Digital Commons Network^™

Safety And Long-Term Survival Results Of The Addition Of Inotuzumab Ozogamicin To The Conditioning Regimen Of Allogeneic Stem Cell Transplantation: A Single-Center Phase 1,2 Trial, Issa F Khouri, Kamal Alzahrani, Hagop Kantarjian, Denái R Milton, Alison M Gulbis, Koji Sasaki, Nitin Jain, Nicholas J Short, Tapan Kadia, May Daher, Hind Rafei, Jin S Im, David Marin, Amanda L Olson, Uday Popat, Muzaffar Qazilbash, Jeremy Ramdial, Gabriela Rondon, Samer Srour, Partow Kebriaei, Elizabeth Shpall, Richard Champlin, Elias J Jabbour

Faculty, Staff and Student Publications

Here we report on the first prospective study evaluating the safety and long-term survival when an escalating dose of inotuzumab ozogamicin (INO) (0.6, 1.2, or 1.8 mg/m2 on day 13) was added to one alkylator-containing conditioning regimen in patients with relapsed CD22 (+) lymphoid malignancies who were candidates for hematopoietic stem cell transplantation (HSCT). Twenty-six patients were enrolled. Six (23%) of these patients entered the phase 1 study: four were treated at an INO dose of 0.6 mg/m2 and two at dose of 1.2 mg/m2. None of these patients experienced dose-limiting toxicities. The remaining 20 (77%) patients entered the phase …

Use Of Advanced Diagnostics For Timely Identification Of Travel-Associated Leptospira Santarosai Infection In Four Adolescents Through Plasma Microbial Cell-Free Dna Sequencing With The Karius Test, Hai Nguyen-Tran, Guliz Erdem, P Marcelo Laufer, Lori Patterson, Asim A Ahmed, William A Bower, Renee Galloway, Sara Saporta-Keating

Faculty, Staff and Student Publications

Background: Leptospirosis is an important zoonotic infection worldwide. Diagnosis of leptospirosis is challenging given its nonspecific clinical symptoms that overlap with other acute febrile illnesses and limitations with conventional diagnostic testing. Alternative advanced diagnostics, such as microbial cell-free DNA (mcfDNA), are increasingly being used to aid in the diagnosis of infections and can be applied to pathogens with public health importance such as Leptospira , a nationally notifiable disease.

Methods: The Karius Test uses plasma mcfDNA sequencing to detect and quantify DNA-based pathogens. This test offered through the Karius lab detected 4 cases of Leptospira santarosai during a 5-month period …

Rich Adventure In Poor Times: Examining Huck Finn And Robinson Crusoe, Lindsey Sears

Research Papers

The hero's journey is a thread in literature connecting centuries worth of stories. Mark Twain draws inspiration from it in his The Adventures of Huckleberry Finn, as does Daniel Defoe in his Robinson Crusoe. Both Huck Finn and Robinson Crusoe are motivated for a bone-deep desire to see more of the world, and must travel into the unknown for any semblance of freedom. Facing adversaries at every turn, they must rely on a non-white counterpart to bring their stories to fruition. Their attitudes about independence and racial inequality say a lot about the conventions of their societies. Despite …

Onc201 (Dordaviprone) In Recurrent H3 K27m-Mutant Diffuse Midline Glioma, Yazmin Odia, Minesh Mehta

All Publications

Purpose: Histone 3 (H3) K27M-mutant diffuse midline glioma (DMG) has a dismal prognosis with no established effective therapy beyond radiation. This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in recurrent H3 K27M-mutant DMG.

Methods: Fifty patients (pediatric, n = 4; adult, n = 46) with recurrent H3 K27M-mutant DMG who received oral ONC201 monotherapy in four clinical trials or one expanded access protocol were included. Eligible patients had measurable disease by Response Assessment in Neuro-Oncology (RANO) high-grade glioma (HGG) criteria and performance score (PS) ≥60 and were ≥90 days from radiation; pontine and spinal tumors were ineligible. The …

Moderation In All Things, Denis Kaiser

Lake Union Herald

No abstract provided.

Hierarchal Single-Cell Lineage Tracing Reveals Differential Fate Commitment Of Cd8 T-Cell Clones In Response To Acute Infection., Leena Abdullah

Dartmouth College Ph.D Dissertations

Generating balanced populations of CD8 effector and memory T cells is necessary for immediate and durable immunity to infections and cancer. Yet, a definitive understanding of CD8 differentiation remains unclear. Here we used CARLIN, a processive lineage recording mouse model with single-cell RNA-seq and TCR-seq to track endogenous antigen-specific CD8 T cells during acute viral infection.

Transcriptional profiling of antigen-specific T cells at the peak of the effector response to Vesicular stomatitis virus uncovered a diverse repertoire of expanded antigen-specific T-cell clones represented by seven transcriptional states. TCR enrichment analysis identified TCR clones with differential memory- or effector-fate biases during …

Thinking From The Home: Emanuele Coccia On Domesticity And Happiness, Evan Edwards

Open Access Publishing Support Funded Articles

This article traces the idea of domesticity through the work of Emanuele Coccia to explain his conception of happiness. Coccia argues that it is only by taking domestic concerns seriously that philosophy can begin to theorize the possibility of happiness today, claiming that rather than beginning with the polis, “philosophy must think the city from the home, and the home from the kitchen.” The article begins by situating Coccia's work in the tradition of Giorgio Agamben's critical project and then explores the idea of the home from his 2016’s The Life of Plants through 2020’s Metamorphoses to understand the reason …

Final 2022 Insufficiently Reclaimed Sites Sampling Bres No. 08 – Belle Of Butte Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Deep Learning Using Vision And Lidar For Global Robot Localization, Brett E. Gowling

Master's Theses

As the field of mobile robotics rapidly expands, precise understanding of a robot’s position and orientation becomes critical for autonomous navigation and efficient task performance. In this thesis, we present a snapshot-based global localization machine learning model for a mobile robot, the e-puck, in a simulated environment. Our model uses multimodal data to predict both position and orientation using the robot’s on-board cameras and LiDAR sensor. In an effort to minimize localization error, we explore different sensor configurations by varying the number of cameras and LiDAR layers used. Additionally, we investigate the performance benefits of different multimodal fusion strategies while …

Optimizing Web Delivery: The Impact Of Rendering Methods On User Experience Across Network Conditions, Cagan Sevencan

Master's Theses

In an era where web applications are pivotal for global information dissemination and user engagement, ensuring the performance and accessibility of static web content is paramount. This need is particularly significant given the diverse accessibility requirements worldwide, influenced by varying network generations and the real-time rendering of static elements such as text, images, and videos on devices ranging from laptops to cell phones. This thesis embarks on a comparative study of client-side rendering (CSR) and server-side rendering (SSR), two fundamental techniques determining how various platforms present static content. Through detailed examination, the study aims to shed light on the nuances …

Catchment-Scale Thawing And Greening Decreases Long-Term Nitrogen Export In Ne Greenland, Shannon L. Speir, Jennifer L. Tank, Ada Pastor, Marc F. Muller, Mikhail Mastepanov, Tenna Riis

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Climate change is expected to alter nitrogen (N) export from Arctic rivers, with potential implications for fragile coastal ecosystems and fisheries. Yet, the directionality of change is poorly understood, as increased mobilization of N in a 'thawing' Arctic is countered by higher rates of vegetative uptake in a 'greening' Arctic, particularly in the understudied region of Greenland. We use an unprecedented dataset of long-term (n = 18 years) river chemistry, streamflow, and catchment-scale changes in snow and vegetation to document changing riverine N loss in Greenland. We documented decreasing inorganic and organic N loads, linked to decreasing snow stores, …

Flood Timing And Flood Loss Impact On Effectiveness Of Florpyrauxifen-Benzyl Coated On Urea In Rice, Bodie L. Cotter, Jason K. Norsworthy, Thomas R. Butts, Trenton L. Roberts, Andy Mauromostakos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Florpyrauxifen-benzyl has generated complaints and concerns around rice injury and off-target movement to soybean since its commercial launch in 2018. Developing a precise method for applying florpyrauxifen-benzyl was imperative for its continued use. Experiments were conducted in 2020 and 2021 to evaluate rice weed control as influenced by preflood application interval and flood loss following florpyrauxifen-benzyl at 30 g ai ha⁻¹ applied as a spray or coated on urea. In a preflood application experiment, coating florpyrauxifen-benzyl on urea and applying it the day of flood establishment and 5 and 10 d prior to flooding (DPTF) resulted in lower yellow …

Barriers To And Facilitators Of Care: Exploring How Low-Income Women Access Reproductive Healthcare In A Rural Community, Sydney Taylor Casey

Electronic Theses, Projects, and Dissertations

The purpose of this research study was to gain a comprehensive understanding of the experiences of low-income women living in a rural community when accessing reproductive care and bring awareness to the barriers and facilitating factors they encounter. The present study adopted a post positivism paradigm and was conducted in a rural county in Northern California. A combination of quantitative and qualitative data was gathered through demographic surveys and individual interviews with twenty-two participants. A bottom-up approach was utilized for the phases of qualitative data analysis, which included open coding, axial coding and selective coding. Data analysis revealed thirteen open …

Progression Of Black Women In Tenure Ranked Positions, Unique Givens

Electronic Theses, Projects, and Dissertations

The intersectionality of race and gender affects the progression and experience of Black women in tenure-ranked positions in higher education. As Black women navigate the tenure process, they encounter systemic issues while fulfilling the criteria of teaching, service, and research. Black women's experiences while obtaining and maintaining tenure-ranked positions in Southern California reflect the discrimination, biases, lack of respect, and value of their roles and contributions to academia. In addition, Black women are being challenged more and questioned regarding their abilities and roles by peers, students, and academic administration. Research studies in the past have demonstrated the underrepresentation of Black …

The Obstacles Facing Homeless Veterans With Mental Illness When Obtaining Housing, Melissa Miro

Electronic Theses, Projects, and Dissertations

This research study explored the barriers that homeless veterans face when seeking housing. The study adopted a post-positivist paradigm, and the data was collected through virtual interviews conducted on Zoom who are in contact with veterans through their employment or personal lives. The barriers mentioned in this study are the type of individual struggles that each veteran faces, the lack of communication between programs assisting veterans, veterans unaware of their services, veterans who have been incarcerated, the type of discharge the service member obtained, and programs being shorthanded. Additionally, the researcher included preferable options for veterans that included The Housing …

What Is The Readiness Of Social Work Students To Work With Autistic Individuals?, Ignacio Aguilar Pelaez

Electronic Theses, Projects, and Dissertations

ABSTRACT

The focus of this research proposal is to assess the readiness of social work graduate students to work with Autistic individuals. The study was conducted in partnership with an undisclosed Southern California university. The study was conducted from a positivist perspective and used the social model of disability theory as a theoretical orientation. Researchers surveyed 64 MSW students utilizing a Qualtrics survey, specifically designed for this study. The results in this study indicate that most of the social work students who participated in this study possess a satisfactory understanding and knowledge of ASD. Although the results showed that over …

Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff

Electronic Theses, Projects, and Dissertations

Escitalopram (EST), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant frequently used during pregnancy, yet there is limited knowledge of its long-term effects on maternal use. Past studies suggest that maternal exposure may adversely affect the fetus, which may be due to the hyperserotonergic environment caused by the nature of SSRIs during early development. Modifications of the serotonergic system in offspring during certain critical periods of development may result in long-term behavioral and cognitive changes in adulthood. Further, recent human studies have demonstrated that prenatal exposure to SSRIs in humans may increase susceptibility to autism spectrum disorder (ASD) and …

Major Factors Of Sustaining Recovery After Relapse From A Substance Use Disorder, Amanda Tei Sandhurst

Electronic Theses, Projects, and Dissertations

Relapse is a common and often-expected occurrence among individuals with substance use disorders. Relapse can be defined as returning to a problematic behavior after abstaining for a period of time (Marlatt & Witkiewitz, 2005). It is the inability to maintain life in sobriety and is not an isolated event, but rather a process (Gorski & Kelley, 1996). The problem with relapse is that it can result in continued substance use and abuse, which can then lead to other major consequences. This study looks at ten individuals in recovery who experienced a past relapse after having a period of abstinence and …

Career Motivation As Mediator Between Cultural Self-Construal And Interest, Mengxuan Zhang

Electronic Theses, Projects, and Dissertations

Understanding the association between career motivations and interest-occupation congruence can help people with different cultural backgrounds make better career decisions. The goal of the study was to examine how cultural differences predicted interest congruence, and whether career motivation was a significant mediator in the prediction. I hypothesized that independent self-construal would be associated with internal career motivation most strongly (H1), while interdependent self-construal will be associated with interpersonal career motivation most strongly (H2). Additionally, internal career motivation would mediate the relationship between independent self-construal and interest congruence (H3), and whether internal career motivation mediated the relationship between interdependent self-construal and …

The Disproportionate Impacts Of Certain Factors That Differentiate The Amount Of Mental Health Referrals Of School A Compared To School B, Jesus Barrientos

Electronic Theses, Projects, and Dissertations

This study explores the relationship between a variety of factors the school of attendance for two schools in the Inland Empire. This research project sought to assess if there are differing rates of exposure to parental substance use, geographical location, diagnosis of anxiety, diagnosis of depression, and exposure to traumatic events based on the high school of attendance. Secondary data was acquired from a school district in the Inland Empire. Fifty assessments from school A and fifty from school B were used; a total of 100 adolescent assessments were used. The adolescent assessment explores the location of living, questions regarding …

The Most Important Voices In The Room: Understanding The Academic Needs Of Us-Educated Latino English Learners In Higher Education, Lisa Davenport

Electronic Theses, Projects, and Dissertations

US-educated English learners (US-ELs) immigrated to the United States as children and enrolled in school where they began learning English. Ultimately, they graduate from high school, and the majority of those wishing to continue in higher education begin in community college. These students face tremendous barriers and have lower rates of access to and completion of higher education than English monolingual students.

The study examines the transitions of US-ELs from high school to community college in the years since the implementation of California Assembly Bills 705 and 1705 and the COVID-19 pandemic. The researcher used three theoretical frameworks – LatCrit, …

Interpreting Geochemical Sourcing In The Northwest Great Basin: The 26wa12962 Sample Study, Tyler Alexander Reinholt

Electronic Theses, Projects, and Dissertations

Located in Northwest Washoe County Nevada along the California and Nevada border, 26WA12962 is an upland spring site consisting of habitation debris and several thousand pieces of debitage on the surface. The purpose of this research project is to interpret energy dispersive x-ray fluorescence (EDXRF) results of 80 random samples of obsidian, and fine grain volcanics such as basalt and dacite from the excavations on 26WA12962 that were conducted in 2021. This thesis will investigate if there is a preference for a specific source, as well as assisting in gathering data within a lithic landscape. To accomplish this goal, I …

Homelessness In The Coachella Valley, Katrina Clarke

Electronic Theses, Projects, and Dissertations

Homelessness continues to be a major social issue, as thousands of individuals and families in the United States continue to be unsheltered. This problem is more acute in the State of California. Despite the implementation of poverty-relief programs, this issue has shown no signs of slowing down. The existing literature contains multiple studies conducted on factors associated with homelessness. However, the Coachella Valley, an area located in Southern California, has received little attention from the literature on homelessness. This study sought to understand the phenomenon of homelessness in the Coachella Valley, mainly its causes and means of prevention. Taking a …

Distribution And Conveyance Of Late Prehistoric Western Mojave Obsidian Artifacts, Nicholas James Shepetuk

Electronic Theses, Projects, and Dissertations

There is a significant lack of publication, synthesis, and analysis of existing Late Prehistoric obsidian artifact sourcing data in the western Mojave Desert. However, a wealth of such data exists, especially in non-published archaeological reports produced mainly by cultural resources management firms. The purpose of this study was to test the validity of two regions which are divided roughly by the Mojave River and which are based on Sutton’s (1989) interaction sphere model. The Northwestern Region occupies the portion of the Mojave Desert to the north and west of the Mojave River, while the Eastern Region makes up the area …

Child Maltreatment Primary Prevention Methods In The U.S.: A Systematic Review Of Recent Studies, Maria Godoy-Murillo

Electronic Theses, Projects, and Dissertations

Background: Child maltreatment remains a widespread issue in the United States of America, (U.S.). Identifying effective methods of preventing child maltreatment is key to reducing the prevalence of this issue. Objective: This systematic review provides an overview of contemporary primary child maltreatment prevention methods in the U.S. to investigate their effectiveness. Methods: Using the OneSearch database, the following keywords were included: (“prevention methods” and “child maltreatment”), (“parental leave” and “child maltreatment”), (“primary prevention” and “child maltreatment”), (WIC and “child maltreatment”), (“home visit” and “child maltreatment”), (“child abuse and neglect” and “primary prevention”), (“affordable housing” and prevention and “child maltreatment”), (“early …

Examining The Effectiveness Of Psychosocial Interventions For Opioid Use Disorder: A Systematic Review, Elizabeth Ashley Contreras

Electronic Theses, Projects, and Dissertations

Background: Due to the increased distribution of synthetic opioids, mortality rates, overdose rates, and addiction related to the consumption of illicit fentanyl have drastically increased over the past years. Although medication-assisted treatment (MAT) is the first-line intervention for Opioid Use Disorder (OUD), less is known about the effectiveness of psychosocial interventions for treating this disorder. Objective: This study aimed to systematically review the literature on psychosocial interventions for treating OUD. Methods: A search was conducted on OneSearch using the keywords “opioid treatment” or “Fentanyl treatment” combined with “psychosocial interventions” or “cognitive behavioral therapy,” or “contingency management” for English articles published …

Treatment Not Punishment: Youth Experiences Of Psychiatric Hospitalizations, Maira Ferrer-Cabrera

Electronic Theses, Projects, and Dissertations

This study aims to better understand adolescent psychiatric hospitalization regarding the use of coercion at the hands of clinical staff from the perspectives of former hospital staff and former patients' family members. This study was conducted from a critical theory perspective. The researcher surveyed a total of fourteen former staff members and former patients' family members. This research study emphasized quantitative data as the way data was collected. The methods utilized to gather data were online surveys that were collected through Qualtrics and further analyzed using SPSS statistic data editor. The findings of this study showed that 25% of former …

Educational Outcomes For Youth That Participated In Extended Foster Care: A Systematic Review, Kassandra Mayorga, Roxana Sanchez

Electronic Theses, Projects, and Dissertations

Background: Transitioning to adulthood poses significant obstacles for foster youth adults, who encounter disproportionately elevated rates of homelessness, school underperformance, unemployment, and mental health concerns in comparison to their peers. Extended Foster Care (EFC) programs seek to tackle these difficulties by offering assistance in housing, employment, and education. However, there have been few systematic efforts to review the effectiveness of the EFC program. Objective: The purpose of this systematic review was to identify, evaluate, and synthesize the empirical evidence on the educational outcomes of foster youth who have participated in EFC. Methods: This review was conducted during …

Information Based Approach For Detecting Change Points In Inverse Gaussian Model With Applications, Alexis Anne Wallace

Electronic Theses, Projects, and Dissertations

Change point analysis is a method used to estimate the time point at which a change in the mean or variance of data occurs. It is widely used as changes appear in various datasets such as the stock market, temperature, and quality control, allowing statisticians to take appropriate measures to mitigate financial losses, operational disruptions, or other adverse impacts. In this thesis, we develop a change point detection procedure in the Inverse Gaussian (IG) model using the Modified Information Criterion (MIC). The IG distribution, originating as the distribution of the first passage time of Brownian motion with positive drift, offers …

A Smart Hybrid Enhanced Recommendation And Personalization Algorithm Using Machine Learning, Aswin Kumar Nalluri

Electronic Theses, Projects, and Dissertations

In today’s age of streaming services, the effectiveness and precision of recommendation systems are crucial in improving user satisfaction. This project introduces the Smart Hybrid Enhanced Recommendation and Personalization Algorithm (SHERPA) a cutting-edge machine learning approach aimed at transforming how movie suggestions are made. By combining Term Frequency Inverse Document Frequency (TF-IDF) for content based filtering and Alternating Squares (ALS) with Weighted Regularization for filtering SHERPA offers a sophisticated method for delivering tailored recommendations.

The algorithm underwent evaluation using a dataset that included over 50 million ratings from 480,000 Netflix users encompassing 17,000 movie titles. The performance of SHERPA was …