development by RM-oriented companies has further exacerbated the situation. Our objective was to summarize current trends in the RM industry and markets, highlighting possible strengths …


Can Listeners Differentiate Varieties Using Prosodic Information? Lect Identification In A Persona-Matching Task, Nicole Holliday, Rachel Steindel Burdin, Paul Reed Apr 2024

Can Listeners Differentiate Varieties Using Prosodic Information? Lect Identification In A Persona-Matching Task, Nicole Holliday, Rachel Steindel Burdin, Paul Reed

Faculty Publications

Sociolinguists and lay people have long been interested in the mechanisms by which dialect and speaker identification occur. The current study aims to test whether realizational differences found in production studies are salient factors in identification of different lects, as well as to examine differences between groups in identification. In this study, listeners were instructed to match clips containing H* and L+H* pitch accents with specific personae who represented speakers of five lects of interest (African American English, Jewish English, Appalachian English, Southern English, and Midwestern English). Listeners from different groups (Appalachian, African American, Jewish, and those who were not …


Induction Ceremony: Pi Kappa Lambda And Epsilon Chi Chapter, April 30, 2024, Illinois State University School Of Music Apr 2024

Induction Ceremony: Pi Kappa Lambda And Epsilon Chi Chapter, April 30, 2024, Illinois State University School Of Music

School of Music Programs

Center for the Performing Arts
April 30, 2024
Tuesday Evening
7:00 p.m.


Recital: Convocation, April 30, 2024, Illinois State University School Of Music Apr 2024

Recital: Convocation, April 30, 2024, Illinois State University School Of Music

School of Music Programs

Center for the Performing Arts
April 30, 2024
Tuesday Morning
11:00 a.m.


Loss Of Tumor Suppressor Tmem127 Drives Ret-Mediated Transformation Through Disrupted Membrane Dynamics, Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa C B Oliveira, Aisha N Rekab, Mathieu J F Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L M Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan Apr 2024

Loss Of Tumor Suppressor Tmem127 Drives Ret-Mediated Transformation Through Disrupted Membrane Dynamics, Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa C B Oliveira, Aisha N Rekab, Mathieu J F Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L M Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan

Faculty, Staff and Student Publications

Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be caused by activating mutations of the rearranged during transfection (RET) receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumor suppressor implicated in trafficking of endosomal cargos. However, the role of aberrant receptor trafficking in PCC is not well understood. Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and …


Developing More Useful Equity Measurements For Flood-Risk Management, Adam Pollack, Casey Helgeson, Carolyn Kousky, Klaus Keller Apr 2024

Developing More Useful Equity Measurements For Flood-Risk Management, Adam Pollack, Casey Helgeson, Carolyn Kousky, Klaus Keller

Dartmouth Scholarship

Decision-makers increasingly invoke equity to motivate, design, implement and evaluate strategies for managing flood risks. Unfortunately, there is little guidance on how analysts can develop measurements that support these tasks. Here we analyse how equity can be defined and measured by surveying 167 peer-reviewed publications that explicitly state an interest in equity in the context of flood-risk management. Our main result is a taxonomy that systematizes how equity has been, and can be, defined and measured in flood-risk research. The taxonomy embodies how equity is a pluralistic and unavoidably ethical concept. Despite this, we find that most quantitative studies fail …


Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto Apr 2024

Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto

Journal of Dentistry Indonesia

The geometric design of an endodontic file includes cross-sectional shape, taper, and pitch. NiTi endodontic files of OneCurve (MicroMega) are made of two variations of cross-sectional shape, that is, double-s shaped and triple helix. Various kinds of modifications were made to increase the resistance of the NiTi endodontic files from fracture. Cyclic fatigue is the most common factor that causes a fracture of the endodontic file. Objective: The purpose of this study was to obtain a NiTi endodontic file design that has the best cyclic resistance value based on its taper size and number of pitch. Methods: This …