Digital Commons Network^™

Trial Of Oxaloacetate In Als (Toals), Katie Lillig, Andrew Heim, Jeffrey Statland, Mazen M. Dimachkie, Russell H. Swerdlow, Sachini P. Karunaratne, In-Young Choi, Phil Lee, Edina Kosa, Abdulbaki Agbas, Heather M. Wilkins, Richard J. Barohn, Omar Jawdat

Faculty and Staff Publications

Background: Mitochondrial dysfunction is a critical therapeutic target in amyotrophic lateral sclerosis (ALS). Oxaloacetate (OAA) is a promising candidate therapy as it crosses the blood brain barrier, reaches motor neurons, and enhances mitochondrial bioenergetics with positive preclinical data in ALS.

Methods: We conducted a prospective, phase 1B, dose escalation study using a standard 3+3 design to assess the safety profile and determine the maximum tolerated dose. Dose-limiting toxicity (DLT) was defined as any serious adverse event (SAE) requiring hospitalization or any adverse event (AE) attributed to OAA that required discontinuation of the medication. Dosages evaluated started at 1000 mg twice …

Effective Technology Strategies Supporting Green Supply Chain Management Within Guyana’S Oil And Gas Industry, Clairmont Andrew Austin

Walden Dissertations and Doctoral Studies

No abstract provided.

How Do Peer Support Officers Perceive Support Provided To Officers Involved In Critical Incidents, Jodi Vanderwier

Walden Dissertations and Doctoral Studies

No abstract provided.

Risk Management Strategies To Reduce Pressure Injuries In Skilled Nursing Homes In Florida, Teresa Latoya Desir

Walden Dissertations and Doctoral Studies

No abstract provided.

Implementation And Evaluation Of A Nurse-Led Telehealth Protocol To Reduce No-Show Rates Among Chronic Care Patients, Yaneisy Puig

Walden Dissertations and Doctoral Studies

No abstract provided.

Examining The Impact Of Design Thinking Practices On Manufacturing Innovation Performance In The U.S. Automotive Industry, Charles Emlin Pluviose

Walden Dissertations and Doctoral Studies

No abstract provided.

The Impact Of Burnout On The Attitudes Of Treatment Providers Towards Sex Offenders, Aklima S. Baksh

Walden Dissertations and Doctoral Studies

No abstract provided.

The Relationships Between Adult Cyberbullying Victimization, Introversion, Extroversion, And Demographic Variables, Amber Paige Arrington

Walden Dissertations and Doctoral Studies

No abstract provided.

K-12 Veteran Teachers’ Perceptions On Teacher Retention In North Carolina, Candace Me'chele Moser, Ed.D

Walden Dissertations and Doctoral Studies

No abstract provided.

Professional Identity And Teaching Self-Efficacy Among Early Career Nurse Educators Across Baccalaureate Nursing Programs, Kerri Chapman

Walden Dissertations and Doctoral Studies

No abstract provided.

The Impact Of The Covid-19 Pandemic On Obstetric Access In Rural And Urban Areas In The United States, Sandali Chandradasa

Walden Dissertations and Doctoral Studies

No abstract provided.

Longitudinal Relationship Between Income Variability And Hypertension Risk Through A Life Course Lens, Mehrnaz Siavoshi

Walden Dissertations and Doctoral Studies

No abstract provided.

Unh Extension Pollinator Garden Certification Application, Shyloh Favreau

UNH Cooperative Extension

When you certify your garden or landscape through The UNH Extension Pollinator Garden Certification Program, you become part of a growing community committed to creating meaningful habitat for pollinators through sustainable, science-based practices. Grounded in research, education, and shared learning, the program supports gardeners of all experience levels in contributing to the health and diversity of native pollinators. From plant selection to pollinator-friendly management practices, this application will guide you in planning, refining, and developing your garden into a safe, resilient habitat for native bees and other pollinating insects.

UNH Extension staff and Master Gardener volunteers are here to …

Global Burden Of Drug-Resistant Tuberculosis In Children: A Systematic Analysis For The Global Burden Of Disease Study, Sylvia M Lacourse, Wulan Talafuhan, Alexander W Kay, Yang Yang, Huarui Liu, Dan Ye, Leonardo Martinez, Shuihua Lu, Adong Shen, Anna M Mandalakas, Feng Li, Christoph Lange, Zhen Huang

Faculty, Staff and Students Publications

Background: Paediatric tuberculosis (TB), particularly drug-resistant TB (DR-TB), is associated with significant mortality. However, the global burden of childhood TB remains poorly understood.

Methods: We analysed incident cases, deaths, and age-standardised incidence and mortality rates among children (0-14 years) with multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) and extensively drug-resistant tuberculosis (XDR-TB) using the Global Burden of Disease (GBD) 2021 database. Data were stratified by age, sex, region, country, and HIV/AIDS status. Annual and average annual percentage changes were assessed using joinpoint regression analysis. Secondary analyses compared adult and paediatric TB trends in the End TB era and evaluated the potential impact of the …

Impact Of Lumen Origin And Gap Distance On Target Vessel Outcomes Following Fenestrated-Branched Endovascular Aortic Repair Of Postdissection Thoracoabdominal Aortic Aneurysms, Randall R Demartino, Emanuel R Tenorio, Fahad Shuja, Dora Babocs, Guilherme B B Lima, Naveed Saqib, Gustavo S Oderich, Bernardo C Mendes

Faculty, Staff and Students Publications

Background: This study evaluated the role of target vessel (TV) lumen origin and fenestration gap (FG) distance between the endograft and the aortic wall on TV outcomes following fenestrated-branched endovascular aortic repair (FB-EVAR) for postdissection thoracoabdominal aortic aneurysms (PD-TAAAs).

Methods: A multicenter review of prospectively and retrospectively collected data of patients undergoing FB-EVAR for PD-TAAAs between 2013 and 2023 was performed. Lumen origin was retrospectively analyzed on preoperative imaging studies and classified as true lumen (TL) only, false lumen (FL) only, or both TL and FL. The FG distance was retrospectively measured on postoperative imaging studies and included as a …

Lipidcruncher: An Open-Source Platform For Processing, Visualizing, And Analyzing Lipidomic Data, Hamed Abdi, Yohannes A Ambaw, Zon Weng Lai, Ritchie Ly, Chandramohan Chitraju, Shubham Singh, Robert V Farese, Tobias C Walther

Faculty, Staff and Students Publications

Background: Advances in mass spectrometry (MS)-based lipidomics have led to a significant surge in data volume, underscoring a need for robust tools to efficiently evaluate and visualize these expansive datasets. While numerous software tools have been developed, current workflows are hindered by manual spreadsheet handling and insufficient data quality assessment prior to analysis. Here, we introduce LipidCruncher, an open-source, web-based platform designed to easily process, visualize, and analyze lipidomic data with high efficiency and rigor.

Results: LipidCruncher consolidates key steps of the lipidomics analysis workflow, including data standardization, normalization, and stringent quality controls. The platform also provides advanced visualization and …

Employment Opportunities As Halal Entrepreneur For Halal Science Graduates: Unissa As Model, Nurdeng Deuraseh, Siti Nora’Aini Pg Sufredin

Nusantara Halal Journal

The high unemployment rate among graduates is not a new issue. This issue is of concern in many countries including Brunei Darussalam. Brunei’s Government could not accommodate all the unemployed graduates with governmental job, therefore, as a brilliant and creative graduates, they need to be independent and creative to create job opportunities. So, one of the measures to reduce this problem is by the introduction of Entrepreneurship. The concept of entrepreneurship is not something new in Islam as it can be observed from the history as a noble profession practiced by the Prophet Muhammad and His companions. However, in recent …

Fake: The Rise Of Food Fraud In The Halal Supply Chain, Adam Voak

Nusantara Halal Journal

We live in increasingly challenging economic times, and the concomitant uncertainty associated with this state within the food industry has led to an emergence of unscrupulous suppliers and supply chain actors committing Halal food fraud. As Halal food supply chains become increasingly complex and global and as the sector continues to develop and grow, more significant opportunities arise for unprincipled practice. Further, catering to rising consumption and the resultant increased demand for Halal products and services means consumers in Halal supply chains are particularly vulnerable to fraud, adulteration and unwitting contamination as global demand outstrips supply. Certification and its associated …

Development Of Gelatin From Halal And Alternative Sources: A Review, Farhani Ahmad, Musfirah Azmi, Nurhamieza Md Huzir, Norhidayu Muhamad Zain

Nusantara Halal Journal

Gelatin is a common ingredient used in various industrial sectors including food and beverage, cosmetic, pharmaceutical as well as biomedical. Due to inexpensive processing cost and shorter processing time, porcine becomes the main source of gelatin. Thus, the application of this ingredient creates several problems especially issues related to its halal status among Muslim community. The present study aims at reviewing the development of gelatin from halal sources and their potential as alternatives to substitute the sources of non-halal gelatins. The applications of gelatin in food industry and the current issues on halal gelatin have been discussed in detail. The …

Halal Education: Curriculum Management Based On Halal Entrepreneurship At Nahdlatul Ulama University Of Sidoarjo, Fatkul Anam, Nurul Istiq’Faroh

Nusantara Halal Journal

Indonesia is well-known for having the world's largest Muslim population. As a result, Indonesia has significant halal market potential. After forming the Institute for the Study of Food, Drugs, and Cosmetics in the Indonesian Ulema Council, halal products became more widely known (LPPOMMUI). Since then, public awareness and demand for Halal products have risen significantly, making Indonesia a lucrative market for halal businesses. In response to the rapid rise of the halal industry, a new curriculum has emerged in education to meet the difficulties of today's industrial world. Halal entrepreneurship is a newly designed university program. This study was implemented …

Can Technology Augment Order Writing Capacity At Regulators?, Natasha Aggarwal, Amrutha Desikan, Bhavin Patel, Satyavrat Bondre, Dipyaman Sanyal

Indian Journal of Law and Technology

This article critically examines the opportunities and challenges of using technology, in particular Large Language Models (‘LLMs’), to assist regulatory order writing in quasi-judicial settings in India. It proposes augmenting rather than replacing human decision-makers, aiming to improve regulatory order writing practice through responsible use of LLMs. This article identifies the core principles of administrative law that must be upheld in these settings and analyses how inherent limitations of LLMs may undermine these principles. The article reviews international frameworks and case studies from various jurisdictions, highlighting common design principles. It proposes a comprehensive Problem-Solution-Evaluation ('PSE') framework for responsibly integrating LLMs …

A Visual-Cultural Study Of The Paisley Motif And Its Application In Contemporary Scarf Design, Reham A. Sanad

Journal of Art, Design and Music

This study aimed to explore a significant source of inspiration in textile and fashion design, originating as an Indo-Persian design motif and becoming widespread through mass production in Europe, namely “Paisley”.  The paisley motif, in the shape of a teardrop, originating in Persia and popularised in 19th-century Scotland, represents life and eternity, showcasing a rich cultural legacy. This concept is investigated visually in the current study by examining its potential to sustain in the field of fashion and textiles. Historically, scarves symbolised status in ancient Egypt and were used in religious contexts in Eastern cultures, proving unique and deep roles …

The Communicative Impact Of Political Dress Culture On Contemporary Fashion Styles In Nigerian, Afeez Babatunde Siyanbola, Akinmoye Oluwambe, Adebayo Abiodun Adeloye, Evelyn Omotunde Adepeko, Festus O. Uzzi

Journal of Art, Design and Music

This study examines the communicative impact of political dress culture on contemporary fashion style in Nigeria. Nigerian society places importance on what one wears, how one dresses and when one wears a particular garment, which is often an expression of social affiliation and other influences. The power of dress is evident in the political perception of uniformity in the appearance of a particular group of people. This study highlights the richness and originality of Nigerian socio-cultural heritage and its influence on contemporary fashion style. The study highlights the influence of different cultures, ethnicity and religious affiliation on Nigerian political dress …

Sustainable Synthesis Of Low-Fire Metallic Luster Glazes From Local Qena Clays Without Reduction Firing, Rasha Fawzy Ahmed Abd-Elrahim, Ebrahim Dosouky Abd-Elmawgoud Soliman

Journal of Art, Design and Music

This study explores the development of a low-fire metallic luster glaze without employing traditional reduction firing techniques, utilizing locally sourced clays from Qena, Egypt. The research aimed to formulate an environmentally friendly and cost-effective glaze by harnessing the natural chemical composition of agricultural, marl, and Nile clays. Through three structured experimental phases, various combinations of fluxing agents (lead oxide and borax), metal oxides (MnO2, CuO, Cr2O3, AgNO3, CuCO3, Bi2O3), solvents (water- and oil-based), and glaze modifiers (potassium feldspar and wood ash) were systematically tested. The results revealed that manganese oxide, especially in combination with lead oxide, consistently produced a glassy …

The Technical Capabilities Of Traditional Methods And 3d Modeling In Ceramic Mold Manufacturing: An Experimental Comparative Study, Ebrahim Dosouky Abd-Elmawgoud Soliman, Rasha Fawzy Ahmed Abd-Elrahim

Journal of Art, Design and Music

Ceramic mold-making stands at the intersection of artistic heritage and technological innovation, prompting the present study to investigate the technical capabilities of traditional methods versus modern three-dimensional (3D) modeling in ceramic mold manufacturing. The research addresses the core problem of evaluating how each approach meets the demands of contemporary ceramic production in terms of precision, efficiency, cost, and design complexity. Aimed at Comparative The Technical Capabilities of Traditional Methods and 3D modeling in ceramic mold manufacturing. The significance of this work lies in its dual contribution: theoretically enriching the field of ceramic art through a systematic comparative analysis, and practically …

The Effectiveness Of Workplace Experience Learning In Hnd Fashion Design (Tvet) Programmes: Insights From Host Organizations In Ghana, Phyllis Mensah, Harry Barton Essel, Benjamine Tawiah, Akosua Tachie-Menson, Abena Okyerewa Siaw

Journal of Art, Design and Music

Workplace Experience Learning (WEL) has emerged as a vital component of Technical and Vocational Education and Training (TVET) in Ghana, particularly within programmes such as the Higher National Diploma (HND) in Fashion Design. This study examines the effectiveness of WEL from the perspective of host organizations, recognizing their pivotal role in shaping student outcomes. Anchored in Kolb’s Experiential Learning Theory, the research employed a mixed-method approach, gathering both quantitative and qualitative data from 120 host organizations across the Greater Accra, Ashanti, and Western Regions. Findings indicate that although most students demonstrate basic skills in garment design and construction, many struggle …

Processing Freehand Interior Architecture Sketches Using Ai Applications, Khaled M. Zaki Hawas

Journal of Art, Design and Music

The intersection of interior architecture design and artificial intelligence is revolutionizing how designers perceive, inhale, and implement their ideas. One of the most exciting developments in this field is the use of artificial intelligence to process interior architecture design drawings. Handmade sketches have always been an essential tool for designers, allowing them to visualize ideas and spaces and transfer concepts. However, the transition from drawing to final design can be time-consuming and challenging. AI applications are now intervening to streamline this process, providing designers with powerful tools to boost creativity, improve accuracy, and speed up workflows. With the advent of …

The Role Of Robot Aesthetics In User Acceptance: Examining Anthropomorphism, Color, And Form In Smart Home Environments, Aya M. Abd-El Gawad Mahmoud Gouda, Salwa A. El Garib, Hany M. El-Said

Journal of Art, Design and Music

This study examines how the aesthetic features of domestic robots—such as shape, color, proportions, and materials—impact user acceptance in smart home environments. A quantitative survey with 80 participants of varying ages and genders assessed emotional responses including comfort, trust, and connection with different robot designs. Results showed that robots with moderately human-like and friendly appearances generated more positive emotional reactions, suggesting a balance between aesthetics and functionality is essential. Key design elements enhancing attractiveness and usability were identified, offering practical guidelines for robot design. This research contributes to Human-Robot Interaction by integrating emotional, functional, and aesthetic factors, emphasizing the unique …

Utilizing Deep Learning To Generate Biomorphic Furniture Design: A Generative Approach, Asmaa Medhat Abd El Aziz Mostafa, Doaa Abdelrahman Mohamed Goda, Dalia Mohamed Ezzat

Journal of Art, Design and Music

This research paper highlights the relatively unexplored potential of deep learning, a branch of artificial intelligence, to radically transform design in general, and specifically in the field of furniture design, by creating new design concepts inspired by living organisms such as marine biology. The main objective of this research is to explore the role of deep learning and artificial intelligence as tools for generating innovative and novel furniture designs inspired by marine organisms (marine biology). The research followed experimental methodology through a prompt engineering-based protocol, using ChatGPT-4 to produce an optimized prompt to be subsequently used on the (Prome AI) …

Innovative Designs For One-Piece Clothing Inspired By The Textures And Color Of Textile Structures, Macramé And Carpet Stitches, Fatma M. Ahmed, Maysa M. Reda, Heba A. Abd El-Aziz, Ahmed G. Hassabo, Hanan A. Othman

Journal of Art, Design and Music

Social ideals and youth curiosity shape fashion. Technology aids product design, balancing form and function. New designs in kids' garments are important for fashion. Computers can swiftly alter images and designs, switch between apps, and have a broad vision, making them ideal for developing one-piece textile prints. They help designers connect one-piece textile printing to production engineering standards with simple accuracy and visibility. Polyester was tested for textile printing. Transfer printing sublimated and thermofixed the ink from paper to polyester fiber. Design research examined how wool and cotton threads affect non-woven fabric structures (macrame). The design experiment examined the interdependence …