Digital Commons Network^™

Potency Assay To Predict The Anti-Inflammatory Capacity Of A Cell Therapy Product For Macrophage-Driven Diseases: Overcoming The Challenges Of Assay Development And Validation, Samar Sadeghi, Laura Nimtz, Elke Niebergall-Roth, Alexandra Norrick, Stefan Hägele, Lena Vollmer, Jasmina Esterlechner, Markus H. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Mark A. Kluth

Research outputs 2022 to 2026

Background: Given the high level of product complexity and limited regulatory guidance, designing and implementing appropriate potency assays is often the most challenging part of establishing a quality control testing matrix for a cell-based medicinal product. Among the most elusive tasks are the selection of suitable read-out parameters, the development of assay designs that most closely model the pathophysiological conditions, and the validation of the methods. Here we describe these challenges and how they were addressed in developing an assay that measures the anti-inflammatory potency of mesenchymal stromal cells (MSCs) in an M1 macrophage-dominated inflammatory environment. Methods: An in vitro …

The Role Of Pennation Angle And Architectural Gearing To Rate Of Force Development In Dynamic And Isometric Muscle Contractions, Bas Van Hooren, Per Aagaard, Andrea Monte, Anthony J. Blazevich

Research outputs 2022 to 2026

Background: Associations between muscle architecture and rate of force development (RFD) have been largely studied during fixed-end (isometric) contractions. Fixed-end contractions may, however, limit muscle shape changes and thus alter the relationship between muscle architecture an RFD. Aim: We compared the correlation between muscle architecture and architectural gearing and knee extensor RFD when assessed during dynamic versus fixed-end contractions. Methods: Twenty-two recreationally active male runners performed dynamic knee extensions at constant acceleration (2000°s−2) and isometric contractions at a fixed knee joint angle (fixed-end contractions). Torque, RFD, vastus lateralis muscle thickness, and fascicle dynamics were compared during 0–75 and 75–150 ms …

Diagnostic Performance Of The Ggt/Hdl-C Ratio For Nafld In Adults With Obesity Undergoing Bariatric Surgery, Renzo Pajuelo-Vasquez, Jerry K. Benites-Meza, Hilda V. Durango-Chavez, Gustavo Salinas-Sedo, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Background: Non-alcoholic fatty liver disease (NAFLD) has become the most frequent liver disease, closely related with metabolic risk factors such as obesity, insulin resistance, dyslipidemia, diabetes mellitus, and metabolic syndrome. In this context, -Glutamyl transpeptidase (GGT) and high-density lipoprotein cholesterol (HDL-C) have shown correlations with steatosis severity and metabolic syndrome, respectively. This positions the GGT/HDL-C ratio as a potential diagnostic indicator for NAFLD. Objective: To assess the diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery. Methods: We conducted an analytical cross-sectional study, designed as a diagnostic test evaluation. A secondary database of 249 …

A Photocrosslinkable And Hemostatic Bilayer Wound Dressing Based On Gelatin Methacrylate Hydrogel And Polyvinyl Alcohol Foam For Skin Regeneration, Asghar Eskandarinia, Mohammad H. Morowvat, Seyyed V. Niknezhad, Moloud Amini Baghbadorani, Martin Michálek, Si Chen, Mohammad M. Nemati, Manica Negahdaripour, Reza Heidari, Amir Azadi, Younes Ghasemi

Research outputs 2022 to 2026

The enormous potential of multifunctional bilayer wound dressings in various medical interventions for wound healing has led to decades of exploration into this field of medicine. However, it is usually difficult to synthesize a single hydrogel with all the required capabilities simultaneously. This paper proposes a bilayer model with an outer layer intended for hydrogel wound treatment. By adding gelatin methacrylate (GelMA) and tannic acid (TA) to the hydrogel composition and using polyvinyl alcohol-carboxymethyl chitosan (PVA-CMCs) foam layer as supports, a photocrosslinkable hydrogel with an optimal formulation was created. The hydrogels were then examined using a range of analytical procedures, …

The Cooling Impact Of Urban Greening: A Systematic Review Of Methodologies And Data Sources, Saman Galalizadeh, Angus Morrison-Saunders, Pierre Horwitz, Richard Silberstein, David Blake

Research outputs 2022 to 2026

Urban greening is a practical adaptation to improve the liveability of a city by providing urban cooling. This paper systematically evaluates the existing literature to understand the methodologies and associated data sources for determining the cooling effect provided by urban greening. A bibliometric analysis, including research focus parallelship network analysis and keyword co-occurrence network analysis using Gephi and BibExcel, was first performed on 156 articles to identify the main resulting research themes in cooling provided by UGAs. Subsequently, 72 of these were selected to extract more information, such as the focus, the measured parameters, the methods, and tools employed to …

A Computational Investigation Into Thermo-Kinetic Parameters Governing The Decomposition Of Bio-Oil Model Compounds, Ali Huseein Aljefri

Theses

Among notable products from thermal degradation of biomass are simple oxygen-containing aromatics. These compounds typically appear in high loads in collected bio-oil derived from biomass. As such, it is important to comprehend the decomposition chemistry of this category of compounds. This thesis takes on board a general approach to report thermo-kinetic parameters that govern decomposition of a selected set of bio-oil model compounds in two distinct systems: firstly radical-derived pathways in the gas phase and secondly thermal degradation in their condensed media. The first is attained through accurate density functional calculations while the second is accomplished through the use of …

Abnormal Cleavage Up To Day 3 Does Not Compromise Live Birth And Neonatal Outcomes Of Embryos That Have Achieved Full Blastulation: A Retrospective Cohort Study, Tammy Lee, Kelli Peirce, Jay Natalwala, Vincent Chapple, Peter J. Mark, Katherine Sanders, Yanhe Liu

Research outputs 2022 to 2026

STUDY QUESTION: Do embryos displaying abnormal cleavage (ABNCL) up to Day 3 have compromised live birth rates and neonatal outcomes if full blastulation has been achieved prior to transfer? SUMMARY ANSWER: ABNCL is associated with reduced full blastulation rates but does not impact live birth rates and neonatal outcomes once full blastulation has been achieved. WHAT IS KNOWN ALREADY?: It is widely accepted that ABNCL is associated with reduced implantation rates of embryos when transferred at the cleavage stage. However, evidence is scarce in the literature reporting birth outcomes from blastocysts arising from ABNCL embryos, likely because they are ranked …

Biomass Estimation Of Mature Mangrove Trees In The Uae Using Spaceborne Remote Sensing Techniques, Yasmine Ashraf Heikal

Theses

Mangrove forest ecosystems play an essential role in diminishing the effects of climate change caused by the increase in carbon dioxide in the atmosphere. Estimating mangrove forest aboveground biomass (AGB) and hence aboveground carbon (AGC) can assist in decision-making for conservation, sustainable use, and protection of these forests. The goal of this research project was to map the AGB of mangrove forests along the coasts of the United Arab Emirates (UAE) with the aid of Landsat-8-9 satellite imagery data acquired in September 2023. 12 AGB estimation models were developed based on the combination of in situ measurements and Landsat-8-9 derived …

Accuracy Testing Of Different Methods For Estimating Weibull Parameters Of Wind Energy At Various Heights Above Sea Level, Sajid Ali, Hongbae Park, Adnan Aslam Noon, Aamer Sharif, Daeyong Lee

Research outputs 2022 to 2026

The Weibull algorithm is one of the most accurate tools for forecasting and estimating wind energy potential. Two main parameters of the Weibull algorithm are the ‘Weibull shape’ and ‘Weibull scale’ factors. There are six different numerical methods to estimate the two Weibull parameters. These six methods are the empirical method of Justus (method 1), the empirical method of Lysen (method 2), the maximum likelihood method (method 3), the modified maximum likelihood method (method 4), the energy pattern factor method (method 5) and the graphical method (method 6). Many commercial wind energy software programs use the Weibull algorithm, and these …

Association Of Body Iron Stores And Anemia In A Ghanaian Type-2 Diabetes Mellitus Population: A Multicentered Cross-Sectional Study, Wina I.O. Boadu, William K.B.A. Owiredu, Emmanuel Timmy Donkoh, Kwame O. Boadu, Afia A. Kwayie, Joseph Frimpong, Enoch O. Anto, Christian Obirikorang, Emmanuel E. Korsah, Ezekiel Ansah, Michael Nyantakyi, Stephen Opoku, Ebenezer Senu, Elizabeth Aboagye

Research outputs 2022 to 2026

Background and Aims: Anemia has been a common comorbidity in most chronic diseases, but has not been well monitored in type 2 diabetes mellitus (T2DM) patients. In this study, we investigated the prevalence of anemia and its nexus with iron stores among T2DM patients in health facilities in the Ashanti Region of Ghana. Methods: This multicenter cross-sectional study recruited 213 T2DM out-patients attending the diabetic clinics at the Kumasi South Hospital and St. Michaels Hospital, Jachie Pramso, Ghana, for routine check-ups. Self-reported questionnaires were used to collect sociodemographic, lifestyle, and clinical data from study participants. Blood samples were collected to …

Exploring The Phenomenon Of Code-Switching In Immersive Esl Kindergarten In The Uae, Abeer Nabeel Albayari

Theses

This thesis explores the phenomenon of code-switching among those learning English as second language in an immersive kindergarten setting in the United Arab Emirates (UAE). There is a lack of research on code-switching practices, specifically among kindergarten students in immersive language programs in the UAE. They argue that this gap in research is particularly concerning, given the growing number of young learners who are enrolled in such programs in the UAE.
The main objective of this study is to identify when kindergarten students switch from English to Arabic their L1 during their immersive English language classes, intending to understand the …

Defining The Phylogenetics And Resistome Of The Major Clostridioides Difficile Ribotypes Circulating In Australia, Keeley O’Grady, Stacey Hong, Papanin Putsathit, Narelle George, Christine Hemphill, Peter G. Huntington, Tony M. Korman, Despina Kotsanas, Monica Lahra, Rodney Mcdougall, Andrew Mcglinchey, Avram Levy, Casey V. Moore, Graeme Nimmo, Louise Prendergast, Jennifer Robson, David J. Speers, Lynette Waring, Michael C. Wehrhahn, Gerhard F. Weldhagen, Richard M. Wilson, Thomas V. Riley, Daniel R. Knight

Research outputs 2022 to 2026

Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal genomic data on strain diversity, transmission dynamics and antimicrobial resistance (AMR) of C. difficile ribotypes (RTs) 014/020 (n=169), 002 (n=77) and 056 (n=36), the three most prominent C. difficile strains causing CDI in Australia. Genome scrutiny showed that AMR was uncommon in these lineages, with resistance-conferring alleles present in only 15/169 RT014/020 strains (8.9 %), 1/36 RT056 strains (2.78 %) and none of 77 RT002 strains. Notably, ~90 …

Diabetic And Hypertensive Disorders Following Early Pregnancy Loss: A Systematic Review And Meta-Analysis, Jennifer Dunne, Damien Foo, Berihun A. Dachew, Bereket Duko, Amanuel T. Gebremedhin, Sylvester D. Nyadanu, Gavin Pereira, Gizachew A. Tessema

Research outputs 2022 to 2026

Background: Spontaneous and induced abortions are common outcomes of pregnancy. There is inconsistent evidence of an association between early pregnancy loss and subsequent diabetic and hypertensive disorders in women. This systematic review and meta-analysis evaluated evidence on the risk of the subsequent development of pregnancy and non-pregnancy related diabetic and hypertensive disorders in women who experienced an early pregnancy loss.

Methods: Systematic searches were conducted in seven electronic databases (CINAHL Plus, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, and Web of Science) from inception to 22nd December 2023. Studies were included if they reported an exposure of spontaneous abortion (SAB), induced abortion …

Heat Sink Integrating Phase Change Materials (Pcms) For Cooling High Power Electronic Devices, Mohammad Sameer Qasem

Theses

This research explores the numerical analysis of phase change materials (PCMs) heat sinks, focusing on high heat flux dissipation applications, e.g. electronics cooling. Both 2D and 3D numerical models using gallium and paraffin RT31 as PCMs are considered within a heat sink design framework featuring a rectangular cavity and dual opposing vertical copper walls serving as fins to dissipate heat from the hot sink base that receives heat from the heat source. The inclusion of a Triply Periodic Minimal Surface (TPMS) ‘Primitive’ structure as an in-fill thermal conductivity enhancer (TCE) in the case of the gallium heat sink, and a …

Emulsion Stability, Rheological Properties, And Combustion Characteristics Of Water-Jojoba Biofuel Emulsion, Ihab Mohamed Helal

Theses

This thesis comprehensively investigates the stability, rheological properties, and engine performance implications of Water in Jojoba Biodiesel (WJBD) emulsion. The research delves into multiple aspects, including the influence of diverse surfactants and water concentrations on emulsion stability. It also yields valuable insights into the development of stable water in jojoba biodiesel emulsions, specifically tailored for diesel engines. These insights contribute significantly to the body of knowledge of positioning emulsion fuels as viable alternative to traditional diesel fuels. The anticipated benefits include notable reductions in emissions, improvement in combustion efficiency, and lower production cost. Importantly, this study underscores the critical importance …

المسؤولية الجنائية الدولية للقادة, فاطمة محمد الظھوري

Theses

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The International Criminal Liability of Leaders

The primary objective of this research is to explore and elucidate the concepts, principles, and legal frameworks pertaining to the international criminal liability of leaders, particularly in instances where they contravene established norms and statutes of international criminal law. This endeavor seeks to foster a deeper understanding and appreciation for the enforcement mechanisms underpinning such liability, thereby reinforcing respect for international legal standards. The study delves into the evolution of this principle and examines the contemporary acceptance of the idea that leaders and heads of state can be held accountable before a stable …

Vascular Brain Digital Twins For Medical Training And Education In Metaverse, Shamma Khaled Alghafri

Theses

This study addresses the need for innovative educational tools in the field of anatomy, specifically focusing on brain anatomy. The objective is to develop a virtual reality application and a 3D visualization that offer immersive and interactive learning experiences for students. The VR application, developed using Unity and designed for the Oculus Quest 2 headset, creates an immersive virtual laboratory environment. This environment includes interactive elements such as a table with buttons for displaying brain models and a whiteboard for user interaction. Users can manipulate and explore different brain structures, enhancing their understanding of complex anatomical features. Additionally, we integrated …

Head Impact Measurement Using Piezoelectric Sensors, Huda Abdulla Alnuaimi

Theses

The importance of safety measures cannot be overstated, especially when it comes to protecting the human head. Head injuries can have severe, life-altering consequences, as the head is crucial for controlling the entire body. Unlike machines that store data, the human brain's capacity to retain thoughts and memories can be significantly affected by even a single injury. This thesis introduces a method for predicting the specific area of the head that might be injured during an impact. The prediction is based on the intensity and duration of the impact. The innovation of this thesis lies in the use of piezoelectric …

Retrofit Prioritization Of Substandard Buildings For Earthquake Risk Management, Roshen John Joseph

Dissertations

Despite the pressing need for risk mitigation techniques for reinforced concrete (RC) structures designed without considering seismic design provisions, limited research has focused on selecting experimentally verified retrofit measures from various alternatives, particularly considering minimizing disruption to operating real-life buildings. Against this backdrop, this study is directed toward selecting reliable and costeffective retrofit techniques for improving the seismic performance of substandard RC buildings with different structural systems and heights common in medium seismicity regions. Contemporary retrofit approaches are investigated, including polyparaphenylene benzobisoxazole fiber-reinforced cementitious matrix (P-FRCM) composites, carbon FRCM (C-FRCM) composites, thin high-performance reinforced concrete (HPRC) jackets, and self-centering energy …

Exopolysaccharides Of Lactic Acid Bacteria Isolated From Labneh: Characterization, Bioactivities, And Effects On Gut Microbiome And Fermented Milk Rheology, Mohammed Tarique

Dissertations

Exopolysaccharides (EPS), produced by Lactic Acid Bacteria (LAB), are carbohydrate polymers with unique physicochemical properties and various biological activities widely used in food and pharmaceutical industries. This dissertation is aimed to (1) screen 42 new isolates from traditional yogurt-like products (Labneh) for their probiotic nature and identify the LAB strains using 16S rDNA sequencing; (2) optimize the conditions like pH, temperature, time, and quantity of sucrose for the growth of EPS produced by four selected LAB isolates; (3) purify and characterize EPS for the contents and investigate the bioactivities of the partially purified EPS; (4) study the effects of the …

Perovskite Materials For Optoelectronics Applications: Solar Cells And Photodetectors, Abdul Kareem Kalathil Soopy

Dissertations

Perovskite materials have emerged as promising candidates for optoelectronic applications, particularly in solar cells and photodetectors, due to their remarkable properties such as high carrier mobility, tunable bandgap, and low-cost fabrication. This thesis explores two novel approaches, namely monovalent doping and bulk as well as surface passivation, to enhance the performance and stability of perovskite-based devices.

The primary goal of this research is to enhance the properties of perovskite materials to improve their optoelectronic performance, aiming to broaden their use in solar cells and photodetector devices. Specifically, this study seeks to evaluate the effectiveness of Cu doping and Zinc porphyrin …

Choosing Sides: On The Manipulation Of Civil Litigation, Yotam Kaplan, Ittai Paldor

Vanderbilt Law Review

Our litigation system is broken. Scholars have long warned that professional litigants, such as debt-collecting firms, insurance companies, and commercial landlords, enjoy immense and unfair advantages over private individuals. What has gone unnoticed is professional litigants’ ability to manipulate their litigatory position—that is, to choose whether they will litigate as plaintiffs or defendants. Extant literature assumes that the parties’ litigatory positions are determined by the substance of the dispute: the party seeking a remedy is the plaintiff, and the party objecting to the award of a remedy is the defendant. We show that, in reality, professional litigants have both the …

Anti-Transgender Constitutional Law, Katie Eyer

Vanderbilt Law Review

Over the course of the last three decades, gender identity anti-discrimination protections and other transgender-supportive government policies have increased, as government entities have sought to protect and support the transgender community. But constitutional litigation by opponents of transgender equality has also proliferated, seeking to limit or eliminate such trans-protective measures. Such litigation has attacked as unconstitutional everything from laws prohibiting anti-transgender employment discrimination to the efforts of individual public school teachers to support transgender teens.

This Article provides the first systematic account of the phenomenon of anti-transgender constitutional litigation. As described herein, such litigation is surprisingly novel: while trans-protective measures …

Application Of Microphytes For Soil Reclamation, Lalit Saini, Hina Upadhyay, Arindam Chakraborty

Research Publications (2021 to 2025)

Microphytes incorporate several characteristics that are becoming increasingly important in a complex farming setting and the process of land reclamation. Microalgae/microphytes boost soil productivity and structure by adding minerals and improving microbial soil quality metrics and nutrient cycling. Protecting plants from disease, producing phytohormones and other bioactive compounds, and associating with plant roots are the ways through which microalgae contribute to plant development. These results are significant as they could lead to further advancements in the discovery of substances that can boost growth or the development of crops that do not need nitrogen. Microalgae have massive untapped capabilities as natural …

Arkib Universiti Sebagai Repositori Memori Institusi / Siti Mawarni Salim, Noorsuzila Mohamad, Nor Edzan Che Nasir, Salim Siti Mawarni, Mohamad Noorsuzila, Che Nasir Nor Edzan

Research Publications (2021 to 2025)

Arkib universiti merupakan repositori untuk rekod, penerbitan dan artifak sesebuah universiti. Tanggungjawab untuk membangun dan mengurus arkib universiti lazimnya diserahkan kepada perpustakaan universiti berkenaan. Buat masa kini, kebanyakan universiti tertua mempunyai arkib universiti tersendiri seperti Harvard University Archives, Archives at Yale, University of Cambridge University Archives, Oxford University Archives, Kyoto University Archives, Osaka University Archive Repository, Museum of Peking University History, Tsinghua University History Museum dan banyak lagi. Di Malaysia, terdapat 20 buah universiti awam dan pelbagai jumlah universiti swasta, kampus universiti luar negara, kolej, politeknik, kolej komuniti dan kolej swasta. Sehingga kini, tiada rekod rasmi bilangan institusi pengajian tinggi …

Lattice Investigations Of The Chimera Baryon Spectrum In The Sp (4) Gauge Theory, Ed Bennett, Deog Ki Hong, Ho Hsiao, Jong Wan Lee, C. J.David Lin, Biagio Lucini, Maurizio Piai, Davide Vadacchino

School of Engineering, Computing and Mathematics

We report the results of lattice numerical studies of the Sp(4) gauge theory coupled to fermions (hyperquarks) transforming in the fundamental and two-index antisymmetric representations of the gauge group. This strongly coupled theory is the minimal candidate for the ultraviolet completion of composite Higgs models that facilitate the mechanism of partial compositeness for generating the top-quark mass. We measure the spectrum of the low-lying, half-integer spin, bound states composed of two fundamental and one antisymmetric hyperquarks, dubbed chimera baryons, in the quenched approximation. In this first systematic, nonperturbative study, we focus on the three lightest parity-even chimera-baryon states, in analogy …

Enhanced Hoek-Brown (H-B) Criterion For Rocks Exposed To Chemical Corrosion, Hao Li, Leo Pel, Zhenjiang You, David Smeulders

Research outputs 2022 to 2026

Underground constructions often encounter water environments, where water–rock interaction can increase porosity, thereby weakening engineering rocks. Correspondingly, the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such structures. This study enhances the applicability of the Hoek-Brown (H-B) criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi (KPIM). A multiscale experimental investigation, including nuclear magnetic resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), pH and ion chromatography analysis, and triaxial compression tests, is employed to quantify pore structural changes and their linkage with the strength responses …

Retinal Dystrophies Associated With Peripherin-2: Genetic Spectrum And Novel Clinical Observations In 241 Patients, Rachael C. Heath Jeffery, Jennifer A. Thompson, Johnny Lo, Enid S. Chelva, Sean Armstrong, Jose S. Pulido, Rebecca Procopio, Andrea L. Vincent, Lorenzo Bianco, Maurizio Battaglia Parodi, Lucia Ziccardi, Giulio Antonelli, Lucilla Barbano, João P. Marques, Sara Geada, Ana L. Carvalho, Wei C. Tang, Choi M. Chan, Camiel J.F. Boon, Jonathan Hensman, Ta Ching Chen, Chien Yu Lin, Pei Lung Chen, Ajoy Vincent, Anupreet Tumber, Elise Heon

Research outputs 2022 to 2026

Purpose:

To describe the clinical, electrophysiological and genetic spectrum of inherited retinal diseases associated with variants in the PRPH2 gene.

Methods.

A total of 241 patients from 168 families across 15 sites in 9 countries with pathogenic or likely pathogenic variants in PRPH2 were included. Records were reviewed for age at symptom onset, visual acuity, full-field ERG, fundus colour photography, fundus autofluorescence (FAF), and SD-OCT. Images were graded into six phenotypes. Statistical analyses were performed to determine genotype–phenotype correlations.

Results:

The median age at symptom onset was 40 years (range, 4–78 years). FAF phenotypes included normal (5%), butterfly pattern dystrophy, …

Scs 6th Annual Meeting—Eevfa—11th International Congress Of Biochemistry And Physiology Of Exercise, Athens, Greece, 2023, Pedro E. Alcaraz, Elena Marín-Cascales, Anthony J. Blazevich, Tomás T. Freitas, Olyvia Donti, Konstantinos Spyrou, Gregory C. Bogdanis

Research outputs 2022 to 2026

On behalf of the Strength and Conditioning Society (SCS) and the Hellenic Society of Biochemistry and Exercise Physiology (EEVFA), we are pleased to present the abstracts of the SCS 6th Annual Meeting and EEVFA—11th International Congress of Biochemistry and Physiology of Exercise. The event was held at the Hellenic Olympic Committee headquarters in Athens, Greece, on 19–22 October 2023, and comprised several invited sessions from international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application to health, injury prevention and sports performance. These included strength training in high-performance …

Intensity-Dependent Effects Of Tdcs On Motor Learning Are Related To Dopamine, Li Ann Leow, Jiaqin Jiang, Samantha Bowers, Yuhan Zhang, Paul E. Dux, Hannah L. Filmer

Research outputs 2022 to 2026

Non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), are popular methods for inducing neuroplastic changes to alter cognition and behaviour. One challenge for the field is to optimise stimulation protocols to maximise benefits. For this to happen, we need a better understanding of how stimulation modulates cortical functioning/behaviour. To date, there is increasing evidence for a dose-response relationship between tDCS and brain excitability, however how this relates to behaviour is not well understood. Even less is known about the neurochemical mechanisms which may drive the dose-response relationship between stimulation intensities and behaviour. Here, we examine the effect …